DK0490823T3 - - Google Patents
Info
- Publication number
 - DK0490823T3 DK0490823T3 DK91810954.7T DK91810954T DK0490823T3 DK 0490823 T3 DK0490823 T3 DK 0490823T3 DK 91810954 T DK91810954 T DK 91810954T DK 0490823 T3 DK0490823 T3 DK 0490823T3
 - Authority
 - DK
 - Denmark
 - Prior art keywords
 - 4alkoxy
 - acid addition
 - addition salts
 - esters
 - isoquinolines
 - Prior art date
 
Links
Classifications
- 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07D—HETEROCYCLIC COMPOUNDS
 - C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
 - C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
 
 - 
        
- C—CHEMISTRY; METALLURGY
 - C07—ORGANIC CHEMISTRY
 - C07D—HETEROCYCLIC COMPOUNDS
 - C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
 - C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
 - C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
 - C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P11/00—Drugs for disorders of the respiratory system
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P11/00—Drugs for disorders of the respiratory system
 - A61P11/06—Antiasthmatics
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
 - A61P11/00—Drugs for disorders of the respiratory system
 - A61P11/08—Bronchodilators
 
 
Landscapes
- Chemical & Material Sciences (AREA)
 - Organic Chemistry (AREA)
 - Health & Medical Sciences (AREA)
 - Pulmonology (AREA)
 - Pharmacology & Pharmacy (AREA)
 - General Health & Medical Sciences (AREA)
 - General Chemical & Material Sciences (AREA)
 - Medicinal Chemistry (AREA)
 - Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
 - Bioinformatics & Cheminformatics (AREA)
 - Engineering & Computer Science (AREA)
 - Life Sciences & Earth Sciences (AREA)
 - Animal Behavior & Ethology (AREA)
 - Chemical Kinetics & Catalysis (AREA)
 - Public Health (AREA)
 - Veterinary Medicine (AREA)
 - Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
 - Other In-Based Heterocyclic Compounds (AREA)
 - Plural Heterocyclic Compounds (AREA)
 - Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
 - Hydrogenated Pyridines (AREA)
 
