DK0624097T3 - Målsøgende, radioaktive immunpræparater - Google Patents
Målsøgende, radioaktive immunpræparaterInfo
- Publication number
- DK0624097T3 DK0624097T3 DK91920573T DK91920573T DK0624097T3 DK 0624097 T3 DK0624097 T3 DK 0624097T3 DK 91920573 T DK91920573 T DK 91920573T DK 91920573 T DK91920573 T DK 91920573T DK 0624097 T3 DK0624097 T3 DK 0624097T3
- Authority
- DK
- Denmark
- Prior art keywords
- targeting radioactive
- immune preparations
- targeting
- radioactive immune
- preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1054—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61086190A | 1990-11-08 | 1990-11-08 | |
US07/784,333 US5367080A (en) | 1990-11-08 | 1991-10-29 | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
PCT/US1991/008253 WO1992008494A2 (fr) | 1990-11-08 | 1991-11-07 | Immunoreactifs de ciblage radioactifs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0624097T3 true DK0624097T3 (da) | 1998-10-19 |
Family
ID=27086372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91920573T DK0624097T3 (da) | 1990-11-08 | 1991-11-07 | Målsøgende, radioaktive immunpræparater |
Country Status (21)
Country | Link |
---|---|
US (4) | US5367080A (fr) |
EP (1) | EP0624097B1 (fr) |
JP (1) | JP3292301B2 (fr) |
KR (1) | KR930701974A (fr) |
AT (1) | ATE164082T1 (fr) |
AU (2) | AU667030B2 (fr) |
BR (1) | BR9107074A (fr) |
CA (1) | CA2095123A1 (fr) |
DE (1) | DE69129127T2 (fr) |
DK (1) | DK0624097T3 (fr) |
ES (1) | ES2113892T3 (fr) |
FI (1) | FI932083A (fr) |
GR (1) | GR3026713T3 (fr) |
HU (1) | HUT67298A (fr) |
IE (1) | IE913907A1 (fr) |
MX (1) | MX9101999A (fr) |
NO (1) | NO931631L (fr) |
NZ (1) | NZ240521A (fr) |
PT (1) | PT99460B (fr) |
TW (1) | TW201271B (fr) |
WO (1) | WO1992008494A2 (fr) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
DE69231952T2 (de) * | 1992-05-07 | 2002-04-04 | Nycomed Imaging As | Komplexbildnermittel und zielimmunoreagenzien |
CA2146990A1 (fr) * | 1992-10-14 | 1994-04-28 | Robert A. Snow | Polymeres de chelation |
WO1994014440A1 (fr) * | 1992-12-28 | 1994-07-07 | Taisho Pharmaceutical Co., Ltd. | Emploi pharmaceutique d'un derive de terpyridine |
US5760191A (en) * | 1993-02-05 | 1998-06-02 | Nycomed Imaging As | Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
JPH08512019A (ja) * | 1993-03-10 | 1996-12-17 | ザ・ウエルカム・ファウンデーション・リミテッド | 免疫反応剤およびキレート化された放射性核種からなるl−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング |
US5744119A (en) * | 1993-05-11 | 1998-04-28 | Sterling Winthrop | Preparation of a radioconjugate formulation |
US5559214A (en) | 1993-05-28 | 1996-09-24 | Sterling Winthrop Inc. | Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods |
EP0710244A1 (fr) * | 1993-06-07 | 1996-05-08 | The Wellcome Foundation Limited | Reactifs immunoreactifs utilisant la monoamine-oxydase |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
US5562626A (en) * | 1995-09-11 | 1996-10-08 | Sanpietro; Joseph A. | Safety syringe |
AUPO066096A0 (en) * | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
WO1998009650A1 (fr) | 1996-09-06 | 1998-03-12 | Mitsubishi Chemical Corporation | Preparations vaccinales |
AU9452198A (en) * | 1997-10-15 | 1999-05-17 | Nycomed Imaging As | Complexing agents and targeting immunoreagents |
AU2530199A (en) * | 1998-02-06 | 1999-08-23 | Nycomed Imaging As | Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
AU3375599A (en) * | 1998-03-31 | 1999-10-18 | Trustees Of Boston University | Methods for designing molecular conjugates and compositions thereof |
US6314314B1 (en) | 1999-01-14 | 2001-11-06 | Seth J. Karp | Method for locating an internal bleeding site in a human body |
TWI290146B (en) * | 1999-07-29 | 2007-11-21 | Dyax Corp | Binding moieties for fibrin |
