DK0776975T3 - Fremgangsmåde til anvendelse af gær-palfa-ADH II-promotorsystemet til bioteknologisk produktion af heterologe proteiner i store udbytter - Google Patents

Fremgangsmåde til anvendelse af gær-palfa-ADH II-promotorsystemet til bioteknologisk produktion af heterologe proteiner i store udbytter

Info

Publication number
DK0776975T3
DK0776975T3 DK96118309T DK96118309T DK0776975T3 DK 0776975 T3 DK0776975 T3 DK 0776975T3 DK 96118309 T DK96118309 T DK 96118309T DK 96118309 T DK96118309 T DK 96118309T DK 0776975 T3 DK0776975 T3 DK 0776975T3
Authority
DK
Denmark
Prior art keywords
yeast
adh
promoter system
palfa
heterologous proteins
Prior art date
Application number
DK96118309T
Other languages
English (en)
Inventor
Paul Habermann
Joerg Moeller
Werner Badziong
Werner Aretz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0776975T3 publication Critical patent/DK0776975T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK96118309T 1995-11-28 1996-11-15 Fremgangsmåde til anvendelse af gær-palfa-ADH II-promotorsystemet til bioteknologisk produktion af heterologe proteiner i store udbytter DK0776975T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19544233A DE19544233A1 (de) 1995-11-28 1995-11-28 Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten

Publications (1)

Publication Number Publication Date
DK0776975T3 true DK0776975T3 (da) 2005-01-17

Family

ID=7778564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96118309T DK0776975T3 (da) 1995-11-28 1996-11-15 Fremgangsmåde til anvendelse af gær-palfa-ADH II-promotorsystemet til bioteknologisk produktion af heterologe proteiner i store udbytter

Country Status (11)

Country Link
US (1) US5866371A (da)
EP (1) EP0776975B1 (da)
JP (1) JP3902822B2 (da)
KR (1) KR100429935B1 (da)
AT (1) ATE278025T1 (da)
AU (1) AU711203B2 (da)
CA (1) CA2191407C (da)
DE (2) DE19544233A1 (da)
DK (1) DK0776975T3 (da)
ES (1) ES2229250T3 (da)
PT (1) PT776975E (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (it) * 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
US20070031950A1 (en) * 1998-09-11 2007-02-08 Winkler Aaron A Production of D-lactic acid with yeast
BR0010806B1 (pt) * 1999-05-21 2014-02-18 Métodos e materiais para a síntese de produtos orgânicos
KR100365533B1 (ko) * 2000-05-10 2002-12-18 재단법인 목암생명공학연구소 상처치유 효과를 가진 재조합 거머린의 제조방법 및 이를 함유하는 약학적 조성물
DE10108211A1 (de) * 2001-02-20 2002-08-22 Aventis Pharma Gmbh Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen
US7405068B2 (en) * 2003-05-02 2008-07-29 Tate & Lyle Ingredients Americas, Inc. Pyruvate producing yeast strain
EP1929009A2 (en) * 2005-09-22 2008-06-11 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
KR20130000883A (ko) * 2011-06-24 2013-01-03 삼성전자주식회사 클루이베로마이세스 마르시아누스 내에서의 향상된 단백질 생산
JP6906104B2 (ja) 2018-05-09 2021-07-21 朝日インテック株式会社 医療用チューブ

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1157340B (it) 1982-11-29 1987-02-11 F I M A Dispositivo per collegare amovibilamente utensili abrasivi all'albero di levigatrici e simili
CA1341414C (fr) 1984-03-27 2002-12-31 Paul Tolstoshev Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3506992A1 (de) 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE19775033I2 (de) 1985-04-11 2011-01-20 Bayer Schering Pharma Ag Hirudin-Derivat.
FR2593518B1 (fr) 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
AU604925B2 (en) * 1988-02-23 1991-01-03 Schering Aktiengesellschaft A hirudin derivative
CA1324969C (en) * 1988-05-06 1993-12-07 Jeffrey R. Shuster High level expression of proteins in yeast
ATE101620T1 (de) 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
NZ233255A (en) * 1989-04-11 1993-02-25 Chiron Corp Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope
AU3545795A (en) * 1994-09-08 1996-03-27 Chiron Corporation A method of improved production of insulin-like growth factor
US5712249A (en) * 1994-09-08 1998-01-27 Ciba-Geigy Corporation Use of insulin-like growth factors I and II for inhibition of inflammatory response

Also Published As

Publication number Publication date
DE59611099D1 (de) 2004-11-04
KR100429935B1 (ko) 2004-07-31
ATE278025T1 (de) 2004-10-15
CA2191407A1 (en) 1997-05-29
EP0776975A2 (de) 1997-06-04
CA2191407C (en) 2009-01-06
US5866371A (en) 1999-02-02
PT776975E (pt) 2005-01-31
JP3902822B2 (ja) 2007-04-11
EP0776975B1 (de) 2004-09-29
KR970027317A (ko) 1997-06-24
JPH09163998A (ja) 1997-06-24
DE19544233A1 (de) 1997-06-05
EP0776975A3 (de) 1999-09-29
AU7199696A (en) 1997-06-05
ES2229250T3 (es) 2005-04-16
AU711203B2 (en) 1999-10-07

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