DK0703980T3 - Intracellulære bindingsproteiner og anvendelser deraf - Google Patents

Intracellulære bindingsproteiner og anvendelser deraf

Info

Publication number
DK0703980T3
DK0703980T3 DK94919711T DK94919711T DK0703980T3 DK 0703980 T3 DK0703980 T3 DK 0703980T3 DK 94919711 T DK94919711 T DK 94919711T DK 94919711 T DK94919711 T DK 94919711T DK 0703980 T3 DK0703980 T3 DK 0703980T3
Authority
DK
Denmark
Prior art keywords
pct
binding proteins
date dec
applications
intracellular binding
Prior art date
Application number
DK94919711T
Other languages
English (en)
Inventor
Fabien Schweighoffer
Bruno Tocque
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0703980T3 publication Critical patent/DK0703980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1072—Regulatory proteins, e.g. tat, rev, vpt
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK94919711T 1993-06-16 1994-06-15 Intracellulære bindingsproteiner og anvendelser deraf DK0703980T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9307241A FR2706486B1 (fr) 1993-06-16 1993-06-16 Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
PCT/FR1994/000714 WO1994029446A2 (fr) 1993-06-16 1994-06-15 Proteines intracellulaires de liaison (pil) et leurs utilisations

Publications (1)

Publication Number Publication Date
DK0703980T3 true DK0703980T3 (da) 2003-05-19

Family

ID=9448183

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94919711T DK0703980T3 (da) 1993-06-16 1994-06-15 Intracellulære bindingsproteiner og anvendelser deraf

Country Status (24)

Country Link
US (1) US6159947A (da)
EP (1) EP0703980B1 (da)
JP (1) JP4384260B2 (da)
KR (1) KR100342233B1 (da)
CN (1) CN1076052C (da)
AT (1) ATE231916T1 (da)
AU (1) AU7076394A (da)
BR (1) BR9407512A (da)
CA (1) CA2165458C (da)
CZ (1) CZ289039B6 (da)
DE (1) DE69432075T2 (da)
DK (1) DK0703980T3 (da)
ES (1) ES2191031T3 (da)
FI (1) FI120311B (da)
FR (1) FR2706486B1 (da)
HU (1) HU219138B (da)
NO (1) NO319466B1 (da)
NZ (1) NZ268038A (da)
PL (1) PL180760B1 (da)
RU (1) RU2218400C2 (da)
SK (1) SK285169B6 (da)
UA (1) UA46709C2 (da)
WO (1) WO1994029446A2 (da)
ZA (1) ZA944303B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003342B1 (en) 1990-04-18 2011-08-23 Board Of Regents, The University Of Texas System Method for identifying farnesyl transferase inhibitors
US6790633B1 (en) * 1990-04-18 2004-09-14 Michael S. Brown Method of inhibiting a farnesyl transferase enzyme
FR2724320B1 (fr) * 1994-09-13 1996-12-20 Transgene Sa Nouvel implant pour le traitement des maladies acquises
US5518042A (en) * 1994-09-16 1996-05-21 Huyck Licensco, Inc. Papermaker's forming fabric with additional cross machine direction locator and fiber supporting yarns
FR2738151B1 (fr) * 1995-09-04 1997-09-26 Rhone Poulenc Rorer Sa Antagonistes de l'activite oncogenique de la proteine mdm2, et leur utilisation dans le traitement des cancers
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
CN1167793C (zh) * 1996-12-06 2004-09-22 阿温蒂斯药物公司 人脂酶样基因编码的多肽及利用它的组合物和方法
FR2758569B1 (fr) * 1997-01-20 1999-04-02 Centre Nat Rech Scient Materiel biologique pour le traitement d'un mammifere par transfert de gene d'anticorps et composition pharmaceutique le concernant
WO2000050089A2 (en) * 1999-02-26 2000-08-31 Mindset Biopharmaceuticals (Usa) Ltd. Regulation of the stability of recombinant proteins and antiboodies
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
GB0018307D0 (en) 2000-07-26 2000-09-13 Aventis Pharm Prod Inc Polypeptides
CA2404688C (en) 2000-03-31 2012-07-31 Aventis Pharmaceuticals Products Inc. Nuclear factor .kappa.b inducing factor
AU2002338446A1 (en) * 2001-01-23 2002-11-05 University Of Rochester Medical Center Methods of producing or identifying intrabodies in eukaryotic cells
US9328142B2 (en) 2011-05-25 2016-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of RAS oncoproteins
KR101602870B1 (ko) 2014-07-22 2016-03-21 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용
KR101602876B1 (ko) 2014-07-22 2016-03-11 아주대학교산학협력단 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용
DK3209685T3 (da) * 2014-10-23 2019-07-29 Singh Molecular Medicine Llc Enkeltdomæneantistoffer rettet mod intracellulære antigener
US20180072815A1 (en) 2014-10-23 2018-03-15 Singh Biotechnology, Llc Single Domain Antibodies Directed Against Intracellular Antigens
TWI746473B (zh) 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 針對細胞內抗原之單域抗體
BR112018074275A2 (pt) 2016-05-27 2019-10-01 Orum Therapeutics Inc anticorpo de penetração no citosol e método de produção do mesmo
US10787487B2 (en) 2018-06-21 2020-09-29 Orum Therapeutics Inc. Cell/tissue-specific cell-penetrating antibodies
CN110981943B (zh) * 2019-12-02 2021-08-03 清华大学 多肽及其在制备药物中的用途和药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE3915952A1 (de) * 1989-05-12 1990-12-06 Peter Werner Wirkstoff/medikament/biotechnologisches verfahren zur behandlung von erkrankungen, die mit exo- oder endogenen intrazellulaeren proteinen (onkogene etc.) assoziert sind
WO1992005250A1 (en) * 1990-09-25 1992-04-02 University Of Connecticut Prolonging expression of polynucleotides introduced into a cell
CA2072249C (en) * 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
CA2120153C (en) * 1991-09-30 2006-06-06 Ira Pastan Recombinant immunotoxins
AU668374B2 (en) * 1991-12-10 1996-05-02 Dana-Farber Cancer Institute Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof
CA2137558A1 (en) * 1992-07-17 1994-02-03 Wayne A. Marasco Method of intracellular binding of target molecules

