DK0589719T3 - Modificeret blodpladefaktor-4 - Google Patents

Modificeret blodpladefaktor-4

Info

Publication number
DK0589719T3
DK0589719T3 DK93307592.1T DK93307592T DK0589719T3 DK 0589719 T3 DK0589719 T3 DK 0589719T3 DK 93307592 T DK93307592 T DK 93307592T DK 0589719 T3 DK0589719 T3 DK 0589719T3
Authority
DK
Denmark
Prior art keywords
platelet factor
mpf
cpf
potent
modified platelet
Prior art date
Application number
DK93307592.1T
Other languages
English (en)
Inventor
Shalley Kant Gupta
Jai Pal Singh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0589719T3 publication Critical patent/DK0589719T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK93307592.1T 1992-09-25 1993-09-24 Modificeret blodpladefaktor-4 DK0589719T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95279792A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
DK0589719T3 true DK0589719T3 (da) 1997-09-08

Family

ID=25493243

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93307592.1T DK0589719T3 (da) 1992-09-25 1993-09-24 Modificeret blodpladefaktor-4

Country Status (24)

Country Link
US (3) US5512550A (da)
EP (1) EP0589719B1 (da)
JP (1) JPH06220091A (da)
KR (1) KR940007059A (da)
CN (1) CN1035257C (da)
AT (1) ATE151777T1 (da)
AU (1) AU665114B2 (da)
BR (1) BR9303903A (da)
CA (1) CA2106629A1 (da)
CZ (1) CZ195193A3 (da)
DE (1) DE69309827T2 (da)
DK (1) DK0589719T3 (da)
ES (1) ES2101237T3 (da)
FI (1) FI934183A (da)
GR (1) GR3023356T3 (da)
HK (1) HK100597A (da)
HU (1) HUT69928A (da)
IL (1) IL107040A0 (da)
MX (1) MX9305901A (da)
MY (1) MY109158A (da)
NO (1) NO933423L (da)
NZ (1) NZ248724A (da)
YU (1) YU61893A (da)
ZA (1) ZA936925B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ195193A3 (en) * 1992-09-25 1994-04-13 Lilly Co Eli Modified factor-4 of blood platelets, process of its preparation and pharmaceutical preparation in which it is comprised
CA2148301A1 (en) * 1994-05-09 1995-11-10 Rama Belagaje Expression of recombinant mpf-4, cpf-4, pf-4 and precursor compounds
US5994292A (en) * 1995-05-31 1999-11-30 The United States Of America As Represented By The Department Of Health And Human Services Interferon-inducible protein 10 is a potent inhibitor of angiogenesis
JPH09143199A (ja) * 1995-11-17 1997-06-03 Nippon Chem Res Kk 血小板第４因子の製造方法
CN100389126C (zh) * 1995-12-13 2008-05-21 儿童医学中心公司 内皮细胞增殖抑制剂及其应用方法
FR2774990B1 (fr) * 1998-02-16 2000-07-28 Inst Vaisseaux Et Du Sang Nouveaux peptides, utilisation en therapeutique et compositions pharmaceutiques les renfermant
CA2457719C (en) 2001-09-12 2012-01-03 Benito Casu Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
EP1812468A2 (en) * 2004-09-15 2007-08-01 K.U.Leuven Research & Development Platelet factor 4 variant 1 (pf4var1) related inhibitors of angiogenesis
CN114805536B (zh) * 2022-06-24 2022-09-02 北京百臻生物技术有限公司 一种人血小板因子4蛋白突变体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645828A (en) * 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
US4737580A (en) * 1985-03-15 1988-04-12 Oncogen Platelet related growth regulator
US4844895A (en) * 1985-11-01 1989-07-04 New York University Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses
NZ218634A (en) * 1985-12-20 1991-06-25 Oncogen Peptide identified by its cross reactivity with a cell growth factor, dna, antibodies to peptide and test kits
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity
US5086164A (en) * 1989-01-10 1992-02-04 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5187075A (en) * 1989-01-26 1993-02-16 Sri International Cloning and expression of a variant gene of platelet factor 4 and compositions thereof to modulate immune responses
US5112946A (en) * 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
EP0423641A3 (en) * 1989-10-18 1992-01-15 Nippon Mining Company Limited Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha
WO1992002240A2 (en) * 1990-07-27 1992-02-20 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
CZ195193A3 (en) * 1992-09-25 1994-04-13 Lilly Co Eli Modified factor-4 of blood platelets, process of its preparation and pharmaceutical preparation in which it is comprised

Also Published As

Publication number Publication date
CZ195193A3 (en) 1994-04-13
CN1035257C (zh) 1997-06-25
US5538949A (en) 1996-07-23
AU4757393A (en) 1994-03-31
NZ248724A (en) 1995-10-26
HK100597A (en) 1997-08-08
US5935928A (en) 1999-08-10
ES2101237T3 (es) 1997-07-01
CA2106629A1 (en) 1994-03-26
AU665114B2 (en) 1995-12-14
CN1088216A (zh) 1994-06-22
MY109158A (en) 1996-12-31
FI934183A (fi) 1994-03-26
HU9302687D0 (en) 1993-12-28
FI934183A0 (fi) 1993-09-24
GR3023356T3 (en) 1997-08-29
YU61893A (sh) 1996-02-19
DE69309827D1 (de) 1997-05-22
JPH06220091A (ja) 1994-08-09
KR940007059A (ko) 1994-04-26
DE69309827T2 (de) 1997-08-28
MX9305901A (es) 1994-05-31
HUT69928A (en) 1995-09-28
NO933423D0 (no) 1993-09-24
ATE151777T1 (de) 1997-05-15
ZA936925B (en) 1995-03-20
EP0589719A1 (en) 1994-03-30
EP0589719B1 (en) 1997-04-16
NO933423L (no) 1994-03-28
BR9303903A (pt) 1994-06-14
US5512550A (en) 1996-04-30
IL107040A0 (en) 1993-12-28

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