SK338092A3 - Substituted biphenylpyridones, method for their producing, pharmaceutical composition containing the same and their use - Google Patents

Substituted biphenylpyridones, method for their producing, pharmaceutical composition containing the same and their use Download PDF

Info

Publication number
SK338092A3
SK338092A3 SK3380-92A SK338092A SK338092A3 SK 338092 A3 SK338092 A3 SK 338092A3 SK 338092 A SK338092 A SK 338092A SK 338092 A3 SK338092 A3 SK 338092A3
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
straight
branched alkyl
atom
Prior art date
Application number
SK3380-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK279433B6 (sk
Inventor
Matthias Muller-Gliemann
Martin Beuck
Stanislav Kazda
Johannes-Peter Stasch
Andreas Knorr
Stefan Wohlfeil
Walter Hubsch
Jurgen Dressel
Peter Fey
Rudolf Hanko
Thomas Kramer
Ulrich E Muller
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK338092A3 publication Critical patent/SK338092A3/sk
Publication of SK279433B6 publication Critical patent/SK279433B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK3380-92A 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby, SK279433B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (2)

Publication Number Publication Date
SK338092A3 true SK338092A3 (en) 1998-11-04
SK279433B6 SK279433B6 (sk) 1998-11-04

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
SK3380-92A SK279433B6 (sk) 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby,

Country Status (23)

Country Link
US (2) US5356911A (ko)
EP (1) EP0542059B1 (ko)
JP (1) JPH05255258A (ko)
KR (1) KR930010030A (ko)
CN (1) CN1038935C (ko)
AT (1) ATE135700T1 (ko)
AU (1) AU659235B2 (ko)
CA (1) CA2082306A1 (ko)
CZ (1) CZ281937B6 (ko)
DE (2) DE4221583A1 (ko)
DK (1) DK0542059T3 (ko)
ES (1) ES2086046T3 (ko)
FI (1) FI925100A (ko)
GR (1) GR3019398T3 (ko)
HU (1) HUT67018A (ko)
IL (1) IL103688A (ko)
MX (1) MX9206305A (ko)
MY (1) MY109880A (ko)
NO (1) NO303541B1 (ko)
NZ (1) NZ245073A (ko)
RU (1) RU2100350C1 (ko)
SK (1) SK279433B6 (ko)
TW (1) TW218874B (ko)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
ES2421511T3 (es) * 2001-12-21 2013-09-03 X Ceptor Therapeutics Inc Moduladores de LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
BR0307631A (pt) * 2002-02-14 2004-12-21 Pharmacia Corp Piridinonas substituìdas como moduladores de p38 map-quinase
AU2004236249A1 (en) * 2003-04-30 2004-11-18 The Institutes Of Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1B
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1844043A2 (en) * 2004-11-18 2007-10-17 The Institutes for Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids for the treatment of diabetes
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
WO2007027729A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
US7786120B2 (en) * 2005-08-29 2010-08-31 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
PT2203439E (pt) 2007-09-14 2011-02-11 Ortho Mcneil Janssen Pharm 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas
JP5433579B2 (ja) 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
RU2510396C2 (ru) 2008-09-02 2014-03-27 Янссен Фармасьютикалз, Инк. 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов
WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
WO2010130422A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
NZ600405A (en) * 2009-11-06 2014-08-29 Aerpio Therapeutics Inc Compositions and methods for treating colitis
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
ES2655669T3 (es) * 2011-12-21 2018-02-21 Ono Pharmaceutical Co., Ltd. Derivados de piridinona y pirimidinona como inhibidores del factor XIa
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
EP3431106B1 (en) 2014-01-21 2020-12-30 Janssen Pharmaceutica NV Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
RU2707887C2 (ru) 2014-12-10 2019-12-02 Оно Фармасьютикал Ко., Лтд. Производное дигидроиндолизинона

