DK0499527T3 - Beta-carbolinderivater, som er ligander for benzodiazepinreceptoren og har en omvendt agonistvirkning og en antagonistvirkning over for benzodiazepiner, og lægemidler, som indeholder dem - Google Patents
Beta-carbolinderivater, som er ligander for benzodiazepinreceptoren og har en omvendt agonistvirkning og en antagonistvirkning over for benzodiazepiner, og lægemidler, som indeholder demInfo
- Publication number
- DK0499527T3 DK0499527T3 DK92400351.0T DK92400351T DK0499527T3 DK 0499527 T3 DK0499527 T3 DK 0499527T3 DK 92400351 T DK92400351 T DK 92400351T DK 0499527 T3 DK0499527 T3 DK 0499527T3
- Authority
- DK
- Denmark
- Prior art keywords
- radical
- beta
- benzodiazepines
- ligands
- hydroxyl
- Prior art date
Links
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title abstract 3
- 102000004300 GABA-A Receptors Human genes 0.000 title abstract 2
- 108090000839 GABA-A Receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 229940049706 benzodiazepine Drugs 0.000 title abstract 2
- 150000001557 benzodiazepines Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940125425 inverse agonist Drugs 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9101595A FR2672602B1 (fr) | 1991-02-12 | 1991-02-12 | Composes derives des beta-carbolines ligands du recepteur des benzodiazepines ayant un effet agoniste inverse et antagoniste vis-a-vis des benzodiazepines et medicaments les contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0499527T3 true DK0499527T3 (da) | 1997-11-03 |
Family
ID=9409607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92400351.0T DK0499527T3 (da) | 1991-02-12 | 1992-02-11 | Beta-carbolinderivater, som er ligander for benzodiazepinreceptoren og har en omvendt agonistvirkning og en antagonistvirkning over for benzodiazepiner, og lægemidler, som indeholder dem |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5258385A (da) |
| EP (1) | EP0499527B1 (da) |
| JP (1) | JPH06211841A (da) |
| AT (1) | ATE152452T1 (da) |
| CA (1) | CA2061065A1 (da) |
| DE (1) | DE69219379T2 (da) |
| DK (1) | DK0499527T3 (da) |
| ES (1) | ES2103904T3 (da) |
| FR (1) | FR2672602B1 (da) |
| GR (1) | GR3024291T3 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW251284B (da) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9503601D0 (en) | 1995-02-23 | 1995-04-12 | Merck Sharp & Dohme | Method of treatment and method of manufacture of medicament |
| US20050026884A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050113318A1 (en) * | 2003-07-31 | 2005-05-26 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20090285900A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
| DE3608089A1 (de) * | 1986-03-08 | 1987-09-10 | Schering Ag | Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
-
1991
- 1991-02-12 FR FR9101595A patent/FR2672602B1/fr not_active Expired - Fee Related
-
1992
- 1992-02-11 ES ES92400351T patent/ES2103904T3/es not_active Expired - Lifetime
- 1992-02-11 EP EP92400351A patent/EP0499527B1/fr not_active Expired - Lifetime
- 1992-02-11 DK DK92400351.0T patent/DK0499527T3/da active
- 1992-02-11 AT AT92400351T patent/ATE152452T1/de not_active IP Right Cessation
- 1992-02-11 DE DE69219379T patent/DE69219379T2/de not_active Expired - Fee Related
- 1992-02-12 US US07/834,399 patent/US5258385A/en not_active Expired - Fee Related
- 1992-02-12 JP JP4057216A patent/JPH06211841A/ja active Pending
- 1992-02-12 CA CA002061065A patent/CA2061065A1/fr not_active Abandoned
-
1997
- 1997-07-30 GR GR970401940T patent/GR3024291T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69219379T2 (de) | 1997-12-11 |
| CA2061065A1 (fr) | 1992-08-13 |
| ES2103904T3 (es) | 1997-10-01 |
| EP0499527A1 (fr) | 1992-08-19 |
| GR3024291T3 (en) | 1997-10-31 |
| JPH06211841A (ja) | 1994-08-02 |
| FR2672602A1 (fr) | 1992-08-14 |
| DE69219379D1 (de) | 1997-06-05 |
| EP0499527B1 (fr) | 1997-05-02 |
| ATE152452T1 (de) | 1997-05-15 |
| FR2672602B1 (fr) | 1993-06-04 |
| US5258385A (en) | 1993-11-02 |
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