DK0542059T3 - Substituerede biphenylpyridoner som angiotensin II-antagonister - Google Patents
Substituerede biphenylpyridoner som angiotensin II-antagonisterInfo
- Publication number
- DK0542059T3 DK0542059T3 DK92118597.1T DK92118597T DK0542059T3 DK 0542059 T3 DK0542059 T3 DK 0542059T3 DK 92118597 T DK92118597 T DK 92118597T DK 0542059 T3 DK0542059 T3 DK 0542059T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridones
- angiotensin
- antagonists
- substituted biphenyl
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4137151 | 1991-11-12 | ||
DE4221583A DE4221583A1 (de) | 1991-11-12 | 1992-07-01 | Substituierte biphenylpyridone |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0542059T3 true DK0542059T3 (da) | 1996-07-22 |
Family
ID=25909023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92118597.1T DK0542059T3 (da) | 1991-11-12 | 1992-10-30 | Substituerede biphenylpyridoner som angiotensin II-antagonister |
Country Status (23)
Country | Link |
---|---|
US (2) | US5356911A (ko) |
EP (1) | EP0542059B1 (ko) |
JP (1) | JPH05255258A (ko) |
KR (1) | KR930010030A (ko) |
CN (1) | CN1038935C (ko) |
AT (1) | ATE135700T1 (ko) |
AU (1) | AU659235B2 (ko) |
CA (1) | CA2082306A1 (ko) |
CZ (1) | CZ281937B6 (ko) |
DE (2) | DE4221583A1 (ko) |
DK (1) | DK0542059T3 (ko) |
ES (1) | ES2086046T3 (ko) |
FI (1) | FI925100A (ko) |
GR (1) | GR3019398T3 (ko) |
HU (1) | HUT67018A (ko) |
IL (1) | IL103688A (ko) |
MX (1) | MX9206305A (ko) |
MY (1) | MY109880A (ko) |
NO (1) | NO303541B1 (ko) |
NZ (1) | NZ245073A (ko) |
RU (1) | RU2100350C1 (ko) |
SK (1) | SK338092A3 (ko) |
TW (1) | TW218874B (ko) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4129340A1 (de) * | 1991-09-04 | 1993-03-11 | Merck Patent Gmbh | 1,2-dihydro-2-oxopyridine |
US5674883A (en) * | 1992-02-07 | 1997-10-07 | Roussel Uclaf | Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them |
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
DE4319040A1 (de) * | 1992-10-23 | 1994-04-28 | Bayer Ag | Alkoxymethylsubstituierte Pyridonbiphenyle |
DE4319041A1 (de) * | 1992-10-23 | 1994-04-28 | Bayer Ag | Trisubstituierte Biphenyle |
GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
EP0802192A1 (de) * | 1996-04-17 | 1997-10-22 | Bayer Ag | Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung |
DE19619950A1 (de) | 1996-04-17 | 1997-10-23 | Bayer Ag | Heterocyclisch-substituierte Phenylglycinolamide |
TW418204B (en) * | 1997-03-28 | 2001-01-11 | Dev Center Biotechnology | Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists |
HU222773B1 (hu) * | 2000-04-21 | 2003-10-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás egy ismert tetrazolszármazék előállítására |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
ES2421511T3 (es) | 2001-12-21 | 2013-09-03 | X Ceptor Therapeutics Inc | Moduladores de LXR |
US7067540B2 (en) * | 2002-02-14 | 2006-06-27 | Pharmacia Corporation | Substituted pyridinones |
AU2004236249A1 (en) * | 2003-04-30 | 2004-11-18 | The Institutes Of Pharmaceutical Discovery, Llc | Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1B |
GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
AU2005307718A1 (en) * | 2004-11-18 | 2006-05-26 | The Institutes For Pharmaceutical Discovery, Llc | Heterocycle substituted carboxylic acids for the treatment of diabetes |
DE102005030522A1 (de) * | 2005-06-30 | 2007-01-04 | Bayer Healthcare Ag | Salz des Embusartans |
WO2007027528A2 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases |
AU2006285038A1 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
ATE528302T1 (de) | 2005-08-29 | 2011-10-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
EP2200985B1 (en) | 2007-09-14 | 2011-07-13 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
CN102595896B (zh) * | 2009-11-06 | 2016-02-17 | 爱尔皮奥治疗有限公司 | 提高低氧诱导因子-1α的稳定性的方法 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
EP3290413B9 (en) * | 2011-12-21 | 2020-04-29 | ONO Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
