DK0818447T3 - 6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer - Google Patents

6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer

Info

Publication number
DK0818447T3
DK0818447T3 DK97110276T DK97110276T DK0818447T3 DK 0818447 T3 DK0818447 T3 DK 0818447T3 DK 97110276 T DK97110276 T DK 97110276T DK 97110276 T DK97110276 T DK 97110276T DK 0818447 T3 DK0818447 T3 DK 0818447T3
Authority
DK
Denmark
Prior art keywords
hydroxymethyl
hmg
pyridine
ethyl
coa reductase
Prior art date
Application number
DK97110276T
Other languages
English (en)
Inventor
Rolf Dr Angerbauer
Hilmar Dr Bischoff
Delf Dr Schmidt
Peter Dr Fey
Wolfgang Dr Kanhai
Martin Dr Radtke
Wolfgang Dr Karl
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Application granted granted Critical
Publication of DK0818447T3 publication Critical patent/DK0818447T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK97110276T 1996-07-08 1997-06-24 6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer DK0818447T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19627420A DE19627420A1 (de) 1996-07-08 1996-07-08 6-(Hydroxymethyl-ethyl)pyridine

Publications (1)

Publication Number Publication Date
DK0818447T3 true DK0818447T3 (da) 2004-09-20

Family

ID=7799209

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97110276T DK0818447T3 (da) 1996-07-08 1997-06-24 6-(Hydroxymethyl-ethyl)pyridin som HMG-CoA-reduktase inhibitorer

Country Status (9)

Country Link
US (1) US5849749A (da)
EP (1) EP0818447B1 (da)
JP (1) JPH1067744A (da)
AT (1) ATE267807T1 (da)
CA (1) CA2209550A1 (da)
DE (2) DE19627420A1 (da)
DK (1) DK0818447T3 (da)
ES (1) ES2219711T3 (da)
PT (1) PT818447E (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1537068A1 (en) * 2002-07-19 2005-06-08 Aryx Therapeutics Materials and methods for treating hypercholesterolemia

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
EP0307342B1 (de) * 1987-07-10 1996-01-03 Hoechst Aktiengesellschaft 3-Desmethyl-mevalonsäurederivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen, ihre Verwendung sowie Zwischenprodukte
US4997837A (en) * 1987-09-08 1991-03-05 Warner-Lambert Company 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
US5177080A (en) * 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
AU660132B2 (en) * 1992-12-21 1995-06-08 Bayer Aktiengesellschaft Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine
DE4321421A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte 4-Phenyl-pyridone und 4-Phenyl-2-alkoxypyridine
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine

Also Published As

Publication number Publication date
ES2219711T3 (es) 2004-12-01
PT818447E (pt) 2004-08-31
US5849749A (en) 1998-12-15
CA2209550A1 (en) 1998-01-08
JPH1067744A (ja) 1998-03-10
DE59711657D1 (de) 2004-07-01
ATE267807T1 (de) 2004-06-15
EP0818447A1 (de) 1998-01-14
DE19627420A1 (de) 1998-01-15
EP0818447B1 (de) 2004-05-26

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