IS6678A - Hvarfefni og prófanir fyrir ß-sekretasavirkni - Google Patents
Hvarfefni og prófanir fyrir ß-sekretasavirkniInfo
- Publication number
- IS6678A IS6678A IS6678A IS6678A IS6678A IS 6678 A IS6678 A IS 6678A IS 6678 A IS6678 A IS 6678A IS 6678 A IS6678 A IS 6678A IS 6678 A IS6678 A IS 6678A
- Authority
- IS
- Iceland
- Prior art keywords
- reagents
- tests
- secretory activity
- substrates
- asp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21979500P | 2000-07-19 | 2000-07-19 | |
US27525101P | 2001-03-12 | 2001-03-12 | |
PCT/US2001/023035 WO2002006306A2 (en) | 2000-07-19 | 2001-07-19 | SUBSTRATES AND ASSAYS FOR β-SECRETASE ACTIVITY |
Publications (1)
Publication Number | Publication Date |
---|---|
IS6678A true IS6678A (is) | 2003-01-14 |
Family
ID=26914256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IS6678A IS6678A (is) | 2000-07-19 | 2003-01-14 | Hvarfefni og prófanir fyrir ß-sekretasavirkni |
Country Status (11)
Country | Link |
---|---|
US (8) | US7205120B2 (is) |
EP (1) | EP1301604B1 (is) |
JP (1) | JP2004504018A (is) |
AT (1) | ATE397077T1 (is) |
AU (1) | AU2001277950A1 (is) |
CA (1) | CA2410898A1 (is) |
DE (1) | DE60134230D1 (is) |
IL (1) | IL153943A0 (is) |
IS (1) | IS6678A (is) |
TW (2) | TW200628612A (is) |
WO (1) | WO2002006306A2 (is) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2350205A (en) | 1998-04-06 | 2000-11-22 | Imation Corp | Reverse optical mastering for data storage disks |
US7196163B2 (en) | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
TWI243826B (en) * | 2001-07-19 | 2005-11-21 | Akzo Nobel Nv | Process for the preparation of peptides |
IL150601A (en) * | 2001-07-19 | 2010-06-30 | Organon Nv | Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component |
AU2002253468B2 (en) * | 2002-04-18 | 2008-04-03 | Esbatech Ag | Method for the identification of modulators of a secretase activity |
JP2004000060A (ja) * | 2002-05-31 | 2004-01-08 | Otsuka Pharmaceut Co Ltd | アミロイドβ産生に影響を与える化合物のスクリーニング方法 |
CA2505907A1 (en) * | 2002-11-14 | 2004-06-03 | Qtl Biosystems, Llc | Methods of biosensing using fluorescent polymers and quencher-tether-ligand bioconjugates |
US20050112696A1 (en) * | 2003-11-25 | 2005-05-26 | The University Of Texas Southwestern Medical Center | Compositions, methods and assays related to secretase cleavage specificity |
US20060098887A1 (en) * | 2004-05-19 | 2006-05-11 | Hazem El-Bakry | Mehthod for image conversion |
NZ561029A (en) * | 2005-03-14 | 2011-03-31 | High Point Pharmaceuticals Llc | Benzazole dervatives, compositions, and method of use as beta-secretase inhibitors |
DE102005051978A1 (de) * | 2005-10-31 | 2007-05-10 | Forschungszentrum Borstel Zentrum für Medizin und Biowissenschaften | Verfahren zur Bestimmung der Spaltbarkeit von Substraten |
JP4848986B2 (ja) * | 2007-03-22 | 2011-12-28 | 富士ゼロックス株式会社 | 光導波路及びその製造方法 |
US8548257B2 (en) * | 2009-01-05 | 2013-10-01 | Apple Inc. | Distinguishing between faces and non-faces |
MX346500B (es) | 2010-11-10 | 2017-03-22 | Genentech Inc * | Metodos y composiciones para inmunoterapia para enfermedad neural. |
JP2013158281A (ja) * | 2012-02-03 | 2013-08-19 | Shionogi & Co Ltd | 新規bace1活性測定方法 |
WO2016081639A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy |
EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292652A (en) | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
US5798224A (en) * | 1992-12-29 | 1998-08-25 | Doheny Eye Institute | Nucleic acids encoding protocadherin |
JP4052605B2 (ja) * | 1994-05-18 | 2008-02-27 | タカラバイオ株式会社 | α−1,3/4−フコシダーゼ遺伝子 |
US5942400A (en) * | 1995-06-07 | 1999-08-24 | Elan Pharmaceuticals, Inc. | Assays for detecting β-secretase |
US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
GB9701684D0 (en) | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
