FI930221A - 3'-derivatiserade oligonukleotidanaloger med ickenukleotida grupper, deras framstaellning och anvaendning - Google Patents

3'-derivatiserade oligonukleotidanaloger med ickenukleotida grupper, deras framstaellning och anvaendning Download PDF

Info

Publication number
FI930221A
FI930221A FI930221A FI930221A FI930221A FI 930221 A FI930221 A FI 930221A FI 930221 A FI930221 A FI 930221A FI 930221 A FI930221 A FI 930221A FI 930221 A FI930221 A FI 930221A
Authority
FI
Finland
Prior art keywords
oxy
alpha
sulfandiyl
alkyl
formula
Prior art date
Application number
FI930221A
Other languages
English (en)
Other versions
FI115215B (fi
FI930221A0 (fi
Inventor
Eugen Uhlmann
Anuschirwan Peyman
Gerard O'malley
Matthias Helsberg
Irvin Winkler
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI930221A0 publication Critical patent/FI930221A0/fi
Publication of FI930221A publication Critical patent/FI930221A/fi
Application granted granted Critical
Publication of FI115215B publication Critical patent/FI115215B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Graft Or Block Polymers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
FI930221A 1992-01-22 1993-01-20 Menetelmä oligonukleotidianalogien valmistamiseksi, joista on muodostettu 3'-johdannaisia ja joissa on ei-nukleotidisiä ryhmiä ja niiden käyttö FI115215B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4201663 1992-01-22
DE4201663 1992-01-22

Publications (3)

Publication Number Publication Date
FI930221A0 FI930221A0 (fi) 1993-01-20
FI930221A true FI930221A (fi) 1993-07-23
FI115215B FI115215B (fi) 2005-03-31

Family

ID=6450031

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930221A FI115215B (fi) 1992-01-22 1993-01-20 Menetelmä oligonukleotidianalogien valmistamiseksi, joista on muodostettu 3'-johdannaisia ja joissa on ei-nukleotidisiä ryhmiä ja niiden käyttö

Country Status (18)

Country Link
US (1) US5646261A (fi)
EP (2) EP1142902B1 (fi)
JP (1) JP3676388B2 (fi)
KR (1) KR100273824B1 (fi)
AT (2) ATE307821T1 (fi)
AU (1) AU657191B2 (fi)
CA (1) CA2087817C (fi)
DE (2) DE59310287D1 (fi)
DK (2) DK0552767T3 (fi)
ES (2) ES2250268T3 (fi)
FI (1) FI115215B (fi)
HU (1) HUT63172A (fi)
IL (1) IL104460A (fi)
NO (1) NO308609B1 (fi)
NZ (1) NZ245721A (fi)
PL (1) PL172245B1 (fi)
PT (1) PT552767E (fi)
ZA (1) ZA93423B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2966849B2 (ja) * 1987-12-03 1999-10-25 三井化学株式会社 黄色系昇華転写用色材
DE59306170D1 (de) * 1992-09-24 1997-05-22 Hoechst Ag Oligoribonucleotid- und Ribozym-Analoga mit terminalen 3'-3'-bzw.5'-5'-Verknüpfungen
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6358689B1 (en) * 1994-05-11 2002-03-19 Boston University Detection of markers in nascent proteins
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
ATE188479T1 (de) 1994-06-01 2000-01-15 Hybridon Inc Verzweigte oligonukleotide als pathogenhemmende mittel
US5696248A (en) * 1994-06-15 1997-12-09 Hoechst Aktiengesellschaft 3'-modified oligonucleotide derivatives
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6121437A (en) 1999-03-16 2000-09-19 Isis Pharmaceuticals, Inc. Phosphate and thiophosphate protecting groups
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
US20040023367A1 (en) * 2002-07-31 2004-02-05 Affymetrix, Inc. Method of photolithographic production of polymer arrays
US8084589B2 (en) * 2007-08-31 2011-12-27 University Of Massachusetts Phosphoramidite nucleoside analogs
CA2811601A1 (en) * 2010-09-24 2012-03-29 Mallinckrodt Llc Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
DE3751468T2 (de) * 1986-10-30 1996-02-29 Daicel Chem Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
ATE190981T1 (de) * 1989-10-24 2000-04-15 Isis Pharmaceuticals Inc 2'-modifizierte nukleotide
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도

Also Published As

Publication number Publication date
EP0552767A3 (en) 1994-09-07
IL104460A0 (en) 1993-05-13
FI115215B (fi) 2005-03-31
NO930200D0 (no) 1993-01-21
PL172245B1 (pl) 1997-08-29
KR930016438A (ko) 1993-08-26
DE59310380D1 (de) 2005-12-01
NO930200L (no) 1993-07-23
EP1142902A3 (de) 2001-10-17
IL104460A (en) 2003-03-12
ES2177533T3 (es) 2002-12-16
HUT63172A (en) 1993-07-28
CA2087817C (en) 2010-03-16
HU9300161D0 (en) 1993-04-28
DE59310287D1 (de) 2002-06-27
ATE307821T1 (de) 2005-11-15
EP1142902A2 (de) 2001-10-10
NZ245721A (en) 1995-09-26
ZA93423B (en) 1993-09-09
FI930221A0 (fi) 1993-01-20
JP3676388B2 (ja) 2005-07-27
ATE217881T1 (de) 2002-06-15
PT552767E (pt) 2002-10-31
US5646261A (en) 1997-07-08
EP0552767B1 (de) 2002-05-22
EP0552767A2 (de) 1993-07-28
CA2087817A1 (en) 1993-07-23
AU3191193A (en) 1993-07-29
ES2250268T3 (es) 2006-04-16
DK0552767T3 (da) 2002-08-19
DK1142902T3 (da) 2006-03-06
JPH05310778A (ja) 1993-11-22
PL297516A1 (en) 1993-09-06
EP1142902B1 (de) 2005-10-26
AU657191B2 (en) 1995-03-02
NO308609B1 (no) 2000-10-02
KR100273824B1 (ko) 2000-12-15

Similar Documents

Publication Publication Date Title
FI930221A (fi) 3'-derivatiserade oligonukleotidanaloger med ickenukleotida grupper, deras framstaellning och anvaendning
KR930016437A (ko) 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
PT820461E (pt) Derivados de aril-ester de fosforamidato de 2',3'-didesidronucleosidos
WO2001026629A3 (en) Neutral-cationic lipid for nucleic acid and drug delivery
IL64647A (en) 2,8-disubstituted-4-thiomorpholino-pyrimido(5,4-d)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
FI903623A0 (fi) Diaryletercykliska etrar.
FR2787109B1 (fr) Nouveaux derives de 1,2-dithiolane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL94982A0 (en) Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain,their preparation and pharmaceutical compositions containing them
FR2699536B1 (fr) Nouveaux dérivés de p-[di(2-chloroéthyl)amino]phénylalanine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
NZ234450A (en) Substituted pyrrolo(2,1-b)thiazole derivatives, intermediates and pharmaceutical compositions

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115215

Country of ref document: FI

MA Patent expired