DK0699672T3 - Fremgangsmåde til fremstilling af benzoesyrederivatmellemprodukter og farmaceutiske benzothiophen- midler - Google Patents

Fremgangsmåde til fremstilling af benzoesyrederivatmellemprodukter og farmaceutiske benzothiophen- midler

Info

Publication number
DK0699672T3
DK0699672T3 DK95306050T DK95306050T DK0699672T3 DK 0699672 T3 DK0699672 T3 DK 0699672T3 DK 95306050 T DK95306050 T DK 95306050T DK 95306050 T DK95306050 T DK 95306050T DK 0699672 T3 DK0699672 T3 DK 0699672T3
Authority
DK
Denmark
Prior art keywords
chem
formula
reaction product
alkyl
reacting
Prior art date
Application number
DK95306050T
Other languages
Danish (da)
English (en)
Inventor
Douglas Patton Kjell
Fred Mason Perry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0699672T3 publication Critical patent/DK0699672T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
DK95306050T 1994-08-31 1995-08-30 Fremgangsmåde til fremstilling af benzoesyrederivatmellemprodukter og farmaceutiske benzothiophen- midler DK0699672T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/298,636 US5631369A (en) 1994-08-31 1994-08-31 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Publications (1)

Publication Number Publication Date
DK0699672T3 true DK0699672T3 (da) 1998-10-07

Family

ID=23151367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95306050T DK0699672T3 (da) 1994-08-31 1995-08-30 Fremgangsmåde til fremstilling af benzoesyrederivatmellemprodukter og farmaceutiske benzothiophen- midler

Country Status (17)

Country Link
US (2) US5631369A (de)
EP (1) EP0699672B1 (de)
JP (1) JPH08119964A (de)
KR (1) KR100359959B1 (de)
AT (1) ATE165355T1 (de)
BR (1) BR9503846A (de)
CA (1) CA2157236A1 (de)
CY (1) CY2092B1 (de)
DE (1) DE69502152T2 (de)
DK (1) DK0699672T3 (de)
ES (1) ES2114721T3 (de)
FI (1) FI114706B (de)
GR (1) GR3026742T3 (de)
HK (1) HK1006912A1 (de)
HU (2) HU0003473D0 (de)
IL (1) IL115092A0 (de)
TW (1) TW427975B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ333839A (en) * 1996-08-28 2001-06-29 Lilly Co Eli Amorphous benzothiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
US7124425B1 (en) * 1999-03-08 2006-10-17 Immersion Entertainment, L.L.C. Audio/video system and method utilizing a head mounted apparatus with noise attenuation
AU7699800A (en) * 1999-09-27 2001-04-30 Eli Lilly And Company Process for preparing benzoic acids
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
CA2499819A1 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US7012153B2 (en) * 2003-12-22 2006-03-14 Eli Lilly And Company Process for preparing benzoic acids
IN2014MN00380A (de) 2006-06-30 2015-06-19 Iceutica Pty Ltd
CA2759125C (en) 2009-04-24 2017-08-15 Iceutica Pty Ltd A novel formulation of indomethacin
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
KR102117214B1 (ko) 2020-03-26 2020-06-01 유지씨 주식회사 에어 리스 스프레이 건 용 도료 비산 방지 커버 하우징
KR102145873B1 (ko) 2020-06-10 2020-08-20 유지씨 주식회사 에어 리스 스프레이건 용 도료 비산 방지 커버 하우징 및 그 비산 방지 커버 하우징이 결합 된 고소작업대용 도색장치 및 그 비산 방지 커버 하우징이 결합 된 달비계용 도색 장치 및 그 비산 방지 커버 하우징이 결합 된 평면용 도색장치
KR102227020B1 (ko) 2020-12-18 2021-03-12 유지씨 주식회사 스프레이 건 용 도료 비산 방지 커버 하우징 결합체
KR102444617B1 (ko) 2021-05-28 2022-09-16 이다지 도장용 스프레이건의 비산방지장치
KR102607000B1 (ko) 2023-03-24 2023-11-29 이다지 도장용 스프레이 건의 비산방지장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides

Also Published As

Publication number Publication date
HK1006912A1 (en) 1999-03-19
CY2092B1 (en) 2002-04-05
HUT73141A (en) 1996-06-28
DE69502152T2 (de) 1998-09-17
FI114706B (fi) 2004-12-15
JPH08119964A (ja) 1996-05-14
EP0699672B1 (de) 1998-04-22
TW427975B (en) 2001-04-01
HU0003473D0 (de) 1995-08-30
GR3026742T3 (en) 1998-07-31
FI954067A0 (fi) 1995-08-30
US5750688A (en) 1998-05-12
BR9503846A (pt) 1996-09-17
US5631369A (en) 1997-05-20
DE69502152D1 (de) 1998-05-28
HU222121B1 (hu) 2003-04-28
FI954067A (fi) 1996-03-01
KR960007543A (ko) 1996-03-22
ATE165355T1 (de) 1998-05-15
ES2114721T3 (es) 1998-06-01
HU9502537D0 (en) 1995-10-30
IL115092A0 (en) 1995-12-08
KR100359959B1 (ko) 2003-01-14
CA2157236A1 (en) 1996-03-01
EP0699672A1 (de) 1996-03-06

Similar Documents

Publication Publication Date Title
DK0699672T3 (da) Fremgangsmåde til fremstilling af benzoesyrederivatmellemprodukter og farmaceutiske benzothiophen- midler
JP3199741B2 (ja) ミコフェノール酸の直接エステル化
TW368497B (en) Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
EP0094065B1 (de) 2-Aminobenzosäurederivate, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen
ZA200006689B (en) Method for producing enantiomer-free N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidine-1-yl) ethyl]-2,2-diphenyl acetamide.
CA2127292A1 (en) Process for producing hydroxyalkane carboxylic acid amides
KR20010005943A (ko) 0-(3-아미노-2-히드록시-프로필)-히드록심산할라이드의 제조방법
US4091095A (en) Phosphinyl compounds
US5599938A (en) Process for preparing a piperidine derivative
DE60030118D1 (de) Zwischenprodukte zur synthese von benzimidazolverbindungen und ein verfahren zu ihrer herstellung
US4960900A (en) Oxyimino derivatives of thiazole, method of preparation and use in therapy
KR840001732B1 (ko) 폴리프레닐 카르복실산 아미드의 제조방법
DE3567205D1 (en) Method for the preparation of amino-triazinone derivatives
HU209295B (en) Process for producing amine-substituted terciary carbinol derivatives
MXPA99009046A (en) Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
EP1229041A1 (de) Verfahren zur Herstellung von 3-Glutamid Gallensauerderivate durch Verwendung von N-tBoc Methyl-pyroglutamate