DK0668502T3 - Elektrobiokemisk fremgangsmåde, system og elektroder til bestemmelse af en del af et bindingspar - Google Patents
Elektrobiokemisk fremgangsmåde, system og elektroder til bestemmelse af en del af et bindingsparInfo
- Publication number
- DK0668502T3 DK0668502T3 DK95102343T DK95102343T DK0668502T3 DK 0668502 T3 DK0668502 T3 DK 0668502T3 DK 95102343 T DK95102343 T DK 95102343T DK 95102343 T DK95102343 T DK 95102343T DK 0668502 T3 DK0668502 T3 DK 0668502T3
- Authority
- DK
- Denmark
- Prior art keywords
- analyte
- electrobiochemical
- pair
- electrodes
- electrode
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C12Q1/003—Functionalisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10872694A IL108726A (en) | 1994-02-22 | 1994-02-22 | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0668502T3 true DK0668502T3 (da) | 2002-08-19 |
Family
ID=11065843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95102343T DK0668502T3 (da) | 1994-02-22 | 1995-02-20 | Elektrobiokemisk fremgangsmåde, system og elektroder til bestemmelse af en del af et bindingspar |
Country Status (8)
Country | Link |
---|---|
US (1) | US5942388A (fr) |
EP (1) | EP0668502B1 (fr) |
JP (1) | JP3583496B2 (fr) |
AT (1) | ATE217966T1 (fr) |
DE (1) | DE69526747T2 (fr) |
DK (1) | DK0668502T3 (fr) |
ES (1) | ES2177586T3 (fr) |
IL (1) | IL108726A (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
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US6770179B1 (en) * | 1993-05-10 | 2004-08-03 | Universite De Montreal | Biosensors comprising a covalently attached monomolecular biological conjugate layer and a transducing device |
US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
IL114692A (en) | 1995-07-21 | 1999-10-28 | Yissum Res Dev Co | Determination of an analyte in a liquid medium |
IL116921A (en) * | 1996-01-26 | 2000-11-21 | Yissum Res Dev Co | Electrochemical system for determination of an analyte in a liquid medium |
US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
ES2288760T3 (es) | 1996-04-25 | 2008-01-16 | Bioarray Solutions Ltd. | Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies. |
US6165335A (en) | 1996-04-25 | 2000-12-26 | Pence And Mcgill University | Biosensor device and method |
EP0929811A1 (fr) * | 1996-10-07 | 1999-07-21 | Schering Corporation | EPREUVE POUR LA DETECTION D'ANTICORPS CONTRE p53 |
US7381525B1 (en) | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
US7045285B1 (en) | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
EP0988549B1 (fr) * | 1997-04-11 | 2005-03-02 | University Of New Mexico | Ensemble modulaire pour la separation et la detection des analytes par affinite et sans reactif |
US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
DE69842134D1 (de) * | 1997-06-12 | 2011-03-31 | Clinical Micro Sensors Inc | Elektronische verfahren und vorrichtung zum nachweis von analyten |
US6551495B1 (en) * | 1997-11-21 | 2003-04-22 | Inverness Medical Switzerland Gmbh | Electrochemical assays |
JP3105868B2 (ja) * | 1998-08-07 | 2000-11-06 | 新潟日本電気株式会社 | トナー濃度検出装置及びプログラムを記憶した記憶媒体 |
US6281006B1 (en) * | 1998-08-24 | 2001-08-28 | Therasense, Inc. | Electrochemical affinity assay |
CA2341379A1 (fr) * | 1998-09-17 | 2000-03-23 | Clinical Micro Sensors, Inc. | Techniques de detection de signaux pour la detection d'analytes |
US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6468657B1 (en) * | 1998-12-04 | 2002-10-22 | The Regents Of The University Of California | Controllable ion-exchange membranes |
US6833267B1 (en) * | 1998-12-30 | 2004-12-21 | Clinical Micro Sensors, Inc. | Tissue collection devices containing biosensors |
WO2000052456A1 (fr) | 1999-03-02 | 2000-09-08 | Helix Biopharma Corporation | Dispositif biocapteur et methode |
US6300141B1 (en) * | 1999-03-02 | 2001-10-09 | Helix Biopharma Corporation | Card-based biosensor device |
WO2001007665A2 (fr) | 1999-07-26 | 2001-02-01 | Clinical Micro Sensors, Inc. | Determination de sequences d'acides nucleiques par detection electronique |
US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
WO2001098765A1 (fr) | 2000-06-21 | 2001-12-27 | Bioarray Solutions, Ltd. | Analyse moleculaire multi-analyte |
DE20017268U1 (de) * | 2000-10-07 | 2001-03-29 | Dechema | Elektrochemische Messzelle zur Bestimmung der Zellzahl und Aktivität von biologischen Systemen |
US6835552B2 (en) * | 2000-12-14 | 2004-12-28 | The Regents Of The University Of California | Impedance measurements for detecting pathogens attached to antibodies |
US6887667B2 (en) * | 2000-12-28 | 2005-05-03 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Method and apparatus to identify small variations of biomolecules |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
AU2002365115A1 (en) * | 2001-07-20 | 2003-09-02 | North Carolina State University | Light addressable electrochemical detection of duplex structures |
DE10141691A1 (de) * | 2001-08-25 | 2003-03-13 | Friz Biochem Gmbh | Verdrängungsassay zur Detektion von Ligat-Ligand-Assoziationsereignissen |
ES2661167T3 (es) | 2001-10-15 | 2018-03-27 | Bioarray Solutions Ltd. | Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas |
US7074519B2 (en) * | 2001-10-26 | 2006-07-11 | The Regents Of The University Of California | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device |
US7687258B1 (en) * | 2002-05-20 | 2010-03-30 | Maki Wusi C | Direct electric biological agent detector |
US7176036B2 (en) * | 2002-09-20 | 2007-02-13 | Arrowhead Center, Inc. | Electroactive microspheres and methods |
US20040108226A1 (en) * | 2002-10-28 | 2004-06-10 | Constantin Polychronakos | Continuous glucose quantification device and method |
US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
DE10300521A1 (de) * | 2003-01-09 | 2004-07-22 | Siemens Ag | Organoresistiver Speicher |
US20040180369A1 (en) * | 2003-01-16 | 2004-09-16 | North Carolina State University | Photothermal detection of nucleic acid hybridization |
US20040142405A1 (en) * | 2003-01-22 | 2004-07-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of detecting drug resistance |
US8003374B2 (en) * | 2003-03-25 | 2011-08-23 | The Regents Of The University Of California | Reagentless, reusable, bioelectronic detectors |
US20040191801A1 (en) * | 2003-03-25 | 2004-09-30 | Heeger Alan J. | Reagentless, reusable bioelectronic detectors and their use as authentication devices |
WO2005029705A2 (fr) | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Codage numerique pour identification de sous-types des types de supports solides codes |
US7595279B2 (en) | 2003-09-22 | 2009-09-29 | Bioarray Solutions Ltd. | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
CA2544041C (fr) | 2003-10-28 | 2015-12-08 | Bioarray Solutions Ltd. | Optimisation de l'analyse de l'expression genique a l'aide de sondes de capture immobilisees |
AU2004287069B2 (en) | 2003-10-29 | 2009-07-16 | Bioarray Solutions, Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA |
WO2005042785A1 (fr) * | 2003-10-30 | 2005-05-12 | North Carolina State University | Detection electrochimique d'hybridation d'acide nucleique |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
AU2004240178A1 (en) * | 2004-08-20 | 2006-03-09 | Commonwealth Scientific And Industrial Research Organisation | Zwitterionic additives for electrochemical devices |
JP2006133137A (ja) * | 2004-11-08 | 2006-05-25 | Eiichi Tamiya | 被検物質の検出方法 |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US7889347B2 (en) | 2005-11-21 | 2011-02-15 | Plexera Llc | Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism |
US7803542B2 (en) * | 2005-11-29 | 2010-09-28 | The Regents Of The University Of California | Signal-on architecture for electronic, oligonucleotide-based detectors |
US7463358B2 (en) | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
EP2174135B1 (fr) * | 2007-07-26 | 2013-01-02 | Agamatrix, Inc. | Appareil et procede de detection d'analyte electrochimique |
US8004669B1 (en) | 2007-12-18 | 2011-08-23 | Plexera Llc | SPR apparatus with a high performance fluid delivery system |
