DK0778888T3 - Antigen-mærket ikke-infektiös retroviruslignende partikel - Google Patents
Antigen-mærket ikke-infektiös retroviruslignende partikelInfo
- Publication number
- DK0778888T3 DK0778888T3 DK95927611T DK95927611T DK0778888T3 DK 0778888 T3 DK0778888 T3 DK 0778888T3 DK 95927611 T DK95927611 T DK 95927611T DK 95927611 T DK95927611 T DK 95927611T DK 0778888 T3 DK0778888 T3 DK 0778888T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- gene product
- hiv
- antigenic marker
- marker
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title abstract 4
- 230000002458 infectious effect Effects 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 239000003550 marker Substances 0.000 abstract 6
- 230000000890 antigenic effect Effects 0.000 abstract 5
- 101710177291 Gag polyprotein Proteins 0.000 abstract 2
- 241000723873 Tobacco mosaic virus Species 0.000 abstract 2
- 101710132601 Capsid protein Proteins 0.000 abstract 1
- 101710094648 Coat protein Proteins 0.000 abstract 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 101710125418 Major capsid protein Proteins 0.000 abstract 1
- 101710141454 Nucleoprotein Proteins 0.000 abstract 1
- 101710083689 Probable capsid protein Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 108700004025 env Genes Proteins 0.000 abstract 1
- 101150030339 env gene Proteins 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 108010089520 pol Gene Products Proteins 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/290,105 US5955342A (en) | 1994-08-15 | 1994-08-15 | Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0778888T3 true DK0778888T3 (da) | 2006-10-23 |
Family
ID=23114550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95927611T DK0778888T3 (da) | 1994-08-15 | 1995-08-15 | Antigen-mærket ikke-infektiös retroviruslignende partikel |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US5955342A (fr) |
| EP (1) | EP0778888B1 (fr) |
| JP (2) | JP3871708B2 (fr) |
| AT (1) | ATE331026T1 (fr) |
| AU (1) | AU704309B2 (fr) |
| CA (1) | CA2197446A1 (fr) |
| DE (1) | DE69535075T2 (fr) |
| DK (1) | DK0778888T3 (fr) |
| ES (1) | ES2268693T3 (fr) |
| MX (1) | MX9701149A (fr) |
| PT (1) | PT778888E (fr) |
| WO (1) | WO1996005292A1 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| EP0787193A1 (fr) | 1994-10-18 | 1997-08-06 | Scottish Crop Research Institute | Procede de production de proteines chimeres |
| CN1185811A (zh) * | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| GB9607899D0 (en) * | 1996-04-17 | 1996-06-19 | Scottish Crop Research Inst | Virus-like particle |
| US6602505B2 (en) * | 1998-04-30 | 2003-08-05 | University Of Southern California | Viral chimeras comprised of CAEV and HIV-1 genetic elements |
| EP1078105B1 (fr) * | 1998-05-12 | 2004-11-24 | Genecure LLC | Vaccin de vih a deficience de replication |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| AU2221600A (en) * | 1998-12-31 | 2000-07-31 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| DK1141315T3 (da) | 1998-12-31 | 2008-05-19 | Novartis Vaccines & Diagnostic | Modificerede HIV Env-polypeptider |
| CA2388676A1 (fr) * | 1999-10-13 | 2001-04-19 | Chiron Corporation | Procede d'obtention de reponses immunes cellulaires de proteines |
| US20020106798A1 (en) | 2000-03-02 | 2002-08-08 | Robinson Harriet L. | DNA expression vectors and methods of use |
| US20040105871A1 (en) * | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
| US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| CA2414396A1 (fr) * | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agricul Ture | Production de vaccins par utilisation de plantes transgeniques ou de virus de plantes modifies comme vecteurs d'expression et proteines de coque virales transencapsidees utiliseescomme systemes de presentation d'epitopes |
| WO2002020049A2 (fr) * | 2000-09-09 | 2002-03-14 | Akzo Nobel N.V. | Vaccin chimere contre le virus de l'anemie infectieuse equine et diagnostic |
| US6461616B1 (en) * | 2000-09-09 | 2002-10-08 | Akzo Nobel Nv | EIAV p26 deletion vaccine and diagnostic |
| US7122180B2 (en) * | 2000-10-23 | 2006-10-17 | Children's Medical Center Corporation | DNA vectors containing mutated HIV proviruses |
| EP1201750A1 (fr) * | 2000-10-26 | 2002-05-02 | Genopoietic | Virus synthétiques et leurs utilisations |
| ES2334335T3 (es) * | 2001-03-08 | 2010-03-09 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Mva que expresa genes de envoltura, gag y pol de vih modificados. |
| WO2003004620A2 (fr) | 2001-07-05 | 2003-01-16 | Chiron, Corporation | Polynucleotides codant des polypeptides de type c du vih antigeniques, polypeptides et leurs utilisations |
