DK0822986T3 - Antagonister af human interleukin-6, der er fuldstændig ude af stand til at binde GP 130, og deres anvendelse til fremstilling af farmaceutiske forbindelser - Google Patents

Antagonister af human interleukin-6, der er fuldstændig ude af stand til at binde GP 130, og deres anvendelse til fremstilling af farmaceutiske forbindelser

Info

Publication number
DK0822986T3
DK0822986T3 DK96912205T DK96912205T DK0822986T3 DK 0822986 T3 DK0822986 T3 DK 0822986T3 DK 96912205 T DK96912205 T DK 96912205T DK 96912205 T DK96912205 T DK 96912205T DK 0822986 T3 DK0822986 T3 DK 0822986T3
Authority
DK
Denmark
Prior art keywords
human interleukin
antagonists
pct
bind
preparation
Prior art date
Application number
DK96912205T
Other languages
Danish (da)
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Giacomo Paonessa
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0822986T3 publication Critical patent/DK0822986T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96912205T 1995-04-28 1996-04-26 Antagonister af human interleukin-6, der er fuldstændig ude af stand til at binde GP 130, og deres anvendelse til fremstilling af farmaceutiske forbindelser DK0822986T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
PCT/IT1996/000084 WO1996034104A1 (fr) 1995-04-28 1996-04-26 Antagonistes de l'interleukine-6 humaine totalement incapables de se lier a la gp130 et leur utilisation pour l'elaboration de composes pharmaceutiques

Publications (1)

Publication Number Publication Date
DK0822986T3 true DK0822986T3 (da) 2003-04-28

Family

ID=11403338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96912205T DK0822986T3 (da) 1995-04-28 1996-04-26 Antagonister af human interleukin-6, der er fuldstændig ude af stand til at binde GP 130, og deres anvendelse til fremstilling af farmaceutiske forbindelser

Country Status (11)

Country Link
US (1) US5972902A (fr)
EP (1) EP0822986B1 (fr)
JP (2) JP3373856B2 (fr)
AT (1) ATE233320T1 (fr)
CA (1) CA2218372C (fr)
DE (1) DE69626387T2 (fr)
DK (1) DK0822986T3 (fr)
ES (1) ES2191096T3 (fr)
IT (1) IT1276555B1 (fr)
PT (1) PT822986E (fr)
WO (1) WO1996034104A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017441A1 (fr) * 1995-11-07 1997-05-15 Kaneka Corporation Autoantigenes
WO1997029201A2 (fr) * 1996-02-07 1997-08-14 Max-Delbrück-Centrum für Molekulare Medizin Vecteur retroviral pour le transfert genique d'un antagoniste d'il6 dans des cellules souches hematopoietiques humaines
JPH10324639A (ja) 1997-03-21 1998-12-08 Chugai Pharmaceut Co Ltd Ｉｌ−６アンタゴニストを有効成分として含有する感作ｔ細胞関与疾患の予防・治療剤
IT1291932B1 (it) * 1997-06-20 1999-01-21 Angeletti P Ist Richerche Bio Composizioni farmaceutiche antitumorali capaci anche di ridurre la farmacoresistenza in cellule tumorali, in particolare di carcinoma
MXPA02008697A (es) 2000-03-06 2003-04-14 Sigma Tau Ind Farmaceuti Uso de antagonistas de interleucina-6 para el tratamiento de enfermedades caracterizadas por altos niveles de aromatasa.
US7291721B2 (en) * 2001-11-14 2007-11-06 Centocor, Inc. Anti-IL-6 antibodies, compositions, methods and uses
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
ITRM20050103A1 (it) * 2005-03-10 2006-09-11 Rocco Savino Associazione di antagonisti della interleuchina 6 e farmaci antiproliferativi.
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0672144A1 (fr) * 1992-10-20 1995-09-20 Chiron Corporation Antagonistes du recepteur d'interleukine 6
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.

Also Published As

Publication number Publication date
ES2191096T3 (es) 2003-09-01
IT1276555B1 (it) 1997-11-03
ITRM950273A1 (it) 1996-10-28
PT822986E (pt) 2003-07-31
US5972902A (en) 1999-10-26
JPH10506538A (ja) 1998-06-30
WO1996034104A1 (fr) 1996-10-31
DE69626387D1 (de) 2003-04-03
ITRM950273A0 (it) 1995-04-28
CA2218372C (fr) 2001-07-31
JP3373856B2 (ja) 2003-02-04
EP0822986A1 (fr) 1998-02-11
JP2003153691A (ja) 2003-05-27
EP0822986B1 (fr) 2003-02-26
CA2218372A1 (fr) 1996-10-31
ATE233320T1 (de) 2003-03-15
DE69626387T2 (de) 2003-12-11

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