DK0482208T3 - Pyridazinonderivat - Google Patents
PyridazinonderivatInfo
- Publication number
- DK0482208T3 DK0482208T3 DK91907712T DK91907712T DK0482208T3 DK 0482208 T3 DK0482208 T3 DK 0482208T3 DK 91907712 T DK91907712 T DK 91907712T DK 91907712 T DK91907712 T DK 91907712T DK 0482208 T3 DK0482208 T3 DK 0482208T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridazinone derivatives
- salt
- vasodilatory
- cardiotonic
- srs
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10991490 | 1990-04-25 | ||
| PCT/JP1991/000517 WO1991016314A1 (en) | 1990-04-25 | 1991-04-19 | Pyridazinone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0482208T3 true DK0482208T3 (da) | 2000-09-18 |
Family
ID=14522343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91907712T DK0482208T3 (da) | 1990-04-25 | 1991-04-19 | Pyridazinonderivat |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5202323A (cs) |
| EP (1) | EP0482208B1 (cs) |
| JP (1) | JPH07107055B2 (cs) |
| KR (1) | KR970002876B1 (cs) |
| AT (1) | ATE194835T1 (cs) |
| AU (1) | AU634655B2 (cs) |
| CA (1) | CA2053863C (cs) |
| DE (1) | DE69132329T2 (cs) |
| DK (1) | DK0482208T3 (cs) |
| ES (1) | ES2149761T3 (cs) |
| GR (1) | GR3034331T3 (cs) |
| HU (1) | HU208124B (cs) |
| RU (1) | RU2054004C1 (cs) |
| TW (1) | TW204348B (cs) |
| UA (1) | UA27031A1 (cs) |
| WO (1) | WO1991016314A1 (cs) |
| ZA (1) | ZA913134B (cs) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0482208T3 (da) * | 1990-04-25 | 2000-09-18 | Nissan Chemical Ind Ltd | Pyridazinonderivat |
| US5403590A (en) * | 1992-12-21 | 1995-04-04 | New England Deaconess Hospital Corporation | Method of pulsatile drug infusion |
| JP3080131B2 (ja) | 1993-06-29 | 2000-08-21 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| IL110040A (en) * | 1993-06-29 | 2000-07-16 | Nissan Chemical Ind Ltd | Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them |
| US5763439A (en) * | 1993-09-06 | 1998-06-09 | Ishihara Sangyo Kaisha Ltd. | Pyridazinone derivatives or their salts, processes for their production, and anti-shock agents containing them |
| NZ270130A (en) * | 1993-12-16 | 1995-12-21 | Nihon Nohyaku Co Ltd | Pyridazinone derivatives, preparation and pharmaceutical compositions thereof |
| DE69516849T2 (de) * | 1994-01-25 | 2000-10-12 | Nissan Chemical Industries, Ltd. | Pyridazinon-derivate |
| IL112695A (en) * | 1994-02-22 | 1999-04-11 | Green Cross Corp | Pharmaceutical compositions containing pyridazinone derivatives |
| GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
| US5670504A (en) * | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
| HU223093B1 (hu) | 1996-06-27 | 2004-03-29 | Janssen Pharmaceutica N.V. | N-[4-(heteroaril-metil)-fenil]-heteroaril-amin-származékok, előállításuk és a vegyületeket tartalmazó gyógyászati készítmények |
| TW482675B (en) * | 1997-01-31 | 2002-04-11 | Green Cross Corp | Compositions for oral administration containing pyridazinone compounds technical field of the invention |
| AU8886298A (en) * | 1997-08-28 | 1999-03-22 | Nissan Chemical Industries Ltd. | Neovascularization promoters and neovascularization potentiators |
| RU2211217C2 (ru) * | 1998-06-05 | 2003-08-27 | Эгиш Дьёдьсердьяр Рт. | Способ получения 5-хлор-4-аминозамещенного производного 3(2н)-пиридазинона |
| US6369061B1 (en) * | 1998-09-01 | 2002-04-09 | Mitsubishi Pharma Corporation | Therapeutic agent for spinal canal stenosis |
| CZ20012020A3 (cs) * | 1998-12-07 | 2001-10-17 | Nissan Chemical Industries, Ltd. | Činidlo pro léčbu erektilní dysfunkce |
| DE20009841U1 (de) * | 2000-05-31 | 2001-10-25 | Phyt-Immun GmbH, 66424 Homburg | Nasensalbe auf Basis von Vaselin |
| PL365441A1 (en) * | 2001-04-05 | 2005-01-10 | Torrent Pharmaceuticals Ltd. | Heterocyclic compounds for aging-related and diabetic vascular complications |
| US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
| US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
| WO2002094321A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Compositions for promoting healing of bone fracture |
| KR20040007583A (ko) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 연골 질환의 재생치료용 조성물 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| RU2313339C2 (ru) * | 2003-09-09 | 2007-12-27 | Фумафарм Аг | Применение производных фумаровой кислоты для лечения сердечной недостаточности и астмы |
| BRPI0417200A (pt) * | 2003-12-26 | 2007-02-06 | Nissan Chemical Ind Ltd | agente antineutrofilia |
| EP1714654A4 (en) * | 2004-02-09 | 2011-02-16 | Nissan Chemical Ind Ltd | MEDICAMENT FOR INHIBITING VASCULAR INTIMATE HYPERPLASIA |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JPWO2010074090A1 (ja) * | 2008-12-25 | 2012-06-21 | 日産化学工業株式会社 | ピリダジン−３（２ｈ）−オン化合物塩酸塩の結晶及びその製造方法 |