JP5043271B2 (ja) * | 2000-04-12 | 2012-10-10 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドベースの化合物 |
NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
WO2002031865A1 (fr) * | 2000-10-13 | 2002-04-18 | Emcore Corporation | Procede de fabrication d'une electrode |
US7009040B2 (en) * | 2003-01-21 | 2006-03-07 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US6984373B2 (en) * | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
IL159310A0 (en) | 2001-07-10 | 2004-06-01 | Amersham Health As | Peptide-based compounds |
CA2471363C (fr) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Proteines hybrides d'albumine |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
EP1587944A4 (fr) | 2002-03-01 | 2007-03-21 | Dyax Corp | Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
CN100418981C (zh) | 2002-06-10 | 2008-09-17 | 瓦西尼斯公司 | 在乳腺癌和膀胱癌中差异表达的基因及编码多肽 |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
US7468254B2 (en) * | 2003-01-21 | 2008-12-23 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
DK2949658T3 (en) | 2003-03-03 | 2018-10-01 | Dyax Corp | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
BRPI0412824A (pt) * | 2003-07-24 | 2006-09-26 | Bracco Imaging Spa | composições radiofarmacêuticas estáveis e métodos para suas preparações |
EP2962699A3 (fr) | 2003-12-01 | 2016-04-06 | Immunomedics Inc. | Procede ameliore de preparation de conjugues de proteines et d'agents de chelation |
JP5042631B2 (ja) * | 2003-12-04 | 2012-10-03 | バクシネックス インコーポレーティッド | アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法 |
CA2561718A1 (fr) * | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Pyridines polycycliques constituant des modulateurs de canaux ioniques potassiques |
US20060024229A1 (en) * | 2004-07-29 | 2006-02-02 | Seth Karp | Method and product for locating an internal bleeding site |
US20100034748A1 (en) * | 2008-08-07 | 2010-02-11 | Guizhi Li | Molecular imaging probes based on loaded reactive nano-scale latex |
MX2008002233A (es) * | 2005-08-16 | 2008-03-27 | Univ North Carolina At Wilming | Ligandos para iones de metal y metodos para elaborar y usar los mismos. |
US20090098057A1 (en) * | 2007-10-16 | 2009-04-16 | Shiying Zheng | Silica-cored carrier particle |
DOP2007000020A (es) | 2006-01-31 | 2007-09-15 | Bayer Schering Pharma Ag | Modulación de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias |
US20080167544A1 (en) * | 2006-12-01 | 2008-07-10 | Cold Spring Diagnostics, Inc. | Compositions And Methods For Locating An Internal Bleeding Site |
EP2111237B1 (fr) | 2006-12-11 | 2015-03-18 | BRACCO IMAGING S.p.A. | Peptides se fixant à la fibrine, et conjugués correspondants |
US8906354B2 (en) | 2007-02-28 | 2014-12-09 | Bruker Biospin Corporation | Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes |
EP2005970A1 (fr) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Imagerie Diagnostique par combinaison de moyens de contraste |
CA2710680C (fr) * | 2007-12-26 | 2018-10-16 | Vaccinex, Inc. | Therapies de combinaison par anticorps anti-c35 et procedes |
EP2100900A1 (fr) | 2008-03-07 | 2009-09-16 | Universitätsspital Basel | Conjugués d'antagoniste de peptide analogue de bombésine |
EP2147684A1 (fr) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Agents de diagnostics sélectifs contre les métalloprotéases |
US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
WO2010121133A2 (fr) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Imagerie multimodale de fibrine |
CN102356087A (zh) | 2009-03-19 | 2012-02-15 | 惠氏有限责任公司 | [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法 |
WO2011030566A1 (fr) * | 2009-09-14 | 2011-03-17 | Eisai R&D Management Co., Ltd. | Dérivés de phénanthroline et leur utilisation comme ligands |
