DK0669977T3 - Transformerede endothelceller - Google Patents

Transformerede endothelceller

Info

Publication number
DK0669977T3
DK0669977T3 DK93924544T DK93924544T DK0669977T3 DK 0669977 T3 DK0669977 T3 DK 0669977T3 DK 93924544 T DK93924544 T DK 93924544T DK 93924544 T DK93924544 T DK 93924544T DK 0669977 T3 DK0669977 T3 DK 0669977T3
Authority
DK
Denmark
Prior art keywords
cells
kappa
endothelial cells
activity
endothelial
Prior art date
Application number
DK93924544T
Other languages
Danish (da)
English (en)
Inventor
Fritz H Bach
Martin Rainer De
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0669977T3 publication Critical patent/DK0669977T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Animal Husbandry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93924544T 1992-11-02 1993-10-29 Transformerede endothelceller DK0669977T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929222931A GB9222931D0 (en) 1992-11-02 1992-11-02 Organic compounds
PCT/EP1993/003015 WO1994010305A1 (en) 1992-11-02 1993-10-29 Transformed endothelial cells

Publications (1)

Publication Number Publication Date
DK0669977T3 true DK0669977T3 (da) 2000-08-07

Family

ID=10724398

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93924544T DK0669977T3 (da) 1992-11-02 1993-10-29 Transformerede endothelceller

Country Status (16)

Country Link
EP (1) EP0669977B1 (ko)
JP (1) JPH08502653A (ko)
KR (1) KR950704477A (ko)
AT (1) ATE192492T1 (ko)
AU (1) AU680636B2 (ko)
CA (1) CA2143489A1 (ko)
DK (1) DK0669977T3 (ko)
ES (1) ES2146235T3 (ko)
FI (1) FI952088A (ko)
GB (1) GB9222931D0 (ko)
GR (1) GR3033600T3 (ko)
NO (1) NO951628L (ko)
NZ (1) NZ257539A (ko)
PT (1) PT669977E (ko)
RU (1) RU2164415C2 (ko)
WO (1) WO1994010305A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726005B1 (fr) * 1994-10-10 1997-01-03 Adim Lignees immortalisees de cellules endotheliales cerebrales et leurs applications au traitement de differents troubles ou maladies primaires et secondaires neurologiques ou psychiatriques
EP0815252A1 (en) * 1995-03-24 1998-01-07 Novartis AG Gene therapy for transplantation and inflammatory or thrombotic conditions
WO1996032412A1 (fr) * 1995-04-13 1996-10-17 Chugai Seiyaku Kabushiki Kaisha PEPTIDE SUPPRIMANT LA PHOSPHORYLATION IxB$g(a)
JPH0959151A (ja) * 1995-08-24 1997-03-04 Kao Corp ＮＦ−κＢ活性化抑制剤
EP0779361A3 (en) 1995-12-15 1999-11-10 F. Hoffmann-La Roche Ag Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof
CA2245503A1 (en) * 1996-02-14 1997-08-21 Novartis Ag Gene therapy of entothelial cells with anti-apoptotic proteins for transplantation and inflammatory conditions
WO2001052639A1 (en) 2000-01-21 2001-07-26 Beth Israel Deaconess Medical Center Use of pro-apoptotic factors in treatment of atherosclerosis
AU2004320466A1 (en) * 2003-06-11 2006-02-02 Jan Remmereit Nuclear reprogramming of cells for therapeutic use
TW201120210A (en) 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
US11028149B2 (en) 2011-04-01 2021-06-08 Chugai Seiyaku Kabushiki Kaisha Recombinant polypeptide production method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341606C (en) * 1988-03-01 2010-06-08 Whitehead Institute For Biomedical Research Activation of nf-kb precursor
AU656544B2 (en) * 1990-10-31 1995-02-09 Brigham And Women's Hospital Genetic modification of endothelial cells

Also Published As

Publication number Publication date
NO951628L (no) 1995-07-03
FI952088A0 (fi) 1995-05-02
NZ257539A (en) 1996-08-27
FI952088A (fi) 1995-05-02
EP0669977A1 (en) 1995-09-06
ES2146235T3 (es) 2000-08-01
EP0669977B1 (en) 2000-05-03
GB9222931D0 (en) 1992-12-16
RU2164415C2 (ru) 2001-03-27
KR950704477A (ko) 1995-11-20
NO951628D0 (no) 1995-04-28
AU680636B2 (en) 1997-08-07
GR3033600T3 (en) 2000-09-29
AU5440494A (en) 1994-05-24
CA2143489A1 (en) 1994-05-11
JPH08502653A (ja) 1996-03-26
ATE192492T1 (de) 2000-05-15
WO1994010305A1 (en) 1994-05-11
PT669977E (pt) 2000-08-31

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