DK0747347T3 - RAR-gamma specifikke retinobenzoesyrederivater - Google Patents

RAR-gamma specifikke retinobenzoesyrederivater

Info

Publication number
DK0747347T3
DK0747347T3 DK96401097T DK96401097T DK0747347T3 DK 0747347 T3 DK0747347 T3 DK 0747347T3 DK 96401097 T DK96401097 T DK 96401097T DK 96401097 T DK96401097 T DK 96401097T DK 0747347 T3 DK0747347 T3 DK 0747347T3
Authority
DK
Denmark
Prior art keywords
rar
acid derivatives
gamma specific
compounds
formula
Prior art date
Application number
DK96401097T
Other languages
Danish (da)
English (en)
Inventor
R Thomas Swann
Daniel Smith
Kenneth M Tramposch
Fred Christopher Zusi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0747347T3 publication Critical patent/DK0747347T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
DK96401097T 1995-06-06 1996-05-20 RAR-gamma specifikke retinobenzoesyrederivater DK0747347T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/467,429 US5624957A (en) 1995-06-06 1995-06-06 Rary-specific retinobenzoic acid derivatives

Publications (1)

Publication Number Publication Date
DK0747347T3 true DK0747347T3 (da) 2000-02-14

Family

ID=23855669

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96401097T DK0747347T3 (da) 1995-06-06 1996-05-20 RAR-gamma specifikke retinobenzoesyrederivater

Country Status (10)

Country Link
US (2) US5624957A (fr)
EP (1) EP0747347B1 (fr)
JP (1) JPH08333318A (fr)
AT (1) ATE182327T1 (fr)
AU (1) AU693352B2 (fr)
CA (1) CA2175854A1 (fr)
DE (1) DE69603322T2 (fr)
DK (1) DK0747347T3 (fr)
ES (1) ES2136950T3 (fr)
GR (1) GR3031517T3 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100485642B1 (ko) * 1996-03-18 2005-09-30 에자이 가부시키가이샤 축합고리함유카르복실산유도체
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
WO1998046076A1 (fr) * 1997-04-11 1998-10-22 Sidney Kimmel Cancer Center Molecules liees aux retinoides et permettant d'enrayer la surproduction d'endotheline 1 dans l'affection
JP2002526445A (ja) * 1998-09-24 2002-08-20 ブリストルーマイヤーズ スクイブ カンパニー ＲＡＲγ−特異的作用薬の活性エナンチオマー
JP2003502282A (ja) * 1999-04-08 2003-01-21 ザ ゼネラル ホスピタル コーポレーション ヒト転移性細胞の作用因子源から離れた意図された移動
AU4228000A (en) * 1999-04-14 2000-11-14 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease
WO2000061232A2 (fr) 1999-04-14 2000-10-19 Allergan Sales, Inc. Methodes et compositions destinees au traitement et a la prevention de maladies pulmonaires
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
WO2000063196A1 (fr) * 1999-04-20 2000-10-26 Novo Nordisk A/S Nouveaux composes, leur preparation et leur utilisation
US6624154B1 (en) 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
WO2001078700A2 (fr) * 2000-04-13 2001-10-25 Frederic Geissmann Compositions et procedes utilises pour moduler la fonction du systeme immunitaire
FR2819186A1 (fr) * 2001-01-10 2002-07-12 L M D Cystine-voie orale-syndrome de l'oeil sec
CA2509193A1 (fr) * 2002-12-06 2004-06-24 The General Hospital Corporation Methodes et compositions associees a des cellules exposees a un gradient
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
CA2586765A1 (fr) 2004-11-05 2006-12-28 The General Hospital Corporation Eloignement volontaire de cellules migratoires humaines d'une source d'agents
DK2613776T3 (da) 2010-09-01 2020-10-19 Univ Jefferson Sammensætning og fremgangsmåde til muskelreparation og -regenerering
CA2840272C (fr) 2011-06-24 2020-09-15 Glycoregimmune, Inc. Prevention et traitement d'etats inflammatoires
WO2013019653A1 (fr) * 2011-07-29 2013-02-07 Tempero Pharmaceuticals, Inc. Composés et méthodes
US8772273B2 (en) * 2011-10-04 2014-07-08 Quretino Therapeutics, Inc. Formulations and uses of retinoic acid receptor selective agonists
WO2014073209A1 (fr) * 2012-11-08 2014-05-15 国立大学法人山口大学 Agent thérapeutique pour troubles kératoconjonctifs
EP2969031A4 (fr) 2013-03-15 2017-03-08 Avisenna Cosmetics LLC Compositions topiques permettant de réduire les effets du vieillissement
DK3000466T3 (en) 2013-05-22 2018-11-26 Univ Yamaguchi INHIBITOR FOR RETINOCHOROIDAL DISEASES
WO2017210792A1 (fr) 2016-06-08 2017-12-14 Clementia Pharmaceuticals Inc. Méthodes pour le traitement de l'ossification hétérotopique
ES2907696T3 (es) 2016-11-16 2022-04-26 Clementia Pharmaceuticals Inc Métodos para tratar osteocondroma múltiple (MO)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3903988A1 (de) * 1989-02-10 1990-08-30 Basf Ag Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
WO1993003713A1 (fr) * 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Emploi de ligands selectifs dans le traitement d'etats pathologiques sensibles aux hormones steroides ou analogues

Also Published As

Publication number Publication date
JPH08333318A (ja) 1996-12-17
EP0747347A1 (fr) 1996-12-11
US5624957A (en) 1997-04-29
EP0747347B1 (fr) 1999-07-21
AU693352B2 (en) 1998-06-25
ATE182327T1 (de) 1999-08-15
CA2175854A1 (fr) 1996-12-07
US5760084A (en) 1998-06-02
AU5471796A (en) 1996-12-19
GR3031517T3 (en) 2000-01-31
ES2136950T3 (es) 1999-12-01
DE69603322D1 (de) 1999-08-26
DE69603322T2 (de) 2000-04-13

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