DK0610134T3 - Indolderivater som 5-HT,1-lignende agonister - Google Patents

Indolderivater som 5-HT,1-lignende agonister

Info

Publication number
DK0610134T3
DK0610134T3 DK94400215T DK94400215T DK0610134T3 DK 0610134 T3 DK0610134 T3 DK 0610134T3 DK 94400215 T DK94400215 T DK 94400215T DK 94400215 T DK94400215 T DK 94400215T DK 0610134 T3 DK0610134 T3 DK 0610134T3
Authority
DK
Denmark
Prior art keywords
image
alkyl
group
hydrogen atom
agonists
Prior art date
Application number
DK94400215T
Other languages
Danish (da)
English (en)
Inventor
Michel Laubie
Gilbert Lavielle
Tony Verbeuren
Philippe Maillos
Olivier Muller
Jean-Jacques Descombes
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0610134T3 publication Critical patent/DK0610134T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK94400215T 1993-02-02 1994-02-02 Indolderivater som 5-HT,1-lignende agonister DK0610134T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301054A FR2701026B1 (fr) 1993-02-02 1993-02-02 Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
DK0610134T3 true DK0610134T3 (da) 2000-08-21

Family

ID=9443592

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94400215T DK0610134T3 (da) 1993-02-02 1994-02-02 Indolderivater som 5-HT,1-lignende agonister

Country Status (14)

Country Link
US (1) US5348968A (ja)
EP (1) EP0610134B1 (ja)
JP (1) JP2614981B2 (ja)
AT (1) ATE191481T1 (ja)
AU (1) AU669032B2 (ja)
CA (1) CA2114593C (ja)
DE (1) DE69423802T2 (ja)
DK (1) DK0610134T3 (ja)
ES (1) ES2147223T3 (ja)
FR (1) FR2701026B1 (ja)
GR (1) GR3033505T3 (ja)
NZ (1) NZ250800A (ja)
PT (1) PT610134E (ja)
ZA (1) ZA94709B (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
ATE190608T1 (de) * 1991-11-25 2000-04-15 Pfizer 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
ES2122289T3 (es) * 1993-08-31 1998-12-16 Pfizer Derivados de 5-arilindol.
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
PT765322E (pt) * 1994-06-01 2002-01-30 Astrazeneca Ab Derivados indole pro-farmacos de agonistas de receptores tipo 5-ht1
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
FR2735129B1 (fr) * 1995-06-07 1997-07-11 Adir Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5856510A (en) * 1996-12-16 1999-01-05 Allelix Biopharmaceuticals Inc. 5-alkenyl and 5-alkynyl indole compounds
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
WO2002051832A2 (en) * 2000-12-22 2002-07-04 Wyeth Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US20060154897A1 (en) * 2002-11-08 2006-07-13 Doherty James B Ophthalmic compositions for treating ocular hypertension
WO2004050634A1 (en) * 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
EP1651232B1 (en) * 2003-07-23 2010-12-22 Synta Pharmaceuticals Corporation Compounds for inflammation and immune-related uses
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
MX2007006408A (es) 2004-11-29 2007-06-22 Warner Lambert Co Pirazolo[3,4-b]piridinas e indazoles terapeuticos.
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
CN101583593A (zh) * 2006-11-13 2009-11-18 辉瑞产品公司 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
JP2012520257A (ja) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8301210A1 (es) * 1980-08-12 1982-12-01 Glaxo Group Ltd Un procedimiento para la preparacion de un derivado del indol.
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
YU48855B (sh) * 1990-06-07 2002-06-19 The Wellcome Foundation Limited Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja
AU651637B2 (en) * 1990-10-15 1994-07-28 Pfizer Inc. Indole derivatives
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
JPH06508354A (ja) * 1991-06-21 1994-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用

Also Published As

Publication number Publication date
DE69423802D1 (de) 2000-05-11
CA2114593C (fr) 2002-04-16
NZ250800A (en) 1995-03-28
DE69423802T2 (de) 2000-11-09
EP0610134A1 (fr) 1994-08-10
JPH06271571A (ja) 1994-09-27
EP0610134B1 (fr) 2000-04-05
ZA94709B (en) 1994-09-06
GR3033505T3 (en) 2000-09-29
FR2701026B1 (fr) 1995-03-31
US5348968A (en) 1994-09-20
ATE191481T1 (de) 2000-04-15
PT610134E (pt) 2000-07-31
ES2147223T3 (es) 2000-09-01
AU5481794A (en) 1994-08-04
AU669032B2 (en) 1996-05-23
CA2114593A1 (fr) 1994-08-03
JP2614981B2 (ja) 1997-05-28
FR2701026A1 (fr) 1994-08-05

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