DK0668906T3 - Fremgangsmåde til fremstilling af polypeptid via bakteriel fermentering - Google Patents

Fremgangsmåde til fremstilling af polypeptid via bakteriel fermentering

Info

Publication number
DK0668906T3
DK0668906T3 DK94901628T DK94901628T DK0668906T3 DK 0668906 T3 DK0668906 T3 DK 0668906T3 DK 94901628 T DK94901628 T DK 94901628T DK 94901628 T DK94901628 T DK 94901628T DK 0668906 T3 DK0668906 T3 DK 0668906T3
Authority
DK
Denmark
Prior art keywords
bacterial fermentation
polypeptide via
producing polypeptide
via bacterial
producing
Prior art date
Application number
DK94901628T
Other languages
Danish (da)
English (en)
Inventor
James R Swartz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0668906T3 publication Critical patent/DK0668906T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2336—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer
    • B01F23/23362—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the location of the place of introduction of the gas relative to the stirrer the gas being introduced under the stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
    • B01F23/2376—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media characterised by the gas being introduced
    • B01F23/23761—Aerating, i.e. introducing oxygen containing gas in liquids
    • B01F23/237612—Oxygen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/2132—Concentration, pH, pOH, p(ION) or oxygen-demand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2211—Amount of delivered fluid during a period
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/28—Means for regulation, monitoring, measurement or control, e.g. flow regulation of redox potential
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
    • B01F23/2331—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements
    • B01F23/23316—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements characterised by the introduction of the gas along the axis of the stirrer or along the stirrer elements through a separate hollow guide substantially parallel with the stirrer element

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK94901628T 1992-11-23 1993-11-19 Fremgangsmåde til fremstilling af polypeptid via bakteriel fermentering DK0668906T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/989,844 US5342763A (en) 1992-11-23 1992-11-23 Method for producing polypeptide via bacterial fermentation
PCT/US1993/011297 WO1994012630A2 (en) 1992-11-23 1993-11-19 Method for producing polypeptide via bacterial fermentation

Publications (1)

Publication Number Publication Date
DK0668906T3 true DK0668906T3 (da) 2005-02-07

Family

ID=25535522

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94901628T DK0668906T3 (da) 1992-11-23 1993-11-19 Fremgangsmåde til fremstilling af polypeptid via bakteriel fermentering
DK04017942T DK1524316T3 (da) 1992-11-23 1993-11-19 Fremgangsm de til bestemmelse af bakteriers tilbäjelighed til opläst oxygenustabilitet

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK04017942T DK1524316T3 (da) 1992-11-23 1993-11-19 Fremgangsm de til bestemmelse af bakteriers tilbäjelighed til opläst oxygenustabilitet

Country Status (12)

Country Link
US (3) US5342763A (pt)
EP (2) EP1524316B1 (pt)
JP (2) JP3513875B2 (pt)
AT (2) ATE432344T1 (pt)
AU (2) AU669414B2 (pt)
CA (1) CA2147468C (pt)
DE (2) DE69333671T2 (pt)
DK (2) DK0668906T3 (pt)
ES (2) ES2231771T3 (pt)
IL (1) IL107712A (pt)
PT (2) PT1524316E (pt)
WO (1) WO1994012630A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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US5342763A (en) * 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
US6274369B1 (en) * 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
ZA979496B (en) * 1996-10-31 1999-04-23 Genentech Inc Assay using marked microbial host cell strains
US6114137A (en) * 1996-10-31 2000-09-05 Genentech Inc Assay using marked microbial host cell strains
HUP0001650A3 (en) * 1996-11-08 2001-09-28 Neose Technologies Inc Horsham Improved expression vectors
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
DK1141014T3 (da) * 1999-01-06 2005-04-11 Genentech Inc Insulinlignende vækstfaktor (IGF) i mutantvariant
AU762047B2 (en) 1999-01-06 2003-06-19 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
ATE389416T1 (de) 2000-05-16 2008-04-15 Genentech Inc Behandlung von knorpelerkrankungen
SE0003958D0 (sv) 2000-10-31 2000-10-31 Biogaia Fermentation Ab Method for growth of microorganisms
DE60138127D1 (de) 2000-11-03 2009-05-07 Genentech Inc Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine
EP1401476A4 (en) * 2001-03-14 2006-03-08 Genentech Inc IGF ANTAGONIST PEPTIDES
WO2004065574A2 (en) * 2003-01-16 2004-08-05 Bloom Fredric R Bacteria for high efficiency cloning
US7249880B2 (en) 2003-10-14 2007-07-31 Advanced Technology Materials, Inc. Flexible mixing bag for mixing solids, liquids and gases
BRPI0507233B8 (pt) 2004-03-11 2021-05-25 Genentech Inc processo para a produção de um polipeptídeo heterólogo em e. coli
US7078201B2 (en) * 2004-12-01 2006-07-18 Burmaster Brian M Ethanol fermentation using oxidation reduction potential
WO2006069403A2 (en) 2004-12-22 2006-06-29 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
CN101287945B (zh) * 2005-04-15 2012-01-25 加勒特·W·布朗 平衡支撑装置
JP4358785B2 (ja) * 2005-05-27 2009-11-04 麒麟麦酒株式会社 密封容器内の酸素量の測定方法及びこれに用いる密封容器のピアス装置
KR20080074896A (ko) * 2005-10-26 2008-08-13 레브테크 인크. 혼합기와 분사기를 구비한 생물 반응기
MY143274A (en) 2005-12-22 2011-04-15 Genentech Inc Recombinant production of heparin binding proteins
DE102006001623B4 (de) * 2006-01-11 2009-05-07 Sartorius Stedim Biotech Gmbh Behälter und Verfahren zum Mischen von Medien
US8366311B2 (en) 2006-04-21 2013-02-05 Atmi Bvba Systems and devices for mixing substances and methods of making same
EP2018416B1 (en) * 2006-05-13 2018-10-24 Pall Life Sciences Belgium Disposable bioreactor
JP2009072133A (ja) * 2007-09-21 2009-04-09 Hitachi Plant Technologies Ltd 培養槽装置、細胞培養方法及び物質生産方法
EP2216395A1 (en) 2009-02-09 2010-08-11 Lonza Biologics plc. Bioreactor for the cultivation of mammalian cells
JP5827617B2 (ja) * 2009-06-05 2015-12-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 組合せ攪拌機
ES2478294T3 (es) * 2009-07-24 2014-07-21 F. Hoffmann-La Roche Ag Sistema de agitador
US20140024090A1 (en) * 2011-12-19 2014-01-23 Shell Oil Company Method and apparatus for converting a carbon source into a hydrocarbon or hydrocarbon precursor
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US5342763A (en) * 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation

Also Published As

Publication number Publication date
PT1524316E (pt) 2009-08-13
AU5615094A (en) 1994-06-22
CA2147468A1 (en) 1994-06-09
DE69333671D1 (de) 2004-11-25
ATE432344T1 (de) 2009-06-15
IL107712A (en) 2002-09-12
DE69334286D1 (de) 2009-07-09
ATE280223T1 (de) 2004-11-15
JP2004121256A (ja) 2004-04-22
AU5946196A (en) 1996-09-05
JPH08503611A (ja) 1996-04-23
EP1524316A2 (en) 2005-04-20
DE69333671T2 (de) 2006-01-19
JP3674705B2 (ja) 2005-07-20
EP0668906B1 (en) 2004-10-20
WO1994012630A3 (en) 1994-10-13
US5342763A (en) 1994-08-30
EP1524316B1 (en) 2009-05-27
JP3513875B2 (ja) 2004-03-31
PT668906E (pt) 2005-02-28
CA2147468C (en) 2006-05-16
ES2326802T3 (es) 2009-10-20
US5487980A (en) 1996-01-30
ES2231771T3 (es) 2005-05-16
US5633165A (en) 1997-05-27
IL107712A0 (en) 1994-02-27
AU679880B2 (en) 1997-07-10
AU669414B2 (en) 1996-06-06
DK1524316T3 (da) 2009-09-07
EP0668906A1 (en) 1995-08-30
WO1994012630A2 (en) 1994-06-09
EP1524316A3 (en) 2005-04-27

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