DK0705263T3 - Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner - Google Patents

Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner

Info

Publication number
DK0705263T3
DK0705263T3 DK94918130.9T DK94918130T DK0705263T3 DK 0705263 T3 DK0705263 T3 DK 0705263T3 DK 94918130 T DK94918130 T DK 94918130T DK 0705263 T3 DK0705263 T3 DK 0705263T3
Authority
DK
Denmark
Prior art keywords
pro
alkyl
compounds
inflammatory cytokines
agents useful
Prior art date
Application number
DK94918130.9T
Other languages
Danish (da)
English (en)
Inventor
Carl K Edwards Iii
David R Borcherding
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0705263T3 publication Critical patent/DK0705263T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94918130.9T 1993-06-21 1994-05-25 Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner DK0705263T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8024993A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
DK0705263T3 true DK0705263T3 (da) 1997-05-05

Family

ID=22156170

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94918130.9T DK0705263T3 (da) 1993-06-21 1994-05-25 Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner

Country Status (20)

Country Link
US (1) US6541482B2 (ja)
EP (1) EP0705263B1 (ja)
JP (1) JP3479077B2 (ja)
KR (1) KR100337720B1 (ja)
CN (1) CN1041631C (ja)
AT (1) ATE151423T1 (ja)
AU (1) AU677851B2 (ja)
CA (1) CA2165779C (ja)
DE (1) DE69402548T2 (ja)
DK (1) DK0705263T3 (ja)
ES (1) ES2103131T3 (ja)
FI (1) FI956142A0 (ja)
GR (1) GR3023373T3 (ja)
HU (1) HUT73412A (ja)
IL (1) IL110041A0 (ja)
NO (1) NO312836B1 (ja)
NZ (1) NZ267322A (ja)
TW (1) TW356471B (ja)
WO (1) WO1995000514A1 (ja)
ZA (1) ZA944256B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111497D0 (en) * 2001-05-11 2001-07-04 Medical Res Council Therapeutic methods
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
US20070042978A1 (en) * 2002-12-19 2007-02-22 Jean-Philippe Girard Nf-hev compositions and methods of use
US7868011B2 (en) 2003-04-09 2011-01-11 General Atomics Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
US7196093B2 (en) 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US7517887B2 (en) 2003-04-09 2009-04-14 General Atomics Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US11033821B2 (en) 2003-09-02 2021-06-15 Jeffrey D. Mullen Systems and methods for location based games and employment of the same on location enabled devices
WO2005118588A1 (ja) * 2004-06-02 2005-12-15 Takeda Pharmaceutical Company Limited 縮合複素環化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164556B (ja) 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4916224A (en) 1988-01-20 1990-04-10 Regents Of The University Of Minnesota Dideoxycarbocyclic nucleosides
US4931559A (en) 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
AU642526B2 (en) 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
AU647822B2 (en) * 1990-09-14 1994-03-31 Marion Merrell Dow Inc. Novel carbocyclic adenosine analogs useful as immunosuppressants
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
AU658698B2 (en) 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
JPH11255768A (ja) * 1998-03-09 1999-09-21 Ajinomoto Co Inc 抗ウイルス剤の製造方法

Also Published As

Publication number Publication date
WO1995000514A1 (en) 1995-01-05
CA2165779C (en) 1998-06-16
NO955197L (no) 1996-02-16
DE69402548D1 (de) 1997-05-15
KR100337720B1 (ko) 2002-11-02
KR960703122A (ko) 1996-06-19
US6541482B2 (en) 2003-04-01
US20020004508A1 (en) 2002-01-10
NO312836B1 (no) 2002-07-08
JP3479077B2 (ja) 2003-12-15
EP0705263A1 (en) 1996-04-10
FI956142A7 (fi) 1995-12-20
CN1125946A (zh) 1996-07-03
AU677851B2 (en) 1997-05-08
HU9503689D0 (en) 1996-02-28
CN1041631C (zh) 1999-01-13
FI956142L (fi) 1995-12-20
ATE151423T1 (de) 1997-04-15
IL110041A0 (en) 1994-10-07
CA2165779A1 (en) 1995-01-05
HUT73412A (en) 1996-07-29
JPH08511558A (ja) 1996-12-03
GR3023373T3 (en) 1997-08-29
EP0705263B1 (en) 1997-04-09
ES2103131T3 (es) 1997-08-16
FI956142A0 (fi) 1995-12-20
NO955197D0 (no) 1995-12-20
ZA944256B (en) 1995-02-08
DE69402548T2 (de) 1997-07-17
TW356471B (en) 1999-04-21
AU6958394A (en) 1995-01-17
NZ267322A (en) 1997-09-22

Similar Documents

Publication Publication Date Title
HUP0001446A2 (hu) HIV reverz transzkriptáz inhibitor hatású 4,4-diszubsztituált-3,4-dihidro-2(1H)-kinazolinon-származékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
HRP20040977B1 (hr) Derivati n-[fenil(piperidin-2-il)metil]benzamida,postupak njihovog pripravljanja i primjena istih u terapiji
ES2188280T3 (es) Acetales heteroaril-ciclicos.
NO892381D0 (no) 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner.
YU17092A (sh) Derivati 2,4-diaminohinazolina
MY116280A (en) A combination of a 5-ht reuptake inhibitor and a h5-ht 1b antagonist or partial agonist
DK0686142T3 (da) Polyaminderivater som radioprotektive midler
DK0759027T3 (da) Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase
NO955197L (no) Nye carbosykliske nukleoside midler som er anvendbare som selektive inhibitorer av pro-inflammatoriske cytokiner
MY129304A (en) Carbamate compounds for use in preventing or treating bipolar disorder
NO912298L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksanderivater.
DK0934278T3 (da) Bis(acridincarboxamid) og bis(phenazincarboxamid) som antitumormidler
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
ATE275133T1 (de) 1,2-dihydro-2-oxochinolin-derivate
MY131365A (en) Carbamic acid derivatives
EA200000116A1 (ru) Противогрибковые соединения на основе 2,4,4-тризамещенных-1,3-диоксоланов
NO922523L (no) Aminopyrimidinkarboksamiddrivater med terapeutisk virkning
ATE139444T1 (de) Carbocyklische nukleosidanaloge als immunsuppressoren
FI955680A0 (fi) Psoraleenijohdannaiset, niiden valmistus ja käyttö
EA200401193A1 (ru) Дипиридодиазепиноны в качестве ингибиторов обратной транскриптазы