DK0776331T3 - Struktur af højere orden og binding af peptidnukleinsyrer - Google Patents

Struktur af højere orden og binding af peptidnukleinsyrer

Info

Publication number
DK0776331T3
DK0776331T3 DK94921413T DK94921413T DK0776331T3 DK 0776331 T3 DK0776331 T3 DK 0776331T3 DK 94921413 T DK94921413 T DK 94921413T DK 94921413 T DK94921413 T DK 94921413T DK 0776331 T3 DK0776331 T3 DK 0776331T3
Authority
DK
Denmark
Prior art keywords
nucleic acids
peptide nucleic
binding
order structure
analogues
Prior art date
Application number
DK94921413T
Other languages
English (en)
Inventor
Ole Buchardt
Michael Egholm
Peter E Nielsen
Rolf H Berg
David J Ecker
Niels E Mollegaard
Original Assignee
Ole Buchardt
Michael Egholm
Nielsen Peter Eigil
Berg Rolf
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ole Buchardt, Michael Egholm, Nielsen Peter Eigil, Berg Rolf, Isis Pharmaceuticals Inc filed Critical Ole Buchardt
Application granted granted Critical
Publication of DK0776331T3 publication Critical patent/DK0776331T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK94921413T 1993-07-02 1994-06-28 Struktur af højere orden og binding af peptidnukleinsyrer DK0776331T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/088,658 US5641625A (en) 1992-05-22 1993-07-02 Cleaving double-stranded DNA with peptide nucleic acids
PCT/US1994/007319 WO1995001370A1 (en) 1993-07-02 1994-06-28 Higher order structure and binding of peptide nucleic acids

Publications (1)

Publication Number Publication Date
DK0776331T3 true DK0776331T3 (da) 2003-03-03

Family

ID=22212648

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94921413T DK0776331T3 (da) 1993-07-02 1994-06-28 Struktur af højere orden og binding af peptidnukleinsyrer

Country Status (9)