| CN102482278B (zh) | 2009-06-29 | 2015-04-22 | 因塞特公司 | 作为pi3k抑制剂的嘧啶酮类 |
| US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| US8680108B2 (en) * | 2009-12-18 | 2014-03-25 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| JP5699339B2 (ja) | 2010-02-12 | 2015-04-08 | 日産化学工業株式会社 | 徐放性製剤 |
| EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| EP2681236B1 (en) | 2011-03-01 | 2018-01-03 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| EP3196202B1 (en) | 2011-09-02 | 2019-02-27 | Incyte Holdings Corporation | Heterocyclylamines as pi3k inhibitors |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| MX375926B (es) | 2013-08-09 | 2025-03-07 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
| LT3030549T (lt) | 2013-09-12 | 2019-06-25 | Janssen Biopharma, Inc. | Piridazinono junginiai ir jų panaudojimas |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| HRP20210036T1 (hr) | 2015-02-27 | 2021-03-05 | Incyte Corporation | Soli inhibitora pi3k i postupci za njihovo dobivanje |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN107793362B (zh) * | 2016-08-30 | 2022-04-22 | 江苏恩华药业股份有限公司 | 一种苯基哒嗪酮类衍生物的合成及其应用 |
| SG11202011680YA (en) | 2018-06-01 | 2020-12-30 | Incyte Corp | Dosing regimen for the treatment of pi3k related disorders |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2534893A1 (de) * | 1975-08-05 | 1977-02-17 | Bayer Ag | (thiono)(thiol)pyridazinonalkanphosphonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide |
| CA1265798A (en) * | 1984-12-10 | 1990-02-13 | Motoo Mutsukado | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| ZW20586A1 (en) * | 1985-10-17 | 1988-05-25 | Smith Kline French Lab | Chemical compounds |
| US4978665A (en) * | 1987-01-20 | 1990-12-18 | Nissan Chemical Industries Ltd. | 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it |
| JP2550631B2 (ja) * | 1987-01-20 | 1996-11-06 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| JPH02256668A (ja) * | 1988-12-20 | 1990-10-17 | Nissan Chem Ind Ltd | ピリダジノン誘導体 |
| DK0482208T3 (da) * | 1990-04-25 | 2000-09-18 | Nissan Chemical Ind Ltd | Pyridazinonderivat |
-
1991
- 1991-04-19 DK DK91907712T patent/DK0482208T3/da active
- 1991-04-19 DE DE69132329T patent/DE69132329T2/de not_active Expired - Lifetime
- 1991-04-19 AU AU76511/91A patent/AU634655B2/en not_active Expired
- 1991-04-19 KR KR1019910701537A patent/KR970002876B1/ko not_active Expired - Lifetime
- 1991-04-19 RU SU915010505A patent/RU2054004C1/ru active
- 1991-04-19 JP JP3-507543A patent/JPH07107055B2/ja not_active Expired - Lifetime
- 1991-04-19 US US07/768,182 patent/US5202323A/en not_active Expired - Fee Related
- 1991-04-19 ES ES91907712T patent/ES2149761T3/es not_active Expired - Lifetime
- 1991-04-19 WO PCT/JP1991/000517 patent/WO1991016314A1/ja not_active Ceased
- 1991-04-19 UA UA5010505A patent/UA27031A1/uk unknown
- 1991-04-19 EP EP91907712A patent/EP0482208B1/en not_active Expired - Lifetime
- 1991-04-19 AT AT91907712T patent/ATE194835T1/de not_active IP Right Cessation
- 1991-04-19 CA CA002053863A patent/CA2053863C/en not_active Expired - Lifetime
- 1991-04-19 HU HU913497A patent/HU208124B/hu unknown
- 1991-04-23 TW TW080103191A patent/TW204348B/zh not_active IP Right Cessation
- 1991-04-25 ZA ZA913134A patent/ZA913134B/xx unknown
-
1992
- 1992-12-21 US US07/994,413 patent/US5318968A/en not_active Expired - Fee Related
- 1992-12-21 US US07/994,404 patent/US5314883A/en not_active Expired - Lifetime
-
2000
- 2000-09-05 GR GR20000402019T patent/GR3034331T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5318968A (en) | 1994-06-07 |
| HUT60253A (en) | 1992-08-28 |
| KR970002876B1 (ko) | 1997-03-12 |
| KR920701169A (ko) | 1992-08-11 |
| DE69132329T2 (de) | 2000-11-30 |
| CA2053863A1 (en) | 1991-10-26 |
| CA2053863C (en) | 1996-10-29 |
| ES2149761T3 (es) | 2000-11-16 |
| HU913497D0 (en) | 1992-01-28 |
| US5202323A (en) | 1993-04-13 |
| AU634655B2 (en) | 1993-02-25 |
| RU2054004C1 (ru) | 1996-02-10 |
| EP0482208A4 (en) | 1992-10-07 |
| JPH07107055B1 (cs) | 1995-11-15 |
| HU208124B (en) | 1993-08-30 |
| AU7651191A (en) | 1991-11-11 |
| US5314883A (en) | 1994-05-24 |
| UA27031A1 (uk) | 2000-02-28 |
| ZA913134B (en) | 1992-04-29 |
| JPH07107055B2 (ja) | 1995-11-15 |
| TW204348B (cs) | 1993-04-21 |
| EP0482208B1 (en) | 2000-07-19 |
| DE69132329D1 (de) | 2000-08-24 |
| ATE194835T1 (de) | 2000-08-15 |
| WO1991016314A1 (en) | 1991-10-31 |
| EP0482208A1 (en) | 1992-04-29 |
| GR3034331T3 (en) | 2000-12-29 |
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