DK0732333T3 - Indazolcarboxamider - Google Patents

Indazolcarboxamider

Info

Publication number
DK0732333T3
DK0732333T3 DK96301682T DK96301682T DK0732333T3 DK 0732333 T3 DK0732333 T3 DK 0732333T3 DK 96301682 T DK96301682 T DK 96301682T DK 96301682 T DK96301682 T DK 96301682T DK 0732333 T3 DK0732333 T3 DK 0732333T3
Authority
DK
Denmark
Prior art keywords
alkyl
phenyl
naphthyl
amino
substituted
Prior art date
Application number
DK96301682T
Other languages
Danish (da)
English (en)
Inventor
John Mehnert Schaus
Marlene Lois Cohen
John Thomas Catlow
Michael John Martinelli
Steven Phillip Swanson
Dennis Charles Thompson
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/485,956 external-priority patent/US5654320A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0732333T3 publication Critical patent/DK0732333T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paper (AREA)
  • Luminescent Compositions (AREA)
DK96301682T 1995-03-16 1996-03-12 Indazolcarboxamider DK0732333T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40511995A 1995-03-16 1995-03-16
US08/485,956 US5654320A (en) 1995-03-16 1995-06-07 Indazolecarboxamides

Publications (1)

Publication Number Publication Date
DK0732333T3 true DK0732333T3 (da) 2001-10-08

Family

ID=27018928

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96301682T DK0732333T3 (da) 1995-03-16 1996-03-12 Indazolcarboxamider

Country Status (23)

Country Link
US (2) US5798367A (no)
EP (1) EP0732333B1 (no)
JP (1) JPH11502230A (no)
CN (1) CN1112923C (no)
AT (1) ATE203748T1 (no)
AU (1) AU700842B2 (no)
BR (1) BR9608223A (no)
CA (1) CA2215359A1 (no)
DE (1) DE69614164T2 (no)
DK (1) DK0732333T3 (no)
EA (1) EA000699B1 (no)
ES (1) ES2159345T3 (no)
GR (1) GR3037029T3 (no)
HU (1) HU223973B1 (no)
IL (1) IL117438A (no)
NO (1) NO312833B1 (no)
NZ (1) NZ315971A (no)
PL (1) PL183867B1 (no)
PT (1) PT732333E (no)
RO (1) RO119617B1 (no)
SK (1) SK283924B6 (no)
TR (1) TR199700956T1 (no)
WO (1) WO1996033713A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US5914405A (en) * 1997-10-07 1999-06-22 Eli Lilly And Company Process for preparing 3-substituted indazoles
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DK1104289T3 (da) * 1998-08-21 2006-05-15 Novartis Ag Hidtil ukendte orale formuleringer for 5-HT4-agonister eller -antagonister
AU758807B2 (en) 1998-09-10 2003-03-27 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
AU2001270304A1 (en) 2000-07-07 2002-01-21 The Administrators Of The Tulane Educational Fund Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
CA2418904A1 (en) * 2000-08-07 2002-02-14 Laboratoire Glaxosmithkline S.A.S. Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation
EP1321142A1 (en) * 2001-12-21 2003-06-25 Novartis AG Solid pharmaceutical composition for oral administration of Tegaserod
WO2003068220A1 (en) * 2002-02-12 2003-08-21 Akzo Nobel N.V. 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders
ITMI20030287A1 (it) * 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ITMI20031467A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco attivo nel dolore neuropatico
SE0401969D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Piperidine derivatives
US7906532B2 (en) 2005-07-22 2011-03-15 Pfizer Inc. Indazole derivatives
WO2009106980A2 (en) * 2008-02-29 2009-09-03 Pfizer Inc. Indazole derivatives
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
JP2795460B2 (ja) * 1988-06-20 1998-09-10 協和醗酵工業株式会社 ピラゾロアクリドン誘導体
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
EP0410509A1 (en) * 1989-07-25 1991-01-30 Duphar International Research B.V New substituted 1H-indazole-3-carboxamides
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
AU2435092A (en) * 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
US5552398A (en) * 1991-09-12 1996-09-03 Smithkline Beecham P.L.C. Azabicyclic compounds as 5-HT4 receptor antagonists
EP0641198A1 (en) * 1992-05-23 1995-03-08 Smithkline Beecham Plc Medicaments for the treatment of anxiety
WO1994000113A2 (en) * 1992-06-27 1994-01-06 Smithkline Beecham Plc Medicaments containing 5-ht4 receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
TW251287B (no) * 1993-04-30 1995-07-11 Nissei Co Ltd
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
IL117438A (en) 2001-12-23
HUP9801386A3 (en) 2000-03-28
NZ315971A (en) 1999-01-28
US5798367A (en) 1998-08-25
PT732333E (pt) 2001-11-30
BR9608223A (pt) 1998-12-29
SK283924B6 (sk) 2004-05-04
DE69614164D1 (de) 2001-09-06
ATE203748T1 (de) 2001-08-15
NO312833B1 (no) 2002-07-08
WO1996033713A1 (en) 1996-10-31
CN1112923C (zh) 2003-07-02
RO119617B1 (ro) 2005-01-28
CN1183041A (zh) 1998-05-27
JPH11502230A (ja) 1999-02-23
CA2215359A1 (en) 1996-10-31
EA199700242A1 (ru) 1998-04-30
US5817676A (en) 1998-10-06
PL183867B1 (pl) 2002-07-31
EP0732333B1 (en) 2001-08-01
EA000699B1 (ru) 2000-02-28
SK124297A3 (en) 1998-02-04
EP0732333A1 (en) 1996-09-18
ES2159345T3 (es) 2001-10-01
NO974221D0 (no) 1997-09-12
GR3037029T3 (en) 2002-01-31
MX9706967A (es) 1997-11-29
TR199700956T1 (xx) 1998-02-21
HUP9801386A2 (hu) 1999-06-28
DE69614164T2 (de) 2002-04-25
AU700842B2 (en) 1999-01-14
NO974221L (no) 1997-10-27
AU6894896A (en) 1996-11-18
PL322362A1 (en) 1998-01-19
HU223973B1 (hu) 2005-03-29
IL117438A0 (en) 1996-07-23

Similar Documents

Publication Publication Date Title
DE69614164T2 (de) Indazolcarboxamide
WO2020140005A3 (en) 1 h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
SE0104332D0 (sv) Therapeutic agents
AR030959A1 (es) Derivados de aminoalcoholes, procedimiento para prepararlos, el uso de los mismos para preparar medicamentos y las composiciones farmaceuticas que las contienen
GB9524157D0 (en) Therapeutic agents
NO933452L (no) Et terapeutisk middel for Parkinson's sykdom
CO5550421A2 (es) Derivados de indol utiles para el tratamiento de enfermeda- des
AP1860A (en) Aryl fused azapolycyclic compounds.
SE0104330D0 (sv) Therapeutic agents
DK455488D0 (da) Indolderivater
HUP0400343A2 (hu) Ciklopropil-indol-származékok mint szelektív szerotonin-újrafelvétel inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
DK391289D0 (da) Indolderivater
NZ332240A (en) Substituted indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) and are therefor useful for treating inflammatory diseases
PE20030332A1 (es) Terapia de combinacion para el tratamiento del cancer
DE69323667D1 (de) 4-substituierte 1,2,4-Triazolderivate
ATE104145T1 (de) 4-substituierten imidazolen zur senkung des intraokularen druckes.
NO920438L (no) N-(aryloksyalkyl)heteroaryl-8-azabicyklo(3.2.1.)oktaner, mellomprodukter og en fremgangsmaate for fremstilling deravsamt anvendelse som medikamenter
MY125562A (en) Hexahydro-pyrido (4,3-b) indole derivatives as antipsychotic drugs
TR200200969T2 (tr) Karbonilamino türevlerinin CNS bozukluklarına karşı kullanılması
SE9904177D0 (sv) Novel compounds
ES8705405A1 (es) Procedimiento de preparar nuevos derivados morfolinicos
ES2181387T3 (es) Derivados de azetidinocarboxamida para el tratamiento de trastornos del sistema nervioso central.
DK0667860T3 (da) Azaspiroalkan-derivater som terapeutiske midler