Country Link
US (2) US5641625A (da)
EP (1) EP0776331B1 (da)
JP (2) JPH09503198A (da)
AT (1) ATE228534T1 (da)
CA (1) CA2166461A1 (da)
DE (1) DE69431805T2 (da)
DK (1) DK0776331T3 (da)
ES (1) ES2187527T3 (da)
WO (1) WO1995001370A1 (da)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770738B1 (en) * 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
EP0813610A1 (de) * 1995-03-04 1997-12-29 Roche Diagnostics GmbH Sequenzspezifischer nachweis von nukleinsäuren
US5770715A (en) * 1995-03-22 1998-06-23 Toagosei Co., Ltd. Hammerhead-like nucleic acid analogues and their synthesis
WO1996040245A1 (en) * 1995-06-07 1996-12-19 Immunomedics, Inc. Improved delivery of diagnostic and therapeutic agents to a target site
WO1997014026A2 (en) 1995-10-12 1997-04-17 Dako A/S Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule
WO1997014793A1 (en) * 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6110676A (en) * 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
EP0857791B1 (en) * 1996-12-21 2004-03-31 PNA Diagnostics A/S Method of analysis using signal amplification
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
EP0897991B1 (en) * 1997-08-22 2004-12-08 PNA Diagnostics ApS Small Triplex Forming PNA Oligos
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
US6962778B1 (en) 1997-09-25 2005-11-08 Boston Probes, Inc. Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US6723560B2 (en) * 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6472209B1 (en) 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
ATE343586T1 (de) 1998-07-09 2006-11-15 Biocept Inc Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung
GB9815933D0 (en) * 1998-07-23 1998-09-23 Secr Defence Detection method
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
SE9803099D0 (sv) 1998-09-13 1998-09-13 Karolinska Innovations Ab Nucleic acid transfer
US6492111B1 (en) * 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6403313B1 (en) * 1999-12-21 2002-06-11 Ingeneus Corporation Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
US6613524B1 (en) 2000-01-24 2003-09-02 Ingeneus Corporation Amperometric affinity assay and electrically stimulated complexes of nucleic acids
US7220541B2 (en) 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US6982147B2 (en) 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
US6265170B1 (en) * 2000-01-24 2001-07-24 Ingeneus Corporation Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions
WO2001068673A1 (en) 2000-03-14 2001-09-20 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
WO2001073001A2 (en) * 2000-03-24 2001-10-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Establishment of cellular manipulations which enhance oligo-mediated gene targeting
ES2263651T3 (es) * 2000-08-30 2006-12-16 Avi Biopharma, Inc. Metodo para analidis de analogos de oligonucleotidos.
ATE432994T1 (de) 2000-09-26 2009-06-15 Boston Probes Inc Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
ATE544473T1 (de) * 2000-11-09 2012-02-15 Cold Spring Harbor Lab Chimäre moleküle zur modulation der genexpression
AU2002246676A1 (en) * 2000-12-15 2002-07-30 Boston Probes, Inc. Methods for determining organisms
JP2002186481A (ja) * 2000-12-18 2002-07-02 Eiken Chem Co Ltd 光学的特性の測定による核酸増幅産物の検出方法
CA2439750A1 (en) * 2001-03-09 2002-09-19 Boston Probes, Inc. Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
EP2332896A3 (en) * 2001-03-19 2012-09-26 President and Fellows of Harvard College Evolving new molecular function
EP2364990A1 (en) 2001-05-25 2011-09-14 Duke University Modulators of pharmacological agents
WO2002097134A2 (en) * 2001-05-25 2002-12-05 Isis Pharmaceuticals, Inc. Modified peptide nucleic acid
EP1905829B1 (en) 2001-06-20 2016-02-17 Nuevolution A/S Templated molecules and methods for using such molecules
US20030129626A1 (en) * 2001-09-24 2003-07-10 Nielsen Kirsten Vang Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
WO2003080857A2 (en) * 2002-03-21 2003-10-02 Boston Probes,Inc. Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis
WO2003091455A1 (en) * 2002-04-23 2003-11-06 U.S.Genomics, Inc. Compositions and methods related to two-arm nucleic acid probes
WO2003100076A2 (en) * 2002-05-17 2003-12-04 Applera Corporation Pna probes, probe sets, method and kits pertaining to the determination of listeria
JP2005533256A (ja) * 2002-07-17 2005-11-04 ユー．エス． ジェノミクス， インコーポレイテッド キメラタグを用いるポリマーを分析するための方法と組成物
EP1540013B1 (en) * 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
EP2161276A3 (en) * 2002-09-08 2010-05-26 Applera Corporation Methods, compositions and libraries pertaining PNA dimer and PNA oligomer systhesis
EP1576188B1 (en) 2002-11-21 2008-10-15 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2005017181A2 (en) * 2003-05-20 2005-02-24 Investigen, Inc. System for detecting polynucleotides
WO2005012575A1 (en) * 2003-08-01 2005-02-10 U.S. Genomics, Inc. Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
US20060142227A1 (en) * 2003-10-14 2006-06-29 Itschak Lamensdorf Amphiphylic peptide-PNA conjugates for the delivery of PNA through the blood brain barrier
EP1680439A2 (en) * 2003-10-14 2006-07-19 Kernel Biopharma Inc. Dual phase-pna conjugates for the delivery of pna through the blood brain barrier
WO2005111235A2 (en) * 2004-05-04 2005-11-24 Dak Denmark A/S Methods for detecting chromosome aberrations
NL1027479C2 (nl) * 2004-10-21 2006-05-01 Synvolux Ip B V Bescherming van biologisch actieve moleculen met behulp van amphifielen.
US7700287B2 (en) * 2005-01-28 2010-04-20 Life Technologies Corporation Compositions and methods for terminating a sequencing reaction at a specific location in a target DNA template
CA2610710C (en) 2005-06-02 2016-10-11 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
WO2007023390A2 (en) 2005-07-01 2007-03-01 Dako Denmark A/S Immunohistochemistry detection method
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
US8021839B2 (en) * 2006-02-24 2011-09-20 Investigen, Inc. Methods and compositions for detecting polynucleotides
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080241838A1 (en) * 2006-12-29 2008-10-02 Applera Corporation, Applied Biosystems Group Methods and systems for detecting nucleic acids
AU2007339793A1 (en) * 2006-12-29 2008-07-10 Applied Biosystems, Llc Systems and methods for detecting nucleic acids
US7771947B2 (en) * 2007-02-23 2010-08-10 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
ES2641290T3 (es) 2007-11-20 2017-11-08 Ionis Pharmaceuticals, Inc Modulación de la expresión de CD40
JP5592357B2 (ja) 2008-05-27 2014-09-17 ダコ・デンマーク・エー／エス 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法
US7964355B2 (en) * 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
US9388456B2 (en) 2009-02-26 2016-07-12 Dako Denmark A/S Compositions and methods for performing a stringent wash step in hybridization applications
ES2601237T3 (es) 2009-12-02 2017-02-14 Dako Denmark A/S Composiciones y métodos para realizar hibridaciones sin desnaturalización
US9404160B2 (en) 2009-12-22 2016-08-02 Becton, Dickinson And Company Methods for the detection of microorganisms
US10662465B2 (en) 2011-09-30 2020-05-26 Agilent Technologies, Inc. Hybridization compositions and methods using formamide
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
WO2014033314A1 (en) 2012-09-03 2014-03-06 Uab Bioseka Antisense oligonucleotide targeting bacterial glucosyltransferases
US10260089B2 (en) * 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
EP2929050A1 (en) 2012-12-10 2015-10-14 AdvanDx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
CA2904440C (en) 2013-03-15 2021-09-07 Techulon Inc. Antisense molecules for treatment of staphylococcus aureus infection
BR112015022829B1 (pt) 2013-03-15 2022-06-14 Cibus Europe B.V. Método para a introdução de uma mutação mediada por oligonucleobase de reparação de gene (gron) em uma sequência alvo de ácido desoxirribonucleico (dna) em uma célula vegetal
JP2016515381A (ja) 2013-03-15 2016-05-30 テチュロン インコーポレイテッド 黄色ブドウ球菌感染の治療のためのアンチセンス分子
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
CA2927358C (en) 2013-10-16 2021-12-21 The University Of British Columbia Device for formulating particles at small volumes
KR20160106684A (ko) 2014-01-10 2016-09-12 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 히드록시포름아미드 유도체 및 그의 용도
EP4357452A3 (en) 2014-03-14 2024-07-17 Cibus US LLC Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
CA2977768A1 (en) 2015-02-24 2016-09-01 The University Of British Columbia Continuous flow microfluidic system
US12492423B2 (en) 2015-09-16 2025-12-09 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
US11046999B2 (en) 2015-09-16 2021-06-29 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
JP7011830B2 (ja) 2015-10-14 2022-01-27 エックス－サーマ インコーポレイテッド 氷晶形成を低減するための組成物および方法
EP3400097B1 (en) 2016-01-06 2021-01-27 The University Of British Columbia Bifurcating mixers and methods of their use and manufacture
EA201891629A1 (ru) 2016-02-09 2019-03-29 Сибас Юс Ллс Способы и композиции для повышения эффективности нацеленной модификации генов с применением опосредуемой олигонуклеотидами репарации генов
US20210284998A1 (en) 2016-10-03 2021-09-16 Precision Nanosystems Inc. Compositions for Transfecting Resistant Cell Types
EP3737766A4 (en) 2018-01-09 2021-11-24 Cibus US LLC BREAK-PROOF GENES AND MUTATIONS
CA3095047A1 (en) 2018-04-04 2019-10-10 Cibus Us Llc Fad2 genes and mutations
EP3844278A4 (en) * 2018-08-27 2022-05-25 North Carolina State University Targeting kit with splice switching oligonucleotides to induce apoptosis of mast cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Also Published As

