DK0656360T3 - Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf - Google Patents

Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf

Info

Publication number
DK0656360T3
DK0656360T3 DK94908108T DK94908108T DK0656360T3 DK 0656360 T3 DK0656360 T3 DK 0656360T3 DK 94908108 T DK94908108 T DK 94908108T DK 94908108 T DK94908108 T DK 94908108T DK 0656360 T3 DK0656360 T3 DK 0656360T3
Authority
DK
Denmark
Prior art keywords
trifluoromethylpyrroloindole
ester derivatives
preparation
carboxyl ester
arylsulfonyloxy
Prior art date
Application number
DK94908108T
Other languages
Danish (da)
English (en)
Inventor
Shiro Terashima
Yasumichi Fukuda
Yasuo Oomori
Original Assignee
Sagami Chem Res
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chem Res, Kyorin Seiyaku Kk filed Critical Sagami Chem Res
Application granted granted Critical
Publication of DK0656360T3 publication Critical patent/DK0656360T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Laminated Bodies (AREA)
DK94908108T 1992-08-21 1993-08-19 Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf DK0656360T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22286292 1992-08-21
JP20425593A JP3514490B2 (ja) 1992-08-21 1993-08-18 トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法
PCT/JP1993/001159 WO1994004535A1 (en) 1992-08-21 1993-08-19 Trifluoromethylpyrroloindole carboxylic ester derivative and process for producing the same

Publications (1)

Publication Number Publication Date
DK0656360T3 true DK0656360T3 (da) 2003-03-17

Family

ID=26514369

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94908108T DK0656360T3 (da) 1992-08-21 1993-08-19 Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf

Country Status (13)

Country Link
US (1) US5629430A (de)
EP (1) EP0656360B1 (de)
JP (1) JP3514490B2 (de)
KR (2) KR100312444B1 (de)
AT (1) ATE228132T1 (de)
CA (1) CA2142869C (de)
DE (1) DE69332504T2 (de)
DK (1) DK0656360T3 (de)
ES (1) ES2188608T3 (de)
HU (1) HU221041B1 (de)
PT (1) PT656360E (de)
TW (1) TW394774B (de)
WO (1) WO1994004535A1 (de)

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CA2205872A1 (en) * 1994-11-29 1996-06-06 Kyorin Pharmaceutical Co., Ltd. Acrylamide derivatives and process for production thereof
AU3463197A (en) * 1996-07-23 1998-02-10 Kyowa Hakko Kogyo Co. Ltd. Dc-89 derivatives
EP0972775B1 (de) * 1997-01-24 2004-12-08 Kyorin Pharmaceutical Co., Ltd. Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung
JP2001525382A (ja) 1997-12-08 2001-12-11 ザ スクリップス リサーチ インスティテュート Ｃｃ−１０６５／デュオカルマイシン類似体の合成
MXPA03011094A (es) * 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
AU2003287160A1 (en) * 2002-10-15 2004-05-04 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
GB0403038D0 (en) 2004-02-11 2004-03-17 Novartis Ag Organic compounds
RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
EP1747021B1 (de) * 2004-05-19 2015-09-09 E. R. Squibb & Sons, L.L.C. Selbstimmolative verbinder und arzneimittelkonjugate
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
MX2007009878A (es) * 2005-02-18 2007-10-03 Medarex Inc Anticuerpos monoclonales para antigeno de membrana especifica para prostata (amep).
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
BRPI0617546A2 (pt) * 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
BRPI0619331A2 (pt) 2005-10-26 2011-09-27 Medarex Inc método para fazer um composto para preparar um análogo de cbi cc-1065, método para preparar um análogo de cbi cc-1065 e composto
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja) 2007-02-21 2010-06-03 メダレックス インコーポレイテッド 単一のアミノ酸を有する化学リンカーおよびその複合体
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
EP2219619B1 (de) * 2007-11-20 2020-07-15 Lankenau Institute for Medical Research Disulfid-chemotherapeutika und anwendungsverfahren dafür
WO2010062171A2 (en) * 2008-11-03 2010-06-03 Syntarga B.V. Novel cc-1065 analogs and their conjugates
EP2430178B1 (de) 2009-05-15 2014-07-09 Lankenau Institute for Medical Research Verfahren und kits zur messung der toxizität und des oxidativen stress in lebenden zellen
DK3056203T3 (da) * 2010-04-21 2018-01-29 Syntarga Bv Konjugater af cc-1065-analoger og bifunktionelle linkere.
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
CN105899237B (zh) 2014-01-10 2019-09-03 斯索恩生物制药有限公司 用于治疗子宫内膜癌的倍癌霉素adc
KR102344354B1 (ko) 2014-01-10 2021-12-28 비온디스 비.브이. 향상된 생체내 항종양 활성을 나타내는 듀오카르마이신 adc
DK3122757T3 (da) 2014-02-28 2023-10-09 Hangzhou Dac Biotech Co Ltd Ladede linkere og anvendelse deraf til konjugering
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
CN112724068A (zh) * 2020-12-30 2021-04-30 蔡桂坡 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用

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US4978757A (en) * 1984-02-21 1990-12-18 The Upjohn Company 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
JP2598116B2 (ja) * 1988-12-28 1997-04-09 協和醗酵工業株式会社 新規物質ｄｃ１１３
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
JP3037965B2 (ja) * 1990-06-20 2000-05-08 財団法人相模中央化学研究所 ２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
JPH0499774A (ja) * 1990-08-14 1992-03-31 Sagami Chem Res Center ２―エピデュオカルマイシンａおよびその製造中間体

Also Published As

Publication number Publication date
ATE228132T1 (de) 2002-12-15
EP0656360B1 (de) 2002-11-20
DE69332504D1 (de) 2003-01-02
WO1994004535A1 (en) 1994-03-03
PT656360E (pt) 2003-02-28
KR100312444B1 (ko) 2002-02-28
EP0656360A1 (de) 1995-06-07
ES2188608T3 (es) 2003-07-01
EP0656360A4 (de) 1995-08-30
CA2142869A1 (en) 1994-03-03
CA2142869C (en) 2002-01-01
KR100312445B1 (ko) 2001-11-09
HU9500494D0 (en) 1995-04-28
DE69332504T2 (de) 2003-10-02
TW394774B (en) 2000-06-21
US5629430A (en) 1997-05-13
HU221041B1 (hu) 2002-07-29
HUT71493A (en) 1995-11-28
JP3514490B2 (ja) 2004-03-31
JPH06116269A (ja) 1994-04-26
AU4761893A (en) 1994-03-15
AU689443B2 (en) 1998-04-02

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