DK0732928T3 - Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler - Google Patents

Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Info

Publication number
DK0732928T3
DK0732928T3 DK95901141T DK95901141T DK0732928T3 DK 0732928 T3 DK0732928 T3 DK 0732928T3 DK 95901141 T DK95901141 T DK 95901141T DK 95901141 T DK95901141 T DK 95901141T DK 0732928 T3 DK0732928 T3 DK 0732928T3
Authority
DK
Denmark
Prior art keywords
alkyl
silyl
phenols
cholesterol levels
serum cholesterol
Prior art date
Application number
DK95901141T
Other languages
Danish (da)
English (en)
Inventor
Simon J T Mao
Mark T Yates
Roger A Parker
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0732928T3 publication Critical patent/DK0732928T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
DK95901141T 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler DK0732928T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10
EP95901141A EP0732928B1 (de) 1993-12-10 1994-11-03 Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl-phenol derivaten

Publications (1)

Publication Number Publication Date
DK0732928T3 true DK0732928T3 (da) 2005-04-18

Family

ID=22598245

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04016883T DK1468692T3 (da) 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
DK95901141T DK0732928T3 (da) 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04016883T DK1468692T3 (da) 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom

Country Status (16)

Country Link
EP (3) EP0732928B1 (de)
JP (1) JPH09511222A (de)
CN (1) CN1092517C (de)
AT (2) ATE324113T1 (de)
AU (1) AU681731B2 (de)
CA (1) CA2177968C (de)
DE (2) DE69434198T2 (de)
DK (2) DK1468692T3 (de)
ES (2) ES2263094T3 (de)
HU (1) HU220761B1 (de)
IL (1) IL111905A (de)
NO (1) NO311868B1 (de)
NZ (1) NZ276285A (de)
PT (2) PT732928E (de)
WO (1) WO1995015760A1 (de)
ZA (1) ZA949663B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
EA009987B1 (ru) * 1997-05-14 2008-04-28 Атеродженикс, Инк. Производные пробукола для лечения заболеваний, опосредованных vcam-1
NZ501342A (en) * 1997-06-24 2001-10-26 Aventis Pharma Inc Alkyl-4-silyl(furanyl or thienyl) phenols as antioxidant agents
EP0996623A1 (de) * 1997-06-25 2000-05-03 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl4-[(dimethyl-4-methoxyphenylsilyl)-methyloxy]phenol und 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)-methyloxy]phenol
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EA200000087A1 (ru) 1997-07-01 2000-08-28 Атеродженикс, Инк. Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
MXPA01004683A (es) * 1998-11-09 2002-09-18 Atherogenics Inc Metodos y composiciones para disminuir los niveles de colesterol en el plasma.
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
US6545007B2 (en) 2000-11-17 2003-04-08 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2003053368A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en) 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (de) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Also Published As

Publication number Publication date
CA2177968A1 (en) 1995-06-15
HU9601590D0 (en) 1996-08-28
IL111905A (en) 2001-04-30
DE69434198D1 (de) 2005-01-27
PT732928E (pt) 2005-03-31
ZA949663B (en) 1995-08-15
HUT74015A (en) 1996-10-28
PT1468692E (pt) 2006-09-29
ATE324113T1 (de) 2006-05-15
IL111905A0 (en) 1995-03-15
WO1995015760A1 (en) 1995-06-15
DK1468692T3 (da) 2006-08-28
EP0732928A1 (de) 1996-09-25
CN1092517C (zh) 2002-10-16
NZ276285A (en) 2004-11-26
AU681731B2 (en) 1997-09-04
ES2263094T3 (es) 2006-12-01
EP1468692A3 (de) 2004-11-03
CA2177968C (en) 2000-03-28
ATE285238T1 (de) 2005-01-15
DE69434198T2 (de) 2005-12-29
HU220761B1 (hu) 2002-05-28
EP1468693A3 (de) 2004-11-03
NO311868B1 (no) 2002-02-11
AU1049995A (en) 1995-06-27
DE69434720D1 (de) 2006-06-01
EP1468693A2 (de) 2004-10-20
EP0732928B1 (de) 2004-12-22
EP1468692B1 (de) 2006-04-26
ES2233937T3 (es) 2005-06-16
DE69434720T2 (de) 2007-05-16
EP1468692A2 (de) 2004-10-20
CN1140995A (zh) 1997-01-22
NO962415L (no) 1996-06-07
JPH09511222A (ja) 1997-11-11
NO962415D0 (no) 1996-06-07

Similar Documents

Publication Publication Date Title
DK0732928T3 (da) Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler
LU91196I2 (fr) Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
NO179142C (no) 3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
DK0842661T3 (da) Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
ES2046202T3 (es) Un procedimiento para preparar un analogo de distamicina a.
CA2046051A1 (en) 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
ATE181066T1 (de) Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
FI864618A (fi) Nya 3-oxadiazol- och 3-karboksylsyra- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
FI882873A (fi) Tiofenderivat och foerfarande foer dess framstaellning.
IE880772L (en) Benzoxazines
AU598229B2 (en) Novel indenothiazole derivatives and process for their preparation
DK0410305T3 (da) Anvendelse af bis(4-hydroxyphenylthio)methanderivater til behandling af diabetes mellitus
NO960308L (no) Terapeutisk aktive benzoksaziner og benzotioanoner
ATE156487T1 (de) Mercapto-acetamid-derivate
DK0532725T3 (da) Isoxazolderivater som lysfilterpræparater
DE69214180D1 (de) Verwendung von Bis-(p-Hydroxyphenylthio)methanderivaten zur Hemmung der fortschreitenden Entwicklung von insulinabhängingem Diabetes mellitus
SE8000138L (sv) Nya 3-cyklopentan-1,2'(1'h)-naftalen-derivat, framstellning derav och lekemedel innehallande desamma
AU8292787A (en) Fluorine-containing macrolide compounds and their use