DK0759757T3 - Orale, væskeformige alendronatformuleringer - Google Patents

Orale, væskeformige alendronatformuleringer

Info

Publication number
DK0759757T3
DK0759757T3 DK95924570T DK95924570T DK0759757T3 DK 0759757 T3 DK0759757 T3 DK 0759757T3 DK 95924570 T DK95924570 T DK 95924570T DK 95924570 T DK95924570 T DK 95924570T DK 0759757 T3 DK0759757 T3 DK 0759757T3
Authority
DK
Denmark
Prior art keywords
oral
alendronate
liquid
alendronate formulations
formulations
Prior art date
Application number
DK95924570T
Other languages
Danish (da)
English (en)
Inventor
Ashok V Katdare
Gerald S Brenner
Denise Pretzer
Donna T Whiteford
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0759757T3 publication Critical patent/DK0759757T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95924570T 1994-05-17 1995-05-12 Orale, væskeformige alendronatformuleringer DK0759757T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/245,289 US5462932A (en) 1994-05-17 1994-05-17 Oral liquid alendronate formulations
PCT/US1995/005926 WO1995031203A1 (en) 1994-05-17 1995-05-12 Oral liquid alendronate formulations

Publications (1)

Publication Number Publication Date
DK0759757T3 true DK0759757T3 (da) 2002-10-07

Family

ID=22926074

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95924570T DK0759757T3 (da) 1994-05-17 1995-05-12 Orale, væskeformige alendronatformuleringer

Country Status (33)

Country Link
US (1) US5462932A (cs)
EP (1) EP0759757B1 (cs)
JP (1) JP4111536B2 (cs)
KR (1) KR100372966B1 (cs)
CN (1) CN1079672C (cs)
AT (1) ATE222495T1 (cs)
AU (1) AU691634B2 (cs)
CA (1) CA2190148C (cs)
CO (1) CO4600739A1 (cs)
CY (1) CY2336B1 (cs)
CZ (1) CZ285860B6 (cs)
DE (1) DE69527842T2 (cs)
DK (1) DK0759757T3 (cs)
DZ (1) DZ1884A1 (cs)
ES (1) ES2180646T3 (cs)
FI (1) FI118296B (cs)
HR (1) HRP950293B1 (cs)
HU (1) HU220626B1 (cs)
IL (1) IL113651A (cs)
MX (1) MX9605660A (cs)
MY (1) MY112285A (cs)
NO (1) NO310179B1 (cs)
NZ (1) NZ289231A (cs)
PL (1) PL179634B1 (cs)
PT (1) PT759757E (cs)
RU (1) RU2176507C2 (cs)
SI (1) SI0759757T1 (cs)
SK (1) SK281098B6 (cs)
TW (1) TW402501B (cs)
UA (1) UA29505C2 (cs)
WO (1) WO1995031203A1 (cs)
YU (1) YU49354B (cs)
ZA (1) ZA953960B (cs)

