GR3033505T3 - Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists. - Google Patents

Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists.

Info

Publication number
GR3033505T3
GR3033505T3 GR20000401196T GR20000401196T GR3033505T3 GR 3033505 T3 GR3033505 T3 GR 3033505T3 GR 20000401196 T GR20000401196 T GR 20000401196T GR 20000401196 T GR20000401196 T GR 20000401196T GR 3033505 T3 GR3033505 T3 GR 3033505T3
Authority
GR
Greece
Prior art keywords
image
alkyl
group
hydrogen atom
indazole
Prior art date
Application number
GR20000401196T
Other languages
English (en)
Inventor
Gilbert Lavielle
Philippe Maillos
Olivier Muller
Michel Laubie
Tony Verbeuren
Jean-Jacques Descombes
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of GR3033505T3 publication Critical patent/GR3033505T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
GR20000401196T 1993-02-02 2000-05-25 Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists. GR3033505T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301054A FR2701026B1 (fr) 1993-02-02 1993-02-02 Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
GR3033505T3 true GR3033505T3 (en) 2000-09-29

Family

ID=9443592

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000401196T GR3033505T3 (en) 1993-02-02 2000-05-25 Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists.

Country Status (14)

Country Link
US (1) US5348968A (el)
EP (1) EP0610134B1 (el)
JP (1) JP2614981B2 (el)
AT (1) ATE191481T1 (el)
AU (1) AU669032B2 (el)
CA (1) CA2114593C (el)
DE (1) DE69423802T2 (el)
DK (1) DK0610134T3 (el)
ES (1) ES2147223T3 (el)
FR (1) FR2701026B1 (el)
GR (1) GR3033505T3 (el)
NZ (1) NZ250800A (el)
PT (1) PT610134E (el)
ZA (1) ZA94709B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
DK0619805T3 (da) * 1991-11-25 2000-06-05 Pfizer 5-(Hetero-eller carbocyclylamino)-indolderivater, deres fremstilling og anvendelse som 5-HT1-agonister
HUT75646A (en) * 1993-08-31 1997-05-28 Pfizer 5-arylindole derivatives and pharmaceutical compositions containing them
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
US5962486A (en) * 1994-06-01 1999-10-05 Zeneca Limited Indole derivatives as prodrugs of 5-HT1 -like receptor agonists
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
FR2735129B1 (fr) * 1995-06-07 1997-07-11 Adir Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5856510A (en) * 1996-12-16 1999-01-05 Allelix Biopharmaceuticals Inc. 5-alkenyl and 5-alkynyl indole compounds
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
IL156518A0 (en) 2000-12-22 2004-01-04 Wyeth Corp Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US20060154897A1 (en) * 2002-11-08 2006-07-13 Doherty James B Ophthalmic compositions for treating ocular hypertension
ATE399768T1 (de) * 2002-12-02 2008-07-15 Hoffmann La Roche Indazolderivate und ihre verwendung als crf antagonisten
MXPA06000836A (es) * 2003-07-23 2006-05-04 Synta Pharmaceuticals Corp Compuestos para usos inmuno-relacionados e inflamacion.
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
CA2588812A1 (en) * 2004-11-29 2006-06-01 Warner-Lambert Company Llc Therapeutic pyrazolo[3,4-b] pyridines and indazoles
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
WO2008059335A1 (en) * 2006-11-13 2008-05-22 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548467B2 (en) * 1980-08-12 1985-12-12 Glaxo Group Limited Tryptamines and their isoindolylethyl derivatives
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
MY110226A (en) * 1990-06-07 1998-03-31 Astrazeneca Ab Therapeutic heterocyclic compounds.
DE9190141U1 (de) * 1990-10-15 1993-07-15 Pfizer Inc., New York, N.Y. Indolderivate
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
JPH06508354A (ja) * 1991-06-21 1994-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー トリプタミン類似体、その合成法およびその５−ｈｔ↓１様または５−ｈｔ↓２受容体作用物質としての使用

Also Published As

Publication number Publication date
NZ250800A (en) 1995-03-28
ATE191481T1 (de) 2000-04-15
EP0610134B1 (fr) 2000-04-05
ES2147223T3 (es) 2000-09-01
JPH06271571A (ja) 1994-09-27
ZA94709B (en) 1994-09-06
CA2114593C (fr) 2002-04-16
FR2701026B1 (fr) 1995-03-31
US5348968A (en) 1994-09-20
FR2701026A1 (fr) 1994-08-05
AU5481794A (en) 1994-08-04
DE69423802T2 (de) 2000-11-09
JP2614981B2 (ja) 1997-05-28
CA2114593A1 (fr) 1994-08-03
PT610134E (pt) 2000-07-31
DK0610134T3 (da) 2000-08-21
DE69423802D1 (de) 2000-05-11
EP0610134A1 (fr) 1994-08-10
AU669032B2 (en) 1996-05-23

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