ATE131165T1 - Leukotrien-b4-antagonisten. - Google Patents
Leukotrien-b4-antagonisten.Info
- Publication number
- ATE131165T1 ATE131165T1 AT91916271T AT91916271T ATE131165T1 AT E131165 T1 ATE131165 T1 AT E131165T1 AT 91916271 T AT91916271 T AT 91916271T AT 91916271 T AT91916271 T AT 91916271T AT E131165 T1 ATE131165 T1 AT E131165T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- antagonists
- compounds
- formula
- image
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Spray-Type Burners (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/545,430 US5124350A (en) | 1990-06-28 | 1990-06-28 | Leukotriene b4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE131165T1 true ATE131165T1 (de) | 1995-12-15 |
Family
ID=24176217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91916271T ATE131165T1 (de) | 1990-06-28 | 1991-06-27 | Leukotrien-b4-antagonisten. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US5124350A (de) |
| EP (1) | EP0593478B1 (de) |
| JP (1) | JP2942630B2 (de) |
| AT (1) | ATE131165T1 (de) |
| AU (1) | AU8528291A (de) |
| CA (1) | CA2081766C (de) |
| DE (1) | DE69115297T2 (de) |
| DK (1) | DK0593478T3 (de) |
| ES (1) | ES2080334T3 (de) |
| GR (1) | GR3018322T3 (de) |
| IE (1) | IE62680B1 (de) |
| PT (1) | PT98140B (de) |
| WO (1) | WO1992000011A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| US5273999A (en) * | 1991-09-10 | 1993-12-28 | Hoffmann-La Roche Inc. | Carboxylic acid leukotriene B4 antagonists |
| US5252599A (en) * | 1992-08-27 | 1993-10-12 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
| US5455274A (en) * | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
| US5324743A (en) * | 1992-12-10 | 1994-06-28 | Eli Lilly And Company | Leukotriene B4 antagonists |
| US5516917A (en) * | 1994-06-08 | 1996-05-14 | G. D. Searle & Co. | Leukotriene B4 antagonists |
| RU2128655C1 (ru) * | 1994-10-13 | 1999-04-10 | Пфайзер Инк. | Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования |
| NZ285154A (en) * | 1994-10-13 | 1998-11-25 | Pfizer | Optionally heterocyclically substituted benzopyran and benzo-fused derivatives, preparation and use as leukotriene antagonists |
| EP0833664A1 (de) | 1995-06-12 | 1998-04-08 | G.D. SEARLE & CO. | Kombination aus einem cyclooxygenase-2 inhibitor und einem leukotrien b4 rezeptorantagonisten zur behandlung von entzündungen |
| ES2243978T3 (es) * | 1996-02-13 | 2005-12-01 | G.D. SEARLE & CO. | Composiciones que comprenden un inhibidor de la ciclooxigenasa-2 y un antagonista del receptor de leucotrieno b4. |
| US6403684B1 (en) * | 1998-12-16 | 2002-06-11 | General Electric Company | Polyetherimide resin/polyester resin blends having improved visual clarity |
| PE20020453A1 (es) | 2000-09-27 | 2002-06-06 | Merck & Co Inc | Derivados del acido benzopirancarboxilico para el tratamiento de la diabetes y los trastornos de lipidos |
| WO2002060434A2 (en) | 2000-10-31 | 2002-08-08 | Merck & Co., Inc. | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
| JP2008506768A (ja) * | 2004-07-22 | 2008-03-06 | ファルマシア コーポレーション | Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物 |
| US7572600B2 (en) * | 2004-08-04 | 2009-08-11 | Chemocentryx, Inc. | Enzymatic activities in chemokine-mediated inflammation |
| EP1883402A2 (de) * | 2005-04-13 | 2008-02-06 | Astex Therapeutics Limited | Hydroxybenzamidderivate und ihre verwendung als hsp90-inhibitoren |
| US7754725B2 (en) * | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5528806B2 (ja) * | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| JP5528807B2 (ja) * | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| EP2081891A2 (de) * | 2006-10-12 | 2009-07-29 | Astex Therapeutics Limited | Pharmazeutische verbindungen mit hsp90-hemmender oder modulierender wirkung |
| JP5721949B2 (ja) * | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | 複合薬剤 |
| WO2008044054A2 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in therapy |
| GB0806527D0 (en) * | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| EP3268085A4 (de) | 2015-03-13 | 2018-10-31 | The Board of Trustees of The Leland Stanford Junior University | Ltb4-hemmung zur vorbeugung und behandlung von lymphödem beim menschen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
| DE3070912D1 (en) * | 1979-03-20 | 1985-09-05 | Fisons Plc | Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them |
| DE3068213D1 (en) * | 1979-09-05 | 1984-07-19 | Glaxo Group Ltd | Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them |
