DK0684254T3 - Propiophenonderivat og fremgangsmåde til fremstilling deraf - Google Patents

Propiophenonderivat og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0684254T3
DK0684254T3 DK95107150T DK95107150T DK0684254T3 DK 0684254 T3 DK0684254 T3 DK 0684254T3 DK 95107150 T DK95107150 T DK 95107150T DK 95107150 T DK95107150 T DK 95107150T DK 0684254 T3 DK0684254 T3 DK 0684254T3
Authority
DK
Denmark
Prior art keywords
glucopyranosyl
preparation
beta
propiophenone derivative
groups
Prior art date
Application number
DK95107150T
Other languages
Danish (da)
English (en)
Inventor
Kenji Tsujihara
Mitsuya Hongu
Nobuyuki Funami
Masanori Inamasu
Kenji Arakawa
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of DK0684254T3 publication Critical patent/DK0684254T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
DK95107150T 1994-05-11 1995-05-11 Propiophenonderivat og fremgangsmåde til fremstilling deraf DK0684254T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9680594 1994-05-11
JP28234494 1994-11-17

Publications (1)

Publication Number Publication Date
DK0684254T3 true DK0684254T3 (da) 1999-10-11

Family

ID=26437976

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95107150T DK0684254T3 (da) 1994-05-11 1995-05-11 Propiophenonderivat og fremgangsmåde til fremstilling deraf

Country Status (15)

Country Link
US (1) US5830873A (de)
EP (1) EP0684254B1 (de)
KR (1) KR100318793B1 (de)
CN (1) CN1042637C (de)
AT (1) ATE178069T1 (de)
AU (1) AU680118B2 (de)
BR (1) BR9502016A (de)
CA (1) CA2149160C (de)
DE (1) DE69508463T2 (de)
DK (1) DK0684254T3 (de)
ES (1) ES2133614T3 (de)
FI (1) FI116975B (de)
GR (1) GR3029795T3 (de)
IL (1) IL113581A (de)
MY (1) MY119134A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
JP3059088B2 (ja) * 1995-11-07 2000-07-04 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
PT850948E (pt) * 1996-12-26 2002-08-30 Tanabe Seiyaku Co Derivados propiofenona e processo para a preparacao dos mesmos
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
CA2443325C (en) * 2001-04-04 2011-06-14 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
ES2321815T3 (es) * 2001-04-04 2009-06-12 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Combinacion terapeutica que comprende inhibidores de reabsorcion e glucosa y moduladores ppar.
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
AU2004261663A1 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
WO2005011592A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indazole-o-glucosides
PL1651658T5 (pl) 2003-08-01 2020-11-30 Mitsubishi Tanabe Pharma Corporation Nowe związki o działaniu inhibitującym transporter zależny od sodu
US7129220B2 (en) * 2003-08-01 2006-10-31 Janssen Pharmaceutica N.V Substituted indole-O-glucosides
WO2005012318A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv Substituted fused heterocyclic c-glycosides
TW200606129A (en) 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
TWI365186B (en) * 2005-01-31 2012-06-01 Mitsubishi Tanabe Pharma Corp Indole derivatives
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
TWI418556B (zh) * 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
CN101611032B (zh) * 2006-12-04 2012-07-18 詹森药业有限公司 作为抗糖尿病药的含噻吩基的吡喃葡糖基衍生物
UY30730A1 (es) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
EP2200606B1 (de) 2007-09-10 2017-10-25 Janssen Pharmaceutica, N.V. Verfahren zur herstellung von verbindungen als sglt-hemmer
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
US8791077B2 (en) 2008-05-22 2014-07-29 Astrazeneca Ab Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
EA022186B1 (ru) 2009-07-10 2015-11-30 Янссен Фармацевтика Нв СПОСОБ КРИСТАЛЛИЗАЦИИ 1-(β-D-ГЛЮКОПИРАНОЗИЛ)-4-МЕТИЛ-3-[5-(4-ФТОРФЕНИЛ)-2-ТИЕНИЛМЕТИЛ]БЕНЗОЛА
BR112012008939B1 (pt) * 2009-10-14 2021-06-22 Janssen Pharmaceutica Nv Processo para a preparação de compostos úteis como inibidores de sglt2
PT2568988T (pt) 2010-05-11 2016-09-22 Janssen Pharmaceutica Nv Formulações farmacêuticas compreendendo derivados de 1-(beta-d-glucopiranosil)-2-tienilmetilbenzeno como inhibidoras de sglt
ME02469B (de) 2011-04-13 2017-02-20 Janssen Pharmaceutica Nv Verfahren zur herstellung von sglt2-hemmenden verbindungen
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
SG11202100417RA (en) 2018-07-19 2021-02-25 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
WO2022022865A1 (en) 2020-07-27 2022-02-03 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
EP4315350A1 (de) 2021-04-01 2024-02-07 AstraZeneca UK Limited Systeme und verfahren zur verwaltung von prädiabetes mit einer pharmazeutischen gliflozin-natrium-glucose-cotransport-2-inhibitorzusammensetzung
CN118510504A (zh) 2022-01-26 2024-08-16 阿斯利康(瑞典)有限公司 用于在治疗糖尿病前期或降低发展2型糖尿病的风险中使用的达格列净

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984394A (en) * 1971-05-14 1976-10-05 Nutrilite Products, Inc. Salts of dihydrochalcone derivatives and their use as sweeteners
US4031260A (en) * 1971-05-14 1977-06-21 Nutrilite Products, Inc. Salts of dihydrochalcone derivatives and their use as sweeteners
US4049715A (en) * 1973-10-01 1977-09-20 Sterling Drug Inc. 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols
US4684627A (en) * 1981-09-08 1987-08-04 Leveen Harry H Treatment of cancer with phlorizin and its derivatives
US5110801A (en) * 1984-08-13 1992-05-05 Leveen Harry H Treatment of acne
CA1289077C (en) * 1984-08-13 1991-09-17 Harry H. Leveen Treatment of cancer with phlorizin and its derivatives
US4760135A (en) * 1984-09-06 1988-07-26 University Of Kentucky Research Foundation Phloretin and phlorizin derivative containing compounds
US4665058A (en) * 1985-03-16 1987-05-12 The University Of Kentucky Research Foundation Compositions and method of treatment for sickle cell anemia
CA2102591C (en) * 1992-11-12 2000-12-26 Kenji Tsujihara Hypoglycemic agent

Also Published As

Publication number Publication date
EP0684254B1 (de) 1999-03-24
CN1042637C (zh) 1999-03-24
DE69508463T2 (de) 1999-08-19
FI952260A0 (fi) 1995-05-10
CA2149160C (en) 2002-01-29
FI116975B (fi) 2006-04-28
US5830873A (en) 1998-11-03
ES2133614T3 (es) 1999-09-16
FI952260A (fi) 1995-11-12
GR3029795T3 (en) 1999-06-30
IL113581A (en) 1999-07-14
ATE178069T1 (de) 1999-04-15
BR9502016A (pt) 1995-12-12
EP0684254A1 (de) 1995-11-29
KR950032262A (ko) 1995-12-20
DE69508463D1 (de) 1999-04-29
CN1121925A (zh) 1996-05-08
IL113581A0 (en) 1995-08-31
AU1779095A (en) 1995-11-16
AU680118B2 (en) 1997-07-17
CA2149160A1 (en) 1995-11-12
MY119134A (en) 2005-04-30
KR100318793B1 (ko) 2002-07-04

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