DK0553248T3 - - Google Patents

Info

Publication number
DK0553248T3
DK0553248T3 DK91919667.5T DK91919667T DK0553248T3 DK 0553248 T3 DK0553248 T3 DK 0553248T3 DK 91919667 T DK91919667 T DK 91919667T DK 0553248 T3 DK0553248 T3 DK 0553248T3
Authority
DK
Denmark
Prior art keywords
iodo
metabolites
amino
treatment
infections
Prior art date
Application number
DK91919667.5T
Other languages
English (en)
Inventor
Ernest Kun
Jerome Mendeleyev
Original Assignee
Octamer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octamer Inc filed Critical Octamer Inc
Application granted granted Critical
Publication of DK0553248T3 publication Critical patent/DK0553248T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK91919667.5T 1990-10-19 1991-10-16 DK0553248T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/600,593 US5484951A (en) 1990-10-19 1990-10-19 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents

Publications (1)

Publication Number Publication Date
DK0553248T3 true DK0553248T3 (da) 1997-03-10

Family

ID=24404223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91919667.5T DK0553248T3 (da) 1990-10-19 1991-10-16

Country Status (11)

Country Link
US (2) US5484951A (da)
EP (1) EP0553248B1 (da)
JP (1) JP3042711B2 (da)
AT (1) ATE142876T1 (da)
AU (1) AU8872991A (da)
CA (1) CA2094121C (da)
DE (1) DE69122259T2 (da)
DK (1) DK0553248T3 (da)
ES (1) ES2095332T3 (da)
GR (1) GR3022041T3 (da)
WO (1) WO1992006687A1 (da)

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US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
JPH10504517A (ja) * 1992-11-02 1998-05-06 オクタマー，インコーポレイティド 抗レトロウイルス剤および抗腫瘍剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
EP0711356A4 (en) * 1994-05-26 1999-11-24 New York Medical College DETECTION OF HALOGEN PRECURSORS INCORPORATED IN DNA
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
CA2230753A1 (en) * 1995-08-30 1997-03-06 New York Medical College Methods for labeling dna ends with halogenated nucleotides and detecting same with antibodies
US6407125B1 (en) 1995-12-29 2002-06-18 Novactyl, Inc. Pharmacological agent and method of treatment
US6743771B2 (en) 1995-12-29 2004-06-01 Novactyl, Inc. Methods and compositions for controlling protein assembly or aggregation
US6127393A (en) 1995-12-29 2000-10-03 Novactyl, Inc. Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
US6579891B1 (en) 1995-12-29 2003-06-17 Novactyl, Inc. Agent and method for prevention and treatment of cancer in animals
CN1198614C (zh) 1997-05-13 2005-04-27 奥科特默股份有限公司 pADPRT抑制剂在用于制备治疗炎症和炎性疾病的药物中的方法
US5908861A (en) 1997-05-13 1999-06-01 Octamer, Inc. Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
US6441009B1 (en) 1998-08-01 2002-08-27 Novactyl, Inc. Agent and method of preventing and treating heavy metal exposure and toxicity
US6277990B1 (en) 1999-12-07 2001-08-21 Inotek Corporation Substituted phenanthridinones and methods of use thereof
US6476048B1 (en) 1999-12-07 2002-11-05 Inotek Pharamaceuticals Corporation Substituted phenanthridinones and methods of use thereof
US6531464B1 (en) 1999-12-07 2003-03-11 Inotek Pharmaceutical Corporation Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
US6403618B1 (en) 2000-02-15 2002-06-11 Novactyl, Inc. Agent and method for controlling angiogenesis
AU2002367173A1 (en) * 2001-12-21 2003-07-15 Achillion Pharmaceuticals, Inc. Antifungal compositions
GB0317466D0 (en) 2003-07-25 2003-08-27 Univ Sheffield Use
TWI338000B (en) * 2003-12-01 2011-03-01 Kudos Pharm Ltd Dna damage repair inhibitors for treatment of cancer
EP1904468A4 (en) * 2005-06-10 2009-04-22 Bipar Sciences Inc PARP MODULATORS AND TREATMENT OF CANCER
CA2615374A1 (en) 2005-07-18 2007-01-25 Ernest Kun Kun Treatment of cancer
US20080262062A1 (en) * 2006-11-20 2008-10-23 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20070292883A1 (en) * 2006-06-12 2007-12-20 Ossovskaya Valeria S Method of treating diseases with PARP inhibitors
US20100160442A1 (en) * 2006-07-18 2010-06-24 Ossovskaya Valeria S Formulations for cancer treatment
US7538252B2 (en) * 2006-09-05 2009-05-26 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
AU2007292306A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008030887A2 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing parp inhibitors and uses thereof
GB2447796C (en) * 2007-01-16 2009-11-12 Bipar Sciences Inc Iodonitrobenzamide formulations for cancer and viral diseases.
WO2009051815A1 (en) * 2007-10-19 2009-04-23 Bipar Sciences, Inc. Methods and compositions for the treatment of cancer using benzopyrone-type parp inhibitors
KR20100102607A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법
CN103169973A (zh) * 2007-11-12 2013-06-26 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌
CN101888777A (zh) * 2007-12-07 2010-11-17 彼帕科学公司 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症
WO2009100159A2 (en) * 2008-02-04 2009-08-13 Bipar Sciences, Inc. Methods of diagnosing and treating parp-mediated diseases
US10874641B2 (en) 2016-07-28 2020-12-29 Mitobridge, Inc. Methods of treating acute kidney injury
US10903026B2 (en) 2016-08-03 2021-01-26 Hewlett-Packard Development Company, L.P. Modular keyboard
CN110300600A (zh) 2016-11-02 2019-10-01 伊缪诺金公司 利用抗体-药物缀合物和parp抑制剂的组合治疗
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
EP3687501A4 (en) 2017-09-29 2021-06-23 Triact Therapeutics, Inc. INIPARIB FORMS AND USES THEREOF
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling

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GB1432809A (en) * 1973-04-19 1976-04-22 Beecham Group Ltd Coumarin derivatives
US4032544A (en) * 1974-05-04 1977-06-28 Beecham Group Limited 3-cyano-4-hydroxy coumarin derivatives
GB1509904A (en) * 1974-05-04 1978-05-04 Beecham Group Ltd Nitriles derived from indane-1,3-dione and coumarin
IT1100069B (it) * 1978-11-06 1985-09-28 Fidia Spa Procedimento selettivo per la preparazione di derivati della 7-idrossicumarina
IT1212882B (it) * 1983-07-29 1989-11-30 Della Valle Francesco Derivati basici della cumarina
US4845121A (en) * 1986-06-13 1989-07-04 The Ohio State University Research Foundation Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties
WO1989007441A1 (en) * 1988-02-10 1989-08-24 The Regents Of The University Of California 6-amino-1,2-benzopyrone antitumorigenic agents and method
AU4074789A (en) * 1988-03-01 1989-09-22 Upjohn Company, The Coumarins to inhibit reverse transcriptase in humans
US5206152A (en) * 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
GB8827850D0 (en) * 1988-11-29 1988-12-29 Shell Int Research Biocidal compounds
EP0494231A4 (en) * 1989-09-26 1992-09-16 The Regents Of The University Of California 6-amino-1,2-benzopyrones useful for treatment of viral diseases
JPH03227923A (ja) * 1990-01-30 1991-10-08 Sawai Seiyaku Kk ひと免疫不全ウイルス疾患処置剤
GB9011833D0 (en) * 1990-05-25 1990-07-18 Collins Mary K L Inhibition of viral infection

Also Published As

Publication number Publication date
JP3042711B2 (ja) 2000-05-22
ES2095332T3 (es) 1997-02-16
GR3022041T3 (en) 1997-03-31
AU8872991A (en) 1992-05-20
EP0553248A1 (en) 1993-08-04
US5519053A (en) 1996-05-21
CA2094121C (en) 2002-12-31
JPH06503068A (ja) 1994-04-07
EP0553248B1 (en) 1996-09-18
WO1992006687A1 (en) 1992-04-30
DE69122259T2 (de) 1997-02-06
ATE142876T1 (de) 1996-10-15
CA2094121A1 (en) 1992-04-20
US5484951A (en) 1996-01-16
DE69122259D1 (de) 1996-10-24

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