DK0527922T3 - Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf - Google Patents

Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf

Info

Publication number
DK0527922T3
DK0527922T3 DK91910026.3T DK91910026T DK0527922T3 DK 0527922 T3 DK0527922 T3 DK 0527922T3 DK 91910026 T DK91910026 T DK 91910026T DK 0527922 T3 DK0527922 T3 DK 0527922T3
Authority
DK
Denmark
Prior art keywords
alkyl
alkoxy
derivatives
hydrogen
carboxylic acids
Prior art date
Application number
DK91910026.3T
Other languages
English (en)
Inventor
Stevan Wakefield Djuric
Thomas Dale Penning
James Patrick Snyder
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0527922T3 publication Critical patent/DK0527922T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91910026.3T 1990-05-10 1991-05-01 Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf DK0527922T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/521,777 US5073562A (en) 1990-05-10 1990-05-10 Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
DK0527922T3 true DK0527922T3 (da) 1995-05-22

Family

ID=24078110

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91910026.3T DK0527922T3 (da) 1990-05-10 1991-05-01 Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf

Country Status (16)

Country Link
US (1) US5073562A (da)
EP (1) EP0527922B1 (da)
JP (1) JPH05507084A (da)
AT (1) ATE119528T1 (da)
AU (1) AU647487B2 (da)
CA (1) CA2082500A1 (da)
DE (1) DE69108025T2 (da)
DK (1) DK0527922T3 (da)
ES (1) ES2069295T3 (da)
GR (1) GR3015349T3 (da)
IE (1) IE62719B1 (da)
IL (1) IL98090A (da)
NZ (1) NZ238092A (da)
PT (1) PT97614A (da)
WO (1) WO1991017160A1 (da)
ZA (1) ZA913546B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2677021B1 (fr) * 1991-05-31 1993-10-01 Upsa Laboratoires Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
AU2585595A (en) * 1994-05-25 1995-12-18 G.D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists
US5516917A (en) * 1994-06-08 1996-05-14 G. D. Searle & Co. Leukotriene B4 antagonists
CA2202056A1 (en) * 1994-10-13 1996-04-25 Mark A. Dombroski Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4' (ltb4) antagonists
MX9702731A (es) * 1994-10-13 1997-06-28 Pfizer Compuestos de benzopirano y benzo fusionados, composiciones que los contienen y uso de los mismos.
AU1707700A (en) 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
EP1324995A2 (en) 2000-09-27 2003-07-09 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
EP1347755A2 (en) * 2000-10-31 2003-10-01 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
US7446127B2 (en) * 2003-08-27 2008-11-04 Sk Holdings Co, Ltd. Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders
US7709197B2 (en) 2005-06-15 2010-05-04 Callida Genomics, Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
EP2546360A1 (en) 2005-10-07 2013-01-16 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
JP5180845B2 (ja) 2006-02-24 2013-04-10 カリダ・ジェノミックス・インコーポレイテッド Ｄｎａアレイ上でのハイスループットゲノム配列決定
EP2766498B1 (en) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequencing by structure assembly
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
US9540685B2 (en) 2013-03-15 2017-01-10 President And Fellows Of Harvard College Methods of identifying homologous genes using FISH
WO2016028843A2 (en) 2014-08-19 2016-02-25 President And Fellows Of Harvard College Rna-guided systems for probing and mapping of nucleic acids
CA3158317A1 (en) 2019-10-18 2021-04-22 The Board Of Trustees Of The Leland Stanford Junior University Clinical- and industrial-scale intact-tissue sequencing
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
CN117396613A (zh) 2021-06-01 2024-01-12 10X基因组学有限公司 用于分析物检测和探针解析的方法和组合物
US20230084407A1 (en) 2021-06-02 2023-03-16 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
US20230026886A1 (en) 2021-07-13 2023-01-26 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
EP4326898B1 (en) 2021-08-16 2024-07-31 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
WO2023141588A1 (en) 2022-01-21 2023-07-27 10X Genomics, Inc. Multiple readout signals for analyzing a sample
US20240254537A1 (en) 2022-02-23 2024-08-01 Insitro, Inc. Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
US20240026427A1 (en) 2022-05-06 2024-01-25 10X Genomics, Inc. Methods and compositions for in situ analysis of v(d)j sequences
WO2023245190A1 (en) 2022-06-17 2023-12-21 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
US20240167081A1 (en) 2022-11-08 2024-05-23 10X Genomics,Inc. Immobilization methods and compositions for in situ detection
US20240158852A1 (en) 2022-11-16 2024-05-16 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
WO2024130203A1 (en) 2022-12-16 2024-06-20 10X Genomics, Inc. Methods and compositions for assessing performance
US20240263219A1 (en) 2023-01-06 2024-08-08 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
US20240263220A1 (en) 2023-02-03 2024-08-08 10X Genomics, Inc. In situ analysis of variant sequences in biological samples