Publication number Publication date
ES2187527T3 (es) 2003-06-16
ATE228534T1 (de) 2002-12-15
US5986053A (en) 1999-11-16
EP0776331A4 (en) 1998-11-25
DE69431805T2 (de) 2003-07-03
EP0776331B1 (en) 2002-11-27
JPH11236396A (ja) 1999-08-31
JPH09503198A (ja) 1997-03-31
DE69431805D1 (de) 2003-01-09
EP0776331A1 (en) 1997-06-04
US5641625A (en) 1997-06-24
WO1995001370A1 (en) 1995-01-12
CA2166461A1 (en) 1995-01-12

Similar Documents

Publication Publication Date Title
DK0776331T3 (da) Struktur af højere orden og binding af peptidnukleinsyrer
DE10199059I2 (de) Erythropoietin-Analoga mit zusätzlichen Glycosylierungsstellen
ATE380875T1 (de) Chimäre proteine zur vermeidung der komplementaktivierung
DK1009832T3 (da) Cytokin betegnet LERK-6
DK1724354T3 (da) Cirkulær DNA-molekyle med en afhængig replikationsoprindelse, fremgangsmåde til fremstilling heraf og anvendelse heraf i genterapi
FI962247A7 (fi) Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden kä yttömenetelmät
DE69331946D1 (de) Nukleozyme
ATE500323T1 (de) Subtilisin-variante
DE3685626D1 (de) Sequenzierung von peptiden.
FI920670A7 (fi) Apolipoproteiinin E polypeptidianalogit, diagnostiset systeemit ja men etelmät, joissa käytettiin näitä analogeja
NO910982D0 (no) Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller.
DE69941049D1 (de) Retrovirales verabreichungssystem
DK372086A (da) Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved
DK0601154T3 (da) BPC-peptider, deres fremstilling og anvendelse
DK568287D0 (da) Relativt lavmolekylaere peptider og deres anvendelse som renininhibitorer
DK397086D0 (da) 1-aryl-pyrazoler, deres fremstilling og anvendelse til bekaempelse af skadelige organismer
DK17686D0 (da) Fremgangsmaade til isolering af hoenseaeggehvide-cystatin, farmaceutiske praeparater indeholdende dette og dets anvendelse som inhibitor for viral protease
FI972170A7 (fi) Peptidejä, jotka kykenevät sitoutumaan GAP-proteiinin SH3-domeeniin, n äitä peptidejä koodittavia nukleotidisekvenssejä, niiden valmistus ja käyttö
ATE206458T1 (de) T-zellen stimulierendes protein von pestivirus
DK312787A (da) Polypeptider, fremgangsmaade til deres fremstilling, dna som koder for polypeptiderne, vektorer indeholdende saadanne gensekvenser og laegemidler indeholdende polypeptiderne
EP0728015A4 (en) COMBINATIVE POLYPEPTIDANTANTIGENS
DK0952982T3 (da) Hidtil ukendte hepatitis B inhibitorer
PT870015E (pt) Novas xilanases os genes que as codificam e as suas utilizacoes
DK416488D0 (da) Fremgangsmaade til kloning og udtrykkelse af gener, der koder for proteiner, som udviser organiserede funktionelle strukturer
SE8802176D0 (sv) Fusion protein and its use