ATE178069T1 - Propiophenonderivate und verfahren zu deren herstellung - Google Patents

Propiophenonderivate und verfahren zu deren herstellung

Info

Publication number
ATE178069T1
ATE178069T1 AT95107150T AT95107150T ATE178069T1 AT E178069 T1 ATE178069 T1 AT E178069T1 AT 95107150 T AT95107150 T AT 95107150T AT 95107150 T AT95107150 T AT 95107150T AT E178069 T1 ATE178069 T1 AT E178069T1
Authority
AT
Austria
Prior art keywords
glucopyranosyl
production
beta
propiophenone derivatives
groups
Prior art date
Application number
AT95107150T
Other languages
English (en)
Inventor
Kenji Tsujihara
Mitsuya Hongu
Cho
Nobuyuki Funami
Masanori Inamasu
Kenji Arakawa
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of ATE178069T1 publication Critical patent/ATE178069T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
AT95107150T 1994-05-11 1995-05-11 Propiophenonderivate und verfahren zu deren herstellung ATE178069T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9680594 1994-05-11
JP28234494 1994-11-17

Publications (1)

Publication Number Publication Date
ATE178069T1 true ATE178069T1 (de) 1999-04-15

Family

ID=26437976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95107150T ATE178069T1 (de) 1994-05-11 1995-05-11 Propiophenonderivate und verfahren zu deren herstellung

Country Status (15)

Country Link
US (1) US5830873A (de)
EP (1) EP0684254B1 (de)
KR (1) KR100318793B1 (de)
CN (1) CN1042637C (de)
AT (1) ATE178069T1 (de)
AU (1) AU680118B2 (de)
BR (1) BR9502016A (de)
CA (1) CA2149160C (de)
DE (1) DE69508463T2 (de)
DK (1) DK0684254T3 (de)
ES (1) ES2133614T3 (de)
FI (1) FI116975B (de)
GR (1) GR3029795T3 (de)
IL (1) IL113581A (de)
MY (1) MY119134A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
JP3059088B2 (ja) * 1995-11-07 2000-07-04 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
AU719726B2 (en) * 1996-12-26 2000-05-18 Tanabe Seiyaku Co., Ltd. Propiophenone derivatives and process for preparing the same
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US6838442B2 (en) * 2001-04-04 2005-01-04 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
CN100577175C (zh) 2001-04-04 2010-01-06 奥索-麦克尼尔药品公司 包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
RS20060320A (en) * 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Substituted indazole-o-glucosides
PL1651658T5 (pl) 2003-08-01 2020-11-30 Mitsubishi Tanabe Pharma Corporation Nowe związki o działaniu inhibitującym transporter zależny od sodu
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
EP1679965A4 (de) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv Substituierte anellierte heterocyclische c-glycoside
TW200526678A (en) * 2003-08-01 2005-08-16 Janssen Pharmaceutica Nv Substituted indole-O-glucosides
US7094764B2 (en) * 2003-08-01 2006-08-22 Janssen Pharmaceutica N.V. Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
TW200606129A (en) 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
TWI365186B (en) * 2005-01-31 2012-06-01 Mitsubishi Tanabe Pharma Corp Indole derivatives
TWI418556B (zh) * 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
CA2671699C (en) * 2006-12-04 2014-07-08 Janssen Pharmaceutica N.V. Thienyl-containing glycopyranosyl derivatives as antidiabetics
UY30730A1 (es) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
KR101552187B1 (ko) 2007-09-10 2015-09-10 얀센 파마슈티카 엔.브이. Ｓｇｌｔ 억제제로서 유용한 화합물의 제조 방법
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
US8791077B2 (en) 2008-05-22 2014-07-29 Astrazeneca Ab Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
CA2767258C (en) 2009-07-10 2016-09-13 Janssen Pharmaceutica Nv Crystallisation process for 1-(.beta.-d-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene
EA024368B1 (ru) * 2009-10-14 2016-09-30 Янссен Фармацевтика Нв Процесс получения соединений для применения в качестве ингибиторов sglt2
JP6227406B2 (ja) 2010-05-11 2017-11-08 ヤンセン ファーマシューティカ エヌ．ベー． ＳＧＬＴの阻害剤としての１−（β−Ｄ−グルコピラノシル）−２−チエニル−メチルベンゼン誘導体を含有する医薬製剤
CA2832938C (en) 2011-04-13 2019-09-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CA3105626A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
WO2022022865A1 (en) 2020-07-27 2022-02-03 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
EP4315350A1 (de) 2021-04-01 2024-02-07 AstraZeneca UK Limited Systeme und verfahren zur verwaltung von prädiabetes mit einer pharmazeutischen gliflozin-natrium-glucose-cotransport-2-inhibitorzusammensetzung
WO2023144722A1 (en) 2022-01-26 2023-08-03 Astrazeneca Ab Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984394A (en) * 1971-05-14 1976-10-05 Nutrilite Products, Inc. Salts of dihydrochalcone derivatives and their use as sweeteners
US4031260A (en) * 1971-05-14 1977-06-21 Nutrilite Products, Inc. Salts of dihydrochalcone derivatives and their use as sweeteners
US4049715A (en) * 1973-10-01 1977-09-20 Sterling Drug Inc. 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols
US4684627A (en) * 1981-09-08 1987-08-04 Leveen Harry H Treatment of cancer with phlorizin and its derivatives
CA1289077C (en) * 1984-08-13 1991-09-17 Harry H. Leveen Treatment of cancer with phlorizin and its derivatives
US5110801A (en) * 1984-08-13 1992-05-05 Leveen Harry H Treatment of acne
US4760135A (en) * 1984-09-06 1988-07-26 University Of Kentucky Research Foundation Phloretin and phlorizin derivative containing compounds
US4665058A (en) * 1985-03-16 1987-05-12 The University Of Kentucky Research Foundation Compositions and method of treatment for sickle cell anemia
CA2102591C (en) * 1992-11-12 2000-12-26 Kenji Tsujihara Hypoglycemic agent

Also Published As

Publication number Publication date
AU680118B2 (en) 1997-07-17
EP0684254A1 (de) 1995-11-29
CN1042637C (zh) 1999-03-24
FI952260A (fi) 1995-11-12
AU1779095A (en) 1995-11-16
US5830873A (en) 1998-11-03
FI952260A0 (fi) 1995-05-10
MY119134A (en) 2005-04-30
CA2149160A1 (en) 1995-11-12
FI116975B (fi) 2006-04-28
IL113581A (en) 1999-07-14
IL113581A0 (en) 1995-08-31
DE69508463D1 (de) 1999-04-29
KR100318793B1 (ko) 2002-07-04
DE69508463T2 (de) 1999-08-19
KR950032262A (ko) 1995-12-20
EP0684254B1 (de) 1999-03-24
CA2149160C (en) 2002-01-29
DK0684254T3 (da) 1999-10-11
BR9502016A (pt) 1995-12-12
GR3029795T3 (en) 1999-06-30
ES2133614T3 (es) 1999-09-16
CN1121925A (zh) 1996-05-08

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Legal Events

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UEP Publication of translation of european patent specification