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| GB909027055A GB9027055D0 (en) | 1990-12-13 | 1990-12-13 | Organic compounds | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| DK0490823T3 true DK0490823T3 (forum.php) | 1997-02-17 | 
Family
ID=10686945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| DK91810954.7T DK0490823T3 (forum.php) | 1990-12-13 | 1991-12-09 | 
Country Status (25)
| Country | Link | 
|---|---|
| US (1) | US5177085A (forum.php) | 
| EP (1) | EP0490823B1 (forum.php) | 
| JP (1) | JPH0764820B2 (forum.php) | 
| KR (1) | KR920012040A (forum.php) | 
| AT (1) | ATE145201T1 (forum.php) | 
| AU (1) | AU643575B2 (forum.php) | 
| CA (1) | CA2057524A1 (forum.php) | 
| CZ (1) | CZ281669B6 (forum.php) | 
| DE (1) | DE69123124T2 (forum.php) | 
| DK (1) | DK0490823T3 (forum.php) | 
| ES (1) | ES2093694T3 (forum.php) | 
| FI (1) | FI915844L (forum.php) | 
| GB (1) | GB9027055D0 (forum.php) | 
| GR (1) | GR3022034T3 (forum.php) | 
| HU (1) | HUT61729A (forum.php) | 
| IE (1) | IE914325A1 (forum.php) | 
| IL (1) | IL100328A (forum.php) | 
| MX (1) | MX9102502A (forum.php) | 
| MY (1) | MY129941A (forum.php) | 
| NZ (1) | NZ240936A (forum.php) | 
| PL (1) | PL168329B1 (forum.php) | 
| PT (1) | PT99775B (forum.php) | 
| RU (1) | RU2060992C1 (forum.php) | 
| TW (1) | TW201736B (forum.php) | 
| ZA (1) | ZA919858B (forum.php) | 
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| GB9212673D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds | 
| GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds | 
| GB9226830D0 (en) * | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds | 
| US5622977A (en) * | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same | 
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds | 
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds | 
| GB9322828D0 (en) * | 1993-11-05 | 1993-12-22 | Sandoz Ltd | Organic compounds | 
| GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process | 
| WO1995017399A1 (en) * | 1993-12-22 | 1995-06-29 | Celltech Therapeutics Limited | Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors | 
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives | 
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation | 
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds | 
| GB9412573D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds | 
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds | 
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same | 
| RU2161967C2 (ru) * | 1994-08-18 | 2001-01-20 | Дзе Проктер Энд Гэмбл Компани | Соединения 7-(2-имидазолиниламино) хинолина, пригодные в качестве агонистов альфа-2-адренорецептора | 
| JP3870419B2 (ja) * | 1994-08-22 | 2007-01-17 | 三菱ウェルファーマ株式会社 | ベンゼン化合物およびその医薬としての用途 | 
| US5948820A (en) | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof | 
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines | 
| CA2206804C (en) * | 1994-12-13 | 2002-03-19 | Euro-Celtique, S.A. | Trisubstituted thioxanthines | 
| US6268373B1 (en) * | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines | 
| GB9523267D0 (en) * | 1995-11-14 | 1996-01-17 | Sandoz Ltd | Organic compounds | 
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds | 
| AU2593997A (en) * | 1996-03-21 | 1997-10-10 | Trustees Of Columbia University In The City Of New York, The | Craf1 (traf-3) isoforms and uses thereof | 
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity | 
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds | 
| AU4674797A (en) * | 1996-10-22 | 1998-05-15 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders | 
| GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds | 
| ID19155A (id) * | 1996-12-13 | 1998-06-18 | Tanabe Seiyaku Co | Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya | 
| JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式2−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 | 
| AU6230098A (en) * | 1997-02-27 | 1998-09-18 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors | 
| GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds | 
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds | 
| JP2001510825A (ja) * | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規テトラゾール誘導体 | 
| EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE | 
| IT1296985B1 (it) | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 | 
| IT1302677B1 (it) * | 1998-10-15 | 2000-09-29 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 | 
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds | 
| TR200201317T2 (tr) | 1999-08-21 | 2002-11-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Sinerjistik kombinasyon. | 
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds | 
| CA2404226A1 (en) * | 2000-03-23 | 2001-09-27 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof | 
| AU2954102A (en) | 2000-11-14 | 2002-05-27 | Byk Gulden Lomberg Chem Fab | (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors | 
| AU2002224835A1 (en) * | 2000-11-14 | 2002-05-27 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Dihydroisoquinolines as novel phosphodiesterase inhibitors | 
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same | 
| RS94703A (en) * | 2001-05-29 | 2007-02-05 | Schering Aktiengesellschaft, | Cdk inhibiting pyrimidines, production thereof and their use as medicaments | 
| AU2003202495B2 (en) * | 2002-01-11 | 2006-07-20 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these | 
| US7745180B2 (en) * | 2002-04-24 | 2010-06-29 | Hitachi Chemical Co., Ltd. | Device and method for high-throughput quantification of mRNA from whole blood | 
| US20060116518A1 (en) * | 2002-08-17 | 2006-06-01 | Altana Pharma Ag | Novel phenanthridines | 
| CA2495603A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Benzonaphthyridines with pde 3/4 inhibiting activity | 
| AU2003255493B8 (en) | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors | 
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors | 
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists | 
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders | 
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility | 
| CA2541690A1 (en) * | 2003-10-16 | 2005-05-06 | F. Hoffmann-La Roche Ag | Glutamine fructose-6-phosphate amidotransferase (gfat) inhibitors | 
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors | 
| KR20110136901A (ko) | 2004-02-24 | 2011-12-21 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 | 
| ME01955B (me) * | 2004-03-03 | 2015-05-20 | Takeda Gmbh | Novi hidroksi-6-heteroarilfenantridini i njihova primena kao pde4 inhibitori | 
| RU2281100C1 (ru) * | 2005-01-11 | 2006-08-10 | Общество с ограниченной ответственностью "Синтез-2000" | Спазмолитическое средство | 
| CA2598860C (en) | 2005-03-02 | 2017-01-17 | Nycomed Gmbh | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | 
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders | 
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases | 
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders | 
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros | 
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use | 
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 | 
| AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing | 
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders | 
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses | 
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same | 
| KR20160042039A (ko) | 2013-08-09 | 2016-04-18 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 | 
| WO2015022418A1 (en) | 2013-08-16 | 2015-02-19 | Takeda Gmbh | Treatment of cognitive impairment with pde4 inhibitor | 
| EP3972599A1 (en) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient | 
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives | 
| PH25651A (en) * | 1986-05-21 | 1991-08-21 | Duphar Int Res | New di, tetrahydroisoquinoline derivatives | 
| HU196758B (en) * | 1986-05-21 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them | 
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds | 
- 
        1990
        
- 1990-12-13 GB GB909027055A patent/GB9027055D0/en active Pending
 
 - 
        1991
        
- 1991-12-02 HU HU913760A patent/HUT61729A/hu unknown
 - 1991-12-09 DK DK91810954.7T patent/DK0490823T3/da active
 - 1991-12-09 DE DE69123124T patent/DE69123124T2/de not_active Expired - Fee Related
 - 1991-12-09 EP EP91810954A patent/EP0490823B1/en not_active Expired - Lifetime
 - 1991-12-09 AT AT91810954T patent/ATE145201T1/de not_active IP Right Cessation
 - 1991-12-09 ES ES91810954T patent/ES2093694T3/es not_active Expired - Lifetime
 - 1991-12-10 MY MYPI91002283A patent/MY129941A/en unknown
 - 1991-12-11 CZ CS913757A patent/CZ281669B6/cs unknown
 - 1991-12-11 FI FI915844A patent/FI915844L/fi not_active Application Discontinuation
 - 1991-12-11 MX MX9102502A patent/MX9102502A/es unknown
 - 1991-12-11 AU AU88985/91A patent/AU643575B2/en not_active Ceased
 - 1991-12-11 IL IL10032891A patent/IL100328A/en not_active IP Right Cessation
 - 1991-12-11 NZ NZ240936A patent/NZ240936A/xx unknown
 - 1991-12-12 PL PL91292738A patent/PL168329B1/pl unknown
 - 1991-12-12 RU SU915010401A patent/RU2060992C1/ru active
 - 1991-12-12 JP JP3328665A patent/JPH0764820B2/ja not_active Expired - Lifetime
 - 1991-12-12 PT PT99775A patent/PT99775B/pt not_active IP Right Cessation
 - 1991-12-12 IE IE432591A patent/IE914325A1/en unknown
 - 1991-12-12 CA CA002057524A patent/CA2057524A1/en not_active Abandoned
 - 1991-12-12 KR KR1019910022728A patent/KR920012040A/ko not_active Ceased
 - 1991-12-12 US US07/805,662 patent/US5177085A/en not_active Expired - Fee Related
 - 1991-12-13 ZA ZA919858A patent/ZA919858B/xx unknown
 - 1991-12-13 TW TW080109769A patent/TW201736B/zh active
 
