ATE182327T1 - Rar-gamma-spezifische retinobenzoesäurederivate - Google Patents

Rar-gamma-spezifische retinobenzoesäurederivate

Info

Publication number
ATE182327T1
ATE182327T1 AT96401097T AT96401097T ATE182327T1 AT E182327 T1 ATE182327 T1 AT E182327T1 AT 96401097 T AT96401097 T AT 96401097T AT 96401097 T AT96401097 T AT 96401097T AT E182327 T1 ATE182327 T1 AT E182327T1
Authority
AT
Austria
Prior art keywords
rar
gamma
specific
acid derivatives
compounds
Prior art date
Application number
AT96401097T
Other languages
English (en)
Inventor
R Thomas Swann
Daniel Smith
Kenneth M Tramposch
Fred Christopher Zusi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE182327T1 publication Critical patent/ATE182327T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
AT96401097T 1995-06-06 1996-05-20 Rar-gamma-spezifische retinobenzoesäurederivate ATE182327T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/467,429 US5624957A (en) 1995-06-06 1995-06-06 Rary-specific retinobenzoic acid derivatives

Publications (1)

Publication Number Publication Date
ATE182327T1 true ATE182327T1 (de) 1999-08-15

Family

ID=23855669

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96401097T ATE182327T1 (de) 1995-06-06 1996-05-20 Rar-gamma-spezifische retinobenzoesäurederivate

Country Status (10)

Country Link
US (2) US5624957A (de)
EP (1) EP0747347B1 (de)
JP (1) JPH08333318A (de)
AT (1) ATE182327T1 (de)
AU (1) AU693352B2 (de)
CA (1) CA2175854A1 (de)
DE (1) DE69603322T2 (de)
DK (1) DK0747347T3 (de)
ES (1) ES2136950T3 (de)
GR (1) GR3031517T3 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889032A4 (de) * 1996-03-18 2000-01-05 Eisai Co Ltd Carbonsaure derivate mit kondensierten ringen
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
AU6895198A (en) * 1997-04-11 1998-11-11 Sidney Kimmel Cancer Center Retinoid related molecules for the inhibition of endothelin-1 overproduction in disease
US6331570B1 (en) 1998-09-24 2001-12-18 Bristol-Myers Squibb Company Active enantiomer of RARγ-specific agonist
AU4230900A (en) * 1999-04-08 2000-10-23 General Hospital Corporation, The Purposeful movement of human migratory cells away from an agent source
WO2000061232A2 (en) 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist
WO2000061233A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist
WO2000063196A1 (en) * 1999-04-20 2000-10-26 Novo Nordisk A/S New compounds, their preparation and use
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
US6624154B1 (en) 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
US20020090352A1 (en) * 2000-04-13 2002-07-11 Frederick Geissmann Compositions and methods for use in modulating immune system function
FR2819186A1 (fr) * 2001-01-10 2002-07-12 L M D Cystine-voie orale-syndrome de l'oeil sec
JP2006508697A (ja) * 2002-12-06 2006-03-16 ザ・ジェネラル・ホスピタル・コーポレイション 勾配に暴露された細胞に関する方法および組成物
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
JP2008519052A (ja) 2004-11-05 2008-06-05 ザ ジェネラル ホスピタル コーポレイション 薬剤によるヒト遊走性細胞の合目的的挙動
EP2613776B1 (de) 2010-09-01 2020-07-29 Thomas Jefferson University Zusammensetzungen und verfahren zur muskelreparatur und -regeneration
CN103732231B (zh) * 2011-06-24 2020-04-10 格里生物公司 炎性病症的预防和治疗
EP2736332A4 (de) * 2011-07-29 2015-03-18 Tempero Pharmaceuticals Inc Verbindungen und verfahren
US8772273B2 (en) * 2011-10-04 2014-07-08 Quretino Therapeutics, Inc. Formulations and uses of retinoic acid receptor selective agonists
EP2918290B1 (de) * 2012-11-08 2020-09-02 Yamaguchi University Therapeutikum für keratokonjunktivitis
WO2014145295A1 (en) * 2013-03-15 2014-09-18 Avisenna Cosmetics, Llc Topical compositions for reducing aging effects
EP3446690A1 (de) 2013-05-22 2019-02-27 Yamaguchi University Inhibitor für retinochoroidale erkrankungen
EP4249490A3 (de) 2016-06-08 2023-12-13 Clementia Pharmaceuticals Inc. Verfahren zur behandlung von heterotopischer ossifikation
KR20190100187A (ko) 2016-11-16 2019-08-28 클레멘티아 파마슈티컬즈, 인크. 다중 골연골종(mo)을 치료하는 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3903988A1 (de) * 1989-02-10 1990-08-30 Basf Ag Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
WO1993003713A1 (en) * 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones

Also Published As

Publication number Publication date
AU693352B2 (en) 1998-06-25
AU5471796A (en) 1996-12-19
ES2136950T3 (es) 1999-12-01
GR3031517T3 (en) 2000-01-31
DE69603322D1 (de) 1999-08-26
US5760084A (en) 1998-06-02
EP0747347A1 (de) 1996-12-11
JPH08333318A (ja) 1996-12-17
DK0747347T3 (da) 2000-02-14
DE69603322T2 (de) 2000-04-13
EP0747347B1 (de) 1999-07-21
CA2175854A1 (en) 1996-12-07
US5624957A (en) 1997-04-29

Similar Documents

Publication Publication Date Title
DE69603322D1 (de) RAR-gamma-spezifische Retinobenzoesäurederivate
ATE317691T1 (de) Benzochinonderivate enthaltende hemmer von nf-kb
ATE174899T1 (de) Zytotoxische stilben-derivate und diese enthaltende pharmazeutische zusammensetzungen
LU91587I2 (fr) Agomélatine et ses dérivés pharmaceutiquement acceptables (VALDOXAN)
DE69219885D1 (de) 7-chromanylester von phenolen und benzoesäuren mit retinoidähnlicher aktivität
ATE185792T1 (de) Stilbenderivate und diese enthaltende pharmazeutische zusammensetzungen
AU3258589A (en) Tetralin esters of phenols or benzoic acids having retinoid like activity
HUP0402649A2 (hu) 6-Fluor-biciklo[3.1.0]hexán-származékok
DE3866010D1 (de) Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung.
DK0984934T3 (da) Hidtil ukendte oralt aktive jern(III)chelateringsmidler
KR960031422A (ko) 신규한 레티노이드
KR900009677A (ko) 신규 화합물들
UA43338C2 (uk) Похідні бензолу
DE69430383D1 (de) Chroman-derivate
EP1270569A4 (de) Substituierte tryptophanderivate
ES2062271T3 (es) Preparaciones farmaceuticas.
ES2006361A6 (es) Un procedimiento para preparar derivados de insoindolinilo opticamente activos.
FI933468A (fi) Tetrahydronaftalenderivat, framstaellning av dessa och terapeutisk anvaendning av dessa
AU4697593A (en) Use of prostane derivatives of formulae i and ii for the production of a medicament for the treatment of chronic polyarthritis
DE69828037D1 (de) Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung
DE69314929T2 (de) Benzolderivate
IE32514B1 (en) Synthesis of adamantyl compounds
KR890013001A (ko) 자극성 아미노산 수용체 길항제인 테트라졸 유도체

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee