DK0720471T3 - Hydrofobe polymere mikropartikler - Google Patents

Hydrofobe polymere mikropartikler

Info

Publication number
DK0720471T3
DK0720471T3 DK94928640T DK94928640T DK0720471T3 DK 0720471 T3 DK0720471 T3 DK 0720471T3 DK 94928640 T DK94928640 T DK 94928640T DK 94928640 T DK94928640 T DK 94928640T DK 0720471 T3 DK0720471 T3 DK 0720471T3
Authority
DK
Denmark
Prior art keywords
microparticle
substance
polymer
ionic
dispersion
Prior art date
Application number
DK94928640T
Other languages
Danish (da)
English (en)
Inventor
Alexander K Andrianov
Robert S Langer
Original Assignee
Massachusetts Inst Technology
Virus Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Virus Res Inst filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0720471T3 publication Critical patent/DK0720471T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK94928640T 1993-09-21 1994-09-21 Hydrofobe polymere mikropartikler DK0720471T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/124,816 US5500161A (en) 1993-09-21 1993-09-21 Method for making hydrophobic polymeric microparticles
PCT/US1994/010692 WO1995008320A1 (fr) 1993-09-21 1994-09-21 Microparticules de polymeres hydrophobes

Publications (1)

Publication Number Publication Date
DK0720471T3 true DK0720471T3 (da) 2001-05-07

Family

ID=22416932

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928640T DK0720471T3 (da) 1993-09-21 1994-09-21 Hydrofobe polymere mikropartikler

Country Status (11)

Country Link
US (1) US5500161A (fr)
EP (1) EP0720471B1 (fr)
AT (1) ATE200616T1 (fr)
AU (1) AU7800194A (fr)
CA (1) CA2172040A1 (fr)
DE (1) DE69427126T2 (fr)
DK (1) DK0720471T3 (fr)
ES (1) ES2159305T3 (fr)
GR (1) GR3036224T3 (fr)
PT (1) PT720471E (fr)
WO (1) WO1995008320A1 (fr)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5417671A (en) * 1990-05-23 1995-05-23 Jackson; Richard R. Medical devices having local anesthetic effect and methods of their manufacture
ATE265540T1 (de) * 1995-08-17 2004-05-15 Crucell Holland Bv Poly(organo)phosphazene in synthetischen transfektions-systemen
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
DE19611769A1 (de) * 1996-03-14 1997-09-18 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik
WO1998004743A1 (fr) * 1996-07-29 1998-02-05 The Regents Of The University Of California Ensembles polymeriques pour essais colorimetriques sensibles
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5958414A (en) * 1997-09-03 1999-09-28 Heska Corporation Composition to protect a mammal against Bartonella henselae infection
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
US6986902B1 (en) * 1998-04-28 2006-01-17 Inex Pharmaceuticals Corporation Polyanionic polymers which enhance fusogenicity
KR100395320B1 (ko) * 1998-08-19 2003-12-24 주식회사 원진신약 공기분사법에의해제조되는미세분말및그의제조방법
US20050153926A1 (en) * 1998-12-04 2005-07-14 Adams Christopher P. Method for the immobilization of oligonucleotides
DE10011564C1 (de) * 2000-03-09 2001-09-27 Goldschmidt Ag Th Verfahren zur Herstellung von Polyorganosiloxanemulsionen
EP1272213B1 (fr) 2000-04-06 2006-03-08 SEER Pharmaceuticals, LLC. Systeme d'administration microbienne
WO2002049620A2 (fr) 2000-12-21 2002-06-27 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophobic active agents
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DK1392254T3 (da) 2001-04-20 2007-07-02 Univ British Columbia Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler
US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
WO2004026457A1 (fr) * 2002-09-18 2004-04-01 Koyama, Yuu Procede de production d'une microcapsule
US20040058008A1 (en) * 2002-09-20 2004-03-25 Tarcha Peter J. Microparticles having serum as a dispersing agent and process for their preparation and use
US20040131631A1 (en) * 2002-11-22 2004-07-08 Alexander Andrianov Polyphosphazene immunostimulants
TWI350762B (en) * 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
WO2005079856A1 (fr) * 2004-02-23 2005-09-01 The University Of British Columbia Compositions de medicaments contenant des polymeres hydrophobes et des molecules amphipathiques
US9498563B2 (en) * 2004-04-23 2016-11-22 Boston Scientific Scimed, Inc. Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles
US8119153B2 (en) 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
CA2584122C (fr) 2004-10-25 2013-04-30 Polyzenix Gmbh Particules polymeres chargeables pour des applications therapeutiques et/ou diagnostiques et methodes de preparation et d'utilisation de ces particules
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
WO2007001448A2 (fr) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Particules polymeres revetues a diffusion regulee comme vecteurs efficaces d'administration par voie orale de produits biopharmaceutiques
US20060193820A1 (en) 2005-02-18 2006-08-31 Andrianov Alexander K Immunostimulating polyphosphazene compounds
US9267937B2 (en) * 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2008105773A2 (fr) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology Système pour l'administration ciblée d'agents thérapeutiques
US20070254012A1 (en) * 2006-04-28 2007-11-01 Ludwig Florian N Controlled degradation and drug release in stents
CN101573141B (zh) 2006-05-15 2016-05-04 麻省理工学院 用于功能性颗粒的聚合物
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
FR2902007B1 (fr) * 2006-06-09 2012-01-13 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s) ainsi que leurs applications notamment therapeutiques
WO2007150030A2 (fr) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Synthèse microfluidique de nanoparticules organiques
EP2078052B1 (fr) * 2006-10-31 2010-07-28 Surmodics Pharmaceuticals, Inc. Particules polymères mises sous forme de sphères
EP2433635A1 (fr) 2006-11-10 2012-03-28 Massachusetts Institute Of Technology Modulateurs PAK
WO2008147456A2 (fr) * 2006-11-20 2008-12-04 Massachusetts Institute Of Technology Systèmes d'administration de médicaments en utilisant des fragments fc
WO2008098165A2 (fr) * 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Bioréacteur oscillant pour la culture de cellules
US20090074828A1 (en) 2007-04-04 2009-03-19 Massachusetts Institute Of Technology Poly(amino acid) targeting moieties
WO2008124634A1 (fr) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Micelles inverses encapsulées par un polymère
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080292663A1 (en) * 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
BRPI0817664A2 (pt) 2007-10-12 2015-03-24 Massachusetts Inst Technology Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
WO2010009291A1 (fr) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Procédé pour préparer des microparticules contenant des peptides bioactifs
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) * 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
BRPI0920240B8 (pt) 2008-10-16 2021-05-25 Univ Dalhousie composição adjuvante
EP4032538A3 (fr) * 2009-03-02 2022-10-26 Massachusetts Institute of Technology Procédés et produits pour établir un profil enzymatique in vivo
WO2010114770A1 (fr) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Conjugués polymère-agent, particules, compositions et procédés d'utilisation apparentés
EP2413901A4 (fr) * 2009-03-30 2015-05-06 Cerulean Pharma Inc Conjugués polymère-agent, particules, compositions et procédés d'utilisation apparentés
WO2010114768A1 (fr) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Conjugués polymère-épothilone, particules, compositions et procédés d'utilisation apparentés
EP2421561A2 (fr) * 2009-04-21 2012-02-29 Selecta Biosciences, Inc. Composés immunonanothérapeutiques fournissant une réponse immunitaire à forte composante th1
AU2010254549B2 (en) * 2009-05-27 2016-10-20 Selecta Biosciences, Inc. Nanocarriers possessing components with different rates of release
US9278998B2 (en) 2009-07-02 2016-03-08 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
WO2011018504A2 (fr) 2009-08-12 2011-02-17 Sigmoid Pharma Limited Compositions immunomodulatrices comprenant une matrice polymère et une phase huileuse
CA2793959C (fr) 2010-03-25 2019-06-04 Oregon Health & Science University Glycoproteines du cmv et vecteurs recombines
WO2011150258A1 (fr) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Sélection de dose de nanovecteurs synthétiques avec adjuvant
ES2656971T3 (es) 2010-09-10 2018-03-01 Biosceptre (Aust) Pty Ltd Tratamientos para el cáncer en animales de compañía con un anticuerpo anti P2X7
JP2013541528A (ja) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置
CA2813078A1 (fr) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Polypeptides de l'hemagglutinine, et reactifs et procedes associes a ceux-ci
CA3214092A1 (fr) 2011-03-15 2012-09-20 Massachusetts Institute Of Technology Detection multiplexee avec rapporteurs contenant un isotope d'identification
PL2691530T3 (pl) 2011-06-10 2019-02-28 Oregon Health & Science University Glikoproteiny i rekombinowane wektory CMV
BR112013033974A2 (pt) 2011-07-01 2017-02-14 Biosceptre Int Ltd terapia de combinação
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
EP2568289A3 (fr) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunosélection du virus de la stomatite vésiculaire recombinant exprimant les protéines du VIH-1 par des anticorps largement neutralisants
EP2586461A1 (fr) 2011-10-27 2013-05-01 Christopher L. Parks Particules virales dérivées d'un virus enveloppé
CA3166278A1 (fr) 2011-11-11 2013-05-16 Variation Biotechnologies Inc. Compositions et methodes pour le traitement d'infections par cytomegalovirus
EP4218808A3 (fr) 2012-03-12 2023-08-09 Advanced BioAdjuvants, LLC Compositions d'adjuvant et de vaccin
CA2871160C (fr) 2012-05-10 2023-03-14 Massachusetts Institute Of Technology Agents convenant a la neutralisation de la grippe
EP3937179A1 (fr) 2012-05-21 2022-01-12 Distributed Bio Inc Focalisation d'épitope par concentration de surface effective variable d'antigène
EP2679596B1 (fr) 2012-06-27 2017-04-12 International Aids Vaccine Initiative Variante de la protéine env du VIH-1
AU2013299986B2 (en) 2012-08-07 2018-05-17 Massachusetts Institute Of Technology Anti-dengue virus antibodies and uses thereof
AU2014214844B2 (en) 2013-02-07 2017-12-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
WO2014197723A2 (fr) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Adaptation humaine de h7 ha
JP6847660B2 (ja) 2013-06-07 2021-03-24 マサチューセッツ インスティテュート オブ テクノロジー リガンドをコードする合成バイオマーカーのアフィニティベースの検出
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CA2938495A1 (fr) 2014-02-11 2015-08-20 Massachusetts Institute Of Technology Anticorps anti-dengue de spectre complet
CN104086724A (zh) * 2014-07-08 2014-10-08 成都市绿科华通科技有限公司 新型六方孔医用生物材料
US10010607B2 (en) 2014-09-16 2018-07-03 Institut Curie Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response
EP3069730A3 (fr) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Trimères de glycoprotéines de l'enveloppe du vih-1 soluble
EP3072901A1 (fr) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Trimères de glycoprotéines de l'enveloppe du vih-1 soluble
US20190298854A1 (en) * 2016-03-07 2019-10-03 Glaxosmithkline Biologicals, Sa Drug delivery particles
CA3017541A1 (fr) 2016-03-16 2017-09-21 Institut Curie Procede de preparation de particules virales a dinucleotide cyclique et utilisation desdites particules pour le traitement du cancer
WO2017177115A1 (fr) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Procédés pour profiler spécifiquement l'activité de la protéase au niveau de ganglions lymphatiques
CA3022928A1 (fr) 2016-05-05 2017-11-09 Massachusetts Institute Of Technology Methodes et utilisations aux fins de mesures d'activite proteasique declenchees a distance
EP3484511A4 (fr) 2016-07-18 2020-04-29 Variation Biotechnologies Inc. Compositions vaccinales pour le traitement d'une infection par le virus zika
AU2017300392B2 (en) * 2016-07-18 2022-06-16 Tissuegen, Inc. Methods and compositions for maintaining the conformation and structural integrity of biomolecules
CA3059358A1 (fr) 2017-04-07 2018-10-11 Massachusetts Institute Of Technology Procedes de profilage spatial d'activite protease dans un tissu et des coupes
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
WO2020150560A1 (fr) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Capteurs pour détecter et imager une métastase cancéreuse
WO2021198769A1 (fr) 2020-03-30 2021-10-07 Variation Biotechnologies Inc. Compositions de vaccin pour le traitement du coronavirus
EP4326321A1 (fr) 2021-04-20 2024-02-28 Institut Curie Compositions et procédés destinés à être utilisés en immunothérapie
WO2022223619A1 (fr) 2021-04-20 2022-10-27 Institut Curie Compositions et procédés destinés à être utilisés en immunothérapie

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CH594444A5 (fr) * 1972-12-04 1978-01-13 Gerd Birrenbach
JPS5090578A (fr) * 1973-12-13 1975-07-19
DE2543824C3 (de) * 1975-10-01 1980-05-14 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Fibrillen aus Poly(amid-imid)-harzen und die Fibrillen aus diesen Harzen
US4063017A (en) * 1976-04-22 1977-12-13 Purdue Research Foundation Porous cellulose beads and the immobilization of enzymes therewith
IT1096661B (it) * 1978-06-13 1985-08-26 Montedison Spa Procedimento per la preparazione di prodotti in forma sferoidale solidi a temperatura ambiente
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4495174A (en) * 1982-06-21 1985-01-22 Research Corporation Anesthetic polyorganophosphazenes
US4440921A (en) * 1982-06-21 1984-04-03 Research Corporation Coupling of polyorganophosphazenes to carboxylic acid
JPS6034731A (ja) * 1983-08-04 1985-02-22 Kohjin Co Ltd 新規なマイクロカプセルとその製造方法
JPS60155245A (ja) * 1984-01-24 1985-08-15 Daicel Chem Ind Ltd 酢酸セルロ−ス多孔質球状粒子及びその製造方法
US4765973A (en) * 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4908233A (en) * 1985-05-08 1990-03-13 Lion Corporation Production of microcapsules by simple coacervation
US4880622A (en) * 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
US5047180A (en) * 1987-07-24 1991-09-10 Hoechst Celanese Corporation Process for making cellulose ester microparticles
US5225278A (en) * 1987-08-26 1993-07-06 Rohm And Haas Company Process for microencapsulation
US5063109A (en) * 1988-10-11 1991-11-05 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
US5126381A (en) * 1988-12-19 1992-06-30 Dow Corning Corporation Bead processor
IL92344A0 (en) * 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
US5089272A (en) * 1989-03-29 1992-02-18 Snow Brand Milk Products Co., Ltd. Process for producing capsules having a permeability-controllable membrane
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US4946938A (en) * 1989-08-01 1990-08-07 The University Of Pittsburgh A process for the catalytic synthesis of polyphosphazenes
US5132117A (en) * 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
US5334394A (en) * 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5120349A (en) * 1990-12-07 1992-06-09 Landec Labs, Inc. Microcapsule having temperature-dependent permeability profile
DE4205882A1 (de) * 1992-02-26 1993-09-02 Basf Ag Verfahren zur erzeugung teilchenfoermiger poly(meth)acrylimid-polymerisate

Also Published As

Publication number Publication date
DE69427126T2 (de) 2001-08-23
AU7800194A (en) 1995-04-10
DE69427126D1 (de) 2001-05-23
GR3036224T3 (en) 2001-10-31
CA2172040A1 (fr) 1995-03-30
ES2159305T3 (es) 2001-10-01
EP0720471A1 (fr) 1996-07-10
US5500161A (en) 1996-03-19
PT720471E (pt) 2001-08-30
ATE200616T1 (de) 2001-05-15
EP0720471B1 (fr) 2001-04-18
WO1995008320A1 (fr) 1995-03-30

Similar Documents

Publication Publication Date Title
DK0720471T3 (da) Hydrofobe polymere mikropartikler
NO982364L (no) FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕten
ATE245022T1 (de) Verfahren zur herstellung von mikropartikeln
DK1689425T3 (da) Farmaceutiske formuleringer til frisætning i længere tid af et eller flere aktive stoffer samt deres terapeutiske anvendelser
ATE278713T1 (de) Verfahren zur agglomeration dispergierter kautschuke
BRPI0416044A (pt) sistema e método para distribuição transdérmica
KR970703133A (ko) 중합체 매트릭스 중의 활성제의 고용체 형태로서의 활성제 제제의 제조 방법 및 그에 의해 얻어진 활성제 제제(Process for Producing Active Agent Preparations in the Form of a Solid Solution of the Active Agent in a Polymer Matrix and Active Agent Preparations Obtained Thereby)
BR8701753A (pt) Materia seca hidratavel em um gel aquosa,seu processo de preparacao e sua utilizacao
DE3685992T2 (de) System zur kontrollierten freigabe von makromolekuelen.
PT1033973E (pt) Metodo de encapsulacao
AU2003230658A1 (en) Microparticles and method for their production
NO165112C (no) Fremgangsmaate til fremstilling av biologisk inaktive fyllstoffholdige polymer-bundne baeremasser og deres anvendelse.
ES2010155T3 (es) Metodo de encapsulacion.
CN100509923C (zh) 一种温度敏感型的壳聚糖/聚乙烯醇凝胶及其制备方法
NZ235297A (en) Aqueous solution containing a protein and anionic polymer or salt and method of increasing the protein concentration of an aqueous solution
CN108295780A (zh) 一种变色微胶囊的制备工艺
ATE339544T1 (de) Textile flüssigkeiten zur behandlung von kunstofffasern
CN108295781A (zh) 一种微胶囊的制备工艺
SU1370136A1 (ru) Способ диссоциации клеток гиппокампа
JPS5551435A (en) Emulsified oil adsorbent
TH20612A (th) สารแขวนลอยแอคเควียสของเซลลูโลส อีเธอร์ วิธีการผลิตสารแขวนลอยนี้ และสารผสม
TH31217B (th) สารแขวนลอยแอคเควียสของเซลลูโลส อีเธอร์ วิธีการผลิตสารแขวนลอยนี้ และสารผสม
CN107969553A (zh) 一种硒纳米颗粒高分子复合微凝胶的制备方法
ES8601271A1 (es) Procedimiento para disolver rapidamente en agua un polimero o goma soluble en agua