| EP0079637B1 (de) * | 1981-11-12 | 1987-01-28 | FISONS plc | Anti srs-a Carbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Formulierungen |
| ZA844519B (en) * | 1983-06-24 | 1985-02-27 | Hoffmann La Roche | Dihydrobenzopyran derivatives |
| US4665203A (en) * | 1983-08-08 | 1987-05-12 | G. D. Searle & Co. | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors |
| US4778903A (en) * | 1983-12-12 | 1988-10-18 | G. D. Searle & Co. | Substituted dihydrobenzopyrans |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| US4546194A (en) * | 1984-05-29 | 1985-10-08 | G. D. Searle & Co. | Substituted chromanon-2-yl alkanols and derivatives thereof |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| EP0336068A1 (de) * | 1988-02-11 | 1989-10-11 | F. Hoffmann-La Roche Ag | Phenoxyalkoxy-3,4-dihydro-2H-1-benzopyran-Derivate |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| DE4206523A1 (de) * | 1992-03-02 | 1993-09-09 | Vdo Schindling | Vorrichtung zur verstellung einer drosselklappe |
-
1990
- 1990-06-28 US US07/545,430 patent/US5124350A/en not_active Expired - Lifetime
-
1991
- 1991-06-27 ES ES91916271T patent/ES2080334T3/es not_active Expired - Lifetime
- 1991-06-27 WO PCT/US1991/004386 patent/WO1992000011A2/en not_active Ceased
- 1991-06-27 IE IE225591A patent/IE62680B1/en not_active IP Right Cessation
- 1991-06-27 DE DE69115297T patent/DE69115297T2/de not_active Expired - Fee Related
- 1991-06-27 DK DK91916271.9T patent/DK0593478T3/da active
- 1991-06-27 AT AT91916271T patent/ATE131165T1/de not_active IP Right Cessation
- 1991-06-27 AU AU85282/91A patent/AU8528291A/en not_active Abandoned
- 1991-06-27 CA CA002081766A patent/CA2081766C/en not_active Expired - Fee Related
- 1991-06-27 EP EP91916271A patent/EP0593478B1/de not_active Expired - Lifetime
- 1991-06-27 JP JP3515594A patent/JP2942630B2/ja not_active Expired - Fee Related
- 1991-06-28 PT PT98140A patent/PT98140B/pt not_active IP Right Cessation
-
1992
- 1992-12-23 US US07/995,859 patent/US5310951A/en not_active Expired - Lifetime
-
1994
- 1994-03-03 US US08/205,909 patent/US5439937A/en not_active Expired - Fee Related
-
1995
- 1995-05-19 US US08/445,059 patent/US5532383A/en not_active Expired - Fee Related
- 1995-12-07 GR GR950403300T patent/GR3018322T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3018322T3 (en) | 1996-03-31 |
| JP2942630B2 (ja) | 1999-08-30 |
| WO1992000011A3 (en) | 1992-02-06 |
| DK0593478T3 (da) | 1996-01-08 |
| DE69115297D1 (de) | 1996-01-18 |
| PT98140A (pt) | 1993-09-30 |
| PT98140B (pt) | 1998-12-31 |
| US5124350A (en) | 1992-06-23 |
| JPH05507720A (ja) | 1993-11-04 |
| IE912255A1 (en) | 1992-01-01 |
| US5439937A (en) | 1995-08-08 |
| IE62680B1 (en) | 1995-02-22 |
| EP0593478B1 (de) | 1995-12-06 |
| AU8528291A (en) | 1992-01-23 |
| WO1992000011A2 (en) | 1992-01-09 |
| ES2080334T3 (es) | 1996-02-01 |
| US5310951A (en) | 1994-05-10 |
| DE69115297T2 (de) | 1996-06-13 |
| US5532383A (en) | 1996-07-02 |
| CA2081766A1 (en) | 1991-12-29 |
| EP0593478A1 (de) | 1994-04-27 |
| CA2081766C (en) | 2002-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0593478T3 (da) | Leukotrien-B4-antagonister | |
| ES2069295T3 (es) | Acidos dihidrobenzopiran-2-carboxilicos substituidos con alcoxi y derivados de los mismos. | |
| SE8201854L (sv) | N-substituerade amino-aminosyror | |
| ES477457A1 (es) | Procedimiento de preparacion de amidas de alcohilendiaminas. | |
| NZ190816A (en) | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanes and pharmaceutical compositions | |
| ZM987A1 (en) | New dihydrobenzofuran and chroman-carboxamide derivatives,processes for the preparation thereof and use thereof as neuroleptics | |
| ES2046641T3 (es) | Composicion antitumoral. | |
| ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
| ES482285A1 (es) | Procedimiento de preparacion de compuestos de benzofurano. | |
| ES2062792T3 (es) | Acidos dihidrobenzopiran-2-carboxilicos alcoxi-sustituidos y derivados de los mismos. | |
| GB8921792D0 (en) | New compositions of matter | |
| ATE86117T1 (de) | Zusammensetzung gegen leberkrankheiten. | |
| TW225989B (de) | ||
| TW334428B (en) | Novel benzodiazepine derivatives | |
| ES488387A1 (es) | Procedimiento de preparacion de derivados condensados de pi-rrolidina | |
| TNSN86099A1 (fr) | Nouveaux benzamides, leur procede de preparation et leur application dans le domaine therapeutique | |
| ATE81465T1 (de) | Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten. | |
| GR3035010T3 (en) | New derivatives of glycylanilides, preparation and therapeutical application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |