DK0641195T3 - Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning - Google Patents
Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkningInfo
- Publication number
- DK0641195T3 DK0641195T3 DK93912763.5T DK93912763T DK0641195T3 DK 0641195 T3 DK0641195 T3 DK 0641195T3 DK 93912763 T DK93912763 T DK 93912763T DK 0641195 T3 DK0641195 T3 DK 0641195T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- delayed
- preparation
- sec
- date
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4216948 | 1992-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0641195T3 true DK0641195T3 (da) | 1996-08-05 |
Family
ID=6459487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912763.5T DK0641195T3 (da) | 1992-05-22 | 1993-05-21 | Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning |
Country Status (11)
Country | Link |
---|---|
US (1) | US5792474A (fr) |
EP (1) | EP0641195B1 (fr) |
AT (1) | ATE136459T1 (fr) |
AU (1) | AU4316393A (fr) |
DE (1) | DE59302200D1 (fr) |
DK (1) | DK0641195T3 (fr) |
ES (1) | ES2086229T3 (fr) |
FI (1) | FI110233B (fr) |
GR (1) | GR3019734T3 (fr) |
HK (1) | HK1005307A1 (fr) |
WO (1) | WO1993024110A1 (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19522899C1 (de) * | 1995-06-23 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Verfahren zum kontinuierlichen Ersintern eines Granulats |
DE19705538C1 (de) * | 1997-02-14 | 1998-08-27 | Goedecke Ag | Verfahren zur Trennung von Wirkstoffen in festen pharmazeutischen Zubereitungen |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
CA2509958A1 (fr) * | 2003-02-03 | 2004-08-19 | Novartis Ag | Formulation pharmaceutique |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
CA2547774A1 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Procede de fabrication de formes multiparticulaires pharmaceutiques |
WO2005053652A1 (fr) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Compositions medicamenteuses cristallines multiparticulaires contenant un poloxamere et un glyceride |
ES2600577T3 (es) * | 2003-12-04 | 2017-02-09 | Bend Research, Inc. | Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos |
JP2007513139A (ja) * | 2003-12-04 | 2007-05-24 | ファイザー・プロダクツ・インク | 安定性の改善した多粒子組成物 |
BRPI0416535A (pt) * | 2003-12-04 | 2007-01-09 | Pfizer Prod Inc | processo de congelamento por vaporização empregando um extrusor para preparar composições de azitromicina de multiparticulado contendo preferivelmente um poloxámero e um glicerìdeo |
WO2005053639A2 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Formes multiparticulaires a liberation controlee produites avec des optimiseurs de dissolution |
WO2005053640A2 (fr) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Formes posologiques multiparticulaires d'azithromycine obtenues par des procedes se deroulant en milieu liquide |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
ES2441550T3 (es) * | 2007-12-21 | 2014-02-05 | Ludwig-Maximilians-Universität | Dispositivos extruidos con forma de varilla para la Iiberación controlada de sustancias biológicas a humanos y animales |
AU2009207796B2 (en) | 2008-01-25 | 2014-03-27 | Grunenthal Gmbh | Pharmaceutical dosage form |
ES2599031T3 (es) | 2008-05-09 | 2017-01-31 | Grünenthal GmbH | Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización |
PT2456424E (pt) | 2009-07-22 | 2013-09-30 | Gruenenthal Gmbh | Forma de dosagem resistente à adulteração e estabilizada contra a oxidação |
NZ596667A (en) | 2009-07-22 | 2013-09-27 | Gruenenthal Chemie | Hot-melt extruded controlled release dosage form |
WO2011095314A2 (fr) | 2010-02-03 | 2011-08-11 | Grünenthal GmbH | Préparation d'une composition pharmaceutique pulvérulente au moyen d'une extrudeuse |
MX2013002377A (es) | 2010-09-02 | 2013-04-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica. |
CA2808541C (fr) | 2010-09-02 | 2019-01-08 | Gruenenthal Gmbh | Forme pharmaceutique inviolable comportant un polymere anionique |
MX348054B (es) | 2011-07-29 | 2017-05-25 | Gruenenthal Gmbh | Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco. |
AR087360A1 (es) | 2011-07-29 | 2014-03-19 | Gruenenthal Gmbh | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
AU2013225106B2 (en) | 2012-02-28 | 2017-11-02 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
RS57913B1 (sr) | 2012-04-18 | 2019-01-31 | Gruenenthal Gmbh | Farmaceutske dozne forme otporne na neovlašćenu upotrebu i naglo oslobađanje celokupne doze |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形 |
JP6449871B2 (ja) | 2013-07-12 | 2019-01-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エチレン−酢酸ビニルポリマーを含有する改変防止剤形 |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
WO2015173195A1 (fr) | 2014-05-12 | 2015-11-19 | Grünenthal GmbH | Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol |
JP2017516789A (ja) | 2014-05-26 | 2017-06-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エタノール過量放出に対して防護されている多粒子 |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
EP3492070A1 (fr) * | 2017-11-30 | 2019-06-05 | BIT Pharma GmbH | Procédé et dispositif de préparation d'une dispersion solide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3013839A1 (de) * | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
DE3024416C2 (de) * | 1980-06-28 | 1982-04-15 | Gödecke AG, 1000 Berlin | Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung |
FR2581541B1 (fr) * | 1985-05-09 | 1988-05-20 | Rhone Poulenc Sante | Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation |
US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
-
1993
- 1993-05-21 US US08/362,592 patent/US5792474A/en not_active Expired - Lifetime
- 1993-05-21 AU AU43163/93A patent/AU4316393A/en not_active Abandoned
- 1993-05-21 DE DE59302200T patent/DE59302200D1/de not_active Expired - Lifetime
- 1993-05-21 AT AT93912763T patent/ATE136459T1/de active
- 1993-05-21 EP EP93912763A patent/EP0641195B1/fr not_active Expired - Lifetime
- 1993-05-21 ES ES93912763T patent/ES2086229T3/es not_active Expired - Lifetime
- 1993-05-21 DK DK93912763.5T patent/DK0641195T3/da active
- 1993-05-21 WO PCT/EP1993/001289 patent/WO1993024110A1/fr active IP Right Grant
-
1994
- 1994-11-21 FI FI945465A patent/FI110233B/fi not_active IP Right Cessation
-
1996
- 1996-04-23 GR GR960401120T patent/GR3019734T3/el unknown
-
1998
- 1998-05-22 HK HK98104468A patent/HK1005307A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE136459T1 (de) | 1996-04-15 |
HK1005307A1 (en) | 1998-12-31 |
AU4316393A (en) | 1993-12-30 |
FI110233B (fi) | 2002-12-31 |
WO1993024110A1 (fr) | 1993-12-09 |
US5792474A (en) | 1998-08-11 |
FI945465A (fi) | 1994-11-21 |
EP0641195A1 (fr) | 1995-03-08 |
DE59302200D1 (de) | 1996-05-15 |
FI945465A0 (fi) | 1994-11-21 |
EP0641195B1 (fr) | 1996-04-10 |
ES2086229T3 (es) | 1996-06-16 |
GR3019734T3 (en) | 1996-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0641195T3 (da) | Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning | |
DE69326163D1 (de) | Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen | |
DE3562555D1 (en) | Galenical form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion | |
HUP9802996A2 (hu) | Eljárás többrétegű, szilárd gyógyszerformák előállítására orális vagy rektális beadásra | |
KR0166599B1 (ko) | 활성성분 방출이 지연되는 용매없는 경구투여약제 조성물 및 상기 조성물의 제조방법 | |
FI905781A (fi) | Menetelmä farmaseuttisten koostumusten valmistamiseksi, jotka sisältävät sokerialkoholia ja homogeenisesti dispergoituna hiukkasmaista aktiivista yhdistettä | |
NO175620C (no) | Fremgangsmåte for fremstilling av et antitumorvirksomt legemiddel | |
DK1173265T3 (da) | Apparat og fremgangsmåde til krystallisation med ultralydstråler | |
ES2143089T3 (es) | Procedimiento para la fabricacion de pildoras con recubrimiento. | |
OA09528A (fr) | Nouveaux dérivés N-substitues de la quinoléine leur procédé de préparation les nouveaux intermédiaires obtenus leur application à titre de médicaments et les compositions pharmaceutiques les renfermant | |
HUP0002121A2 (hu) | Eljárás flurbiprofen gyógypasztillák előállítására | |
US4143156A (en) | Analgetic ester compounds, compositions and method of use | |
NZ337584A (en) | Preparing a glass-like plastic mass from sweetening agents in charging, melting and vacuum zones of an extruder | |
PT999828E (pt) | Processo para a producao de preparacoes de substancia activa com libertacao controlada a partir de uma matriz | |
US3474107A (en) | N-aromatic substituted acid amides | |
DK287982A (da) | Fremgangsmaade til tidsstyring af frigoerelsen af aktive stoffer fra midler med indhold deraf navnlig fra farmaceutiske praeparater | |
DK1123937T3 (da) | Substans GM-95, fremgangsmåde til dets fremstilling samt anvendelse deraf | |
FR2623501B1 (fr) | Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant | |
Burger et al. | Domino reactions with fluorinated five-membered heterocycles–syntheses of trifluoromethyl substituted butenolides and γ-ketoacids | |
JPH09183764A (ja) | N−ベンゾイルプロリンエステル誘導体 | |
DE60005805D1 (de) | Verfahren zur mikroverkapselung von arzneistoffen | |
MX9700821A (es) | Nueva utilizacion y derivados novedosos del imidazol, su procedimiento de preparacion, los nuevos intermediarios obtenidos, su aplicacion a manera de medicamentos y las composiciones farmaceuticas que los incluyen. | |
JPS55157586A (en) | N,n'-tetramethylene-cis-epoxysuccinic acid amide and its preparation |