DK0808305T3 - 3,4-Diaryl-substituerede pyridiner til behandling af inflammation - Google Patents

3,4-Diaryl-substituerede pyridiner til behandling af inflammation

Info

Publication number
DK0808305T3
DK0808305T3 DK96903715T DK96903715T DK0808305T3 DK 0808305 T3 DK0808305 T3 DK 0808305T3 DK 96903715 T DK96903715 T DK 96903715T DK 96903715 T DK96903715 T DK 96903715T DK 0808305 T3 DK0808305 T3 DK 0808305T3
Authority
DK
Denmark
Prior art keywords
inflammation
diaryl
treatment
haloalkyl
halo
Prior art date
Application number
DK96903715T
Other languages
Danish (da)
English (en)
Inventor
F Lee Len
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23527293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0808305(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0808305T3 publication Critical patent/DK0808305T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK96903715T 1995-02-10 1996-02-08 3,4-Diaryl-substituerede pyridiner til behandling af inflammation DK0808305T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/386,843 US5596008A (en) 1995-02-10 1995-02-10 3,4-Diaryl substituted pyridines for the treatment of inflammation
PCT/US1996/001110 WO1996024585A1 (fr) 1995-02-10 1996-02-08 Pyridines a substitution 3,4-diaryl pour le traitement des inflammations

Publications (1)

Publication Number Publication Date
DK0808305T3 true DK0808305T3 (da) 2000-08-28

Family

ID=23527293

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96903715T DK0808305T3 (da) 1995-02-10 1996-02-08 3,4-Diaryl-substituerede pyridiner til behandling af inflammation

Country Status (10)

Country Link
US (1) US5596008A (fr)
EP (1) EP0808305B1 (fr)
AT (1) ATE192436T1 (fr)
AU (1) AU4770796A (fr)
DE (1) DE69608096T2 (fr)
DK (1) DK0808305T3 (fr)
ES (1) ES2145996T3 (fr)
GR (1) GR3033428T3 (fr)
PT (1) PT808305E (fr)
WO (1) WO1996024585A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
DK0932402T3 (da) 1996-10-15 2004-11-08 Searle Llc Metode til anvendelse af cyclooxygenase-2-inhibitorer ved behandling og forebyggelse af neoplasi
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US7041694B1 (en) 1997-12-17 2006-05-09 Cornell Research Foundation, Inc. Cyclooxygenase-2 inhibition
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
ATE253559T1 (de) * 1999-01-14 2003-11-15 Lonza Ag Verfahren zur herstellung von 1-(6-methylpyridin- 3-yl)-2- 4-(methylsulfonyl phenyl)ethanon
MXPA01007169A (es) * 1999-01-14 2003-06-06 Lonza Ag 1-(6-metilpiridin-3-il)-2-(4-(metilsulfonil)fenil)etanona y metodo para su elaboracion.
JP2003523954A (ja) * 1999-12-08 2003-08-12 ファルマシア コーポレイション 治療効果が迅速に開始されるシクロオキシゲナーゼ−2阻害剤組成物
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
CA2414674A1 (fr) * 2000-07-13 2002-01-24 Pharmacia Corporation Utilisation d'inhibiteurs de cox-2 pour le traitement et la prevention de troubles oculaires a mediation cox-2
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
GB0119477D0 (en) 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7329401B2 (en) 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
ES2263058T3 (es) 2002-08-19 2006-12-01 Glaxo Group Limited Derivados de pirimidina como inhibidores selectivos de cox-2.
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
JP2006511606A (ja) 2002-12-13 2006-04-06 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 下部尿路症状を治療するα−2−δリガンド
CA2519189C (fr) 2003-05-07 2012-07-17 Osteologix A/S Sels de strontium solubles dans l'eau pour le traitement de maladies des cartilages et/ou des os
WO2005044227A1 (fr) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Compositions pharmaceutiques topiques
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
BRPI0506994A (pt) 2004-01-22 2007-07-03 Pfizer derivados de triazol que inibem a atividade antagonista da vasopressina
US7429667B2 (en) * 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
TW200716594A (en) * 2005-04-18 2007-05-01 Neurogen Corp Substituted heteroaryl CB1 antagonists
EP1767161A1 (fr) * 2005-09-22 2007-03-28 Zimmer Spine, Inc. Système de mise en forme d'une tige de fixation spinale
CN101360717B (zh) * 2006-01-19 2014-04-16 幽兰化学医药有限公司 包含嘧啶环的化合物
US7842836B2 (en) 2006-04-11 2010-11-30 Ardea Biosciences N-aryl-N'alkyl sulfamides as MEK inhibitors
EA016674B1 (ru) * 2006-04-18 2012-06-29 Ардеа Байосайенсиз, Инк. Пиридон сульфонамиды и пиридон сульфамиды в качестве ингибиторов mek
WO2008033466A2 (fr) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions et procédés pour le traitement de maladies virales
RS51940B (en) 2006-12-22 2012-02-29 Recordati Ireland Limited Combined TH2δ LIGANAD THERAPY AND NSAID FOR LOWER URINARY TRACT DISORDERS
US20100111858A1 (en) * 2007-01-19 2010-05-06 Howard Carol P Diangostic and Therapeutic Cyclooxygenase-2 Binding Ligands
US8509487B2 (en) * 2007-04-19 2013-08-13 Avago Technologies General Ip (Singapore) Pte. Ltd. System and method for optically measuring a parameter of an object
WO2008141013A1 (fr) * 2007-05-08 2008-11-20 Allergan, Inc. Inhibiteurs de récepteur s1p3 pour traiter la douleur

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6816241A (fr) * 1967-12-01 1969-06-03
US3655679A (en) * 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
FR2248027B2 (fr) * 1973-10-18 1977-09-09 Serdex
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
CA1322004C (fr) * 1987-11-25 1993-09-07 Merck Frosst Canada Incorporated Acides pyridylstyrenedialcanoiques
US5593994A (en) * 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors

Also Published As

Publication number Publication date
ES2145996T3 (es) 2000-07-16
US5596008A (en) 1997-01-21
GR3033428T3 (en) 2000-09-29
PT808305E (pt) 2000-10-31
DE69608096T2 (de) 2000-11-02
DE69608096D1 (de) 2000-06-08
EP0808305B1 (fr) 2000-05-03
WO1996024585A1 (fr) 1996-08-15
ATE192436T1 (de) 2000-05-15
AU4770796A (en) 1996-08-27
EP0808305A1 (fr) 1997-11-26

Similar Documents

Publication Publication Date Title
DK0808305T3 (da) 3,4-Diaryl-substituerede pyridiner til behandling af inflammation
DK0808304T3 (da) 2,3-substituerede pyridiner til behandling af inflammation
DE69425442D1 (de) 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen
DK0772601T3 (da) 4,5-Substituerede imidazolylforbindelser til behandling af inflammation
DK0934308T3 (da) 3-pyridyloxymethylheterocykliske etherforbindelser anvendelige til kontrollering af kemisk synaptisk transmission
DK0772597T3 (da) 3,4-Substituerede pyrazoler til behandling af inflammation
NL300128I1 (nl) Gesubstitueerde isoxyzolen voor de behandeling vanontsteking.
EP1528059A3 (fr) Isoxazoles substitués pour le traitement de l'inflammation
DE69720965D1 (de) Chinazolinderivate und deren verwendung als vegf hemmer
BG101934A (en) Imidazo(1,2-a)pyridine derivatives
NO996178L (no) 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister
DK142084A (da) N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf
UA35550C2 (uk) Похідні урацилу, що проявляють гербіцидну активність
NO20003398L (no) Substituerte 2-benzylamino-2-fenyl-acetamid-forbindelser
DK0625516T3 (da) Benzensulfonamidderivater til behandling af blæreustabilitet
MX9300412A (es) Derivados de 1h-bencimidazol sustituidos con pirroloimidazolilo e imadazopiridinilo
DK0743938T3 (da) Substituerede spiroforbindelser til behandling af inflammation
DK1072601T3 (da) 4-Arylpiperidinderivater til behandling af pruritus
DK0664802T3 (da) N-Arylheteroarylalkyl-1-phenyl-imidazol-2-on-forbindelser til behandling af kredsløbssygdomme
DK0784973T3 (da) Quinoxalinderivater til behandling af tinnitus
DE69403896D1 (de) 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten