ES2188608T3 - Derivado de ester trifluorometilpirroloindol carboxilico y proceso para su produccion. - Google Patents
Derivado de ester trifluorometilpirroloindol carboxilico y proceso para su produccion.Info
- Publication number
- ES2188608T3 ES2188608T3 ES94908108T ES94908108T ES2188608T3 ES 2188608 T3 ES2188608 T3 ES 2188608T3 ES 94908108 T ES94908108 T ES 94908108T ES 94908108 T ES94908108 T ES 94908108T ES 2188608 T3 ES2188608 T3 ES 2188608T3
- Authority
- ES
- Spain
- Prior art keywords
- trifluorometilpirroloindol
- ester
- carboxilico
- derived
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Laminated Bodies (AREA)
Abstract
DERIVADOS DE ESTER CARBOXILICO DE TRIFLUOROMETILPIRROLOINDOL REPRESENTADO POR LA FORMULA GENERAL (1) Y (2) QUE TIENE UNA ACTIVIDAD ANTITUMORAL ISOMEROS OPTICAMENTE ACTIVOS DE ESTOS, Y SALES FARMACEUTICAMENTE ACEPTABLES DE ESTOS, DONDE R REPRESENTA ALQUILO INFERIOR; R1 REPRESENTA UN RESIDUO DE ALFAAMINOACIDO, ETC. R2 REPRESENTA HIDROGENO, UN GRUPO PROTECTOR DE HIDROXILO, ETC; E Y REPRESENTA HALOGENO, ARILSULFONILOXI, ETC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22286292 | 1992-08-21 | ||
JP20425593A JP3514490B2 (ja) | 1992-08-21 | 1993-08-18 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2188608T3 true ES2188608T3 (es) | 2003-07-01 |
Family
ID=26514369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94908108T Expired - Lifetime ES2188608T3 (es) | 1992-08-21 | 1993-08-19 | Derivado de ester trifluorometilpirroloindol carboxilico y proceso para su produccion. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5629430A (es) |
EP (1) | EP0656360B1 (es) |
JP (1) | JP3514490B2 (es) |
KR (2) | KR100312444B1 (es) |
AT (1) | ATE228132T1 (es) |
CA (1) | CA2142869C (es) |
DE (1) | DE69332504T2 (es) |
DK (1) | DK0656360T3 (es) |
ES (1) | ES2188608T3 (es) |
HU (1) | HU221041B1 (es) |
PT (1) | PT656360E (es) |
TW (1) | TW394774B (es) |
WO (1) | WO1994004535A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1051552C (zh) * | 1994-11-29 | 2000-04-19 | 杏林制药株式会社 | 丙烯酰胺衍生物及其制造方法 |
AU3463197A (en) * | 1996-07-23 | 1998-02-10 | Kyowa Hakko Kogyo Co. Ltd. | Dc-89 derivatives |
AU5576098A (en) * | 1997-01-24 | 1998-08-18 | Kyorin Pharmaceutical Co. Ltd. | Pyrroloindole derivatives and intermediates in producing the same |
JP2001525382A (ja) | 1997-12-08 | 2001-12-11 | ザ スクリップス リサーチ インスティテュート | Cc−1065/デュオカルマイシン類似体の合成 |
CN101671335A (zh) | 2001-05-31 | 2010-03-17 | 梅达莱克斯公司 | 细胞毒素、其有用的前体药物、连接基团和稳定剂 |
AU2003287160A1 (en) * | 2002-10-15 | 2004-05-04 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
GB0403038D0 (en) * | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
MXPA06013413A (es) * | 2004-05-19 | 2007-01-23 | Medarex Inc | Enlazadores quimicos y conjugados de los mismos. |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
KR20070115967A (ko) * | 2005-02-18 | 2007-12-06 | 메다렉스, 인코포레이티드 | 전립선 특이 막 항원(psma)에 대한 인간 모노클로날항체 |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
EA016577B1 (ru) * | 2005-09-26 | 2012-06-29 | Медарекс, Инк. | Конъюгаты антитело-лекарство и их применение |
DK1940789T3 (da) | 2005-10-26 | 2012-03-19 | Medarex Inc | Fremgangsmåder og forbindelser til fremstilling af CC-1065-analoger |
CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
EP2121667B1 (en) | 2007-02-21 | 2016-06-08 | E. R. Squibb & Sons, L.L.C. | Chemical linkers with single amino acids and conjugates thereof |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
EP2219619B1 (en) * | 2007-11-20 | 2020-07-15 | Lankenau Institute for Medical Research | Disulfide chemotherapeutic agents and methods of use thereof |
AU2009320481C1 (en) * | 2008-11-03 | 2016-12-08 | Syntarga B.V. | Novel CC-1065 analogs and their conjugates |