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US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
NZ303022A (en) * 1995-02-17 2000-07-28 Merck & Co Inc Treatment of osteoporotic diseases with alendronate
EP0824341A4 (en) * 1995-05-12 1999-07-07 Merck & Co Inc PREVENTING TOOTH LOSS THROUGH ADMINISTRATION OF ALENDRONATE OR ITS SALTS
IL118422A0 (en) * 1995-06-02 1996-09-12 Merck & Co Inc Use of alendronate for the prevention of osteoporosis
US5616571A (en) * 1995-06-06 1997-04-01 Merck & Co., Inc. Bisphosphonates prevent bone loss associated with immunosuppressive therapy
EP0831843A1 (en) * 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
IL120270A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US6100301A (en) * 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
IL129127A0 (en) * 1996-10-04 2000-02-17 Merck & Co Inc Liquid alendronate formulations
US6376477B2 (en) 1996-11-25 2002-04-23 Merck & Co., Inc. Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
GB9802617D0 (en) * 1998-02-07 1998-04-01 Knoll Ag Pharmaceutical formulation
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6194469B1 (en) * 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
HK1047399A1 (en) * 1999-06-02 2003-02-21 Sumitomo Pharmaceuticals Company, Limited Oral preparations of etidronate disodium
US6677320B2 (en) * 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
US7008640B2 (en) 2000-07-17 2006-03-07 Yamanouchi Pharmaceutical Co., Ltd. Pharmaceutical composition for oral use with improved absorption
BRPI0116865B8 (pt) * 2001-01-23 2021-05-25 Gador Sa composição compreendendo bisfosfonatos para prevenção e/ou tratamento de doenças metabólicas dos ossos, processo para preparar tal composição e uso desta
US7695535B2 (en) 2001-10-10 2010-04-13 River Basin Energy, Inc. Process for in-situ passivation of partially-dried coal
US8197561B2 (en) 2001-10-10 2012-06-12 River Basin Energy, Inc. Process for drying coal
US7537622B2 (en) * 2001-10-10 2009-05-26 Fmi Newcoal, Inc. Process for drying coal
EP1458400A1 (en) * 2001-12-13 2004-09-22 Merck & Co., Inc. Liquid bisphosphonate formulations for bone disorders
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
CA2763775C (en) * 2002-05-10 2014-01-07 F. Hoffmann-La Roche Ag Bisphosphonic acids for the treatment and prevention of osteoporosis
ITTO20020406A1 (it) * 2002-05-13 2003-11-13 Chiesi Farma Spa Formulazioni di bisfosfonati ad uso iniettabile.
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
GR1004331B (el) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας αλενδρονικου οξεος
NZ536273A (en) * 2002-12-20 2007-08-31 Hoffmann La Roche High dose ibandronate formulation
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
KR20070015596A (ko) * 2004-05-24 2007-02-05 더 프록터 앤드 갬블 캄파니 킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용경구 투여 형태
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
CA2574766A1 (en) * 2004-06-23 2006-01-26 Merck & Co., Inc. Estrogen receptor modulators
WO2006019843A1 (en) * 2004-07-15 2006-02-23 Nanobac Life Sciences Methods and compositions for the administration of calcium chelators, bisphosphonates and/or citrate compounds and their pharmaceutical uses
WO2006020009A1 (en) * 2004-07-23 2006-02-23 The Procter & Gamble Company Solid oral dosage form of a bisphosphonate containing a chelating agent
EP1802641B8 (en) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
AU2007226964B2 (en) * 2006-03-17 2012-03-22 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
EP1894557B1 (en) * 2006-09-04 2011-02-16 Gador S.A. Liquid composition for prevention and/or treatment of different bone metabolic diseases, uses thereof, and preparation process therefore
EP2086330A4 (en) * 2006-11-21 2010-10-20 Teikoku Pharma Usa Inc BIPHOSPHONATE FORMULATIONS FOR INHALING AND METHOD FOR THEIR USE
US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
CA2711413A1 (en) * 2008-02-05 2009-08-13 Actavis Group Ptc Ehf Alendronate formulations, method of making and method of use thereof
US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
US9057037B2 (en) 2010-04-20 2015-06-16 River Basin Energy, Inc. Post torrefaction biomass pelletization
US8956426B2 (en) 2010-04-20 2015-02-17 River Basin Energy, Inc. Method of drying biomass
US9889225B2 (en) * 2010-08-20 2018-02-13 Kaohsiung Medical University Method for bone formation by administering poly(lactic-co-glycolic acid) cross-linked alendronate
BR112013010476B1 (pt) * 2010-12-06 2021-07-06 Effrx Pharmaceuticals Sa formulações efervescentes estáveis de bisfosfonato com características de solubilização rápida
CN103070824B (zh) * 2013-01-24 2014-07-16 天津红日药业股份有限公司 一种含有伊班膦酸钠的注射液
JP2016532660A (ja) * 2013-10-08 2016-10-20 イノファーマ インク アプレピタント経口液体製剤

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CA2035179C (en) * 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
RU2029550C1 (ru) * 1992-03-20 1995-02-27 Светлана Семеновна Родионова Способ коррекции метаболизма костной ткани
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Also Published As

Publication number Publication date
FI118296B (fi) 2007-09-28
YU31795A (sh) 1999-06-15
HK1009245A1 (en) 1999-05-28
PT759757E (pt) 2002-11-29
FI964593L (fi) 1996-11-15
US5462932A (en) 1995-10-31
MY112285A (en) 2001-05-31
UA29505C2 (uk) 2000-11-15
KR970703151A (ko) 1997-07-03
AU691634B2 (en) 1998-05-21
EP0759757A1 (en) 1997-03-05
JP4111536B2 (ja) 2008-07-02
HUT76317A (en) 1997-08-28
HRP950293A2 (en) 1997-04-30
ES2180646T3 (es) 2003-02-16
NZ289231A (en) 1998-04-27
FI964593A0 (fi) 1996-11-15
EP0759757B1 (en) 2002-08-21
CZ336796A3 (en) 1997-06-11
IL113651A0 (en) 1995-08-31
DE69527842D1 (de) 2002-09-26
YU49354B (sh) 2005-09-19
ZA953960B (en) 1996-01-19
AU2901095A (en) 1995-12-05
HU9603162D0 (en) 1997-01-28
ATE222495T1 (de) 2002-09-15
CN1079672C (zh) 2002-02-27
CN1148341A (zh) 1997-04-23
TW402501B (en) 2000-08-21
SK147796A3 (en) 1997-07-09
SI0759757T1 (en) 2002-12-31
NO964864D0 (no) 1996-11-15
MX9605660A (es) 1998-02-28
JPH10504020A (ja) 1998-04-14
CA2190148C (en) 2006-02-14
KR100372966B1 (ko) 2003-05-12
HRP950293B1 (en) 2003-08-31
RU2176507C2 (ru) 2001-12-10
SK281098B6 (sk) 2000-11-07
NO964864L (no) 1996-11-15
HU220626B1 (hu) 2002-03-28
NO310179B1 (no) 2001-06-05
CZ285860B6 (cs) 1999-11-17
CO4600739A1 (es) 1998-05-08
IL113651A (en) 1999-08-17
WO1995031203A1 (en) 1995-11-23
PL179634B1 (pl) 2000-10-31
CY2336B1 (en) 2004-02-06
PL320614A1 (en) 1997-10-13
DE69527842T2 (de) 2003-04-10
CA2190148A1 (en) 1995-11-23
DZ1884A1 (fr) 2002-02-17

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