WO1999040930A1 (en) * | 1998-02-12 | 1999-08-19 | Center For Blood Research, Inc. | Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases |
US7090976B2 (en) * | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
IL139739A0 (en) * | 1998-06-05 | 2002-02-10 | Aventis Pharma Sa | Polypeptides with beta-secretase type activity |
EP1100520B1 (en) * | 1998-07-21 | 2004-09-22 | Cytovia, Inc. | Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
CN1300320C (zh) | 1998-09-24 | 2007-02-14 | 法玛西雅厄普约翰美国公司 | 阿尔茨海默氏疾病分泌酶 |
US6313268B1 (en) * | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
CN1390232A (zh) | 1999-02-10 | 2003-01-08 | 艾兰制药公司 | 人β分泌酶、抑制剂、其组合物和用途 |
AU3770800A (en) | 1999-03-26 | 2000-10-16 | Amgen, Inc. | Beta secretase genes and polypeptides |
JP4484410B2 (ja) * | 1999-06-28 | 2010-06-16 | オクラホマ メディカル リサーチ ファウンデーション | メマプシン2のインヒビターおよびその使用 |
US7429639B2 (en) * | 1999-09-29 | 2008-09-30 | Ludwig Institute For Cancer Research | SSX-2 peptides presented by HLA class II molecules |
GB9925136D0 (en) * | 1999-10-22 | 1999-12-22 | Smithkline Beecham Plc | Novel treatment |
DE60031792T2 (de) * | 1999-12-08 | 2007-02-22 | Intellect Neurosciences, Inc. | Schimärische amyloid-beta peptide |
JP2003528071A (ja) * | 2000-03-23 | 2003-09-24 | エラン ファーマスーティカルズ インコーポレイテッド | アルツハイマー病治療用組成物および方法 |
US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
WO2002094985A2 (en) | 2001-05-22 | 2002-11-28 | Merck & Co., Inc. | Beta-secretase substrates and uses thereof |
-
2001
- 2001-07-19 AU AU2001277950A patent/AU2001277950A1/en not_active Abandoned
- 2001-07-19 EP EP01955899A patent/EP1301604B1/en not_active Expired - Lifetime
- 2001-07-19 CA CA002410898A patent/CA2410898A1/en not_active Abandoned
- 2001-07-19 WO PCT/US2001/023035 patent/WO2002006306A2/en active Application Filing
- 2001-07-19 AT AT01955899T patent/ATE397077T1/de not_active IP Right Cessation
- 2001-07-19 TW TW095116459A patent/TW200628612A/zh unknown
- 2001-07-19 JP JP2002512206A patent/JP2004504018A/ja not_active Withdrawn
- 2001-07-19 IL IL15394301A patent/IL153943A0/xx not_active IP Right Cessation
- 2001-07-19 TW TW090117695A patent/TWI316960B/zh not_active IP Right Cessation
- 2001-07-19 US US09/908,943 patent/US7205120B2/en not_active Expired - Fee Related
- 2001-07-19 DE DE60134230T patent/DE60134230D1/de not_active Expired - Lifetime
-
2003
- 2003-01-14 IS IS6678A patent/IS6678A/is unknown
-
2004
- 2004-03-16 US US10/801,486 patent/US20040254342A1/en not_active Abandoned
- 2004-03-16 US US10/801,938 patent/US20040253706A1/en not_active Abandoned
- 2004-03-16 US US10/801,487 patent/US7803739B2/en not_active Expired - Fee Related
- 2004-03-16 US US10/801,493 patent/US20050096457A1/en not_active Abandoned
- 2004-03-16 US US10/801,509 patent/US7888291B2/en not_active Expired - Fee Related
-
2007
- 2007-03-01 US US11/713,091 patent/US20080299596A1/en not_active Abandoned
- 2007-05-24 US US11/753,331 patent/US20080090260A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7888291B2 (en) | 2011-02-15 |
US20040254341A1 (en) | 2004-12-16 |
DE60134230D1 (de) | 2008-07-10 |
CA2410898A1 (en) | 2002-01-24 |
EP1301604B1 (en) | 2008-05-28 |
US20040253706A1 (en) | 2004-12-16 |
ATE397077T1 (de) | 2008-06-15 |
WO2002006306A2 (en) | 2002-01-24 |
US20030017991A1 (en) | 2003-01-23 |
TW200628612A (en) | 2006-08-16 |
EP1301604A2 (en) | 2003-04-16 |
AU2001277950A1 (en) | 2002-01-30 |
US20040254342A1 (en) | 2004-12-16 |
WO2002006306A3 (en) | 2002-07-25 |
US20080299596A1 (en) | 2008-12-04 |
US7205120B2 (en) | 2007-04-17 |
US20080090260A1 (en) | 2008-04-17 |
US20050096457A1 (en) | 2005-05-05 |
US20040241792A1 (en) | 2004-12-02 |
IL153943A0 (en) | 2003-07-31 |
US7803739B2 (en) | 2010-09-28 |
JP2004504018A (ja) | 2004-02-12 |
TWI316960B (en) | 2009-11-11 |
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