DK0490823T3 - - Google Patents

Info

Publication number
DK0490823T3
DK0490823T3 DK91810954.7T DK91810954T DK0490823T3 DK 0490823 T3 DK0490823 T3 DK 0490823T3 DK 91810954 T DK91810954 T DK 91810954T DK 0490823 T3 DK0490823 T3 DK 0490823T3
Authority
DK
Denmark
Prior art keywords
4alkoxy
acid addition
addition salts
esters
isoquinolines
Prior art date
Application number
DK91810954.7T
Other languages
Danish (da)
English (en)
Inventor
Reto Naef
Original Assignee
Sandoz Ltd
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd, Sandoz Ag filed Critical Sandoz Ltd
Application granted granted Critical
Publication of DK0490823T3 publication Critical patent/DK0490823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DK91810954.7T 1990-12-13 1991-12-09 DK0490823T3 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (1)

Publication Number Publication Date
DK0490823T3 true DK0490823T3 (hr) 1997-02-17

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91810954.7T DK0490823T3 (hr) 1990-12-13 1991-12-09

Country Status (25)

Country Link
US (1) US5177085A (hr)
EP (1) EP0490823B1 (hr)
JP (1) JPH0764820B2 (hr)
KR (1) KR920012040A (hr)
AT (1) ATE145201T1 (hr)
AU (1) AU643575B2 (hr)
CA (1) CA2057524A1 (hr)
CZ (1) CZ281669B6 (hr)
DE (1) DE69123124T2 (hr)
DK (1) DK0490823T3 (hr)
ES (1) ES2093694T3 (hr)
FI (1) FI915844A (hr)
GB (1) GB9027055D0 (hr)
GR (1) GR3022034T3 (hr)
HU (1) HUT61729A (hr)
IE (1) IE914325A1 (hr)
IL (1) IL100328A (hr)
MX (1) MX9102502A (hr)
MY (1) MY129941A (hr)
NZ (1) NZ240936A (hr)
PL (1) PL168329B1 (hr)
PT (1) PT99775B (hr)
RU (1) RU2060992C1 (hr)
TW (1) TW201736B (hr)
ZA (1) ZA919858B (hr)

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US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
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GB9412571D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
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US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
DE69524962T4 (de) * 1994-08-22 2003-08-28 Mitsubishi Pharma Corp., Osaka Benzolderivate und deren medizinische verwendung
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
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US6268373B1 (en) * 1995-06-07 2001-07-31 Euro-Celtique S.A. Trisubstituted thioxanthines
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WO1997034473A1 (en) * 1996-03-21 1997-09-25 The Trustees Of Columbia University In The City Of New York Craf1 (traf-3) isoforms and uses thereof
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GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
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US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
AU6230098A (en) * 1997-02-27 1998-09-18 Tanabe Seiyaku Co., Ltd. Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
US6410551B1 (en) 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
EP1023269A4 (en) * 1997-09-30 2001-06-27 Molecular Design Int BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
GB9924862D0 (en) * 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
EP1270577B1 (en) * 2000-03-23 2006-12-06 Takeda Pharmaceutical Company Limited Furoisoquinoline derivatives, process for producing the same and use thereof
WO2002040450A1 (en) 2000-11-14 2002-05-23 Altana Pharma Ag (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
WO2002040449A1 (en) * 2000-11-14 2002-05-23 Altana Pharma Ag Dihydroisoquinolines as novel phosphodiesterase inhibitors
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
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WO2003059880A1 (fr) 2002-01-11 2003-07-24 Sankyo Company, Limited Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
JP2005537312A (ja) * 2002-08-17 2005-12-08 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のフェナントリジン
EP1581533A2 (en) * 2002-08-17 2005-10-05 ALTANA Pharma AG Novel benzonaphthyridines
ATE348616T1 (de) 2002-08-29 2007-01-15 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
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HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
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GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
DE69123124D1 (de) 1996-12-19
HU913760D0 (en) 1992-02-28
FI915844A0 (fi) 1991-12-11
CA2057524A1 (en) 1992-06-14
DE69123124T2 (de) 1997-05-15
EP0490823A1 (en) 1992-06-17
IL100328A (en) 1995-12-08
JPH04275276A (ja) 1992-09-30
CS375791A3 (en) 1992-06-17
TW201736B (hr) 1993-03-11
MX9102502A (es) 1992-06-01
CZ281669B6 (cs) 1996-12-11
MY129941A (en) 2007-05-31
GR3022034T3 (en) 1997-03-31
IL100328A0 (en) 1992-09-06
KR920012040A (ko) 1992-07-25
US5177085A (en) 1993-01-05
FI915844A (fi) 1992-06-14
PT99775B (pt) 1999-05-31
PT99775A (pt) 1992-11-30
RU2060992C1 (ru) 1996-05-27
IE914325A1 (en) 1992-06-17
EP0490823B1 (en) 1996-11-13
JPH0764820B2 (ja) 1995-07-12
AU8898591A (en) 1992-06-18
AU643575B2 (en) 1993-11-18
PL168329B1 (pl) 1996-02-29
HUT61729A (en) 1993-03-01
GB9027055D0 (en) 1991-02-06
NZ240936A (en) 1993-09-27
ES2093694T3 (es) 1997-01-01
ATE145201T1 (de) 1996-11-15
ZA919858B (en) 1993-06-14
PL292738A1 (en) 1992-12-14

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