 - 
        1996
        
- 1996-12-13 GR GR960403459T patent/GR3022034T3/el unknown
 
 
Also Published As
| Publication number | Publication date | 
|---|---|
| IE914325A1 (en) | 1992-06-17 | 
| CS375791A3 (en) | 1992-06-17 | 
| KR920012040A (ko) | 1992-07-25 | 
| EP0490823A1 (en) | 1992-06-17 | 
| MX9102502A (es) | 1992-06-01 | 
| US5177085A (en) | 1993-01-05 | 
| CA2057524A1 (en) | 1992-06-14 | 
| IL100328A0 (en) | 1992-09-06 | 
| FI915844A0 (fi) | 1991-12-11 | 
| PT99775A (pt) | 1992-11-30 | 
| AU643575B2 (en) | 1993-11-18 | 
| HU913760D0 (en) | 1992-02-28 | 
| RU2060992C1 (ru) | 1996-05-27 | 
| PL292738A1 (en) | 1992-12-14 | 
| EP0490823B1 (en) | 1996-11-13 | 
| TW201736B (forum.php) | 1993-03-11 | 
| MY129941A (en) | 2007-05-31 | 
| HUT61729A (en) | 1993-03-01 | 
| IL100328A (en) | 1995-12-08 | 
| FI915844A7 (fi) | 1992-06-14 | 
| GB9027055D0 (en) | 1991-02-06 | 
| GR3022034T3 (en) | 1997-03-31 | 
| PT99775B (pt) | 1999-05-31 | 
| ZA919858B (en) | 1993-06-14 | 
| JPH0764820B2 (ja) | 1995-07-12 | 
| FI915844L (fi) | 1992-06-14 | 
| AU8898591A (en) | 1992-06-18 | 
| DE69123124T2 (de) | 1997-05-15 | 
| DE69123124D1 (de) | 1996-12-19 | 
| ATE145201T1 (de) | 1996-11-15 | 
| JPH04275276A (ja) | 1992-09-30 | 
| ES2093694T3 (es) | 1997-01-01 | 
| PL168329B1 (pl) | 1996-02-29 | 
| CZ281669B6 (cs) | 1996-12-11 | 
| NZ240936A (en) | 1993-09-27 | 
Similar Documents
| Publication | Publication Date | Title | 
|---|---|---|
| DK0490823T3 (forum.php) | ||
| NO2004004I1 (no) | Bortezomib eller en farmasøytisk akseptabel ester derav, eventuelt i form av et farmasøytisk akseptabelt salt derav | |
| GR3024686T3 (en) | Novel guinolone and naphthyridone derivatives. | |
| NO944531D0 (no) | Diaminsalter av clavulansyre | |
| AU1413788A (en) | Dihydropyridinamides process for their preparation, and their use in medicaments | |
| CA2200742A1 (en) | Quinoxaline derivatives useful in therapy | |
| EP0331092A3 (en) | Alpha-amino-carboxylic-acid derivatives, their preparation and use | |
| NO891679D0 (no) | Fremgangsmaate for fremstilling av 5-klor-3-klorsulfonyl-2-tiofenkarbonsyreestere. | |
| PT87563A (pt) | Process for the preparation of vinylcephalosporins useful as medicaments | |
| GR3020230T3 (en) | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | |
| EP0127389A3 (en) | N,n-diethyl-5-methyl-2h-1-benzothiopyrano-(4,3,2-cd)-indazole-2-ethanamine, compositions comprising the same and uses therefor | |
| WO1995022544A3 (de) | Substituierte 1,3,8-triaza-spiro(4,5)-decan-4-on-derivate als vorstufen zur herstellung von pharmazeutika | |
| DE3476065D1 (en) | L-arginine isoxicamate | |
| DE3562375D1 (en) | Alpha-acyloximino-alkane-phosphonic(and -phosphinic) acid esters, their preparation and their use in plant protection | |
| GR3020597T3 (en) | Phospholipids for the treatment of multiple sclerosis | |
| IL107142A0 (en) | Tetrahydroindazolone pharmaceutical compositions |