DK0818447T3 - 6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer - Google Patents
6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorerInfo
- Publication number
- DK0818447T3 DK0818447T3 DK97110276T DK97110276T DK0818447T3 DK 0818447 T3 DK0818447 T3 DK 0818447T3 DK 97110276 T DK97110276 T DK 97110276T DK 97110276 T DK97110276 T DK 97110276T DK 0818447 T3 DK0818447 T3 DK 0818447T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxymethyl
- hmg
- pyridine
- ethyl
- coa reductase
- Prior art date
Links
- OXZXELXVPQSDGR-UHFFFAOYSA-N 2-pyridin-2-ylpropan-1-ol Chemical compound OCC(C)C1=CC=CC=N1 OXZXELXVPQSDGR-UHFFFAOYSA-N 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19627420A DE19627420A1 (de) | 1996-07-08 | 1996-07-08 | 6-(Hydroxymethyl-ethyl)pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0818447T3 true DK0818447T3 (da) | 2004-09-20 |
Family
ID=7799209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97110276T DK0818447T3 (da) | 1996-07-08 | 1997-06-24 | 6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5849749A (es) |
| EP (1) | EP0818447B1 (es) |
| JP (1) | JPH1067744A (es) |
| AT (1) | ATE267807T1 (es) |
| CA (1) | CA2209550A1 (es) |
| DE (2) | DE19627420A1 (es) |
| DK (1) | DK0818447T3 (es) |
| ES (1) | ES2219711T3 (es) |
| PT (1) | PT818447E (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003259188B2 (en) * | 2002-07-19 | 2008-03-06 | Aryx Therapeutics, Inc. | Materials and methods for treating hypercholesterolemia |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| ES2082755T3 (es) * | 1987-07-10 | 1996-04-01 | Hoechst Ag | Derivados de acido 3-desmetil-mevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su utilizacion asi como productos intermedios. |
| US4997837A (en) * | 1987-09-08 | 1991-03-05 | Warner-Lambert Company | 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
| US5177080A (en) * | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| DE4321421A1 (de) * | 1992-12-21 | 1994-06-23 | Bayer Ag | Substituierte 4-Phenyl-pyridone und 4-Phenyl-2-alkoxypyridine |
| AU660132B2 (en) * | 1992-12-21 | 1995-06-08 | Bayer Aktiengesellschaft | Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine |
| DE4244029A1 (de) * | 1992-12-24 | 1994-06-30 | Bayer Ag | Neue substituierte Pyridine |
-
1996
- 1996-07-08 DE DE19627420A patent/DE19627420A1/de not_active Withdrawn
-
1997
- 1997-06-24 PT PT97110276T patent/PT818447E/pt unknown
- 1997-06-24 ES ES97110276T patent/ES2219711T3/es not_active Expired - Lifetime
- 1997-06-24 AT AT97110276T patent/ATE267807T1/de not_active IP Right Cessation
- 1997-06-24 DE DE59711657T patent/DE59711657D1/de not_active Expired - Fee Related
- 1997-06-24 DK DK97110276T patent/DK0818447T3/da active
- 1997-06-24 EP EP97110276A patent/EP0818447B1/de not_active Expired - Lifetime
- 1997-06-27 US US08/883,695 patent/US5849749A/en not_active Expired - Fee Related
- 1997-07-03 JP JP9192010A patent/JPH1067744A/ja active Pending
- 1997-07-04 CA CA002209550A patent/CA2209550A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE19627420A1 (de) | 1998-01-15 |
| EP0818447B1 (de) | 2004-05-26 |
| DE59711657D1 (de) | 2004-07-01 |
| PT818447E (pt) | 2004-08-31 |
| ES2219711T3 (es) | 2004-12-01 |
| US5849749A (en) | 1998-12-15 |
| JPH1067744A (ja) | 1998-03-10 |
| ATE267807T1 (de) | 2004-06-15 |
| EP0818447A1 (de) | 1998-01-14 |
| CA2209550A1 (en) | 1998-01-08 |
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