DK0754069T3 - Fremgangsmåde til behandling af pulmonal vasokonstriktion og astma - Google Patents

Fremgangsmåde til behandling af pulmonal vasokonstriktion og astma

Info

Publication number
DK0754069T3
DK0754069T3 DK95915014T DK95915014T DK0754069T3 DK 0754069 T3 DK0754069 T3 DK 0754069T3 DK 95915014 T DK95915014 T DK 95915014T DK 95915014 T DK95915014 T DK 95915014T DK 0754069 T3 DK0754069 T3 DK 0754069T3
Authority
DK
Denmark
Prior art keywords
asthma
treating pulmonary
pulmonary vasoconstriction
active agent
propellant gas
Prior art date
Application number
DK95915014T
Other languages
Danish (da)
English (en)
Inventor
Warren M Zapol
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of DK0754069T3 publication Critical patent/DK0754069T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95915014T 1994-04-01 1995-04-03 Fremgangsmåde til behandling af pulmonal vasokonstriktion og astma DK0754069T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/222,256 US5570683A (en) 1990-12-05 1994-04-01 Methods and devices for treating pulmonary vasoconstriction and asthma
EP95915014A EP0754069B1 (en) 1994-04-01 1995-04-03 Treatment of pulmonary vasoconstriction and asthma

Publications (1)

Publication Number Publication Date
DK0754069T3 true DK0754069T3 (da) 2004-11-01

Family

ID=22831508

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95915014T DK0754069T3 (da) 1994-04-01 1995-04-03 Fremgangsmåde til behandling af pulmonal vasokonstriktion og astma
DK04013974T DK1466641T3 (da) 1994-04-01 1995-04-03 Anordning til levering af en phosphodiesteraseinhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK04013974T DK1466641T3 (da) 1994-04-01 1995-04-03 Anordning til levering af en phosphodiesteraseinhibitor

Country Status (11)

