DK0742791T3 - Makrocykliske difluorstatonderivater, der er nyttige som antivirale midler - Google Patents

Makrocykliske difluorstatonderivater, der er nyttige som antivirale midler

Info

Publication number
DK0742791T3
DK0742791T3 DK95903633T DK95903633T DK0742791T3 DK 0742791 T3 DK0742791 T3 DK 0742791T3 DK 95903633 T DK95903633 T DK 95903633T DK 95903633 T DK95903633 T DK 95903633T DK 0742791 T3 DK0742791 T3 DK 0742791T3
Authority
DK
Denmark
Prior art keywords
pct
hiv
antiviral agents
macrocyclic
useful
Prior art date
Application number
DK95903633T
Other languages
Danish (da)
English (en)
Inventor
Robert A Farr
Brent L Podlogar
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0742791T3 publication Critical patent/DK0742791T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK95903633T 1994-02-04 1994-11-28 Makrocykliske difluorstatonderivater, der er nyttige som antivirale midler DK0742791T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19208094A 1994-02-04 1994-02-04
PCT/US1994/013711 WO1995021186A1 (fr) 1994-02-04 1994-11-28 Derives de difluorostatone macrocyclique utiles en tant qu'agents antiviraux

Publications (1)

Publication Number Publication Date
DK0742791T3 true DK0742791T3 (da) 2001-04-02

Family

ID=22708156

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903633T DK0742791T3 (da) 1994-02-04 1994-11-28 Makrocykliske difluorstatonderivater, der er nyttige som antivirale midler

Country Status (20)

Country Link
US (1) US5969132A (fr)
EP (1) EP0742791B1 (fr)
JP (1) JP3574455B2 (fr)
KR (1) KR100367379B1 (fr)
CN (1) CN1142830A (fr)
AT (1) ATE198602T1 (fr)
AU (1) AU684875B2 (fr)
CA (1) CA2182476C (fr)
DE (1) DE69426574T2 (fr)
DK (1) DK0742791T3 (fr)
ES (1) ES2155515T3 (fr)
FI (1) FI963073A0 (fr)
GR (1) GR3035623T3 (fr)
HU (1) HUT74384A (fr)
IL (1) IL112514A0 (fr)
NO (1) NO963254L (fr)
NZ (1) NZ277410A (fr)
PT (1) PT742791E (fr)
WO (1) WO1995021186A1 (fr)
ZA (1) ZA95756B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210612B1 (fr) 2003-06-18 2016-10-05 Ocera Therapeutics, Inc. Antagonistes macrocycliques du récepteur de motiline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672792A5 (fr) * 1985-02-19 1989-12-29 Sandoz Ag
DE3674131D1 (de) * 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
JPH03505875A (ja) * 1988-07-08 1991-12-19 スミスクライン・ベックマン・コーポレイション レトロウイルス・プロテアーゼ結合ペプチド
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
ES2094344T3 (es) * 1991-01-02 1997-01-16 Merrell Pharma Inc Compuestos anti-virales.
MX9700414A (es) * 1994-07-15 1998-05-31 Merrell Pharma Inc Agentes antivirales de difluoroestatona.

Also Published As

Publication number Publication date
US5969132A (en) 1999-10-19
EP0742791B1 (fr) 2001-01-10
WO1995021186A1 (fr) 1995-08-10
DE69426574D1 (de) 2001-02-15
NO963254D0 (no) 1996-08-02
KR100367379B1 (ko) 2003-04-11
HUT74384A (en) 1996-12-30
DE69426574T2 (de) 2001-08-09
GR3035623T3 (en) 2001-06-29
AU684875B2 (en) 1998-01-08
JPH09508417A (ja) 1997-08-26
HU9602158D0 (en) 1996-09-30
ES2155515T3 (es) 2001-05-16
NZ277410A (en) 1997-02-24
AU1262295A (en) 1995-08-21
FI963073A (fi) 1996-08-02
EP0742791A1 (fr) 1996-11-20
CA2182476C (fr) 2000-12-26
CN1142830A (zh) 1997-02-12
ATE198602T1 (de) 2001-01-15
PT742791E (pt) 2001-06-29
IL112514A0 (en) 1995-05-26
FI963073A0 (fi) 1996-08-02
NO963254L (no) 1996-08-02
ZA95756B (en) 1995-10-05
JP3574455B2 (ja) 2004-10-06

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