DK0656002T3 - 3-Oxo-pyrido(1,2-a)benzimidazol-4-carboxyl- og 4-oxo-azepino(1,2-a)benzimidazol-5-carboxylderivater, som er anvendelige ved - Google Patents

3-Oxo-pyrido(1,2-a)benzimidazol-4-carboxyl- og 4-oxo-azepino(1,2-a)benzimidazol-5-carboxylderivater, som er anvendelige ved

Info

Publication number
DK0656002T3
DK0656002T3 DK93920193T DK93920193T DK0656002T3 DK 0656002 T3 DK0656002 T3 DK 0656002T3 DK 93920193 T DK93920193 T DK 93920193T DK 93920193 T DK93920193 T DK 93920193T DK 0656002 T3 DK0656002 T3 DK 0656002T3
Authority
DK
Denmark
Prior art keywords
benzimidazole
oxo
pct
carboxyl
compounds
Prior art date
Application number
DK93920193T
Other languages
Danish (da)
English (en)
Inventor
Bruce E Maryanoff
David F Mccomsey
Ho Winston
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Application granted granted Critical
Publication of DK0656002T3 publication Critical patent/DK0656002T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93920193T 1992-08-19 1993-08-18 3-Oxo-pyrido(1,2-a)benzimidazol-4-carboxyl- og 4-oxo-azepino(1,2-a)benzimidazol-5-carboxylderivater, som er anvendelige ved DK0656002T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93217692A 1992-08-19 1992-08-19
PCT/US1993/007794 WO1994004532A1 (en) 1992-08-19 1993-08-18 3-oxo-pyrido(1,2-a^_)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a^_)benzimidazole-5-carboxyl derivatives useful in treating central nervous system disorders

Publications (1)

Publication Number Publication Date
DK0656002T3 true DK0656002T3 (da) 2000-11-27

Family

ID=25461897

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93920193T DK0656002T3 (da) 1992-08-19 1993-08-18 3-Oxo-pyrido(1,2-a)benzimidazol-4-carboxyl- og 4-oxo-azepino(1,2-a)benzimidazol-5-carboxylderivater, som er anvendelige ved

Country Status (16)