JP5712129B2 (ja) | 2008-09-02 | 2015-05-07 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | ナノ構造化微小電極およびそれを組み込んだバイオセンシング装置 |
GB2463115B (en) * | 2008-09-08 | 2013-04-10 | Schlumberger Holdings | Assemblies for the purification of a reservoir or process fluid |
GB2463280B (en) * | 2008-09-08 | 2011-02-02 | Schlumberger Holdings | Electro-chemical sensor |
RU2606852C2 (ru) * | 2011-01-11 | 2017-01-10 | Дзе Гавернинг Каунсил Оф Дзе Юниверсити Оф Торонто | Способ детекции белков |
JP6019944B2 (ja) * | 2011-12-28 | 2016-11-02 | 逢坂 哲彌 | 糖化合物固定化半導体センシングデバイス及び生物学的物質の検出方法 |
WO2013117233A1 (fr) | 2012-02-10 | 2013-08-15 | Alere Switzerland Gmbh | Essai et procédé pour déterminer la résistance à l'insuline |
CZ307792B6 (cs) * | 2017-08-23 | 2019-05-09 | Masarykova Univerzita | Způsob stanovení přítomnosti analytu v kapalném vzorku a jeho použití |
CN112213482B (zh) * | 2020-09-30 | 2021-11-09 | 同济大学 | 基于免疫组化空间电化学检测样品中抗原含量的方法 |
Family Cites Families (15)
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GB8328520D0 (en) * | 1983-10-25 | 1983-11-23 | Serono Diagnostics Ltd | Methods of assay |
US4591550A (en) * | 1984-03-01 | 1986-05-27 | Molecular Devices Corporation | Device having photoresponsive electrode for determining analytes including ligands and antibodies |
GB8417301D0 (en) * | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
US5114674A (en) * | 1987-05-01 | 1992-05-19 | Biotronic Systems Corporation | Added array of molecular chains for interfering with electrical fields |
US5135876A (en) * | 1987-09-24 | 1992-08-04 | University Of Utah | Method and apparatus for the regulation of complex binding |
US4927502A (en) * | 1989-01-31 | 1990-05-22 | Board Of Regents, The University Of Texas | Methods and apparatus using galvanic immunoelectrodes |
WO1990010655A1 (fr) * | 1989-03-13 | 1990-09-20 | Allage Associates, Inc. | Polymeres conducteurs fonctionnalises et derives en surface et leurs procedes de production |
JPH02298855A (ja) * | 1989-03-20 | 1990-12-11 | Assoc Univ Inc | 固定化酵素とレドックス重合体を用いた電気化学的バイオセンサー |
US4964972A (en) * | 1989-03-30 | 1990-10-23 | Yeda Research And Development Company Limited | Ionic recognition and selective response in self assembling monolayer membranes on electrodes |
DE59006824D1 (de) * | 1989-04-04 | 1994-09-22 | Fritz Pittner | Verfahren zum immobilisieren von proteinen, peptiden, coenzymen od.dgl. an einem träger. |
US5198367A (en) * | 1989-06-09 | 1993-03-30 | Masuo Aizawa | Homogeneous amperometric immunoassay |
JPH03170500A (ja) * | 1989-11-29 | 1991-07-24 | Fuji Photo Film Co Ltd | 感光性色素蛋白質の配向化方法 |
JPH0795170B2 (ja) * | 1990-08-21 | 1995-10-11 | ダイソー株式会社 | ポリビオロゲン修飾電極およびその用途 |
US5541069A (en) * | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
IL102930A (en) * | 1992-08-25 | 1997-03-18 | Yissum Res Dev Co | Electrobiochemical analytical method and electrodes |
-
1994
- 1994-02-22 IL IL10872694A patent/IL108726A/en not_active IP Right Cessation
-
1995
- 1995-02-20 AT AT95102343T patent/ATE217966T1/de not_active IP Right Cessation
- 1995-02-20 DK DK95102343T patent/DK0668502T3/da active
- 1995-02-20 DE DE69526747T patent/DE69526747T2/de not_active Expired - Fee Related
- 1995-02-20 EP EP95102343A patent/EP0668502B1/fr not_active Expired - Lifetime
- 1995-02-20 ES ES95102343T patent/ES2177586T3/es not_active Expired - Lifetime
- 1995-02-21 US US08/390,978 patent/US5942388A/en not_active Expired - Fee Related
- 1995-02-22 JP JP05815895A patent/JP3583496B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2177586T3 (es) | 2002-12-16 |
EP0668502A3 (fr) | 1996-02-28 |
DE69526747D1 (de) | 2002-06-27 |
IL108726A0 (en) | 1994-05-30 |
US5942388A (en) | 1999-08-24 |
EP0668502B1 (fr) | 2002-05-22 |
DE69526747T2 (de) | 2002-10-10 |
EP0668502A2 (fr) | 1995-08-23 |
JPH07301615A (ja) | 1995-11-14 |
JP3583496B2 (ja) | 2004-11-04 |
IL108726A (en) | 1999-12-31 |
ATE217966T1 (de) | 2002-06-15 |
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