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine

Also Published As

Publication number Publication date
HUT67018A (en) 1995-01-30
HU9203552D0 (en) 1993-01-28
US5599823A (en) 1997-02-04
FI925100A (fi) 1993-05-13
NO303541B1 (no) 1998-07-27
AU659235B2 (en) 1995-05-11
FI925100A0 (fi) 1992-11-10
AU2823292A (en) 1993-05-13
CN1038935C (zh) 1998-07-01
IL103688A (en) 1997-02-18
CA2082306A1 (en) 1993-05-12
DK0542059T3 (da) 1996-07-22
TW218874B (ko) 1994-01-11
DE4221583A1 (de) 1993-05-13
ATE135700T1 (de) 1996-04-15
KR930010030A (ko) 1993-06-21
CN1072180A (zh) 1993-05-19
DE59205752D1 (de) 1996-04-25
CZ338092A3 (en) 1993-09-15
JPH05255258A (ja) 1993-10-05
NO924172D0 (no) 1992-10-29
GR3019398T3 (en) 1996-06-30
US5356911A (en) 1994-10-18
EP0542059B1 (de) 1996-03-20
NZ245073A (en) 1996-02-27
NO924172L (no) 1993-05-14
ES2086046T3 (es) 1996-06-16
RU2100350C1 (ru) 1997-12-27
CZ281937B6 (cs) 1997-04-16
MY109880A (en) 1997-09-30
MX9206305A (es) 1993-05-01
IL103688A0 (en) 1993-04-04
SK279433B6 (sk) 1998-11-04
EP0542059A1 (de) 1993-05-19

Similar Documents

Publication Publication Date Title
SK338092A3 (en) Substituted biphenylpyridones, method for their producing, pharmaceutical composition containing the same and their use
CZ280248B6 (cs) Substituované azoly, způsob jejich výroby, přípravky obsahující tyto sloučeniny a jejich použití
HUT55367A (en) Process for producing biphenylmethane derivatives including condensed carbo or heterocyclic imidazole unit, as well as pharmaceutical compositions comprising such compounds
IE921335A1 (en) Heterocyclically substituted phenylacetic acid derivatives,¹processes for their preparation and their use in medicaments
CZ280584B6 (cs) Substituované azoly, způsob jejich výroby a je jich použití
EP1915377A1 (en) Pyrazolo pyrimidines useful as aurora kinase inhibitors
PL161527B1 (en) Method of obtaining cycloalkyl substituted derivatives of glutaramide
CZ15793A3 (en) Sulfonylbenzyl-substituted pyridones
CA2835596A1 (en) Benzo- or pyrido-imidazole derivative
PL177834B1 (pl) Heterocyklicznie podstawiona pochodna kwasu fenylo-cykloheksano-karboksylowego, sposób jej wytwarzania oraz zawierające ją środek leczniczy
SK297692A3 (en) Imidazolylpropene acid substituted derivatives
CZ275992A3 (en) N-substituted heterocyclic derivatives, process of their preparation and pharmaceutical preparation based thereon
AU725786B2 (en) Novel pyrimido(1,2-a)indoles
CZ297792A3 (en) Cyclically substituted derivatives of imidazolyl-propenoic acid
SK46793A3 (en) Regenarative melting tank and method of working
US5268377A (en) Imidazoindolizine derivatives process for preparation thereof and use thereof to treat hypertension
CZ298892A3 (en) Derivatives of imidazolyl-propenoic acid
SK34993A3 (en) Propenoyl-imidazole derivatives
HU216829B (hu) Kétszeresen kondenzált pirrolcsoporttal helyettesített fenil-ciklohexán-karbonsav-származékok és az ezeket tartalmazó gyógyszerkészítmények, valamint eljárás előállításukra
SK106693A3 (en) Benzimidazole derivatives, process of their production and pharmaceutical agents with the content of those
SK14393A3 (en) Sulfonylbenzene substituted derivatives of imidazolylpropene acid
SK35094A3 (en) Phenylglycinamides heterocyclic substituted derivatives of phenylacetic acid, method of their production, medicines contains these matters, method of their production and using of these matters
PL174330B1 (pl) Nowe pochodne 3-oksadiazolilo-5,6,7,8-tetrahydro-1,6-naftyrydyny, nowe pochodne 5,6,7,8-tetrahydro-1,6-naftyrydyny oraz sposób otrzymywania pochodnych 1,6-naftyrydyny
SK14293A3 (en) Sulfonylbenzyl substituted imidazopyridines
SK27593A3 (en) Cycloalkyl and heterocyclyl substituted derivatives of imidazolylpropenoic acid