Also Published As

Publication number Publication date
JPH08511162A (ja) 1996-11-26
PL180760B1 (pl) 2001-04-30
SK285169B6 (sk) 2006-07-07
UA46709C2 (uk) 2002-06-17
FI956057A0 (fi) 1995-12-15
FR2706486A1 (fr) 1994-12-23
RU2218400C2 (ru) 2003-12-10
DE69432075T2 (de) 2003-09-04
WO1994029446A3 (fr) 1995-02-02
SK156895A3 (en) 1996-05-08
NO319466B1 (no) 2005-08-15
BR9407512A (pt) 1997-01-07
CN1076052C (zh) 2001-12-12
ATE231916T1 (de) 2003-02-15
CZ329595A3 (en) 1996-03-13
CA2165458A1 (fr) 1994-12-22
EP0703980B1 (fr) 2003-01-29
FI956057A (fi) 1995-12-15
ES2191031T3 (es) 2003-09-01
JP4384260B2 (ja) 2009-12-16
FR2706486B1 (fr) 1995-09-01
NZ268038A (en) 1997-12-19
US6159947A (en) 2000-12-12
NO955011D0 (no) 1995-12-11
PL312213A1 (en) 1996-04-01
CA2165458C (fr) 2011-05-10
HU219138B (hu) 2001-02-28
CZ289039B6 (cs) 2001-10-17
CN1126491A (zh) 1996-07-10
AU7076394A (en) 1995-01-03
FI120311B (fi) 2009-09-15
WO1994029446A2 (fr) 1994-12-22
DE69432075D1 (de) 2003-03-06
EP0703980A1 (fr) 1996-04-03
ZA944303B (en) 1995-02-14
NO955011L (no) 1995-12-11
KR100342233B1 (ko) 2002-12-05
HU9503615D0 (en) 1996-02-28
HUT74266A (en) 1996-11-28

Similar Documents

Publication Publication Date Title
DK0703980T3 (da) Intracellulære bindingsproteiner og anvendelser deraf
ATE400651T1 (de) Verwendung von grünem fluoreszenzprotein
FI934811A0 (fi) Stabiliserade enzymer och detergentfoereningar
ATE348175T1 (de) Method eder intrazellularen bindung von zielgerichteten molekülen
PT101297A (pt) Factores mitogenicos gliais, sua preparacao e utilizacao
WO1996039429A3 (en) Serum protein produced exclusively in adipocytes
ATE350472T1 (de) Jmy, mit-aktivator für p300/cbp, dafür kodierendenucleinsäure und deren verwendungen
DK0719328T3 (da) Genet GRB 3-3, varianter deraf og anvendelse deraf
NO951689D0 (no) DNA som koder for en human serotoninreseptor (5-HT4B) og anvendelse av denne
NO972313L (no) Peptider som er i stand til å binde til GAP-protein-SH3-området, nukleotid-sekvenser som koder for dette samt fremstilling og bruk derav
AU669149B2 (en) Expression signal-peptide-free staphylokinases
DK0773999T3 (da) OR-1, en orphan-receptor tilhørende kernereceptorfamilien
DK0788549T3 (da) Regulerende nukleinsyresekvenser og anvendelser
KR940008700A (ko) 사람형 모노클로날 항펩티드 항체 및 이것을 코드하는 dna
ATE423211T1 (de) Produktion von proteinen, dafür kodierende plasmide und organismen, die solche plasmide enthalten
DK0778347T3 (da) Protein med formodede helicase- og ATPase-egenskaber, som binder ATP og nukleinsyre
WO2002074957A3 (en) Stress-responsive activator of p300 (strap) protein
MXPA01011563A (es) Una novedosa proteina 5 relacionada al factro-h y anticuerpos relacionados.
ATE328088T1 (de) Transketolase-verwandtes protein
MX9709459A (es) Metodo para prolongar la expresion de un gen de interes usando moleculas de ctla4 solubles.