Country Link
US (2) US5639760A (ja)
EP (1) EP0656002B1 (ja)
JP (1) JP3463935B2 (ja)
KR (1) KR100262762B1 (ja)
AT (1) ATE197455T1 (ja)
AU (1) AU679938B2 (ja)
BR (1) BR9306929A (ja)
CA (1) CA2142700C (ja)
DE (1) DE69329654T2 (ja)
DK (1) DK0656002T3 (ja)
ES (1) ES2153842T3 (ja)
GR (1) GR3035292T3 (ja)
HU (1) HU221369B1 (ja)
NZ (1) NZ255821A (ja)
PT (1) PT656002E (ja)
WO (1) WO1994004532A1 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE256126T1 (de) * 1996-10-07 2003-12-15 Ortho Mcneil Pharm Inc 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen
SI0935598T1 (en) * 1996-10-07 2004-04-30 Ortho-Mcneil Pharmaceutical, Inc. 5-HETEROATOM-CONTAINING ALKYL SUBSTITUTED-3-OXO-PYRIDO(1,2-a) BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
AU2003204221B2 (en) * 1997-10-07 2006-07-27 Ortho-Mcneil Pharmaceutical, Inc. Dipyridoimidazolderivatives useful in treating central nervous system disorders
CA2305342A1 (en) * 1997-10-07 1999-04-15 Ortho-Mcneil Pharmaceutical, Inc. Novel heterocyclic derivatives useful in treating central nervous system disorders
DE69810340T2 (de) * 1997-10-07 2003-10-30 Ortho-Mcneil Pharmaceutical, Inc. Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
AU2653499A (en) * 1998-02-04 1999-08-23 Neurogen Corporation Oxo-dipyridoimidazole-carboxamides: gaba brain receptor ligands
JP2002523399A (ja) * 1998-08-25 2002-07-30 ニューロゲン コーポレイション オキソ−ピリドイミダゾール−カルボキサミド：ｇａｂａ脳レセプタリガンド
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
CA2371472A1 (en) * 1999-05-06 2000-11-16 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
ES2260034T3 (es) * 1999-08-02 2006-11-01 Ortho-Mcneil Pharmaceutical, Inc. Derivados de pirido (1.2-a) bencimidazol sustituidos en c-6 utiles en el tratamiento de transtornos del sistema nervioso central.
GB0203058D0 (en) 2002-02-09 2002-03-27 Bp Chem Int Ltd Production of olefins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663934B1 (fr) * 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ES2153842T3 (es) 2001-03-16
KR100262762B1 (ko) 2000-08-01
HU221369B1 (en) 2002-09-28
PT656002E (pt) 2001-02-28
US6218384B1 (en) 2001-04-17
NZ255821A (en) 1996-10-28
DE69329654D1 (de) 2000-12-14
AU5080893A (en) 1994-03-15
ATE197455T1 (de) 2000-11-11
EP0656002A1 (en) 1995-06-07
EP0656002B1 (en) 2000-11-08
CA2142700A1 (en) 1994-03-03
JPH08500594A (ja) 1996-01-23
AU679938B2 (en) 1997-07-17
JP3463935B2 (ja) 2003-11-05
US5639760A (en) 1997-06-17
GR3035292T3 (en) 2001-04-30
DE69329654T2 (de) 2001-03-15
BR9306929A (pt) 1999-01-12
HU9500476D0 (en) 1995-04-28
HUT72654A (en) 1996-05-28
WO1994004532A1 (en) 1994-03-03
CA2142700C (en) 2007-01-09

Similar Documents

Publication Publication Date Title
IS5351A (is) Ný efnasambönd
DK0656002T3 (da) 3-Oxo-pyrido(1,2-a)benzimidazol-4-carboxyl- og 4-oxo-azepino(1,2-a)benzimidazol-5-carboxylderivater, som er anvendelige ved
ATE185548T1 (de) Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
PL323931A1 (en) Compositions of reversed emulsion of fluorine derivatives of hydrocarbons for use as drug delivering carriers
FI970150A0 (fi) Substituoituja pyrimidiiniyhdisteitä ja niiden käyttö
DE69804966D1 (de) Neue verbindungen
GEP20033081B (en) Pharmaceutical Agents for Treatment of Parkinson's Disease, ADFD and Microadenomas
ES2134929T3 (es) Derivados de pirrolo-piridina como ligandos para receptores de dopamina.
TR199901433T2 (xx) Pirolo$3,4-D] pirimidinon t�revleri ve bunlar�n ila� olarak kullan�mlar�.
SE9702564D0 (sv) New compounds
SE9702563D0 (sv) Compounds
FI19992039A (fi) Menetelmä atsepinonien valmistamiseksi
IS4367A (is) CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
NO953353L (no) Xantinderivater som adenosin-A -reseptorantagonister
ATE216891T1 (de) Verwendung von immunosuppressiva zur behandlung der schizophrenie
DK0648117T3 (da) Lægemiddel til at forebygge udvikling af tolerance ved behandling med benzodiazepin-receptor-bindende aktive forbindelser
MX9703288A (es) Oxazolil- y tiazolilimidazo-benzo- y tienodiacepinas y su uso como medicamentos.
ATE112256T1 (de) 9-amino-2-phenylbicyclo(3.3.1>nonane und 9-amino- 2-phenylbicyclo(3.3.1>-non-2-ene und diese enthaltende therapeutische mittel.
DK0691846T3 (da) Imidazoquinoxalinoner til behandling af sygdomme i centralnervesystemet
AU2796695A (en) Pyrrolidine derivatives for the treatment of cholecystokinine and gastrine-related disorders