Country Link
US (1) US5570683A (ja)
EP (2) EP0754069B1 (ja)
JP (1) JPH09512523A (ja)
KR (1) KR100371082B1 (ja)
AT (2) ATE269731T1 (ja)
AU (1) AU688027B2 (ja)
CA (1) CA2186892C (ja)
DE (2) DE69533190T2 (ja)
DK (2) DK0754069T3 (ja)
ES (2) ES2255020T3 (ja)
WO (1) WO1995026768A1 (ja)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6250300B1 (en) * 1992-12-11 2001-06-26 Ab Astra System for dispensing pharmaceutically active compounds
GB9320978D0 (en) * 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
US6063407A (en) * 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5823180A (en) * 1995-04-03 1998-10-20 The General Hospital Corporation Methods for treating pulmonary vasoconstriction and asthma
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
US5699790A (en) * 1996-03-21 1997-12-23 Ohmeda Inc. System for predicting NO2 concentrations
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5765548A (en) * 1996-05-07 1998-06-16 Perry; Bryan J. Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6027713A (en) * 1997-03-06 2000-02-22 Meri Charmyne Russell Composition and method for the treatment of exercise induced pulmonary hemorrhage
CA2225013C (en) 1997-04-04 2006-06-06 Institut Du N.O. Inc. Injection system for delivery of a gaseous substance
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US6358536B1 (en) 1997-10-15 2002-03-19 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US6656452B1 (en) * 1997-10-21 2003-12-02 The General Hospital Corporation Use of inhaled NO as anti-inflammatory agent
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6109260A (en) * 1998-02-18 2000-08-29 Datex-Ohmeda, Inc. Nitric oxide administration device with timed pulse
US20070275100A1 (en) * 1998-11-23 2007-11-29 Miller Christopher C Use of gaseous nitric oxide as an anti-cancer agent
FR2795644B1 (fr) 1999-07-02 2004-07-30 Air Liquide Sante Int Utilisations therapeutiques d'un melange helium/oxygene, en particulier dans le traitement de l'asthme
ES2275525T3 (es) 1999-07-12 2007-06-16 Capnia Incorporated Aparato para aliviar dolores de cabeza, rinitis y otras afecciones comunes.
US6314956B1 (en) * 1999-09-08 2001-11-13 Duke University Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
US7045152B2 (en) * 1999-09-08 2006-05-16 Duke University Treating pulmonary disorders with gaseous agent causing repletion of GSNO
US6694969B1 (en) * 1999-09-22 2004-02-24 Instrumentarium Corp. Method to improve oxygenation in subjects suffering impaired oxygenation
TW200400821A (en) * 1999-11-02 2004-01-16 Pfizer Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient
US20070039615A1 (en) * 1999-11-08 2007-02-22 Capnia, Incorporated Methods and apparatus for treating rhinitis
US6959708B1 (en) 1999-11-08 2005-11-01 Capnia, Incorporated Method for co-application of gases and drugs to potentiate their action in relieving headaches, angina and other ailments
US20060172017A1 (en) * 1999-11-08 2006-08-03 Capnia, Incorporated Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US7516742B2 (en) 1999-11-24 2009-04-14 Cardinal Health 207, Inc. Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
US8251070B2 (en) 2000-03-27 2012-08-28 Asthmatx, Inc. Methods for treating airways
GB0014898D0 (en) * 2000-06-19 2000-08-09 Innovata Biomed Ltd Delivery system
US6601580B1 (en) * 2000-06-28 2003-08-05 The General Hospital Corporation Enhancing therapeutic effectiveness of nitric oxide inhalation
EA005649B1 (ru) 2000-08-11 2005-04-28 Дэвид Р. Уитлок Композиции, содержащие аммиакокисляющие бактерии, увеличивающие продуцирование окиси азота и предшественников окиси азота, и способы их использования
US7335181B2 (en) * 2000-12-26 2008-02-26 Pulmonox Technologies Corporation Nitric oxide decontamination of the upper respiratory tract
US6432077B1 (en) 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US7122018B2 (en) 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
AU2002318377B2 (en) 2001-06-21 2008-06-19 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
US7432301B2 (en) * 2001-08-20 2008-10-07 University Of Virginia Patent Foundation Use of S-nitrosothiol signaling to treat disordered control of breathing
WO2003020211A2 (en) * 2001-09-05 2003-03-13 Cyterra Corporation Nitric oxide generation
US20030070674A1 (en) * 2001-10-12 2003-04-17 Bryan Perry Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
BR0306868A (pt) * 2002-01-11 2005-04-12 David R Whitlock Composições incluindo bactérias oxidando amonìaco e métodos para usar as mesmas
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
RS110504A (en) * 2002-06-21 2007-02-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education, Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US7367335B2 (en) * 2002-06-28 2008-05-06 The Research Foundation Of State University Of New York Therapeutic agent delivery device and method
US7531133B2 (en) 2002-09-10 2009-05-12 Pulmonox Technologies Corporation Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
AU2004255268B2 (en) 2003-07-09 2010-04-01 Loma Linda University Use of nitrite salts for the treatment of cardiovascular conditions
US20050255178A1 (en) * 2004-02-04 2005-11-17 Bloch Kenneth D Enhancing the effectiveness of an inhaled therapeutic gas
CA2619590A1 (en) * 2004-04-01 2004-08-08 Methapharm Inc. Solution based methacholine formulations
US20050222267A1 (en) * 2004-04-01 2005-10-06 Truong Van H Solution based methacholine formulations
US8518457B2 (en) 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
AU2005244078A1 (en) 2004-05-11 2005-11-24 Pulmonox Technologies Corporation Intermittent dosing of nitric oxide gas
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
EP1789119B1 (en) 2004-08-18 2017-10-18 Geno LLC Conversion of nitrogen dioxide (no2) to nitric oxide (no)
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US8557300B2 (en) * 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
US8079998B2 (en) 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide
KR101548692B1 (ko) * 2006-11-07 2015-09-01 더 제너럴 하스피탈 코포레이션 가스 전달 장치
EP2131903B1 (en) 2007-03-23 2018-01-24 Geno LLC Conversion of nitrogen dioxide (no2) to nitric oxide (no)
JP2011507968A (ja) * 2007-12-27 2011-03-10 エイヤーズ ファーマシューティカルズ、インク． エアロゾル化ニトライトおよび一酸化窒素供与性化合物ならびにそれらの使用
JP5554723B2 (ja) 2008-01-28 2014-07-23 ゲノ エルエルシー 二酸化窒素（ｎｏ２）から一酸化窒素（ｎｏ）への変換
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
US10960168B2 (en) * 2008-08-21 2021-03-30 Vero Biotech LLC Delivery of high concentration nitric oxide
CA2763804C (en) 2009-06-22 2018-02-06 Geno Llc Nitric oxide therapies
JP2011010865A (ja) * 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
JP5995724B2 (ja) * 2009-11-20 2016-09-21 ゲノ エルエルシー 一酸化窒素送達システム
US8685467B2 (en) * 2010-08-03 2014-04-01 J. W. Randolph Miller Nitric oxide generation, dilution, and topical application apparatus and method
US20120107423A1 (en) 2010-11-01 2012-05-03 Ino Therapeutics Llc Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome
EP2776047A4 (en) * 2011-11-07 2015-07-22 Gen Hospital Corp TREATMENT OF RED GLOBLES
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
WO2015106115A1 (en) 2014-01-10 2015-07-16 Ino Therapeutics Llc Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children
WO2015160911A2 (en) 2014-04-15 2015-10-22 Aobiome Llc Ammonia-oxidizing nitrosomonas eutropha strain d23
US11225640B2 (en) 2014-04-15 2022-01-18 Aobiome Llc Ammonia oxidizing bacteria for treatment of psoriasis
AU2016243801B2 (en) 2015-04-02 2020-05-21 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
WO2017161442A1 (en) 2016-03-24 2017-09-28 Services Medicaux Arnold Et Joan Zidulka Inc. Device and method of delivering particles in the upper respiratory tract
US20200206278A1 (en) * 2017-07-18 2020-07-02 Aobiome Llc Ammonia oxidizing microorganisms for the treatment of pulmonary hypertension
KR102106221B1 (ko) 2018-10-13 2020-04-29 이용운 지열을 이용한 수도미터기 보호통
EP3911393A4 (en) * 2019-01-14 2022-10-19 Bellerophon Therapeutics COMBINATION THERAPIES OF PDE-5 INHIBITORS AND INHALED NITROUS OXIDE
KR102292942B1 (ko) 2019-09-11 2021-08-23 이용운 지열을 이용한 수도미터기 보호통

