DK0630376T3 - Kondenserede indolderivater som 5-HT4-receptorantagonister - Google Patents

Kondenserede indolderivater som 5-HT4-receptorantagonister

Info

Publication number
DK0630376T3
DK0630376T3 DK93905561T DK93905561T DK0630376T3 DK 0630376 T3 DK0630376 T3 DK 0630376T3 DK 93905561 T DK93905561 T DK 93905561T DK 93905561 T DK93905561 T DK 93905561T DK 0630376 T3 DK0630376 T3 DK 0630376T3
Authority
DK
Denmark
Prior art keywords
receptor antagonists
indole derivatives
condensed indole
condensed
derivatives
Prior art date
Application number
DK93905561T
Other languages
Danish (da)
English (en)
Inventor
Laramie Mary Gaster
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205428A external-priority patent/GB9205428D0/en
Priority claimed from GB929218846A external-priority patent/GB9218846D0/en
Priority claimed from GB929227045A external-priority patent/GB9227045D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0630376T3 publication Critical patent/DK0630376T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93905561T 1992-03-12 1993-03-10 Kondenserede indolderivater som 5-HT4-receptorantagonister DK0630376T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929205428A GB9205428D0 (en) 1992-03-12 1992-03-12 Pharmaceuticals
GB929218846A GB9218846D0 (en) 1992-09-05 1992-09-05 Pharmaceuticals
GB929227045A GB9227045D0 (en) 1992-12-29 1992-12-29 Pharmaceuticals
PCT/GB1993/000506 WO1993018036A1 (en) 1992-03-12 1993-03-10 Condensed indole derivatives as 5ht4-receptor antagonists

Publications (1)

Publication Number Publication Date
DK0630376T3 true DK0630376T3 (da) 1999-06-23

Family

ID=27266092

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93905561T DK0630376T3 (da) 1992-03-12 1993-03-10 Kondenserede indolderivater som 5-HT4-receptorantagonister
DK98114130T DK0884319T3 (da) 1992-03-12 1993-03-10 N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98114130T DK0884319T3 (da) 1992-03-12 1993-03-10 N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf

Country Status (30)

Country Link
EP (2) EP0884319B1 (no)
JP (1) JP2831467B2 (no)
KR (1) KR100282730B1 (no)
CN (2) CN1043893C (no)
AP (1) AP401A (no)
AT (2) ATE266033T1 (no)
AU (1) AU671102B2 (no)
CA (1) CA2131797C (no)
CY (1) CY2510B1 (no)
CZ (1) CZ286194B6 (no)
DE (2) DE69325167T2 (no)
DK (2) DK0630376T3 (no)
ES (2) ES2219813T3 (no)
FI (1) FI107158B (no)
GR (1) GR3030668T3 (no)
HK (1) HK1012352A1 (no)
HU (1) HU219121B (no)
IL (1) IL105003A (no)
MA (1) MA22819A1 (no)
MX (1) MX9301348A (no)
MY (1) MY110110A (no)
NO (1) NO303638B1 (no)
NZ (1) NZ249565A (no)
PT (1) PT884319E (no)
RU (1) RU2104279C1 (no)
SG (1) SG50693A1 (no)
SI (1) SI9300114B (no)
SK (1) SK281423B6 (no)
UA (1) UA41311C2 (no)
WO (1) WO1993018036A1 (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) * 1993-08-05 1993-09-22 Smithkline Beecham Plc Pharmaceuticals
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
WO1994010174A1 (en) * 1992-11-05 1994-05-11 Smithkline Beecham Plc Piperidine derivatives as 5-ht4 receptor antagonists
FR2699921B1 (fr) * 1992-12-30 1995-02-10 Synthelabo Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) * 1996-07-02 2000-01-11 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
CZ290517B6 (cs) * 1996-08-16 2002-08-14 Smithkline Beecham Plc Způsob přípravy N-[(1-n-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]-oxazino [3,2-a]indol-10-karboxamidu nebo jeho soli a meziprodukt pro tento způsob
US6100397A (en) * 1996-08-16 2000-08-08 Smithkline Beecham Plc Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) * 1996-09-11 1996-10-23 Smithkline Beecham Plc Pharmaceuticals
GB9725933D0 (en) * 1997-12-05 1998-02-04 Smithkline Beecham Plc Pharmaceuticals
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en) 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
BRPI9913542B8 (pt) * 1998-09-10 2021-05-25 Hoffmann La Roche derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos
GB9820294D0 (en) * 1998-09-17 1998-11-11 Smithkline Beecham Plc Pharmaceuticals
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU2005203196B9 (en) * 2000-08-07 2009-04-09 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) * 2000-08-07 2004-08-12 Smithkline Beecham Corp Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
AU2001276558B2 (en) * 2000-08-08 2005-11-24 Smithkline Beecham P.L.C. Pharmaceutical composition comprising condensed indole compound
NZ535261A (en) * 2000-08-08 2004-12-24 Smithkline Beecham P A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
NZ534333A (en) * 2002-02-14 2006-05-26 Glaxo Group Ltd Pharmaceutical composition comprising N-[(1-n-butyl-4-piperidinyl) methyl]-3,4-dihydro-2H-[1, 3]oxazino[3, 2-a]indole-10-carboxamide or salt, and process for preparing thereof comprising dry granulation
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ITMI20031467A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco attivo nel dolore neuropatico
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
US7834010B2 (en) 2003-12-23 2010-11-16 Serodus As Modulators of peripheral 5-HT receptors
JP4612301B2 (ja) * 2003-12-26 2011-01-12 広栄化学工業株式会社 １−アルキル−４−アミノメチルピペリジンの製造法
EP2173724B1 (en) 2007-06-22 2012-12-05 ArQule, Inc. Quinazolinone compounds and methods of use thereof
GB0905641D0 (en) * 2009-04-01 2009-05-13 Serodus As Compounds
WO2021116487A1 (en) 2019-12-13 2021-06-17 Som Innovation Biotech, S.A. Compounds for use in the treatment of niemann-pick c disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
US5206382A (en) * 1991-06-27 1993-04-27 Fidia Georgetown Institute For The Neurosciences Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders

Also Published As

Publication number Publication date
AP401A (en) 1995-08-29
FI944204A0 (fi) 1994-09-12
IL105003A (en) 1996-09-12
ES2219813T3 (es) 2004-12-01
CA2131797C (en) 2010-05-18
CN1043893C (zh) 1999-06-30
NO943348L (no) 1994-11-09
AU3644893A (en) 1993-10-05
FI107158B (fi) 2001-06-15
HUT71121A (en) 1995-11-28
KR100282730B1 (ko) 2001-02-15
HU9402601D0 (en) 1994-12-28
JPH07504433A (ja) 1995-05-18
UA41311C2 (uk) 2001-09-17
DK0884319T3 (da) 2004-08-30
FI944204A (fi) 1994-09-12
HU219121B (hu) 2001-02-28
MX9301348A (es) 1993-09-01
ATE266033T1 (de) 2004-05-15
RU94040864A (ru) 1996-07-20
SK281423B6 (sk) 2001-03-12
JP2831467B2 (ja) 1998-12-02
CZ286194B6 (cs) 2000-02-16
SG50693A1 (en) 1998-07-20
WO1993018036A1 (en) 1993-09-16
CZ221094A3 (en) 1995-09-13
ATE180785T1 (de) 1999-06-15
ES2132223T3 (es) 1999-08-16
DE69325167D1 (de) 1999-07-08
EP0630376A1 (en) 1994-12-28
CN1085083A (zh) 1994-04-13
AU671102B2 (en) 1996-08-15
SI9300114B (sl) 2006-08-31
DE69333504D1 (de) 2004-06-09
EP0884319B1 (en) 2004-05-06
SI9300114A (sl) 1993-12-31
HK1012352A1 (en) 1999-07-30
EP0630376B1 (en) 1999-06-02
RU2104279C1 (ru) 1998-02-10
SK107894A3 (en) 1995-04-12
AP9300494A0 (en) 1993-04-30
KR950700304A (ko) 1995-01-16
IL105003A0 (en) 1993-07-08
GR3030668T3 (en) 1999-10-29
CA2131797A1 (en) 1993-09-16
NO943348D0 (no) 1994-09-09
EP0884319A2 (en) 1998-12-16
DE69325167T2 (de) 2000-01-20
MY110110A (en) 1998-01-27
DE69333504T2 (de) 2005-05-12
NO303638B1 (no) 1998-08-10
CY2510B1 (en) 2005-12-23
EP0884319A3 (en) 1999-02-10
PT884319E (pt) 2004-09-30
CN1078471A (zh) 1993-11-17
NZ249565A (en) 1997-07-27
MA22819A1 (fr) 1993-10-01

Similar Documents

Publication Publication Date Title
DK0630376T3 (da) Kondenserede indolderivater som 5-HT4-receptorantagonister
FI973205A (fi) Indolijohdannaisia 5-HT-reseptoriantagonisteina
NO985225L (no) Indolderivater nyttige som endotelinreseptorantagonister
DK0856001T3 (da) Pyrimidinderivater som 5-HT2C-receptor-antagonister
DK0393936T3 (da) 3-substituerede 2-oxindolderivater som antiinflammatoriske midler
FI961628A0 (fi) Indolijohdannaisia NMDA-antagonisteina
NO974043D0 (no) Indolderivater som EAA-antagonister
NO985970D0 (no) Indolinderivater anvendelige som 5_HT-2C-reseptor-antagonister
FI951798A0 (fi) Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
NO985972D0 (no) Indolinderivater anvendelige som 5-HT-2C reseptorantagonister
NO963775L (no) Indol-derivater som CCK-reseptorantagonister
FI941117A (fi) Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina
SI0912556T1 (en) Indoline derivatives useful as 5-ht-2c receptor antagonists