FR2969999B1 (fr) * | 2011-01-03 | 2013-02-08 | Commissariat Energie Atomique | Conjugue, son procede de preparation et ses utilisations |
WO2012124310A1 (fr) * | 2011-03-11 | 2012-09-20 | B.R.A.H.M.S Gmbh | Complexe de métaux de terre rare présentant un composé phénanthroline en tant que ligand |
WO2013048832A1 (fr) | 2011-09-29 | 2013-04-04 | Ge Healthcare Limited | 6-(2-fluroéthoxy)-2-naphtaldéhyde marqué au 18f pour détecter des cellules souches cancéreuses |
EP2740726A1 (fr) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Ligands de récepteurs de la neurotensine |
SG11201507287SA (en) | 2013-03-15 | 2015-10-29 | Univ California | Peptides having reduced toxicity that stimulate cholesterol efflux |
WO2015171543A1 (fr) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Agents de capture mutants spécifiques d'akt, compositions et procédés d'utilisation et de préparation associés |
EP2954934A1 (fr) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugué comprenant un ligand du récepteur de la neurotensine et son utilisation |
WO2015188934A1 (fr) | 2014-06-10 | 2015-12-17 | 3B Pharmaceuticals Gmbh | Conjugué comprenant un ligand de récepteur de neurotensine et son utilisation |
EP2954933A1 (fr) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugué comprenant un ligand du récepteur de la neurotensine |
CN115112898A (zh) | 2015-07-15 | 2022-09-27 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
KR20180104166A (ko) | 2016-02-09 | 2018-09-19 | 브라코 스위스 에스.에이. | 셀렉틴 표적화를 위한 재조합 키메라 단백질 |
US20170319722A1 (en) | 2016-04-04 | 2017-11-09 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
EP3279197A1 (fr) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Le diagnostic, le traitement et la prévention d'états associes au récepteur de neurotensine |
EP3519425B1 (fr) | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Compositions pour la détection, l'inhibition et l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1) et leurs méthodes de production et d'utilisation |
EP3535278A4 (fr) | 2016-11-01 | 2020-06-24 | Ohio State Innovation Foundation | Procédés d'iodation de biomolécules |
US11719705B2 (en) | 2017-06-15 | 2023-08-08 | Indi Molecular, Inc. | IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making |
WO2020097531A1 (fr) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Agents de capture théranostiques, compositions et procédés d'utilisation et de fabrication |
WO2020186091A1 (fr) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Épitopes réticulés et leurs méthodes d'utilisation |
WO2020236969A1 (fr) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions et procédés se rapportant à la détection, à l'inhibition et à l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1) |
EP3763726A1 (fr) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Composés comprenant un ligand de protéine d'activation de fibroblastes et leur utilisation |
CA3145872A1 (fr) | 2019-07-08 | 2021-01-14 | 3B Pharmaceuticals Gmbh | Composes comprenant un ligand de proteine d'activation des fibroblastes et leur utilisation |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098743A1 (fr) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imagerie et procédés thérapeutiques ciblant le récepteur 1 de folate (folr1) |
WO2022098745A1 (fr) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, systèmes d'administration et méthodes utiles dans la thérapie antitumorale |
WO2022123462A1 (fr) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Inhibiteurs d'antigène membranaire spécifique de la prostate (psma) radiomarqués et leur utilisation |
