DK0539086T3 - Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister - Google Patents

Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister

Info

Publication number
DK0539086T3
DK0539086T3 DK92309333.0T DK92309333T DK0539086T3 DK 0539086 T3 DK0539086 T3 DK 0539086T3 DK 92309333 T DK92309333 T DK 92309333T DK 0539086 T3 DK0539086 T3 DK 0539086T3
Authority
DK
Denmark
Prior art keywords
angiotensin
antagonists
pyrimidine derivatives
condensed pyrimidine
condensed
Prior art date
Application number
DK92309333.0T
Other languages
Danish (da)
English (en)
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0539086T3 publication Critical patent/DK0539086T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK92309333.0T 1991-10-24 1992-10-14 Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister DK0539086T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number Publication Date
DK0539086T3 true DK0539086T3 (da) 1998-02-02

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92309333.0T DK0539086T3 (da) 1991-10-24 1992-10-14 Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister

Country Status (21)

Country Link
EP (1) EP0539086B1 (sk)
JP (1) JP3240192B2 (sk)
KR (1) KR100286624B1 (sk)
CN (2) CN1039324C (sk)
AT (1) ATE161537T1 (sk)
AU (1) AU653635B2 (sk)
CA (1) CA2080705C (sk)
DE (1) DE69223734T2 (sk)
DK (1) DK0539086T3 (sk)
ES (1) ES2111617T3 (sk)
FI (1) FI103971B (sk)
GR (1) GR3025926T3 (sk)
HK (1) HK1003031A1 (sk)
HU (2) HU218786B (sk)
IL (1) IL103436A (sk)
LV (1) LV12047B (sk)
NO (1) NO301275B1 (sk)
SG (1) SG47626A1 (sk)
SK (1) SK280292B6 (sk)
TW (1) TW226375B (sk)
UA (1) UA27748C2 (sk)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0643704B1 (en) * 1991-11-18 2003-09-17 E.I. Du Pont De Nemours And Company Tetrazolylphenylboronic acid intermediates for the synthesis of aii receptor antagonists
EP0863143A1 (en) * 1993-03-24 1998-09-09 American Home Products Corporation Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists
DK0782996T3 (da) * 1994-09-20 1999-09-20 Wakunaga Seiyaku Kk Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
NZ549535A (en) 2004-03-17 2010-11-26 Novartis Ag Use of aliskiren for treating renal and other disorders
BRPI0516128A (pt) 2004-10-08 2008-08-26 Novartis Ag uso de inibidores de renina para a prevenção ou tratamento de disfunção diastólica ou insuficiência cardìca diastólica
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
NZ579310A (en) 2007-03-01 2012-03-30 Probiodrug Ag Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2998314B1 (en) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2008148812A1 (en) * 2007-06-07 2008-12-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. 5beta, 14beta-androstane derivatives useful for the treatment of restenosis after angioplastic or endoartherectomy and diseases due to organ fibrosis
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20130158080A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating hypertension in black patients
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
ES2981866T3 (es) 2013-06-05 2024-10-10 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclasa C, método de elaboración y uso de los mismos
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
CA2075627A1 (en) * 1990-02-13 1991-08-14 William J. Greenlee Angiotensin ii antagonists incorporating a substituted benzyl element
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
EP0539086B1 (en) 1997-12-29
JP3240192B2 (ja) 2001-12-17
LV12047B (en) 1998-08-20
KR100286624B1 (ko) 2001-05-02
UA27748C2 (uk) 2000-10-16
CN1175414A (zh) 1998-03-11
HU9203161D0 (en) 1992-12-28
FI924397A0 (fi) 1992-09-30
IL103436A (en) 1996-03-31
AU2607992A (en) 1993-04-29
FI924397A (fi) 1993-04-25
HU211915A9 (en) 1996-01-29
HUT62893A (en) 1993-06-28
LV12047A (lv) 1998-05-20
JPH05222039A (ja) 1993-08-31
FI103971B1 (fi) 1999-10-29
NO924121L (no) 1993-04-26
DE69223734D1 (de) 1998-02-05
SK322192A3 (en) 1999-11-08
CN1039324C (zh) 1998-07-29
TW226375B (sk) 1994-07-11
HK1003031A1 (en) 1998-09-30
SK280292B6 (sk) 1999-11-08
ES2111617T3 (es) 1998-03-16
EP0539086A3 (en) 1993-06-16
HU218786B (hu) 2000-12-28
IL103436A0 (en) 1993-03-15
AU653635B2 (en) 1994-10-06
FI103971B (fi) 1999-10-29
ATE161537T1 (de) 1998-01-15
GR3025926T3 (en) 1998-04-30
CA2080705A1 (en) 1993-04-25
DE69223734T2 (de) 1998-04-16
CN1072682A (zh) 1993-06-02
NO924121D0 (no) 1992-10-23
NO301275B1 (no) 1997-10-06
KR930007949A (ko) 1993-05-20
CA2080705C (en) 2002-12-03
SG47626A1 (en) 1998-04-17
EP0539086A2 (en) 1993-04-28

Similar Documents

Publication Publication Date Title
DK0539086T3 (da) Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister
ATE453393T1 (de) Verwendung von pyridylamiden als angiogenesehemmer
NL300006I1 (nl) Imidazolylalkeenzuurderivaten.
DK0611368T3 (da) Substituerede aminopyrimidiner som angiotensin II-antagonister
TR200201057T2 (tr) P38 protein kinazı inhibitörleri olarak heteroalkilamino ikameli bisiklik nitrojen heterosaykılları.
NO20034523D0 (no) Pyrazolderivater for behandling av HIV
CY1109219T1 (el) Ινδολο, αζαινδολο και σχετικα ετεροκυκλικα αμιδοπιπεραζινο παραγωγα
ES2196396T3 (es) Compuestos heteroaromaticos de 5 miembros conteniendo oxigeno o azufre como inhibidores del factor xa.
ATE106404T1 (de) Angiotensin-ii-antagonisten.
DK0807633T3 (da) Hidtil ukendte 2,3-disubstituerede-(5,6)-heteroarylkondenserede pyrimidin-4-oner
ATE324890T1 (de) Zusammensetzung enthaltend einen angiotensin-ii- rezeptor-antagonist und einen diuretikum und deren verwendung zur behandlung von bluthochdruck
ATE282605T1 (de) 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie
BR0002512A (pt) Derivados de 4-arilpiperidina para o tratamento de prurido
NO180779B (no) Pyridinderivater, fremgangsmåte for deres fremstilling, anvendelse derav, sett omfattende slike, og utgangsforbindelse for fremgangsmåten
NO970350D0 (no) Forbindelser anvendelige som anti-formeringsmidler og GARFT-inhibitorer
FI941309A (fi) Substituoituja pyridopyrmidiinejä korkean verenpaineen vastaisina aineina
CY1115291T1 (el) Ινδολη, αζαϊνδολη και σχετικα ετεροκυκλικα αμιδια 4-αλκενυλ πιπεριδινης