DK0552767T3 - 3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotid-grupper, fremstilling og anvendelse deraf - Google Patents

3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotid-grupper, fremstilling og anvendelse deraf

Info

Publication number
DK0552767T3
DK0552767T3 DK93100893T DK93100893T DK0552767T3 DK 0552767 T3 DK0552767 T3 DK 0552767T3 DK 93100893 T DK93100893 T DK 93100893T DK 93100893 T DK93100893 T DK 93100893T DK 0552767 T3 DK0552767 T3 DK 0552767T3
Authority
DK
Denmark
Prior art keywords
oxy
alpha
sulfandiyl
alkyl
formula
Prior art date
Application number
DK93100893T
Other languages
Danish (da)
English (en)
Inventor
Irvin Dr Winkler
Gerard Dr O'malley
Eugen Dr Uhlmann
Anuschirwan Dr Peyman
Matthias Dr Helsberg
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0552767T3 publication Critical patent/DK0552767T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Graft Or Block Polymers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
DK93100893T 1992-01-22 1993-01-21 3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotid-grupper, fremstilling og anvendelse deraf DK0552767T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4201663 1992-01-22

Publications (1)

Publication Number Publication Date
DK0552767T3 true DK0552767T3 (da) 2002-08-19

Family

ID=6450031

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93100893T DK0552767T3 (da) 1992-01-22 1993-01-21 3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotid-grupper, fremstilling og anvendelse deraf
DK01116471T DK1142902T3 (da) 1992-01-22 1993-01-21 3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotide grupperinger, deres fremstilling og anvendelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01116471T DK1142902T3 (da) 1992-01-22 1993-01-21 3'-Derivatiserede oligonukleotidanaloger med ikke-nukleotide grupperinger, deres fremstilling og anvendelse

Country Status (18)

Country Link
US (1) US5646261A (ja)
EP (2) EP1142902B1 (ja)
JP (1) JP3676388B2 (ja)
KR (1) KR100273824B1 (ja)
AT (2) ATE217881T1 (ja)
AU (1) AU657191B2 (ja)
CA (1) CA2087817C (ja)
DE (2) DE59310287D1 (ja)
DK (2) DK0552767T3 (ja)
ES (2) ES2250268T3 (ja)
FI (1) FI115215B (ja)
HU (1) HUT63172A (ja)
IL (1) IL104460A (ja)
NO (1) NO308609B1 (ja)
NZ (1) NZ245721A (ja)
PL (1) PL172245B1 (ja)
PT (1) PT552767E (ja)
ZA (1) ZA93423B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966849B2 (ja) * 1987-12-03 1999-10-25 三井化学株式会社 黄色系昇華転写用色材
DE59306170D1 (de) * 1992-09-24 1997-05-22 Hoechst Ag Oligoribonucleotid- und Ribozym-Analoga mit terminalen 3'-3'-bzw.5'-5'-Verknüpfungen
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
US6358689B1 (en) * 1994-05-11 2002-03-19 Boston University Detection of markers in nascent proteins
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
DE69514351T2 (de) * 1994-06-01 2000-08-10 Hybridon Inc Verzweigte Oligonukleotide als pathogenhemmende Mittel
US5696248A (en) * 1994-06-15 1997-12-09 Hoechst Aktiengesellschaft 3'-modified oligonucleotide derivatives
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6121437A (en) * 1999-03-16 2000-09-19 Isis Pharmaceuticals, Inc. Phosphate and thiophosphate protecting groups
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
US20040023367A1 (en) * 2002-07-31 2004-02-05 Affymetrix, Inc. Method of photolithographic production of polymer arrays
US8084589B2 (en) * 2007-08-31 2011-12-27 University Of Massachusetts Phosphoramidite nucleoside analogs
US20120082616A1 (en) * 2010-09-24 2012-04-05 Mallinckrodt Llc Aptamer Conjugates for Targeting of Therapeutic and/or Diagnostic Nanocarriers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4950745A (en) * 1986-10-30 1990-08-21 Daicel Chemical Industries, Ltd. Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
EP0942000B1 (en) * 1989-10-24 2004-06-23 Isis Pharmaceuticals, Inc. 2'-Modified oligonucleotides
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
IL104461A (en) * 1992-01-22 2001-05-20 Hoechst Ag Analogs of oligonucleotide, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
EP1142902A3 (de) 2001-10-17
ES2250268T3 (es) 2006-04-16
ATE217881T1 (de) 2002-06-15
EP0552767A3 (en) 1994-09-07
DK1142902T3 (da) 2006-03-06
DE59310380D1 (de) 2005-12-01
HUT63172A (en) 1993-07-28
NO930200D0 (no) 1993-01-21
KR930016438A (ko) 1993-08-26
IL104460A0 (en) 1993-05-13
HU9300161D0 (en) 1993-04-28
PL297516A1 (en) 1993-09-06
FI930221A (fi) 1993-07-23
AU3191193A (en) 1993-07-29
EP0552767B1 (de) 2002-05-22
CA2087817A1 (en) 1993-07-23
NO308609B1 (no) 2000-10-02
DE59310287D1 (de) 2002-06-27
EP1142902B1 (de) 2005-10-26
JP3676388B2 (ja) 2005-07-27
ZA93423B (en) 1993-09-09
NZ245721A (en) 1995-09-26
NO930200L (no) 1993-07-23
FI115215B (fi) 2005-03-31
EP1142902A2 (de) 2001-10-10
PL172245B1 (pl) 1997-08-29
ATE307821T1 (de) 2005-11-15
AU657191B2 (en) 1995-03-02
CA2087817C (en) 2010-03-16
ES2177533T3 (es) 2002-12-16
FI930221A0 (fi) 1993-01-20
JPH05310778A (ja) 1993-11-22
EP0552767A2 (de) 1993-07-28
KR100273824B1 (ko) 2000-12-15
US5646261A (en) 1997-07-08
IL104460A (en) 2003-03-12
PT552767E (pt) 2002-10-31

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