DK0489116T3 - Fusionsproteiner omfattende GM-CSF og IL-3 - Google Patents

Fusionsproteiner omfattende GM-CSF og IL-3

Info

Publication number
DK0489116T3
DK0489116T3 DK90914297.8T DK90914297T DK0489116T3 DK 0489116 T3 DK0489116 T3 DK 0489116T3 DK 90914297 T DK90914297 T DK 90914297T DK 0489116 T3 DK0489116 T3 DK 0489116T3
Authority
DK
Denmark
Prior art keywords
csf
fusion proteins
alone
combined
disclosed
Prior art date
Application number
DK90914297.8T
Other languages
English (en)
Inventor
Linda S Park
David J Cosman
Benson M Curtis
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DK0489116T3 publication Critical patent/DK0489116T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK90914297.8T 1989-08-22 1990-08-14 Fusionsproteiner omfattende GM-CSF og IL-3 DK0489116T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39714689A 1989-08-22 1989-08-22

Publications (1)

Publication Number Publication Date
DK0489116T3 true DK0489116T3 (da) 1994-05-02

Family

ID=23570012

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90914297.8T DK0489116T3 (da) 1989-08-22 1990-08-14 Fusionsproteiner omfattende GM-CSF og IL-3

Country Status (11)

Country Link
EP (1) EP0489116B1 (da)
JP (1) JP3115318B2 (da)
AT (1) ATE103932T1 (da)
AU (1) AU632372B2 (da)
DD (1) DD297188A5 (da)
DE (1) DE69007975T2 (da)
DK (1) DK0489116T3 (da)
ES (1) ES2055445T3 (da)
FI (1) FI920764A0 (da)
NO (1) NO301888B1 (da)
WO (1) WO1991002754A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0546124T4 (da) * 1990-08-29 2003-05-19 Inst Genetics Llc Hæmatopoiese-stimulatorer med flere domæner
EP0503050A4 (en) * 1990-09-28 1994-07-06 Ortho Pharma Corp Hybrid growth factors
EP0573551B1 (en) * 1991-02-27 2003-05-21 Micromet AG Serine-rich peptide linkers
EP0586549B1 (en) 1991-05-10 2000-09-20 Genentech, Inc. Selecting ligand agonists and antagonists
US5856115A (en) * 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
DE69227693T2 (de) * 1991-08-30 1999-07-22 Fred Hutchinson Cancer Research Center, Seattle, Wash. Hybride cytokine
FR2686900B1 (fr) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US6361977B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Methods of using multivariant IL-3 hematopoiesis fusion protein
DE69332908T2 (de) * 1992-11-24 2003-12-24 G.D. Searle & Co., Chicago Interleukin-3 (il-3)-polypeptide mith mehreren mutationen
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US5679546A (en) * 1993-09-24 1997-10-21 Cytomed, Inc. Chimeric proteins which block complement activation
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
WO1996001903A1 (en) * 1994-07-07 1996-01-25 Immunex Corporation Fusion proteins comprising gm-csf and antigens and their expression in yeast
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US20100209341A1 (en) 2009-02-18 2010-08-19 Csl Limited Treatment of chronic inflammatory conditions
JP2013519689A (ja) * 2010-02-18 2013-05-30 シーエスエル、リミテッド 慢性炎症状態の治療
AU2013211059B8 (en) 2012-01-20 2017-12-21 Centre Hospitalier Regional Universitaire De Montpellier Targeted mutant alpha-helical bundle cytokines
CN105705641B (zh) * 2013-07-18 2021-07-13 弗拉芒区生物技术研究所 涉及具有强烈降低的受体结合亲和力的细胞因子的融合因子
CA2918363C (en) 2013-07-19 2021-12-14 Centre Hospitalier Regional Universitaire De Montpellier Targeted modified tnf family members
SG11201600165WA (en) 2013-07-19 2016-02-26 Vib Vzw Targeting of cytokine antagonists
US9932409B2 (en) 2013-07-19 2018-04-03 Vib Vzw Targeted modified IL-1 family members
JP6067540B2 (ja) * 2013-11-07 2017-01-25 日本曹達株式会社 防蟻性能試験用器具
WO2017077382A1 (en) 2015-11-06 2017-05-11 Orionis Biosciences Nv Bi-functional chimeric proteins and uses thereof
CN109071632B (zh) 2016-02-05 2022-12-30 奥里尼斯生物科学私人有限公司 靶向性治疗剂及其用途
US11661455B2 (en) 2016-02-05 2023-05-30 Orionis Biosciences BV Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety
JP2019507762A (ja) 2016-03-07 2019-03-22 ブイアイビー ブイゼットダブリュー Ｃｄ２０結合単一ドメイン抗体
WO2017194782A2 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Therapeutic targeting of non-cellular structures
WO2017194783A1 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Targeted mutant interferon-beta and uses thereof
CN110114368B (zh) 2016-10-24 2024-08-02 奥睿尼斯生物科学私人有限公司 靶向突变干扰素-γ及其用途
EP3576765A4 (en) 2017-02-06 2020-12-02 Orionis Biosciences, Inc. TARGETED ENGINEERING INTERFERON AND USES OF IT
CN110546160A (zh) 2017-02-06 2019-12-06 奥里尼斯生物科学公司 靶向嵌合蛋白及其用途
EP3580230A1 (en) 2017-02-07 2019-12-18 VIB vzw Immune-cell targeted bispecific chimeric proteins and uses thereof
EP3664829A4 (en) 2017-08-09 2021-05-05 Orionis Biosciences, Inc. LIAISON OFFICERS AT PD-1 AND PD-L1
EP3665303A4 (en) 2017-08-09 2021-04-28 Orionis Biosciences, Inc. CLEC9A BINDING INGREDIENTS AND USES THEREOF
WO2019032661A1 (en) 2017-08-09 2019-02-14 Orionis Biosciences Inc. CD8 LIAISON AGENTS
EP3833391A4 (en) 2018-08-08 2022-08-10 Orionis Biosciences, Inc. CHIMERIC PROTEINS TARGETED AT SIRP1alpha AND THEIR USES
JP2022534837A (ja) 2019-03-28 2022-08-04 オリオニス バイオサイエンシズ，インコーポレイテッド 治療用インターフェロンアルファ１タンパク質

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0167548B1 (en) * 1983-12-23 1993-02-10 The Australian National University Cloning of cdna and expression of murine-interleukin-3
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
DE3712985A1 (de) * 1987-04-16 1988-11-03 Hoechst Ag Bifunktionelle proteine
EP0276846A3 (en) * 1987-01-29 1989-07-26 Zymogenetics, Inc. Colony-stimulating factor derivatives
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".

Also Published As

Publication number Publication date
JP3115318B2 (ja) 2000-12-04
EP0489116A1 (en) 1992-06-10
JPH05500806A (ja) 1993-02-18
FI920764A0 (fi) 1992-02-21
AU6424090A (en) 1991-04-03
DD297188A5 (de) 1992-01-02
WO1991002754A1 (en) 1991-03-07
NO920703D0 (no) 1992-02-21
NO301888B1 (no) 1997-12-22
DE69007975T2 (de) 1994-07-21
ATE103932T1 (de) 1994-04-15
ES2055445T3 (es) 1994-08-16
DE69007975D1 (de) 1994-05-11
NO920703L (no) 1992-04-14
AU632372B2 (en) 1992-12-24
EP0489116B1 (en) 1994-04-06

Similar Documents

Publication Publication Date Title
DK0489116T3 (da) Fusionsproteiner omfattende GM-CSF og IL-3
MX9203426A (es) Proteinas de fusion que comprenden gm-csf e il-3.
IS5887A (is) Interferón-beta bræðsluprótín og notkun þeirra
ATE339507T1 (de) Erythropoietin-analog-menschliches serum-albumin fusionsprotein
ES2031806T3 (es) Factor de permeabilidad vascular humano.
NO20071415L (no) OB-fusjonsproteinpreparater og fremgangsmater
TR199600357A2 (tr) Rekombinant simanlik (Ob) proteinleri.
DE68917323D1 (de) Expressions-Vektor für Fusions-Proteine und Immunogen-Proteine.
NO953882D0 (no) Biologisk aktive polypeptidfusjonsdimerer
DE69015372D1 (de) Protein-testverfahren.
DE68925304D1 (de) Minimale Derivatisierung von Proteinen
NO905561D0 (no) Proteiner og nukleinsyrer.
NO924165D0 (no) Proteasedefisiente bakterieverter
NO881502L (no) Rekombinante htlv-111-proteiner og anvendelser av disse.
MY114223A (en) Fusion proteins comprising gm-csf and il-3
NO891926D0 (no) Fremgangsmaate for fremstilling av stabile protein- eller peptidpreparater.
FI942467A (fi) Proteesivakaat proteiinit
DE59008693D1 (de) Gewebs-Plasminogen-Aktivator-Derivat.
NO891485D0 (no) Fremgangsmaate til fremstilling av 22 kd-sgh-protein og lineaer genevektor.
ITRM920517A0 (it) Procedimento di produzione della proteina sv-iv ricombinante e proteina sv-iv ricombinante.
NO882836L (no) Fremgangsmaate for kjemisk modifisering av protider (proteiner og peptider).
IT9047978A0 (it) Derivato biamminato della proteina sv-iv e procedimento per la sua preparazione.
NO893572L (no) Lunge-overflateaktivt protein og beslektet polypeptid.
DK362088D0 (da) Fusionsproteiner og fusionsproteinpartikler
DK13093D0 (da) Processing of proteins