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785377A (en) * 1970-11-12 1974-01-15 S Jorgensen Plant, preferably for anaesthesia
US4010897A (en) * 1976-03-31 1977-03-08 Charles F. Kettering Foundation Method and apparatus for home production and application of nitrogen fertilizer
IL57239A (en) * 1979-05-08 1982-04-30 Alamaro Moshe Production of nitric oxides
US4297123A (en) * 1980-02-07 1981-10-27 Wyse Harold G Method and apparatus for producing a nitrate fertilizer
US4336798A (en) * 1980-10-06 1982-06-29 Anthony V. Beran Medical corrugated respiratory tube
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US4877589A (en) * 1988-09-19 1989-10-31 Hare Louis R O Nitrogen fixation by electric arc and catalyst
US4915915A (en) * 1988-10-11 1990-04-10 Treharne Richard W Water-powdered piezoelectric unit for producing nitrogen fertilizer
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5396882A (en) * 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
DE69133584T4 (de) * 1990-12-05 2009-11-19 The General Hospital Corp., Boston Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
IL101406A (en) * 1991-03-29 1998-02-08 Brigham & Womens Hospital Pharmaceutical compositions containing s-nitrosothiol derivatives
AU3237193A (en) * 1991-12-11 1993-07-19 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5246970A (en) * 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation

Also Published As

Publication number Publication date
DE69533190T2 (de) 2005-08-18
DE69534755T2 (de) 2006-11-16
ATE269731T1 (de) 2004-07-15
EP0754069B1 (en) 2004-06-23
WO1995026768A1 (en) 1995-10-12
WO1995026768A9 (en) 1999-10-21
DK1466641T3 (da) 2006-05-29
JPH09512523A (ja) 1997-12-16
EP1466641A1 (en) 2004-10-13
KR100371082B1 (ko) 2003-06-19
DE69533190D1 (de) 2004-07-29
ES2255020T3 (es) 2006-06-16
AU2205895A (en) 1995-10-23
EP0754069A4 (en) 2000-01-19
EP0754069A1 (en) 1997-01-22
CA2186892C (en) 2007-11-27
ES2224123T3 (es) 2005-03-01
AU688027B2 (en) 1998-03-05
ATE316396T1 (de) 2006-02-15
CA2186892A1 (en) 1995-10-12
EP1466641B1 (en) 2006-01-25
US5570683A (en) 1996-11-05
DE69534755D1 (de) 2006-04-13

Similar Documents

Publication Publication Date Title
DK0754069T3 (da) Fremgangsmåde til behandling af pulmonal vasokonstriktion og astma
NO931796D0 (no) Fremgangsmaate for behandling og transport av naturgass fra en gassbroenn
DK0764028T3 (da) Fremgangsmåde til behandling af tilbageholdte lungesekretioner
TR199501595A2 (tr) Gaz akimlarindan karbon dioksitin uzaklastirilmasi.
CA2229416A1 (en) Removal of nitrogen oxides from a gas stream containing same
LU90886I2 (fr) Inomax-oxyde nitrique et ses d-riv-s pharmaceutiquement acceptables
KR100239168B1 (en) Heterocyclic amines useful in the therapy of athma and inflammation of the respiratory tracts
TR199600881A2 (tr) Gaz akimindan karbon dioksitin cikarilmasi.
GB2117648B (en) A method of generating a supply of respiratory gas for, and apparatus for, effecting ventilation of the lungs of a patient
FR2693910B1 (fr) Equipement et procédé de fourniture de doses d'au moins un gaz aux voies respiratoires d'un utilisateur.
DE69231994T2 (de) Fluorchlorkohlenwasserstofffreie Aerosolformulierungen
FR2531097B1 (fr) Procede d'enlevement d'azote gazeux d'un melange comprenant n2 et co ou n2, co2 et co
DK0918507T3 (da) Aerosolformuleringer
KR970701584A (ko) 가스의 정화를 위한 방법 및 장치(process and apparatus for the purification of gas)
BR9712125A (pt) Formulação farmaucêutica em aerosol, uso de uma mistura, produto farmacêutico, e, processo de administração de budesonida a um paciente
FR2768568B1 (fr) Procede et equipement pour la preparation d'un gaz d'helium hyperpolarise a forte pression, application dudit procede
FR2676000B1 (fr) Dispositif d'alimentation en gaz respiratoire.
FI104312B1 (fi) Sovitelma intuboidun potilaan hengityskaasun käsittelemiseksi
FR2593070B1 (fr) Dispositif pour l'enrichissement en oxygene de gaz respiratoire.
NO902018D0 (no) Fremgangsmaate og anlegg for gjenvinning av ammoniakk fra roekgasser.
DK1119501T3 (da) Apparat til organisering af den kombinerede brug af topiske aerosoler og orale medikamenter
FR2690077B1 (fr) Procede et dispositif d'elaboration d'un melange gazeux anesthesique.
HU9402396D0 (en) No-containing gas-composition for treating pulmonal diseases
TR26030A (tr) GAZ AKIMLARINDAN KüKüRT DIOKSIDIN UZAKLASTIRLMASI VE GERI KAZANILMASI.
BA97176A (bs) Aplikator za otpustanje gasa ili para narocito gasovitog sredstva protiv stetocina