EP2430178B1 (en) | 2009-05-15 | 2014-07-09 | Lankenau Institute for Medical Research | Methods and kits for measuring toxicity and oxidative stress in live cells |
RU2578719C9 (ru) | 2010-04-21 | 2016-10-10 | Синтарга Б.В. | Новые конъюгаты аналогов сс-1065 и бифункциональные линкеры |
JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
PL3069735T3 (pl) | 2014-01-10 | 2018-08-31 | Synthon Biopharmaceuticals B.V. | ADC duokarmycyny do zastosowania w leczeniu raka pęcherza |
CA2935430C (en) | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs for use in treatment of endometrial cancer |
PL3092010T3 (pl) | 2014-01-10 | 2019-01-31 | Synthon Biopharmaceuticals B.V. | Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek |
JP6417421B2 (ja) | 2014-02-28 | 2018-11-07 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 荷電連結体及び共役体のためのその使用 |
CN113350518A (zh) | 2015-07-12 | 2021-09-07 | 杭州多禧生物科技有限公司 | 与细胞结合分子的共轭偶联的桥连接体 |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
EP3538080A4 (en) | 2016-11-14 | 2020-07-08 | Hangzhou Dac Biotech Co., Ltd. | CONJUGATION LINERS, MEDICAMENT-MOLECULE CONJUGATES TO A CELL CONTAINING THE SAME, METHODS OF PREPARING AND USING SUCH CONJUGATES WITH THE BINDERS |
CN112724068A (zh) * | 2020-12-30 | 2021-04-30 | 蔡桂坡 | 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978757A (en) * | 1984-02-21 | 1990-12-18 | The Upjohn Company | 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds |
JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
JP2510335B2 (ja) * | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | Dc―88a誘導体 |
JP3037965B2 (ja) * | 1990-06-20 | 2000-05-08 | 財団法人相模中央化学研究所 | 2―アルコキシカルボニル―2―メチル―1―オキソ―1,2,3,6,7,8―ヘキサヒドロ―ベンゾ〔1,2―b;4,3―b´〕ジピロール誘導体 |
JPH0499774A (ja) * | 1990-08-14 | 1992-03-31 | Sagami Chem Res Center | 2―エピデュオカルマイシンaおよびその製造中間体 |
-
1993
- 1993-08-18 JP JP20425593A patent/JP3514490B2/ja not_active Expired - Fee Related
- 1993-08-19 US US08/381,981 patent/US5629430A/en not_active Expired - Fee Related
- 1993-08-19 DK DK94908108T patent/DK0656360T3/da active
- 1993-08-19 EP EP94908108A patent/EP0656360B1/en not_active Expired - Lifetime
- 1993-08-19 PT PT94908108T patent/PT656360E/pt unknown
- 1993-08-19 CA CA002142869A patent/CA2142869C/en not_active Expired - Fee Related
- 1993-08-19 WO PCT/JP1993/001159 patent/WO1994004535A1/ja active IP Right Grant
- 1993-08-19 DE DE69332504T patent/DE69332504T2/de not_active Expired - Fee Related
- 1993-08-19 KR KR1019950700666A patent/KR100312444B1/ko not_active IP Right Cessation
- 1993-08-19 ES ES94908108T patent/ES2188608T3/es not_active Expired - Lifetime
- 1993-08-19 HU HU9500494A patent/HU221041B1/hu not_active IP Right Cessation
- 1993-08-19 AT AT94908108T patent/ATE228132T1/de not_active IP Right Cessation
- 1993-10-04 TW TW082108171A patent/TW394774B/zh not_active IP Right Cessation
-
2001
- 2001-04-13 KR KR1020017004709A patent/KR100312445B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69332504T2 (de) | 2003-10-02 |
WO1994004535A1 (en) | 1994-03-03 |
DE69332504D1 (de) | 2003-01-02 |
CA2142869A1 (en) | 1994-03-03 |
HUT71493A (en) | 1995-11-28 |
PT656360E (pt) | 2003-02-28 |
TW394774B (en) | 2000-06-21 |
US5629430A (en) | 1997-05-13 |
HU221041B1 (hu) | 2002-07-29 |
EP0656360B1 (en) | 2002-11-20 |
AU689443B2 (en) | 1998-04-02 |
KR100312445B1 (ko) | 2001-11-09 |
EP0656360A4 (en) | 1995-08-30 |
HU9500494D0 (en) | 1995-04-28 |
DK0656360T3 (da) | 2003-03-17 |
JP3514490B2 (ja) | 2004-03-31 |
KR100312444B1 (ko) | 2002-02-28 |
JPH06116269A (ja) | 1994-04-26 |
AU4761893A (en) | 1994-03-15 |
EP0656360A1 (en) | 1995-06-07 |
CA2142869C (en) | 2002-01-01 |
ATE228132T1 (de) | 2002-12-15 |
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