ES2814098T3 (es) | 2014-12-10 | 2021-03-26 | Ono Pharmaceutical Co | Derivado de dihidroindolizinona |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0407342A3 (en) | 1989-07-06 | 1991-07-10 | Ciba-Geigy Ag | Pyrimidine derivatives |
US5100897A (en) * | 1989-08-28 | 1992-03-31 | Merck & Co., Inc. | Substituted pyrimidinones as angiotensin ii antagonists |
EP0424317A3 (en) | 1989-10-19 | 1991-09-25 | Ciba-Geigy Ag | Pyrimidines |
EP0435827A3 (en) | 1989-12-28 | 1991-11-13 | Ciba-Geigy Ag | Diaza compounds |
CA2037630C (en) | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
AU653734B2 (en) * | 1990-06-19 | 1994-10-13 | Meiji Seika Kabushiki Kaisha | Substituted 4-biphenylmethoxypyridine derivatives |
CN1068109A (zh) * | 1991-02-16 | 1993-01-20 | 菲索斯有限公司 | 新的血管紧张肽ii拮抗剂及其制剂的制备和应用 |
IL100917A0 (en) * | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
DE4129340A1 (de) * | 1991-09-04 | 1993-03-11 | Merck Patent Gmbh | 1,2-dihydro-2-oxopyridine |
-
1992
- 1992-07-01 DE DE4221583A patent/DE4221583A1/de not_active Withdrawn
- 1992-10-15 MY MYPI92001865A patent/MY109880A/en unknown
- 1992-10-24 TW TW081108494A patent/TW218874B/zh active
- 1992-10-29 NO NO924172A patent/NO303541B1/no not_active IP Right Cessation
- 1992-10-30 ES ES92118597T patent/ES2086046T3/es not_active Expired - Lifetime
- 1992-10-30 DE DE59205752T patent/DE59205752D1/de not_active Expired - Fee Related
- 1992-10-30 DK DK92118597.1T patent/DK0542059T3/da active
- 1992-10-30 EP EP92118597A patent/EP0542059B1/de not_active Expired - Lifetime
- 1992-10-30 AT AT92118597T patent/ATE135700T1/de not_active IP Right Cessation
- 1992-11-02 US US07/970,364 patent/US5356911A/en not_active Expired - Fee Related
- 1992-11-03 MX MX9206305A patent/MX9206305A/es not_active IP Right Cessation
- 1992-11-06 CA CA002082306A patent/CA2082306A1/en not_active Abandoned
- 1992-11-09 IL IL10368892A patent/IL103688A/xx not_active IP Right Cessation
- 1992-11-09 AU AU28232/92A patent/AU659235B2/en not_active Ceased
- 1992-11-10 FI FI925100A patent/FI925100A/fi unknown
- 1992-11-10 NZ NZ245073A patent/NZ245073A/en unknown
- 1992-11-10 JP JP4323799A patent/JPH05255258A/ja active Pending
- 1992-11-11 KR KR1019920021075A patent/KR930010030A/ko not_active Application Discontinuation
- 1992-11-11 RU RU9292004391A patent/RU2100350C1/ru active
- 1992-11-12 CZ CS923380A patent/CZ281937B6/cs not_active IP Right Cessation
- 1992-11-12 SK SK3380-92A patent/SK338092A3/sk unknown
- 1992-11-12 CN CN92112250A patent/CN1038935C/zh not_active Expired - Fee Related
- 1992-11-12 HU HU9203552A patent/HUT67018A/hu unknown
-
1994
- 1994-06-29 US US08/268,903 patent/US5599823A/en not_active Expired - Fee Related
-
1996
- 1996-03-21 GR GR960400703T patent/GR3019398T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5356911A (en) | 1994-10-18 |
EP0542059B1 (de) | 1996-03-20 |
IL103688A (en) | 1997-02-18 |
MY109880A (en) | 1997-09-30 |
CZ338092A3 (en) | 1993-09-15 |
ES2086046T3 (es) | 1996-06-16 |
CN1072180A (zh) | 1993-05-19 |
FI925100A0 (fi) | 1992-11-10 |
NO924172L (no) | 1993-05-14 |
ATE135700T1 (de) | 1996-04-15 |
NZ245073A (en) | 1996-02-27 |
CZ281937B6 (cs) | 1997-04-16 |
IL103688A0 (en) | 1993-04-04 |
MX9206305A (es) | 1993-05-01 |
TW218874B (ko) | 1994-01-11 |
HUT67018A (en) | 1995-01-30 |
GR3019398T3 (en) | 1996-06-30 |
SK279433B6 (sk) | 1998-11-04 |
AU2823292A (en) | 1993-05-13 |
SK338092A3 (en) | 1998-11-04 |
NO303541B1 (no) | 1998-07-27 |
CA2082306A1 (en) | 1993-05-12 |
DE4221583A1 (de) | 1993-05-13 |
RU2100350C1 (ru) | 1997-12-27 |
HU9203552D0 (en) | 1993-01-28 |
JPH05255258A (ja) | 1993-10-05 |
CN1038935C (zh) | 1998-07-01 |
DE59205752D1 (de) | 1996-04-25 |
EP0542059A1 (de) | 1993-05-19 |
KR930010030A (ko) | 1993-06-21 |
US5599823A (en) | 1997-02-04 |
NO924172D0 (no) | 1992-10-29 |
FI925100A (fi) | 1993-05-13 |
AU659235B2 (en) | 1995-05-11 |
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