DK0642513T3 - Indolcarbazolimider og deres anvendelse - Google Patents
Indolcarbazolimider og deres anvendelseInfo
- Publication number
- DK0642513T3 DK0642513T3 DK93912820T DK93912820T DK0642513T3 DK 0642513 T3 DK0642513 T3 DK 0642513T3 DK 93912820 T DK93912820 T DK 93912820T DK 93912820 T DK93912820 T DK 93912820T DK 0642513 T3 DK0642513 T3 DK 0642513T3
- Authority
- DK
- Denmark
- Prior art keywords
- diseases
- general formula
- well
- heart
- immune
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4217964A DE4217964A1 (de) | 1992-05-30 | 1992-05-30 | Indolocarbazol-Imide und deren Verwendung |
PCT/EP1993/001347 WO1993024491A1 (de) | 1992-05-30 | 1993-05-28 | Indolocarbazol-imide und deren verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0642513T3 true DK0642513T3 (da) | 2001-01-02 |
Family
ID=6460104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912820T DK0642513T3 (da) | 1992-05-30 | 1993-05-28 | Indolcarbazolimider og deres anvendelse |
Country Status (18)
Country | Link |
---|---|
US (2) | US5883114A (da) |
EP (1) | EP0642513B1 (da) |
JP (2) | JP3587522B2 (da) |
KR (1) | KR950701811A (da) |
AT (1) | ATE195315T1 (da) |
AU (1) | AU687350B2 (da) |
CA (1) | CA2135768C (da) |
CZ (1) | CZ295394A3 (da) |
DE (2) | DE4217964A1 (da) |
DK (1) | DK0642513T3 (da) |
ES (1) | ES2152252T3 (da) |
FI (1) | FI945625A0 (da) |
HU (1) | HUT71102A (da) |
NO (1) | NO302574B1 (da) |
NZ (1) | NZ253090A (da) |
RU (1) | RU2126007C1 (da) |
SK (1) | SK146394A3 (da) |
WO (1) | WO1993024491A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
EP0610519B1 (en) * | 1992-09-02 | 1999-12-01 | Kyowa Hakko Kogyo Co., Ltd. | Anti-hiv drug |
DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
US5468872A (en) * | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
DK0695755T3 (da) * | 1994-08-04 | 1999-06-28 | Hoffmann La Roche | Pyrrolocarbazoler |
WO1997041854A1 (en) * | 1996-05-07 | 1997-11-13 | The Trustees Of The University Of Pennsylvania | Inhibitors of glycogen synthase kinase-3 and methods for identifying and using the same |
PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US7122679B2 (en) * | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
ES2189597B2 (es) * | 2000-07-18 | 2004-06-16 | Fundacion Universitaria San Pablo-Ceu | Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos. |
WO2002028861A2 (en) * | 2000-09-29 | 2002-04-11 | Eli Lilly And Company | Methods and compounds for treating proliferative diseases |
KR100446090B1 (ko) * | 2000-10-19 | 2004-08-30 | 주식회사 엘컴사이언스 | 사우로락탐계 알카로이드의 퇴행성 뇌신경계 질환의 예방과 치료제로서의 용도 및 이 화합물을 유효성분으로 함유하는 약학적 제제 |
US7122526B2 (en) * | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
AU2002243442B2 (en) | 2000-10-31 | 2004-11-04 | Advanced Life Sciences, Inc. | Indolocarbazole anticancer agents and methods of using them |
EP1390029B1 (en) * | 2001-04-11 | 2009-12-16 | Idenix (Cayman) Limited | Phenylindoles for the treatment of hiv |
US7227019B2 (en) * | 2001-09-13 | 2007-06-05 | Bristol-Myers Squibb Company | Process for the preparation of rebeccamycin and analogs thereof |
TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
DE10161940A1 (de) * | 2001-12-17 | 2003-07-03 | Nad Ag | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
FR2833840B1 (fr) * | 2001-12-21 | 2010-06-18 | Rytek | Methodes et compositions pour le traitement de pathologies respiratoires |
EP1545510A4 (en) * | 2002-08-07 | 2006-11-15 | Idenix Cayman Ltd | SUBSTITUTED PHENYLINDOLE FOR THE TREATMENT OF HIV |
WO2004091663A1 (ja) * | 2003-04-18 | 2004-10-28 | Kyowa Hakko Kogyo Co., Ltd. | 神経再生薬 |
EP1799696B1 (en) | 2004-09-17 | 2008-11-12 | IDENIX Pharmaceuticals, Inc. | Phosphoindoles as hiv inhibitors |
FR2879100B1 (fr) * | 2004-12-09 | 2007-07-06 | Lionel Bueno | Compositions pour le traitement des pathologies oculaires de surface et de la retine |
US20070249590A1 (en) * | 2005-10-28 | 2007-10-25 | Wilson Lawrence J | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders |
JP2010504978A (ja) | 2006-09-29 | 2010-02-18 | アイデニクス ファーマシューティカルズ,インコーポレーテッド | Hiv阻害剤としての鏡像異性的に純粋なホスホインドール |
EP2047849A1 (en) * | 2007-10-08 | 2009-04-15 | KTB Tumorforschungsgesellschaft mbH | Use of indolocarbazole imides as protein kinase inhibitors for the treatment of hematologic and solid tumors |
JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムInserm | 神経筋接合部関連疾患の処置方法 |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
CN107556323B (zh) * | 2017-08-30 | 2019-09-20 | 浙江大学 | 一种氨基取代星孢菌素类化合物及其制备方法和应用 |
US11319320B2 (en) * | 2017-11-06 | 2022-05-03 | Snap Bio, Inc. | PIM kinase inhibitor compositions, methods, and uses thereof |
CN113980000B (zh) * | 2021-12-30 | 2022-05-20 | 北京鑫开元医药科技有限公司 | 甲基酮类衍生物、制备方法、药物组合物及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217885A (en) * | 1989-03-23 | 1993-06-08 | Banyu Pharmaceutical Co., Ltd. | Antitumor substance BE-13793C |
JP3010675B2 (ja) * | 1989-03-23 | 2000-02-21 | 萬有製薬株式会社 | 抗腫瘍性物質be―13793c |
ATE158298T1 (de) * | 1990-05-11 | 1997-10-15 | Banyu Pharma Co Ltd | Be-13793c-derivat mit antitumorwirkung |
EP0630242B1 (en) * | 1992-03-20 | 1999-01-20 | The Wellcome Foundation Limited | Further indole derivatives with antiviral activity |
-
1992
- 1992-05-30 DE DE4217964A patent/DE4217964A1/de not_active Withdrawn
-
1993
- 1993-05-28 WO PCT/EP1993/001347 patent/WO1993024491A1/de not_active Application Discontinuation
- 1993-05-28 EP EP93912820A patent/EP0642513B1/de not_active Expired - Lifetime
- 1993-05-28 HU HU9403419A patent/HUT71102A/hu unknown
- 1993-05-28 RU RU94046306A patent/RU2126007C1/ru not_active IP Right Cessation
- 1993-05-28 KR KR1019940704352A patent/KR950701811A/ko not_active Application Discontinuation
- 1993-05-28 AT AT93912820T patent/ATE195315T1/de not_active IP Right Cessation
- 1993-05-28 CA CA002135768A patent/CA2135768C/en not_active Expired - Fee Related
- 1993-05-28 AU AU43194/93A patent/AU687350B2/en not_active Ceased
- 1993-05-28 DK DK93912820T patent/DK0642513T3/da active
- 1993-05-28 SK SK1463-94A patent/SK146394A3/sk unknown
- 1993-05-28 US US08/343,435 patent/US5883114A/en not_active Expired - Fee Related
- 1993-05-28 NZ NZ253090A patent/NZ253090A/en unknown
- 1993-05-28 CZ CZ942953A patent/CZ295394A3/cs unknown
- 1993-05-28 JP JP50020494A patent/JP3587522B2/ja not_active Expired - Fee Related
- 1993-05-28 ES ES93912820T patent/ES2152252T3/es not_active Expired - Lifetime
- 1993-05-28 DE DE59310085T patent/DE59310085D1/de not_active Expired - Fee Related
-
1994
- 1994-11-29 NO NO944564A patent/NO302574B1/no not_active IP Right Cessation
- 1994-11-29 FI FI945625A patent/FI945625A0/fi unknown
-
1998
- 1998-05-07 US US09/074,139 patent/US5945440A/en not_active Expired - Fee Related
-
2003
- 2003-08-04 JP JP2003285658A patent/JP2004026842A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2004026842A (ja) | 2004-01-29 |
NZ253090A (en) | 1997-02-24 |
ATE195315T1 (de) | 2000-08-15 |
RU2126007C1 (ru) | 1999-02-10 |
CZ295394A3 (en) | 1995-03-15 |
CA2135768C (en) | 2004-11-23 |
NO944564L (no) | 1995-01-30 |
FI945625A (fi) | 1994-11-29 |
AU687350B2 (en) | 1998-02-26 |
DE59310085D1 (de) | 2000-09-14 |
KR950701811A (ko) | 1995-05-17 |
DE4217964A1 (de) | 1993-12-02 |
EP0642513B1 (de) | 2000-08-09 |
EP0642513A1 (de) | 1995-03-15 |
US5945440A (en) | 1999-08-31 |
NO944564D0 (no) | 1994-11-29 |
HU9403419D0 (en) | 1995-02-28 |
ES2152252T3 (es) | 2001-02-01 |
JP3587522B2 (ja) | 2004-11-10 |
WO1993024491A1 (de) | 1993-12-09 |
US5883114A (en) | 1999-03-16 |
FI945625A0 (fi) | 1994-11-29 |
SK146394A3 (en) | 1995-08-09 |
JPH07508268A (ja) | 1995-09-14 |
CA2135768A1 (en) | 1993-12-01 |
RU94046306A (ru) | 1996-10-27 |
AU4319493A (en) | 1993-12-30 |
NO302574B1 (no) | 1998-03-23 |
HUT71102A (en) | 1995-11-28 |
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