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
DE3070912D1 (en) * 1979-03-20 1985-09-05 Fisons Plc Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them
US4474788A (en) * 1981-11-12 1984-10-02 Fisons Plc Anti-SRSA quinoline carboxylic acid derivatives
US4788214A (en) * 1983-06-24 1988-11-29 Hoffman-La Roche Inc. 3,4-dihydro-2H-1-benzopyran derivatives
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4665203A (en) * 1983-08-08 1987-05-12 G. D. Searle & Co. Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
US4778903A (en) * 1983-12-12 1988-10-18 G. D. Searle & Co. Substituted dihydrobenzopyrans
ZA84345B (en) * 1983-08-08 1985-02-27 Searle & Co Substituted dihydrobenzopyrans
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
MX13485A (es) * 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos

Also Published As

Publication number Publication date
ATE119528T1 (de) 1995-03-15
GR3015349T3 (en) 1995-06-30
AU7902091A (en) 1991-11-27
DE69108025T2 (de) 1995-08-10
EP0527922B1 (en) 1995-03-08
US5073562A (en) 1991-12-17
JPH05507084A (ja) 1993-10-14
WO1991017160A1 (en) 1991-11-14
ZA913546B (en) 1992-07-29
EP0527922A1 (en) 1993-02-24
AU647487B2 (en) 1994-03-24
IL98090A (en) 1995-07-31
PT97614A (pt) 1992-01-31
IE62719B1 (en) 1995-02-22
CA2082500A1 (en) 1991-11-11
NZ238092A (en) 1993-10-26
IL98090A0 (en) 1992-06-21
IE911583A1 (en) 1991-11-20
DE69108025D1 (de) 1995-04-13
ES2069295T3 (es) 1995-05-01

Similar Documents

Publication Publication Date Title
DK0527922T3 (da) Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf
FI960155A (fi) Terapeuttisia heterosyklisiä yhdisteitä
ATE131165T1 (de) Leukotrien-b4-antagonisten.
ES520300A0 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas.
KR950010888A (ko) 평활근세포 증식 및 재발협착증을 억제하는 방법
FI930970A0 (fi) Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa
DK1224940T3 (da) Flydende formuleringer af interferon-beta
DK359387A (da) Oploesninger af oxazaphosphoriner med forbedret stabilitet og fremgangsmaade til deres fremstilling
FI910303A0 (fi) Derivat av tiazolidin med blodtrycksnedsaenkande effekt och terapeutisk anvaendning av dessa.
DK283487D0 (da) Thiazolyl-2-yl-imidazo(1,2-a)pyrimidiner, deres fremstilling og brug
DE69006707D1 (de) Verwendung von Fluorochinolon-Derivaten zur Behandlung der Pneumocystis carinii Pneumonie.
ES2062792T3 (es) Acidos dihidrobenzopiran-2-carboxilicos alcoxi-sustituidos y derivados de los mismos.
ES541780A0 (es) Tetrahidrotienopiridinas
FI880386A (fi) 5-(3-alkyl-5-tert.butyl-4 -hydroxifenyl) -2-amino-6h-1,3,4-tiadiazin, foerfarande foer deras framstaellning dessa innehaollande laekemedel och deras anvaendning.
FI941958A0 (fi) 2-heterosyklinenetyyliamiinijohdannaiset ja niiden käyttö lääkkeinä
DE3366181D1 (en) 2-aminomethyl-6-sulfamoylphenol derivatives, process for their preparation, their use and pharmaceutical preparations based on these compounds
DE69523819D1 (de) Quinolin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen
ATE186912T1 (de) Carbamoylpyrrolidon-derivate zur behandlung von depressionen und cerebrovasculären störungen
SE8802162D0 (sv) Nya aminoacylater av glycerolacetal