| US20030198621A1 (en) * | 2001-07-05 | 2003-10-23 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| EP1427806A4 (fr) * | 2001-08-31 | 2006-04-26 | Chiron Corp | Polynucleotides codant des polypeptides de type b du vih antigeniques, polypeptides et leurs utilisations |
| US20050106160A1 (en) * | 2002-03-05 | 2005-05-19 | Dimitrov Dimiter S. | Hiv-1 envelope glycoproteins stabilized by flexible linkers as potent entry inhibitors and immunogens |
| WO2004043286A2 (fr) * | 2002-11-14 | 2004-05-27 | Pfizer Products Inc. | Utilisation de rmlt en tant qu'antigene marqueur pour vaccins et en tant qu'adjuvant synergetique avec amphigen |
| EP1989326A4 (fr) | 2006-01-17 | 2009-09-30 | Health Research Inc | Bio-essai de suivi en heteroduplex |
| EP2152730A4 (fr) * | 2007-05-02 | 2011-08-03 | Univ Emory | Amelioration d'incorporation de glycoproteine dans des particules de type viral |
| WO2011119920A2 (fr) | 2010-03-25 | 2011-09-29 | Oregon Health & Science University | Glycoprotéines du cmv et vecteurs recombinés |
| DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
| AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2848937A1 (fr) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Procédés d'identification de nouveaux immunogènes du VIH-1 |
| EP2873423B1 (fr) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Trimères de glycoprotéines d'enveloppe du vih -1 soluble |
| EP3069730A3 (fr) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Trimères de glycoprotéines de l'enveloppe du vih-1 soluble |
| EP3072901A1 (fr) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Trimères de glycoprotéines de l'enveloppe du vih-1 soluble |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352449A (en) * | 1986-05-30 | 1994-10-04 | Cambridge Biotech Corporation | Vaccine comprising recombinant feline leukemia antigen and saponin adjuvant |
| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| WO1991005860A1 (fr) * | 1989-10-16 | 1991-05-02 | Whitehead Institute For Biomedical Research | Particules non infectieuses de vih-1 et leurs emplois |
| HUT60506A (en) * | 1989-11-20 | 1992-09-28 | Oncogen | Process for producing non-replicable, recombinant retrovirus particles and antiviral and immunogenic preparations |
| WO1991019803A1 (fr) * | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Particules virales autoassemblees defectueuses qui ne se propagent pas d'elles-memes |
| CA2117884A1 (fr) * | 1992-03-27 | 1993-10-14 | Anna Aldovini | Particules de vih non infectieuses et leurs applications |
| AU4685293A (en) * | 1992-07-20 | 1994-02-14 | Immune Response Corporation, The | Prophylactic and therapeutic control of retroviral infections |
| GB9412844D0 (en) * | 1994-06-27 | 1994-08-17 | Medical Res Council | Improvements in or relating to therapeutic methods |
-
1994
- 1994-08-15 US US08/290,105 patent/US5955342A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/470,419 patent/US5866320A/en not_active Expired - Lifetime
- 1995-08-15 DK DK95927611T patent/DK0778888T3/da active
- 1995-08-15 DE DE69535075T patent/DE69535075T2/de not_active Expired - Lifetime
- 1995-08-15 JP JP50688396A patent/JP3871708B2/ja not_active Expired - Fee Related
- 1995-08-15 EP EP95927611A patent/EP0778888B1/fr not_active Expired - Lifetime
- 1995-08-15 AT AT95927611T patent/ATE331026T1/de active
- 1995-08-15 US US08/776,949 patent/US6025125A/en not_active Expired - Lifetime
- 1995-08-15 MX MX9701149A patent/MX9701149A/es active IP Right Grant
- 1995-08-15 WO PCT/CA1995/000483 patent/WO1996005292A1/fr active IP Right Grant
- 1995-08-15 CA CA002197446A patent/CA2197446A1/fr not_active Abandoned
- 1995-08-15 AU AU31599/95A patent/AU704309B2/en not_active Ceased
- 1995-08-15 ES ES95927611T patent/ES2268693T3/es not_active Expired - Lifetime
- 1995-08-15 PT PT95927611T patent/PT778888E/pt unknown
-
1996
- 1996-12-06 US US08/761,209 patent/US5889176A/en not_active Expired - Lifetime
- 1996-12-06 US US08/761,828 patent/US5879925A/en not_active Expired - Lifetime
-
2005
- 2005-07-21 JP JP2005211860A patent/JP2006020635A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10503933A (ja) | 1998-04-14 |
| US6025125A (en) | 2000-02-15 |
| ES2268693T3 (es) | 2007-03-16 |
| CA2197446A1 (fr) | 1996-02-22 |
| ATE331026T1 (de) | 2006-07-15 |
| EP0778888B1 (fr) | 2006-06-21 |
| DE69535075D1 (de) | 2006-08-03 |
| PT778888E (pt) | 2006-11-30 |
| US5866320A (en) | 1999-02-02 |
| AU704309B2 (en) | 1999-04-22 |
| JP2006020635A (ja) | 2006-01-26 |
| DE69535075T2 (de) | 2007-01-04 |
| US5955342A (en) | 1999-09-21 |
| WO1996005292A1 (fr) | 1996-02-22 |
| MX9701149A (es) | 1997-05-31 |
| EP0778888A1 (fr) | 1997-06-18 |
| JP3871708B2 (ja) | 2007-01-24 |
| AU3159995A (en) | 1996-03-07 |
| US5889176A (en) | 1999-03-30 |
| US5879925A (en) | 1999-03-09 |
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