ATE151777T1 - Modifizierter plättchenfaktor-4 - Google Patents

Modifizierter plättchenfaktor-4

Info

Publication number
ATE151777T1
ATE151777T1 AT93307592T AT93307592T ATE151777T1 AT E151777 T1 ATE151777 T1 AT E151777T1 AT 93307592 T AT93307592 T AT 93307592T AT 93307592 T AT93307592 T AT 93307592T AT E151777 T1 ATE151777 T1 AT E151777T1
Authority
AT
Austria
Prior art keywords
mpf
platelet factor
cpf
factor
modified
Prior art date
Application number
AT93307592T
Other languages
English (en)
Inventor
Shalley Kant Gupta
Jai Pal Singh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE151777T1 publication Critical patent/ATE151777T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93307592T 1992-09-25 1993-09-24 Modifizierter plättchenfaktor-4 ATE151777T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95279792A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
ATE151777T1 true ATE151777T1 (de) 1997-05-15

Family

ID=25493243

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93307592T ATE151777T1 (de) 1992-09-25 1993-09-24 Modifizierter plättchenfaktor-4

Country Status (24)

Country Link
US (3) US5512550A (de)
EP (1) EP0589719B1 (de)
JP (1) JPH06220091A (de)
KR (1) KR940007059A (de)
CN (1) CN1035257C (de)
AT (1) ATE151777T1 (de)
AU (1) AU665114B2 (de)
BR (1) BR9303903A (de)
CA (1) CA2106629A1 (de)
CZ (1) CZ195193A3 (de)
DE (1) DE69309827T2 (de)
DK (1) DK0589719T3 (de)
ES (1) ES2101237T3 (de)
FI (1) FI934183A (de)
GR (1) GR3023356T3 (de)
HK (1) HK100597A (de)
HU (1) HUT69928A (de)
IL (1) IL107040A0 (de)
MX (1) MX9305901A (de)
MY (1) MY109158A (de)
NO (1) NO933423L (de)
NZ (1) NZ248724A (de)
YU (1) YU61893A (de)
ZA (1) ZA936925B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ195193A3 (en) * 1992-09-25 1994-04-13 Lilly Co Eli Modified factor-4 of blood platelets, process of its preparation and pharmaceutical preparation in which it is comprised
IL113561A0 (en) * 1994-05-09 1995-08-31 Lilly Co Eli Expression of recombinant mpf-4, cpf-4, pf-4 and precursor compounds
US5994292A (en) * 1995-05-31 1999-11-30 The United States Of America As Represented By The Department Of Health And Human Services Interferon-inducible protein 10 is a potent inhibitor of angiogenesis
JPH09143199A (ja) * 1995-11-17 1997-06-03 Nippon Chem Res Kk 血小板第４因子の製造方法
CN100389126C (zh) * 1995-12-13 2008-05-21 儿童医学中心公司 内皮细胞增殖抑制剂及其应用方法
FR2774990B1 (fr) * 1998-02-16 2000-07-28 Inst Vaisseaux Et Du Sang Nouveaux peptides, utilisation en therapeutique et compositions pharmaceutiques les renfermant
EP2343077B1 (de) 2001-09-12 2013-07-17 SIGMA-TAU Research Switzerland S.A. Derivate von total N-desulfatierten Glycosaminoglycanen als Inhibitoren von Heparanase, mit antiangiogener Wirkung und ohne antikoagulatorische Wirkung
EP1812468A2 (de) * 2004-09-15 2007-08-01 K.U.Leuven Research & Development Mit dem platelet factor 4 variant 1 (pf4var1) verwandte angiogeneseinhibitoren
CN114805536B (zh) * 2022-06-24 2022-09-02 北京百臻生物技术有限公司 一种人血小板因子4蛋白突变体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737580A (en) * 1985-03-15 1988-04-12 Oncogen Platelet related growth regulator
US4645828A (en) * 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
US4844895A (en) * 1985-11-01 1989-07-04 New York University Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses
NZ218634A (en) * 1985-12-20 1991-06-25 Oncogen Peptide identified by its cross reactivity with a cell growth factor, dna, antibodies to peptide and test kits
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity
US5086164A (en) * 1989-01-10 1992-02-04 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5187075A (en) * 1989-01-26 1993-02-16 Sri International Cloning and expression of a variant gene of platelet factor 4 and compositions thereof to modulate immune responses
US5112946A (en) * 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
EP0423641A3 (en) * 1989-10-18 1992-01-15 Nippon Mining Company Limited Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha
EP0541716A1 (de) * 1990-07-27 1993-05-19 Repligen Corporation Neuartige methoden und zusammensetzungen zur behandlung von gefässerkrankungen
CZ195193A3 (en) * 1992-09-25 1994-04-13 Lilly Co Eli Modified factor-4 of blood platelets, process of its preparation and pharmaceutical preparation in which it is comprised

Also Published As

Publication number Publication date
HUT69928A (en) 1995-09-28
FI934183A0 (fi) 1993-09-24
ES2101237T3 (es) 1997-07-01
JPH06220091A (ja) 1994-08-09
KR940007059A (ko) 1994-04-26
YU61893A (sh) 1996-02-19
CN1035257C (zh) 1997-06-25
GR3023356T3 (en) 1997-08-29
DK0589719T3 (da) 1997-09-08
FI934183A (fi) 1994-03-26
HU9302687D0 (en) 1993-12-28
CZ195193A3 (en) 1994-04-13
AU665114B2 (en) 1995-12-14
ZA936925B (en) 1995-03-20
CA2106629A1 (en) 1994-03-26
NO933423L (no) 1994-03-28
BR9303903A (pt) 1994-06-14
MY109158A (en) 1996-12-31
US5935928A (en) 1999-08-10
NZ248724A (en) 1995-10-26
MX9305901A (es) 1994-05-31
NO933423D0 (no) 1993-09-24
CN1088216A (zh) 1994-06-22
HK100597A (en) 1997-08-08
US5512550A (en) 1996-04-30
EP0589719A1 (de) 1994-03-30
DE69309827T2 (de) 1997-08-28
DE69309827D1 (de) 1997-05-22
EP0589719B1 (de) 1997-04-16
US5538949A (en) 1996-07-23
AU4757393A (en) 1994-03-31
IL107040A0 (en) 1993-12-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee