DK0745598T3 - Nye piperazin, piperidin- og 1,2,5,6-tetrahydropyridinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholde disse - Google Patents

Nye piperazin, piperidin- og 1,2,5,6-tetrahydropyridinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholde disse

Info

Publication number
DK0745598T3
DK0745598T3 DK96401156T DK96401156T DK0745598T3 DK 0745598 T3 DK0745598 T3 DK 0745598T3 DK 96401156 T DK96401156 T DK 96401156T DK 96401156 T DK96401156 T DK 96401156T DK 0745598 T3 DK0745598 T3 DK 0745598T3
Authority
DK
Denmark
Prior art keywords
piperidine
processes
preparation
pharmaceutical compositions
compositions contain
Prior art date
Application number
DK96401156T
Other languages
Danish (da)
English (en)
Inventor
Jean-Louis Peglion
Bertrand Goument
Mark Millan
Adrian Newman-Tancredi
Alain Gobert
Aimee Dessinges
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0745598T3 publication Critical patent/DK0745598T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96401156T 1995-05-31 1996-05-30 Nye piperazin, piperidin- og 1,2,5,6-tetrahydropyridinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholde disse DK0745598T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506436A FR2734819B1 (fr) 1995-05-31 1995-05-31 Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
DK0745598T3 true DK0745598T3 (da) 2001-10-08

Family

ID=9479526

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96401156T DK0745598T3 (da) 1995-05-31 1996-05-30 Nye piperazin, piperidin- og 1,2,5,6-tetrahydropyridinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholde disse

Country Status (16)

Country Link
US (2) US5753662A (el)
EP (1) EP0745598B1 (el)
JP (1) JPH08325257A (el)
CN (1) CN1064356C (el)
AT (1) ATE204574T1 (el)
AU (1) AU705374B2 (el)
CA (1) CA2177774C (el)
DE (1) DE69614608T2 (el)
DK (1) DK0745598T3 (el)
ES (1) ES2162989T3 (el)
FR (1) FR2734819B1 (el)
GR (1) GR3037040T3 (el)
NO (1) NO314185B1 (el)
NZ (1) NZ286698A (el)
PT (1) PT745598E (el)
ZA (1) ZA964485B (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US6436940B2 (en) 1996-12-20 2002-08-20 H. Lundbeck A/S Indane or dihydroindole derivatives
ES2205267T3 (es) * 1996-12-20 2004-05-01 H. Lundbeck A/S Derivados de indano o de dihidroindol.
WO1998031679A1 (fr) * 1997-01-21 1998-07-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thiophene et leur application medicinale
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2763589B1 (fr) * 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
ES2241172T3 (es) * 1997-10-24 2005-10-16 Neurogen Corporation 1-(2-naftil) y 1-(2-azanaftil)-4-(1-fenilmetil)piperazinas que son ligandos del subtipo de receptor de dopamina d4.
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
ES2200319T3 (es) 1998-03-18 2004-03-01 Taisho Pharmaceutical Co., Ltd Derivados heteroaromaticos.
CA2324550A1 (en) 1998-03-19 1999-09-23 Shigeyuki Chaki Arylpiperidine derivatives and use thereof
EP0953567A3 (en) * 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
US6177566B1 (en) * 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
BR122015016314B8 (pt) 2001-07-16 2021-05-25 Genzyme Corp método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US7105513B2 (en) * 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US6960611B2 (en) 2002-09-16 2005-11-01 Institute Of Materia Medica Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2004599B1 (de) * 2006-04-06 2011-11-09 Basf Se Verfahren zur Herstellung eines Nn-Alkyl-Lactams mit verbesserter Farbqualität
EP2367789A1 (en) * 2008-11-24 2011-09-28 Basf Se Process for preparing an n-alkyllactam with improved color quality
US8796472B2 (en) 2008-12-04 2014-08-05 Basf Se Mixtures of itaconic acid or itaconic acid derivatives and primary amines for producing 1,3- and 1,4-alkyl methyl pyrrolidones
WO2010084089A1 (en) 2009-01-22 2010-07-29 Basf Se Mixtures of pvdf, n-alkyllactams and organic carbonate and their applications
US8369001B2 (en) * 2009-07-17 2013-02-05 The United States Of America, As Represented By The Secretary Of The Navy Compact high power terahertz radiation cell
SG10201407881WA (en) 2009-11-27 2015-01-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
NZ600008A (en) 2009-12-04 2014-10-31 Sunovion Pharmaceuticals Inc Multicyclic compounds and methods of use thereof
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
JP7146782B2 (ja) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク 統合失調症を処置する方法
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF
EA202091945A1 (ru) 2018-02-16 2021-01-18 Суновион Фармасьютикалз Инк. Соли, кристаллические формы и способы их получения
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
EP4135690A1 (en) 2020-04-14 2023-02-22 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377347A (en) * 1963-06-14 1968-04-09 Ciba Geigy Corp Cyclobutene derivatives
DE2037852C3 (de) * 1970-07-30 1980-06-26 Boehringer Sohn Ingelheim Neue Piperazinderivate und Verfahren zu ihrer Herstellung
US3859438A (en) * 1971-07-08 1975-01-07 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl-2)-n-bicyclic aryl-piperazine and method of use
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DE4321366A1 (de) * 1993-06-26 1995-01-05 Merck Patent Gmbh Piperidine und Piperazine

Also Published As

Publication number Publication date
GR3037040T3 (en) 2002-01-31
CA2177774A1 (fr) 1996-12-01
EP0745598A1 (fr) 1996-12-04
NO314185B1 (no) 2003-02-10
NZ286698A (en) 1998-02-26
ATE204574T1 (de) 2001-09-15
ES2162989T3 (es) 2002-01-16
US5684020A (en) 1997-11-04
FR2734819B1 (fr) 1997-07-04
DE69614608T2 (de) 2002-07-04
AU705374B2 (en) 1999-05-20
JPH08325257A (ja) 1996-12-10
DE69614608D1 (de) 2001-09-27
ZA964485B (en) 1996-12-12
CN1064356C (zh) 2001-04-11
CA2177774C (fr) 2001-07-24
EP0745598B1 (fr) 2001-08-22
CN1142494A (zh) 1997-02-12
AU5455896A (en) 1996-12-12
PT745598E (pt) 2001-11-30
NO962210L (no) 1996-12-02
US5753662A (en) 1998-05-19
FR2734819A1 (fr) 1996-12-06
NO962210D0 (no) 1996-05-30

Similar Documents

Publication Publication Date Title
DK0745598T3 (da) Nye piperazin, piperidin- og 1,2,5,6-tetrahydropyridinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholde disse
DK0778277T3 (da) Substituerede heterocycliske derivater som CRF antagonister
DE69325944T2 (de) s-Triazinderivate als Lichtschutzmittel
DK0491664T3 (da) Indolderivater som serotonin-antagonister
AU8773082A (en) Dibenzo (b,e)-oxepines and 1,4-oxazepines; dibenzo (b,d)- pyrans
DE69422837T2 (de) 2-Cyan-1-sulfonamidophenyl-1,3-dion-Derivate und deren Verwendung als Herbizide
NO934300D0 (no) Pyrrolidin- og tiazolidinderivater, deres fremstilling samt medikamenter inneholdende forbindelsene
DE69332504D1 (de) Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung
NO911158L (no) Hydantoinderivater.
FI851931A0 (fi) Nya -karbolin-3-oxadiazolylderivat, foerfarande foer deras framstaellning samt deras anvaendning.
DE69509875T2 (de) Nipecotinsäurederivate als antithrombische verbindungen
MX9203360A (es) Derivados de hexahidroazepinas y composiciones farmaceuticas que los contienen.
ES2078876B1 (es) Una composicion herbicida a base de fenilpirazol 3-sustituidos.
CO4520266A1 (es) Derivado de 1,3-oxazin-4-ona, el herbicida que lo contiene y los productos intermedios para prepararlo
FI834087A (fi) Piperidindionderivat med myokardisk skyddsverkan samt med rytmstoerningar bekaempande verkan, derasframstaellningsfoerfarande och naemnda derivat innehaollande laekemedel
ES2081810T3 (es) Derivados de 4-fenil-4-(n-(2-fluorofenil)amido)-piperidina.
SE9103453D0 (sv) Flytande diskmedelskomposition
DK439384A (da) Derivater af 4-(3-alkynyloxy-2-hydroxypropyl)-piperazin-1-yl-n-phenylacetamid, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende disse
ES2103675B1 (es) Nuevas piperidinas sustituidas.
ES2189108T3 (es) Nuevas oxazinas dissustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
DK0528209T3 (da) Fremgangsmåde til fremstilling af mellemprodukter til D-Vitaminderivater og nye forbindelser
ATE396187T1 (de) Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
DK549789D0 (da) Fremgangsmaade til fremstilling af optisk aktive acyloxyazetidinoner
CS272085A1 (en) 2,2,6,6 tetremetylpiperidilamidy nasycenych karbonovych aminokyselin jako svetelne a tepelne stabilizatory nara zuvzdorneho polystyrenu
IT1201460B (it) 2,2,6,6-tetrametilpiperidilammidi di acidi carbossilici sostituiti e composizioni polimeriche resistenti alla luce,stabilizzate con le stesse