EP4050018A1 (fr) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Composés comprenant un ligand de protéine d'activation de fibroblastes et leur utilisation |
AU2022205523A1 (en) | 2021-01-07 | 2023-07-13 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
EP4122499A1 (fr) | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Inhibiteurs de protéine d'activation de fibroblastes et son utilisation |
AR128023A1 (es) | 2021-12-17 | 2024-03-20 | 3B Pharmaceuticals Gmbh | Ligandos de anhidrasa carbónica ix |
WO2024052431A1 (fr) | 2022-09-07 | 2024-03-14 | 3B Pharmaceuticals Gmbh | Ligands d'antigène membranaire spécifique de la prostate (psma) et utilisation associée |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4637988A (en) * | 1981-07-01 | 1987-01-20 | Eastman Kodak Company | Fluorescent labels for immunoassay |
US4794191A (en) * | 1981-07-01 | 1988-12-27 | Eastman Kodak Company | Fluorescent chelates |
US4670572A (en) * | 1981-07-01 | 1987-06-02 | Eastman Kodak Company | Phenolic fluorescent labels |
US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
US4801722A (en) * | 1981-07-01 | 1989-01-31 | Eastman Kodak Company | Coumarin chelates |
US4837169A (en) * | 1981-07-01 | 1989-06-06 | Eastman Kodak Company | Polypyridine Fluorescent labels for immunoassay |
US4767611A (en) * | 1984-07-03 | 1988-08-30 | Gordon Robert T | Method for affecting intracellular and extracellular electric and magnetic dipoles |
DE3580420D1 (de) * | 1984-08-13 | 1990-12-13 | Hsc Res Dev Corp | 1,10-phenanthrolin-2,9-dicarbonsaeure-derivate und deren verwendung fuer fluoreszens-immunoassay. |
DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
US5075447A (en) * | 1984-09-17 | 1991-12-24 | Hoffmann-La Roche Inc. | Ruthenium complexes useful as carriers for immunologically active materials |
US4761481A (en) * | 1985-03-18 | 1988-08-02 | Baxter Travenol Laboratories, Inc. | Substituted pyridine derivatives |
SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
DE3789430T2 (de) * | 1986-06-17 | 1994-10-27 | Baxter Diagnostics Inc | Homogenes fluortestverfahren mit abstoss des fluorzenten hintergrundes. |
ZA877727B (en) * | 1986-10-17 | 1988-06-29 | Cytogen Corp | Method for preparation of protein-chelator-metal ion compositions suitable for injection |
SE8702824L (sv) * | 1987-07-10 | 1989-01-11 | Wallac Oy | Metall-kelaterande 2,6-disubstituerade pyridinfoereningar och deras anvaendning |
US5032677A (en) * | 1987-11-06 | 1991-07-16 | Baxter International Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
JPH082878B2 (ja) * | 1988-02-12 | 1996-01-17 | 富士写真フイルム株式会社 | 4’−アルコキシ−2,2’:6’,2〃−デルピリジン誘導体及びその金属錯体 |
SE8800613D0 (sv) * | 1988-02-23 | 1988-02-23 | Wallac Oy | A novel spectrofluorometric method and compounds that are of value for the method |
SE8802575D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Terpyridine derivatives |
US5202423A (en) * | 1988-07-08 | 1993-04-13 | Wallac Oy | Terpyridine derivatives |
FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
GB8927503D0 (en) * | 1989-12-04 | 1990-02-07 | Kronem Systems Inc | Enzyme-amplified lanthanide chelate luminescence |
GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
-
1991
- 1991-10-29 US US07/784,333 patent/US5367080A/en not_active Expired - Lifetime
- 1991-11-07 JP JP50016592A patent/JP3292301B2/ja not_active Expired - Lifetime
- 1991-11-07 DK DK91920573T patent/DK0624097T3/da active
- 1991-11-07 ES ES91920573T patent/ES2113892T3/es not_active Expired - Lifetime
- 1991-11-07 WO PCT/US1991/008253 patent/WO1992008494A2/fr active IP Right Grant
- 1991-11-07 AT AT91920573T patent/ATE164082T1/de active
- 1991-11-07 BR BR919107074A patent/BR9107074A/pt not_active Application Discontinuation
- 1991-11-07 KR KR1019930701386A patent/KR930701974A/ko not_active IP Right Cessation
- 1991-11-07 AU AU90291/91A patent/AU667030B2/en not_active Expired
- 1991-11-07 EP EP91920573A patent/EP0624097B1/fr not_active Expired - Lifetime
- 1991-11-07 HU HU9301328A patent/HUT67298A/hu unknown
- 1991-11-07 DE DE69129127T patent/DE69129127T2/de not_active Expired - Lifetime
- 1991-11-07 CA CA002095123A patent/CA2095123A1/fr not_active Abandoned
- 1991-11-08 MX MX9101999A patent/MX9101999A/es unknown
- 1991-11-08 IE IE390791A patent/IE913907A1/en unknown
- 1991-11-08 NZ NZ240521A patent/NZ240521A/en unknown
- 1991-11-08 PT PT99460A patent/PT99460B/pt not_active IP Right Cessation
-
1992
- 1992-01-07 TW TW081100086A patent/TW201271B/zh active
-
1993
- 1993-05-05 NO NO93931631A patent/NO931631L/no unknown
- 1993-05-07 FI FI932083A patent/FI932083A/fi not_active Application Discontinuation
-
1994
- 1994-08-08 US US08/287,381 patent/US5523402A/en not_active Expired - Lifetime
-
1995
- 1995-01-19 US US08/375,276 patent/US5707603A/en not_active Expired - Lifetime
- 1995-12-15 US US08/573,377 patent/US5677445A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 AU AU55835/96A patent/AU5583596A/en not_active Abandoned
-
1998
- 1998-04-23 GR GR980400901T patent/GR3026713T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI932083A (fi) | 1993-07-02 |
US5677445A (en) | 1997-10-14 |
JPH06501703A (ja) | 1994-02-24 |
TW201271B (fr) | 1993-03-01 |
MX9101999A (es) | 1992-06-01 |
EP0624097A1 (fr) | 1994-11-17 |
ES2113892T3 (es) | 1998-05-16 |
CA2095123A1 (fr) | 1992-05-09 |
AU9029191A (en) | 1992-06-11 |
BR9107074A (pt) | 1993-09-21 |
JP3292301B2 (ja) | 2002-06-17 |
AU5583596A (en) | 1996-08-01 |
PT99460B (pt) | 1999-02-26 |
NO931631D0 (no) | 1993-05-05 |
WO1992008494A3 (fr) | 1993-07-08 |
ATE164082T1 (de) | 1998-04-15 |
EP0624097B1 (fr) | 1998-03-18 |
DE69129127T2 (de) | 1998-10-08 |
IE913907A1 (en) | 1992-05-20 |
DE69129127D1 (de) | 1998-04-23 |
US5367080A (en) | 1994-11-22 |
FI932083A0 (fi) | 1993-05-07 |
NZ240521A (en) | 1995-01-27 |
US5707603A (en) | 1998-01-13 |
WO1992008494A2 (fr) | 1992-05-29 |
HU9301328D0 (en) | 1993-10-28 |
AU667030B2 (en) | 1996-03-07 |
GR3026713T3 (en) | 1998-07-31 |
NO931631L (no) | 1993-06-23 |
PT99460A (pt) | 1992-09-30 |
KR930701974A (ko) | 1993-09-08 |
HUT67298A (en) | 1995-03-28 |
US5523402A (en) | 1996-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0624097T3 (da) | Målsøgende, radioaktive immunpræparater | |
MX9203481A (es) | Formulaciones. | |
DE69114161D1 (de) | Optoelektronische Baugruppe. | |
DE69016649D1 (de) | Schnellkupplung. | |
FR2663154B1 (fr) | Tube cathodique. | |
DE69101443D1 (de) | Übertragungsverbindung. | |
DE69109776D1 (de) | Hochfluss-Neutronenröhre. | |
DE69100600D1 (de) | Kupplungsanordnung. | |
FI912608A (fi) | Skruvhjulspump och stator. | |
FI910821A0 (fi) | Naolar omfattande suturfoerpackning. | |
DE69106636D1 (de) | Abbildungssystem. | |
ITTO910643A1 (it) | Procedimento di galvanostegia. | |
FI923024A0 (fi) | Foerfarande och anordning foer likstroemsmatning till en telefonlinje. | |
FI910728A (fi) | Leukotrien-antagonister beroerande och till dessa hoerande foerbaettringar. | |
DE69103945D1 (de) | Cyclohexapeptidverbindung. | |
DE69102438D1 (de) | Magnetische Abschirmung. | |
DE69108732D1 (de) | Thermoaktivierbare kupplung. | |
FR2667516B1 (fr) | Tube broyeur. | |
DE59103806D1 (de) | Lecksuchgerät. | |
DE69114479D1 (de) | Lagedetektor. | |
FI913548A (fi) | Uppblaosbar och toembar dyna och med en saodan dyna foersett lyftdon. | |
DE69108851D1 (de) | Verbund-Supraleiter. | |
FI902174A0 (fi) | Arakidonsyraderivat innehaollande fluor. | |
FI914033A0 (fi) | Madrass. p2 path slues6208 s911113 mlues6208 m911118 | |
DE59106165D1 (de) | Kathodenstrahlröhre. |