DK0490823T3 - - Google Patents

Info

Publication number
DK0490823T3
DK0490823T3 DK91810954.7T DK91810954T DK0490823T3 DK 0490823 T3 DK0490823 T3 DK 0490823T3 DK 91810954 T DK91810954 T DK 91810954T DK 0490823 T3 DK0490823 T3 DK 0490823T3
Authority
DK
Denmark
Prior art keywords
4alkoxy
acid addition
addition salts
esters
isoquinolines
Prior art date
Application number
DK91810954.7T
Other languages
Danish (da)
English (en)
Inventor
Reto Naef
Original Assignee
Sandoz Ltd
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd, Sandoz Ag filed Critical Sandoz Ltd
Application granted granted Critical
Publication of DK0490823T3 publication Critical patent/DK0490823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DK91810954.7T 1990-12-13 1991-12-09 DK0490823T3 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (1)

Publication Number Publication Date
DK0490823T3 true DK0490823T3 (no) 1997-02-17

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91810954.7T DK0490823T3 (no) 1990-12-13 1991-12-09

Country Status (25)

Country Link
US (1) US5177085A (no)
EP (1) EP0490823B1 (no)
JP (1) JPH0764820B2 (no)
KR (1) KR920012040A (no)
AT (1) ATE145201T1 (no)
AU (1) AU643575B2 (no)
CA (1) CA2057524A1 (no)
CZ (1) CZ281669B6 (no)
DE (1) DE69123124T2 (no)
DK (1) DK0490823T3 (no)
ES (1) ES2093694T3 (no)
FI (1) FI915844A (no)
GB (1) GB9027055D0 (no)
GR (1) GR3022034T3 (no)
HU (1) HUT61729A (no)
IE (1) IE914325A1 (no)
IL (1) IL100328A (no)
MX (1) MX9102502A (no)
MY (1) MY129941A (no)
NZ (1) NZ240936A (no)
PL (1) PL168329B1 (no)
PT (1) PT99775B (no)
RU (1) RU2060992C1 (no)
TW (1) TW201736B (no)
ZA (1) ZA919858B (no)

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AU5330698A (en) 1996-12-23 1998-07-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
WO1998038168A1 (en) * 1997-02-27 1998-09-03 Tanabe Seiyaku Co., Ltd. Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
IL133824A (en) * 1997-07-25 2005-12-18 Altana Pharma Ag Tetrazole derivatives and medicaments containing the same
JP2001518468A (ja) * 1997-09-30 2001-10-16 モレキュラー デザインズ インターナショナル，インコーポレイテッド β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) * 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
DK1212089T3 (da) 1999-08-21 2006-07-24 Altana Pharma Ag Synergistisk kombination af Roflumilast og Salmeterol
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
DE60125026T2 (de) * 2000-03-23 2007-06-28 Takeda Pharmaceutical Co. Ltd. Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
MXPA03004262A (es) 2000-11-14 2003-09-22 Altana Pharma Ag Derivados de (dihidro)isoquinolina como inhibidores de fosfodiesterasa.
WO2002040449A1 (en) * 2000-11-14 2002-05-23 Altana Pharma Ag Dihydroisoquinolines as novel phosphodiesterase inhibitors
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
ES2320204T3 (es) * 2001-05-29 2009-05-20 Bayer Schering Pharma Aktiengesellschaft Pirimidinas inhibidoras de cdk, su preparacion y su utilizacion como medicamentos.
KR100836547B1 (ko) * 2002-01-11 2008-06-10 상꾜 가부시키가이샤 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물
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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
ATE145201T1 (de) 1996-11-15
CZ281669B6 (cs) 1996-12-11
CA2057524A1 (en) 1992-06-14
FI915844A (fi) 1992-06-14
GB9027055D0 (en) 1991-02-06
IL100328A (en) 1995-12-08
PL292738A1 (en) 1992-12-14
CS375791A3 (en) 1992-06-17
RU2060992C1 (ru) 1996-05-27
JPH0764820B2 (ja) 1995-07-12
KR920012040A (ko) 1992-07-25
PT99775B (pt) 1999-05-31
DE69123124D1 (de) 1996-12-19
DE69123124T2 (de) 1997-05-15
PT99775A (pt) 1992-11-30
PL168329B1 (pl) 1996-02-29
JPH04275276A (ja) 1992-09-30
MX9102502A (es) 1992-06-01
GR3022034T3 (en) 1997-03-31
IL100328A0 (en) 1992-09-06
US5177085A (en) 1993-01-05
IE914325A1 (en) 1992-06-17
TW201736B (no) 1993-03-11
HUT61729A (en) 1993-03-01
FI915844A0 (fi) 1991-12-11
HU913760D0 (en) 1992-02-28
MY129941A (en) 2007-05-31
EP0490823B1 (en) 1996-11-13
ES2093694T3 (es) 1997-01-01
NZ240936A (en) 1993-09-27
AU8898591A (en) 1992-06-18
AU643575B2 (en) 1993-11-18
EP0490823A1 (en) 1992-06-17
ZA919858B (en) 1993-06-14

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